메뉴 건너뛰기




Volumn 30, Issue 1, 2014, Pages 54-62

The cross talk between microbiota and the immune system: Metabolites take center stage

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARGINASE 1; ARGININE; ASCORBIC ACID; BILE ACID; CARNITINE; CYANOCOBALAMIN; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR; G PROTEIN COUPLED RECEPTOR; HISTONE DEACETYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LONG CHAIN FATTY ACID; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYSACCHARIDE; RETINOL; SHORT CHAIN FATTY ACID; VITAMIN; VITAMIN B GROUP; FATTY ACID;

EID: 84904892129     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2014.07.003     Document Type: Review
Times cited : (144)

References (114)
  • 1
    • 84876414806 scopus 로고    scopus 로고
    • The gut microbiota-masters of host development and physiology
    • Sommer F., Backhed F. The gut microbiota-masters of host development and physiology. Nat Rev Microbiol 2013, 11:227-238.
    • (2013) Nat Rev Microbiol , vol.11 , pp. 227-238
    • Sommer, F.1    Backhed, F.2
  • 2
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper L.V., Littman D.R., Macpherson A.J. Interactions between the microbiota and the immune system. Science 2012, 336:1268-1273.
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 3
    • 84888084911 scopus 로고    scopus 로고
    • The interplay between the innate immune system and the microbiota
    • Thaiss C.A., et al. The interplay between the innate immune system and the microbiota. Curr Opin Immunol 2014, 26:41-48.
    • (2014) Curr Opin Immunol , vol.26 , pp. 41-48
    • Thaiss, C.A.1
  • 4
    • 84892828465 scopus 로고    scopus 로고
    • Diet rapidly and reproducibly alters the human gut microbiome
    • David L.A., et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014, 505:559-563.
    • (2014) Nature , vol.505 , pp. 559-563
    • David, L.A.1
  • 5
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • Maslowski K.M., et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 2009, 461:1282-1286.
    • (2009) Nature , vol.461 , pp. 1282-1286
    • Maslowski, K.M.1
  • 6
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith P.M., et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013, 341:569-573.
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1
  • 7
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • Arpaia N., et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 2013, 504:451-455.
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1
  • 8
    • 84893859801 scopus 로고    scopus 로고
    • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    • Chang P.V., et al. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A 2014, 111:2247-2252.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 2247-2252
    • Chang, P.V.1
  • 9
    • 84892449521 scopus 로고    scopus 로고
    • Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
    • Singh N., et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 2014, 40:128-139.
    • (2014) Immunity , vol.40 , pp. 128-139
    • Singh, N.1
  • 10
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav E., et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011, 145:745-757.
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1
  • 11
    • 77952303410 scopus 로고    scopus 로고
    • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
    • Allen I.C., et al. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med 2010, 207:1045-1056.
    • (2010) J Exp Med , vol.207 , pp. 1045-1056
    • Allen, I.C.1
  • 12
    • 77955350419 scopus 로고    scopus 로고
    • MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18
    • Salcedo R., et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med 2010, 207:1625-1636.
    • (2010) J Exp Med , vol.207 , pp. 1625-1636
    • Salcedo, R.1
  • 13
    • 77950002937 scopus 로고    scopus 로고
    • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    • Zaki M.H., et al. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 2010, 32:379-391.
    • (2010) Immunity , vol.32 , pp. 379-391
    • Zaki, M.H.1
  • 14
    • 79955579989 scopus 로고    scopus 로고
    • The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
    • Donohoe D.R., et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab 2011, 13:517-526.
    • (2011) Cell Metab , vol.13 , pp. 517-526
    • Donohoe, D.R.1
  • 15
    • 84893704050 scopus 로고    scopus 로고
    • Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
    • Trompette A., et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 2014, 20:159-166.
    • (2014) Nat Med , vol.20 , pp. 159-166
    • Trompette, A.1
  • 16
    • 84922270328 scopus 로고    scopus 로고
    • Omega-3 fatty acids: cardiovascular benefits, sources and sustainability
    • Lee J.H., et al. Omega-3 fatty acids: cardiovascular benefits, sources and sustainability. Nat Rev Cardiol 2009, 6:753-758.
