Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry

Angewandte Chemie - International Edition

Volumn 52, Issue 20, 2013, Pages 5342-5345

  Gregory, Michael ^a   Mak, Piotr J ^c   Sligar, Stephen G ^a,b   Kincaid, James R ^c  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c Marquette University   (United States)

Author keywords

biophysics; heme proteins; lyases; oxidoreductases; Raman spectroscopy

Indexed keywords

HEME PROTEINS; HYDROGEN BONDING INTERACTIONS; LYASES; NATURAL SUBSTRATES; OXIDO-REDUCTASES; PREGNENOLONE; REACTION PATHWAYS; SUBSTRATE STRUCTURE;

BIOPHYSICS; ENZYMES; RAMAN SPECTROSCOPY; SUBSTRATES;

HYDROGEN BONDS;

17 HYDROXYPREGNENOLONE; ANDROSTENEDIONE; CYP17A1 PROTEIN, HUMAN; HYDROXYPROGESTERONE; LYASE; PRASTERONE; STEROID 17ALPHA MONOOXYGENASE;

ARTICLE; BIOCATALYSIS; BIOSYNTHESIS; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; HUMAN; HYDROGEN BOND; HYDROXYLATION; OXIDATION REDUCTION REACTION; RAMAN SPECTROMETRY;

17-ALPHA-HYDROXYPREGNENOLONE; 17-ALPHA-HYDROXYPROGESTERONE; ANDROSTENEDIONE; BIOCATALYSIS; BIOSYNTHETIC PATHWAYS; CARBON-CARBON LYASES; DEHYDROEPIANDROSTERONE; HUMANS; HYDROGEN BONDING; HYDROXYLATION; OXIDATION-REDUCTION; SPECTRUM ANALYSIS, RAMAN; STEROID 17-ALPHA-HYDROXYLASE; SUBSTRATE SPECIFICITY;

EID: 84877309505     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201300760     Document Type: Article

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