Studies of membrane topology of mitochondrial cholesterol hydroxylases CYPs 27A1 and 11A1

Lipids

Volumn 43, Issue 12, 2008, Pages 1127-1132

  Pikuleva, Irina A ^a,b   Mast, Natalia ^a,b   Liao, Wei Li ^c   Turko, Illarion V ^c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

Author keywords

CYP11A1; CYP27A1; Mass spectrometry analysis; Membrane topology

Indexed keywords

CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); OXYGENASE; POLYPEPTIDE; PROTEINASE;

ARTICLE; BACTERIAL MEMBRANE; ESCHERICHIA COLI; INFORMATION; MASS SPECTROMETRY; MEMBRANE STRUCTURE; MITOCHONDRION; NONHUMAN; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CYTOCHROME P-450 CYP27A1; HUMANS; INTRACELLULAR MEMBRANES; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PEPTIDES; TRYPSIN;

EID: 57149125431     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-008-3234-x     Document Type: Article

References (18)

1. T Omura 2006 Mitochondrial P450s Chem Biol Interact 163 86 93
2. IA Pikuleva 2006 Cholesterol-metabolizing cytochromes P450 Drug Metab Dispos 34 513 520
3. IA Pikuleva 2006 Cytochrome P450s and cholesterol homeostasis Pharmacol Ther 112 761 773
4. Bjorkhem I, Boberg KM, Leitersdorf E (1995) Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol. In: Scriver AL, Beaudet AL, Sly WS, Valle D, Childs B, (eds) The metabolic and molecular bases of inherited disease. vol 2, 7th edn. McGraw-Hill, New York, 2073-2099
5. D Stone O Hechter 1954 Studies on ACTH action in perfused bovine adrenals: site of action of ACTH in corticosteroids Arch Biochem Biophys 51 457 469
6. WJ Ou A Ito K Morohashi Y Fujii-Kuriyama T Omura 1986 Processing-independent in vitro translocation of cytochrome P-450(SCC) precursor across mitochondrial membranes J Biochem 100 1287 1296
7. SA Usanov AA Chernogolov VL Chashchin 1990 Is cytochrome P-450scc a transmembrane protein? FEBS Lett 275 33 35
8. D Murtazina AV Puchkaev CH Schein N Oezguen W Braun A Nanavati IA Pikuleva 2002 Membrane-protein interactions contribute to efficient 27-hydroxylation of cholesterol by mitochondrial cytochrome P450 27A1 J Biol Chem 277 37582 37589
9. IA Pikuleva 2004 Putative F-G loop is involved in association with the membrane in P450scc (P450 11A1) Mol Cell Endocrinol 215 161 164
10. MJ Headlam MC Wilce RC Tuckey 2003 The F-G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane Biochim Biophys Acta 1617 96 108
11. IA Pikuleva A Puchkaev I Bjorkhem 2001 Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1 Biochemistry 40 7621 7629
12. IA Pikuleva RL Mackman N Kagawa MR Waterman PR Ortiz de Montellano 1995 Active-site topology of bovine cholesterol side-chain cleavage cytochrome P450 (P450scc) and evidence for interaction of tyrosine 94 with the side chain of cholesterol Arch Biochem Biophys 322 189 197
13. IA Pikuleva I Bjorkhem MR Waterman 1997 Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27) Arch Biochem Biophys 343 123 130
14. D Eisenberg RM Weiss TC Terwilliger 1982 The helical hydrophobic moment: a measure of the amphiphilicity of a helix Nature 299 371 374
15. D Eisenberg RM Weiss TC Terwilliger 1984 The hydrophobic moment detects periodicity in protein hydrophobicity Proc Natl Acad Sci USA 81 140 144
16. von Wachenfeldt C, Johnson EF (1995) Structures of eukaryotic cytochrome P450 enzymes. In: Ortiz de Montellano PR (ed) Cytochrome P450: structure, mechanism, and biochemistry. Plenum Press, New York, pp 183-244
17. PA Williams J Cosme V Sridhar EF Johnson DE McRee 2000 Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity Mol Cell 5 121 131
18. LA Eichacker B Granvogl O Mirus BC Muller C Miess E Schleiff 2004 Hiding behind hydrophobicity. Transmembrane segments in mass spectrometry J Biol Chem 279 50915 50922