    • (2009) Nat Rev Cardiol , vol.6 , pp. 753-758
    • Lee, J.H.1
  • 17
    • 33947124087 scopus 로고    scopus 로고
    • Metabolism of linoleic acid by human gut bacteria: different routes for biosynthesis of conjugated linoleic acid
    • Devillard E., et al. Metabolism of linoleic acid by human gut bacteria: different routes for biosynthesis of conjugated linoleic acid. J Bacteriol 2007, 189:2566-2570.
    • (2007) J Bacteriol , vol.189 , pp. 2566-2570
    • Devillard, E.1
  • 18
    • 77955553302 scopus 로고    scopus 로고
    • Production of conjugated linoleic acid and conjugated linolenic acid isomers by Bifidobacterium species
    • Gorissen L., et al. Production of conjugated linoleic acid and conjugated linolenic acid isomers by Bifidobacterium species. Appl Microbiol Biotechnol 2010, 87:2257-2266.
    • (2010) Appl Microbiol Biotechnol , vol.87 , pp. 2257-2266
    • Gorissen, L.1
  • 19
    • 61449248271 scopus 로고    scopus 로고
    • Mechanism of conjugated linoleic acid and vaccenic acid formation in human faecal suspensions and pure cultures of intestinal bacteria
    • Mcintosh F.M., et al. Mechanism of conjugated linoleic acid and vaccenic acid formation in human faecal suspensions and pure cultures of intestinal bacteria. Microbiology 2009, 155:285-294.
    • (2009) Microbiology , vol.155 , pp. 285-294
    • Mcintosh, F.M.1
  • 20
    • 65549108323 scopus 로고    scopus 로고
    • Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues
    • Wall R., et al. Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues. Am J Clin Nutr 2009, 89:1393-1401.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1393-1401
    • Wall, R.1
  • 21
    • 84887122496 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition
    • Kishino S., et al. Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci U S A 2013, 110:17808-17813.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 17808-17813
    • Kishino, S.1
  • 22
    • 70449726656 scopus 로고    scopus 로고
    • Trans-10,cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats
    • Gudbrandsen O.A., et al. Trans-10,cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats. Br J Nutr 2009, 102:803-815.
    • (2009) Br J Nutr , vol.102 , pp. 803-815
    • Gudbrandsen, O.A.1
  • 23
    • 33744511921 scopus 로고    scopus 로고
    • Profound resolution of early atherosclerosis with conjugated linoleic acid
    • Toomey S., et al. Profound resolution of early atherosclerosis with conjugated linoleic acid. Atherosclerosis 2006, 187:40-49.
    • (2006) Atherosclerosis , vol.187 , pp. 40-49
    • Toomey, S.1
  • 24
    • 51349100657 scopus 로고    scopus 로고
    • Structural basis for the activation of PPARgamma by oxidized fatty acids
    • Itoh T., et al. Structural basis for the activation of PPARgamma by oxidized fatty acids. Nat Struct Mol Biol 2008, 15:924-931.
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 924-931
    • Itoh, T.1
  • 25
    • 0032796505 scopus 로고    scopus 로고
    • Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha
    • Moya-Camarena S.Y., et al. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. J Lipid Res 1999, 40:1426-1433.
    • (1999) J Lipid Res , vol.40 , pp. 1426-1433
    • Moya-Camarena, S.Y.1
  • 26
    • 41149098050 scopus 로고    scopus 로고
    • Enterococcus faecalis from newborn babies regulate endogenous PPARgamma activity and IL-10 levels in colonic epithelial cells
    • Are A., et al. Enterococcus faecalis from newborn babies regulate endogenous PPARgamma activity and IL-10 levels in colonic epithelial cells. Proc Natl Acad Sci U S A 2008, 105:1943-1948.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 1943-1948
    • Are, A.1
  • 27
    • 0347756655 scopus 로고    scopus 로고
    • Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA
    • Kelly D., et al. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat Immunol 2004, 5:104-112.
    • (2004) Nat Immunol , vol.5 , pp. 104-112
    • Kelly, D.1
  • 28
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • Ridlon J.M., Kang D.J., Hylemon P.B. Bile salt biotransformations by human intestinal bacteria. J Lipid Res 2006, 47:241-259.
    • (2006) J Lipid Res , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.J.2    Hylemon, P.B.3
  • 29
    • 48749113401 scopus 로고    scopus 로고
    • Targeting bile-acid signalling for metabolic diseases
    • Thomas C., et al. Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov 2008, 7:678-693.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 678-693
    • Thomas, C.1
  • 30
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: regulation of synthesis
    • Chiang J.Y. Bile acids: regulation of synthesis. J Lipid Res 2009, 50:1955-1966.
