Kinetic analysis of human CYP24A1 metabolism of vitamin D via the C24-oxidation pathway

FEBS Journal

Volumn 281, Issue 14, 2014, Pages 3280-3296

  Tieu, Elaine W ^a   Tang, Edith K Y ^a   Tuckey, Robert C ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

CYP24A1; cytochrome P450; enzyme kinetics; phospholipid vesicles; vitamin D3

Indexed keywords

1 HYDROXY 23 OXO 24,25,26,27 TETRANORVITAMIN D3; 1,23 DIHYDROXY 24,25,26,27 TETRANORCOLECALCIFEROL; 1,24,25 TRIHYDROXYCOLECALCIFEROL; 24 OXO 1,23,25 TRIHYDROXYVITAMIN D3; 24 OXO 1,25 DIHYDROXYVITAMIN D3; CALCITRIOL; CALCITRIOL DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 24A1; TETRANOR 1,23 DIHYDROXYVITAMIN D3; UNCLASSIFIED DRUG;

ARTICLE; C24 OXIDATION PATHWAY; CONCENTRATION (PARAMETERS); ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; HUMAN; METABOLIC RATE; NONHUMAN; OXIDATION; PHOSPHOLIPID BILAYER; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; VITAMIN METABOLISM;

ESCHERICHIA COLI; RATTUS;

CYP24A1; CYTOCHROME P450; ENZYME KINETICS; PHOSPHOLIPID VESICLES; VITAMIN D3;

ADRENODOXIN; ANIMALS; CALCITRIOL; HUMANS; HYDROXYCHOLECALCIFEROLS; KINETICS; MITOCHONDRIAL MEMBRANES; RATS; STEROID HYDROXYLASES;

EID: 84904719387     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12862     Document Type: Article

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