Probing the interaction of bovine cytochrome P450scc (CYP11A1) with adrenodoxin: Evaluating site-directed mutations by molecular modeling

Biochemistry

Volumn 41, Issue 26, 2002, Pages 8310-8320

  Usanov, Sergey A ^a   Graham, Sandra E ^b   Lepesheva, Galina I ^a   Azeva, Tamara N ^a   Strushkevich, Natalya V ^a   Gilep, Andrei A ^a   Estabrook, Ronald W ^b   Peterson, Julian A ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b INSTITUTE OF BIOORGANIC CHEMISTRY   (Belarus)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROSTATIC INTERACTION;

AMINO ACIDS; CHOLESTEROL; ENZYMES;

BIOCHEMISTRY;

ADRENODOXIN; AMINO ACID; ARGININE; ASPARTIC ACID; CARBON MONOXIDE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450 11A1; CYTOCHROME P450 ISOENZYME; GLUTAMIC ACID; GLUTAMINE; LYSINE; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; ELECTRICITY; ELECTRON; ENZYME ACTIVITY; ENZYME BINDING; MOLECULAR MODEL; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REDUCTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SURFACE CHARGE;

ADRENODOXIN; AMINO ACID SEQUENCE; ANIMALS; CATTLE; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CLONING, MOLECULAR; ESCHERICHIA COLI; HUMANS; KINETICS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

BOVINAE;

EID: 0037008007     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0255928     Document Type: Article

References (52)