    • (2009) J Lipid Res , vol.50 , pp. 1955-1966
    • Chiang, J.Y.1
  • 31
    • 0016357193 scopus 로고
    • Microbial bile acid transformation
    • Midtvedt T. Microbial bile acid transformation. Am J Clin Nutr 1974, 27:1341-1347.
    • (1974) Am J Clin Nutr , vol.27 , pp. 1341-1347
    • Midtvedt, T.1
  • 32
    • 53949089441 scopus 로고    scopus 로고
    • Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes
    • Claus S.P., et al. Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes. Mol Syst Biol 2008, 4:p219.
    • (2008) Mol Syst Biol , vol.4
    • Claus, S.P.1
  • 33
    • 84869503270 scopus 로고    scopus 로고
    • Enterobacteria-mediated deconjugation of taurocholic acid enhances ileal farnesoid X receptor signaling
    • Kuribayashi H., et al. Enterobacteria-mediated deconjugation of taurocholic acid enhances ileal farnesoid X receptor signaling. Eur J Pharmacol 2012, 697:132-138.
    • (2012) Eur J Pharmacol , vol.697 , pp. 132-138
    • Kuribayashi, H.1
  • 34
    • 84873342775 scopus 로고    scopus 로고
    • Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
    • Sayin S.I., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 2013, 17:225-235.
    • (2013) Cell Metab , vol.17 , pp. 225-235
    • Sayin, S.I.1
  • 35
    • 79952749979 scopus 로고    scopus 로고
    • Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
    • Swann J.R., et al. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc Natl Acad Sci U S A 2011, 108(Suppl. 1):4523-4530.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.SUPPL. 1 , pp. 4523-4530
    • Swann, J.R.1
  • 36
    • 33644867569 scopus 로고    scopus 로고
    • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    • Inagaki T., et al. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A 2006, 103:3920-3925.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3920-3925
    • Inagaki, T.1
  • 37
    • 84883478660 scopus 로고    scopus 로고
    • Gut microbiota from twins discordant for obesity modulate metabolism in mice
    • Ridaura V.K., et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 2013, 341:1241214.
    • (2013) Science , vol.341 , pp. 1241214
    • Ridaura, V.K.1
  • 38
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • Yoshimoto S., et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 2013, 499:97-101.
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1
  • 39
    • 77149159568 scopus 로고    scopus 로고
    • The bile acid receptor FXR is a modulator of intestinal innate immunity
    • Vavassori P., et al. The bile acid receptor FXR is a modulator of intestinal innate immunity. J Immunol 2009, 183:6251-6261.
    • (2009) J Immunol , vol.183 , pp. 6251-6261
    • Vavassori, P.1
  • 40
    • 80053308007 scopus 로고    scopus 로고
    • The G-protein-coupled bile acid receptor Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-kappaB) in mice
    • Wang Y.D., et al. The G-protein-coupled bile acid receptor Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-kappaB) in mice. Hepatology 2011, 54:1421-1432.
    • (2011) Hepatology , vol.54 , pp. 1421-1432
    • Wang, Y.D.1
  • 41
    • 82955168360 scopus 로고    scopus 로고
    • TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
    • Pols T.W., et al. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab 2011, 14:747-757.
    • (2011) Cell Metab , vol.14 , pp. 747-757
    • Pols, T.W.1
  • 42
    • 78650666211 scopus 로고    scopus 로고
    • The role of the transcription factor CREB in immune function
    • Wen A.Y., Sakamoto K.M., Miller L.S. The role of the transcription factor CREB in immune function. J Immunol 2010, 185:6413-6419.
    • (2010) J Immunol , vol.185 , pp. 6413-6419
    • Wen, A.Y.1    Sakamoto, K.M.2    Miller, L.S.3
  • 43
    • 84876896348 scopus 로고    scopus 로고
    • Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease
    • Mcmahan R.H., et al. Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J Biol Chem 2013, 288:11761-11770.
    • (2013) J Biol Chem , vol.288 , pp. 11761-11770
    • Mcmahan, R.H.1
  • 44
    • 79952535597 scopus 로고    scopus 로고
    • Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
    • Gadaleta R.M., et al. Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 2011, 60:463-472.
