Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines

Journal of Biological Chemistry

Volumn 280, Issue 31, 2005, Pages 28394-28401

  Braun, Hannes A ^a   Umbreen, Sumaira ^a   Groll, Michael ^b   Kuckelkorn, Ulrike ^c   Mlynarczuk, Izabela ^c,d   Wigand, Moritz E ^c   Drung, Ilse ^c   Kloetzel, Peter Michael ^c   Schmidt, Boris ^a  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; DRUG PRODUCTS; HYDROLYSIS; MOLECULAR BIOLOGY; POLYPEPTIDES; PROTEINS; TUMORS;

INHIBITORY EFFECTS; INTRACELLULAR REDUCTION; NEOPLASTIC GROWTH; PROTEASOMES;

BIOMIMETIC MATERIALS;

7 AMINOMETHYLCOUMARIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; CASPASE; CHYMOTRYPSIN; COUMARIN; EPOXOMICIN; LACTACYSTIN; PROTEASOME; PROTEASOME INHIBITOR; THREONINE; TMC 95A; TRIPEPTIDE; TRYPSIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER THERAPY; CELL CYCLE; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ERYTHROCYTES; HUMANS; KINETICS; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CONFORMATION; THREONINE;

EID: 23344435097     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M502453200     Document Type: Article

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