    • (2011) Gut , vol.60 , pp. 463-472
    • Gadaleta, R.M.1
  • 45
    • 77952674868 scopus 로고    scopus 로고
    • The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis
    • Mencarelli A., et al. The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis. J Immunol 2009, 183:6657-6666.
    • (2009) J Immunol , vol.183 , pp. 6657-6666
    • Mencarelli, A.1
  • 46
    • 84863436944 scopus 로고    scopus 로고
    • -/- mice
    • -/- mice. Nature 2012, 487:104-108.
    • (2012) Nature , vol.487 , pp. 104-108
    • Devkota, S.1
  • 47
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian S.K., et al. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005, 122:107-118.
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1
  • 48
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • Mazmanian S.K., Round J.L., Kasper D.L. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008, 453:620-625.
    • (2008) Nature , vol.453 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 49
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • Round J.L., et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 2011, 332:974-977.
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1
  • 50
    • 79952748674 scopus 로고    scopus 로고
    • Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
    • Lee Y.K., et al. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2011, 108(Suppl. 1):4615-4622.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.SUPPL. 1 , pp. 4615-4622
    • Lee, Y.K.1
  • 51
    • 77958119730 scopus 로고    scopus 로고
    • Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression
    • Ochoa-Reparaz J., et al. Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression. J Immunol 2010, 185:4101-4108.
    • (2010) J Immunol , vol.185 , pp. 4101-4108
    • Ochoa-Reparaz, J.1
  • 52
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • Hsiao E.Y., et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013, 155:1451-1463.
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1
  • 53
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: a new therapeutic target in cancer
    • Wise D.R., Thompson C.B. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci 2010, 35:427-433.
    • (2010) Trends Biochem Sci , vol.35 , pp. 427-433
    • Wise, D.R.1    Thompson, C.B.2
  • 54
    • 84880876347 scopus 로고    scopus 로고
    • Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism
    • Fendt S.M., et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res 2013, 73:4429-4438.
    • (2013) Cancer Res , vol.73 , pp. 4429-4438
    • Fendt, S.M.1
  • 55
    • 84856014884 scopus 로고    scopus 로고
    • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    • Metallo C.M., et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2012, 481:380-384.
    • (2012) Nature , vol.481 , pp. 380-384
    • Metallo, C.M.1
  • 56
    • 84887027984 scopus 로고    scopus 로고
    • Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain
    • Harvey R.J., Yee B.K. Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. Nat Rev Drug Discov 2013, 12:866-885.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 866-885
    • Harvey, R.J.1    Yee, B.K.2
  • 57
    • 0033519278 scopus 로고    scopus 로고
    • Inhibition of T cell proliferation by macrophage tryptophan catabolism
    • Munn D.H., et al. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 1999, 189:1363-1372.
    • (1999) J Exp Med , vol.189 , pp. 1363-1372
    • Munn, D.H.1
  • 58
    • 84864270714 scopus 로고    scopus 로고
    • ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
    • Hashimoto T., et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 2012, 487:477-481.
    • (2012) Nature , vol.487 , pp. 477-481
    • Hashimoto, T.1
  • 59
    • 34748835898 scopus 로고    scopus 로고
    • IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation
    • Puccetti P., Grohmann U. IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation. Nat Rev Immunol 2007, 7:817-823.
    • (2007) Nat Rev Immunol , vol.7 , pp. 817-823
    • Puccetti, P.1    Grohmann, U.2
  • 60
    • 84882664672 scopus 로고    scopus 로고
    • Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
    • Zelante T., et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity 2013, 39:372-385.
    • (2013) Immunity , vol.39 , pp. 372-385
    • Zelante, T.1
  • 61
    • 84855917402 scopus 로고    scopus 로고
    • AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
    • Lee J.S., et al. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol 2012, 13:144-151.
    • (2012) Nat Immunol , vol.13 , pp. 144-151
    • Lee, J.S.1
  • 62
    • 84856237141 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
    • Qiu J., et al. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity 2012, 36:92-104.
    • (2012) Immunity , vol.36 , pp. 92-104
    • Qiu, J.1
  • 63
    • 77952977625 scopus 로고    scopus 로고
    • Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    • 32ra36
    • Favre D., et al. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med 2010, 2. 32ra36.
    • (2010) Sci Transl Med , vol.2
    • Favre, D.1
  • 64
    • 0031900585 scopus 로고    scopus 로고
    • Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients
    • Huengsberg M., et al. Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients. Clin Chem 1998, 44:858-862.
    • (1998) Clin Chem , vol.44 , pp. 858-862
    • Huengsberg, M.1
  • 65
    • 71749103051 scopus 로고    scopus 로고
    • Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis
    • Desvignes L., Ernst J.D. Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis. Immunity 2009, 31:974-985.
    • (2009) Immunity , vol.31 , pp. 974-985
    • Desvignes, L.1    Ernst, J.D.2
  • 66
    • 38049115134 scopus 로고    scopus 로고
    • Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    • Romani L., et al. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 2008, 451:211-215.
    • (2008) Nature , vol.451 , pp. 211-215
    • Romani, L.1
  • 67
    • 84865163472 scopus 로고    scopus 로고
    • Microbial translocation in HIV infection: causes, consequences and treatment opportunities
    • Sandler N.G., Douek D.C. Microbial translocation in HIV infection: causes, consequences and treatment opportunities. Nat Rev Microbiol 2012, 10:655-666.
    • (2012) Nat Rev Microbiol , vol.10 , pp. 655-666
    • Sandler, N.G.1    Douek, D.C.2
  • 68
    • 34249788716 scopus 로고    scopus 로고
    • Arginine metabolism: boundaries of our knowledge
    • Morris S.M. Arginine metabolism: boundaries of our knowledge. J Nutr 2007, 137(Suppl. 2):1602S-1609S.
    • (2007) J Nutr , vol.137 , Issue.SUPPL. 2
    • Morris, S.M.1
  • 69
    • 77954895585 scopus 로고    scopus 로고
    • Immunosupression and infection after major surgery: a nutritional deficiency
    • ix
    • Zhu X., Herrera G., Ochoa J.B. Immunosupression and infection after major surgery: a nutritional deficiency. Crit Care Clin 2010, 26:491-500. ix.
    • (2010) Crit Care Clin , vol.26 , pp. 491-500
    • Zhu, X.1    Herrera, G.2    Ochoa, J.B.3
  • 70
    • 0025210125 scopus 로고
    • Arginine and immune function
    • (discussion 59-62)
    • Barbul A. Arginine and immune function. Nutrition 1990, 6:53-58. (discussion 59-62).
    • (1990) Nutrition , vol.6 , pp. 53-58
    • Barbul, A.1
  • 71
    • 4143130091 scopus 로고    scopus 로고
    • Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
    • Rodriguez P.C., et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res 2004, 64:5839-5849.
    • (2004) Cancer Res , vol.64 , pp. 5839-5849
    • Rodriguez, P.C.1
  • 72
    • 33748127113 scopus 로고    scopus 로고
    • Suppression of T-cell functions by human granulocyte arginase
    • Munder M., et al. Suppression of T-cell functions by human granulocyte arginase. Blood 2006, 108:1627-1634.
    • (2006) Blood , vol.108 , pp. 1627-1634
    • Munder, M.1
  • 73
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
    • Koeth R.A., et al. Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013, 19:576-585.
    • (2013) Nat Med , vol.19 , pp. 576-585
    • Koeth, R.A.1
  • 74
    • 0030978427 scopus 로고    scopus 로고
    • Intestinal flora and endogenous vitamin synthesis
    • Hill M.J. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997, 6(Suppl. 1):S43-S45.
    • (1997) Eur J Cancer Prev , vol.6 , Issue.SUPPL. 1
    • Hill, M.J.1
  • 75
    • 0036186329 scopus 로고    scopus 로고
    • Microbial production of vitamin B12
    • Martens J.H., et al. Microbial production of vitamin B12. Appl Microbiol Biotechnol 2002, 58:275-285.
    • (2002) Appl Microbiol Biotechnol , vol.58 , pp. 275-285
    • Martens, J.H.1
  • 76
    • 0029658689 scopus 로고    scopus 로고
    • Cobalamin (coenzyme B12): synthesis and biological significance
    • Roth J.R., Lawrence J.G., Bobik T.A. Cobalamin (coenzyme B12): synthesis and biological significance. Annu Rev Microbiol 1996, 50:137-181.
    • (1996) Annu Rev Microbiol , vol.50 , pp. 137-181
    • Roth, J.R.1    Lawrence, J.G.2    Bobik, T.A.3
  • 77
    • 58149121764 scopus 로고    scopus 로고
    • Quantification of folic acid in human feces after administration of Bifidobacterium probiotic strains
    • Strozzi G.P., Mogna L. Quantification of folic acid in human feces after administration of Bifidobacterium probiotic strains. J Clin Gastroenterol 2008, 42(Suppl. 3):S179-S184.
    • (2008) J Clin Gastroenterol , vol.42 , Issue.SUPPL. 3
    • Strozzi, G.P.1    Mogna, L.2
  • 79
    • 33846166436 scopus 로고    scopus 로고
    • Folate production by bifidobacteria as a potential probiotic property
    • Pompei A., et al. Folate production by bifidobacteria as a potential probiotic property. Appl Environ Microbiol 2007, 73:179-185.
    • (2007) Appl Environ Microbiol , vol.73 , pp. 179-185
    • Pompei, A.1
  • 80
    • 70349544153 scopus 로고    scopus 로고
    • Probiotic and gut lactobacilli and bifidobacteria: molecular approaches to study diversity and activity
    • Kleerebezem M., Vaughan E.E. Probiotic and gut lactobacilli and bifidobacteria: molecular approaches to study diversity and activity. Annu Rev Microbiol 2009, 63:269-290.
    • (2009) Annu Rev Microbiol , vol.63 , pp. 269-290
    • Kleerebezem, M.1    Vaughan, E.E.2
  • 81
    • 84892928571 scopus 로고    scopus 로고
    • Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity
    • Spencer S.P., et al. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science 2014, 343:432-437.
    • (2014) Science , vol.343 , pp. 432-437
    • Spencer, S.P.1
  • 82
    • 0025089433 scopus 로고
    • Reduced mortality among children in southern India receiving a small weekly dose of vitamin A
    • Rahmathullah L., et al. Reduced mortality among children in southern India receiving a small weekly dose of vitamin A. N Engl J Med 1990, 323:929-935.
    • (1990) N Engl J Med , vol.323 , pp. 929-935
    • Rahmathullah, L.1
  • 83
    • 79960438236 scopus 로고    scopus 로고
    • The role of retinoic acid in tolerance and immunity
    • Hall J.A., et al. The role of retinoic acid in tolerance and immunity. Immunity 2011, 35:13-22.
    • (2011) Immunity , vol.35 , pp. 13-22
    • Hall, J.A.1
  • 84
    • 0037111380 scopus 로고    scopus 로고
    • Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion
    • Ertesvag A., et al. Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion. J Immunol 2002, 169:5555-5563.
    • (2002) J Immunol , vol.169 , pp. 5555-5563
    • Ertesvag, A.1
  • 85
    • 34247367589 scopus 로고    scopus 로고
    • Vitamin A potentiates CpG-mediated memory B-cell proliferation and differentiation: involvement of early activation of p38MAPK
    • Ertesvag A., et al. Vitamin A potentiates CpG-mediated memory B-cell proliferation and differentiation: involvement of early activation of p38MAPK. Blood 2007, 109:3865-3872.
    • (2007) Blood , vol.109 , pp. 3865-3872
    • Ertesvag, A.1
  • 86
    • 0031892614 scopus 로고    scopus 로고
    • The role of vitamin A and related retinoids in immune function
    • Semba R.D. The role of vitamin A and related retinoids in immune function. Nutr Rev 1998, 56:S38-S48.
    • (1998) Nutr Rev , vol.56
    • Semba, R.D.1
  • 87
    • 78650816072 scopus 로고    scopus 로고
    • Effects of vitamin A deficiency on mucosal immunity and response to intestinal infection in rats
    • Yang Y., et al. Effects of vitamin A deficiency on mucosal immunity and response to intestinal infection in rats. Nutrition 2011, 27:227-232.
    • (2011) Nutrition , vol.27 , pp. 227-232
    • Yang, Y.1
  • 88
    • 0022702519 scopus 로고
    • Assessment of lymphocyte function during vitamin A deficiency
    • Butera S.T., Krakowka S. Assessment of lymphocyte function during vitamin A deficiency. Am J Vet Res 1986, 47:850-855.
    • (1986) Am J Vet Res , vol.47 , pp. 850-855
    • Butera, S.T.1    Krakowka, S.2
  • 89
    • 0025374599 scopus 로고
    • Antibody production in vitamin A-depleted rats is impaired after immunization with bacterial polysaccharide or protein antigens
    • Pasatiempo A.M., et al. Antibody production in vitamin A-depleted rats is impaired after immunization with bacterial polysaccharide or protein antigens. FASEB J 1990, 4:2518-2527.
    • (1990) FASEB J , vol.4 , pp. 2518-2527
    • Pasatiempo, A.M.1
  • 90
    • 0023394233 scopus 로고
    • Contrasting impairments in IgM and IgG responses of vitamin A-deficient mice
    • Smith S.M., Hayes C.E. Contrasting impairments in IgM and IgG responses of vitamin A-deficient mice. Proc Natl Acad Sci U S A 1987, 84:5878-5882.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 5878-5882
    • Smith, S.M.1    Hayes, C.E.2
  • 91
    • 0027276857 scopus 로고
    • 9-Cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development
    • Yang Y., Vacchio M.S., Ashwell J.D. 9-Cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development. Proc Natl Acad Sci U S A 1993, 90:6170-6174.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6170-6174
    • Yang, Y.1    Vacchio, M.S.2    Ashwell, J.D.3
  • 92
    • 0026447129 scopus 로고
    • Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes
    • Iwata M., et al. Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes. J Immunol 1992, 149:3302-3308.
    • (1992) J Immunol , vol.149 , pp. 3302-3308
    • Iwata, M.1
  • 93
    • 0029671026 scopus 로고    scopus 로고
    • Vitamin A deficiency predisposes to Staphylococcus aureus infection
    • Wiedermann U., et al. Vitamin A deficiency predisposes to Staphylococcus aureus infection. Infect Immun 1996, 64:209-214.
    • (1996) Infect Immun , vol.64 , pp. 209-214
    • Wiedermann, U.1
  • 94
    • 5644300399 scopus 로고    scopus 로고
    • Retinoic acid imprints gut-homing specificity on T cells
    • Iwata M., et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004, 21:527-538.
    • (2004) Immunity , vol.21 , pp. 527-538
    • Iwata, M.1
  • 95
    • 0018844018 scopus 로고
    • The prevalence, metabolism and migration of goblet cells in rat intestine following the induction of rapid, synchronous vitamin A deficiency
    • Rojanapo W., Lamb A.J., Olson J.A. The prevalence, metabolism and migration of goblet cells in rat intestine following the induction of rapid, synchronous vitamin A deficiency. J Nutr 1980, 110:178-188.
    • (1980) J Nutr , vol.110 , pp. 178-188
    • Rojanapo, W.1    Lamb, A.J.2    Olson, J.A.3
  • 96
    • 77953626974 scopus 로고    scopus 로고
    • Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid
    • Cha H.R., et al. Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid. J Immunol 2010, 184:6799-6806.
    • (2010) J Immunol , vol.184 , pp. 6799-6806
    • Cha, H.R.1
  • 97
    • 35748934494 scopus 로고    scopus 로고
    • Metabolites induce gut-homing FoxP3+ regulatory T cells
    • Kang S.G., Vitamin A., et al. metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol 2007, 179:3724-3733.
    • (2007) J Immunol , vol.179 , pp. 3724-3733
    • Kang, S.G.1    Vitamin, A.2
  • 98
    • 79952740974 scopus 로고    scopus 로고
    • + T cell effector responses via retinoic acid receptor alpha
    • + T cell effector responses via retinoic acid receptor alpha. Immunity 2011, 34:435-447.
    • (2011) Immunity , vol.34 , pp. 435-447
    • Hall, J.A.1
  • 99
    • 80054831231 scopus 로고    scopus 로고
    • + T cell-mediated immunity
    • + T cell-mediated immunity. J Exp Med 2011, 208:1767-1775.
    • (2011) J Exp Med , vol.208 , pp. 1767-1775
    • Pino-Lagos, K.1
  • 100
    • 0030585713 scopus 로고    scopus 로고
    • Retinoids as Ig isotype-switch modulators. The role of retinoids in directing isotype switching to IgA and IgG1 (IgE) in association with IL-4 and IL-5
    • Tokuyama Y., Tokuyama H. Retinoids as Ig isotype-switch modulators. The role of retinoids in directing isotype switching to IgA and IgG1 (IgE) in association with IL-4 and IL-5. Cell Immunol 1996, 170:230-234.
    • (1996) Cell Immunol , vol.170 , pp. 230-234
    • Tokuyama, Y.1    Tokuyama, H.2
  • 101
    • 51049092467 scopus 로고    scopus 로고
    • Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
    • Jaensson E., et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med 2008, 205:2139-2149.
    • (2008) J Exp Med , vol.205 , pp. 2139-2149
    • Jaensson, E.1
  • 102
    • 33751223544 scopus 로고    scopus 로고
    • Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    • Mora J.R., et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 2006, 314:1157-1160.
    • (2006) Science , vol.314 , pp. 1157-1160
    • Mora, J.R.1
  • 103
    • 79960400021 scopus 로고    scopus 로고
    • MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties
    • Wang S., et al. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J Immunol 2011, 187:141-150.
    • (2011) J Immunol , vol.187 , pp. 141-150
    • Wang, S.1
  • 104
    • 0032924614 scopus 로고    scopus 로고
    • + T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment
    • + T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol 1999, 116:28-32.
    • (1999) Clin Exp Immunol , vol.116 , pp. 28-32
    • Tamura, J.1
  • 105
    • 84857419586 scopus 로고    scopus 로고
    • A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo
    • Kunisawa J., et al. A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PLOS ONE 2012, 7:e32094.
    • (2012) PLOS ONE , vol.7
    • Kunisawa, J.1
  • 106
    • 84870284140 scopus 로고    scopus 로고
    • MR1 presents microbial vitamin B metabolites to MAIT cells
    • Kjer-Nielsen L., et al. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 2012, 491:717-723.
    • (2012) Nature , vol.491 , pp. 717-723
    • Kjer-Nielsen, L.1
  • 107
    • 84877044428 scopus 로고    scopus 로고
    • MAIT cells, surveyors of a new class of antigen: development and functions
    • Le Bourhis L., Mburu Y.K., Lantz O. MAIT cells, surveyors of a new class of antigen: development and functions. Curr Opin Immunol 2013, 25:174-180.
    • (2013) Curr Opin Immunol , vol.25 , pp. 174-180
    • Le Bourhis, L.1    Mburu, Y.K.2    Lantz, O.3
  • 108
    • 77949873898 scopus 로고    scopus 로고
    • Vitamin D controls T cell antigen receptor signaling and activation of human T cells
    • von Essen M.R., et al. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol 2010, 11:344-349.
    • (2010) Nat Immunol , vol.11 , pp. 344-349
    • von Essen, M.R.1
  • 109
    • 77958485853 scopus 로고    scopus 로고
    • Vitamin D and mucosal immune function
    • Sun J. Vitamin D and mucosal immune function. Curr Opin Gastroenterol 2010, 26:591-595.
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 591-595
    • Sun, J.1
  • 110
    • 3242666889 scopus 로고    scopus 로고
    • Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density
    • Abreu M.T., et al. Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density. Gut 2004, 53:1129-1136.
    • (2004) Gut , vol.53 , pp. 1129-1136
    • Abreu, M.T.1
  • 111
    • 70449338588 scopus 로고    scopus 로고
    • Vitamin D receptor expression is associated with colon cancer in ulcerative colitis
    • Wada K., et al. Vitamin D receptor expression is associated with colon cancer in ulcerative colitis. Oncol Rep 2009, 22:1021-1025.
    • (2009) Oncol Rep , vol.22 , pp. 1021-1025
    • Wada, K.1
  • 112
    • 79959242498 scopus 로고    scopus 로고
    • Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
    • Sander L.E., et al. Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature 2011, 474:385-389.
    • (2011) Nature , vol.474 , pp. 385-389
    • Sander, L.E.1
  • 113
    • 84880417771 scopus 로고    scopus 로고
    • Probiotic bacteria reduce salmonella typhimurium intestinal colonization by competing for iron
    • Deriu E., et al. Probiotic bacteria reduce salmonella typhimurium intestinal colonization by competing for iron. Cell Host Microbe 2013, 14:26-37.
    • (2013) Cell Host Microbe , vol.14 , pp. 26-37
    • Deriu, E.1
  • 114
    • 84890297415 scopus 로고    scopus 로고
    • Microbiota-derived hydrogen fuels salmonella typhimurium invasion of the gut ecosystem
    • Maier L., et al. Microbiota-derived hydrogen fuels salmonella typhimurium invasion of the gut ecosystem. Cell Host Microbe 2013, 14:641-651.
    • (2013) Cell Host Microbe , vol.14 , pp. 641-651
    • Maier, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.