Novel Metabolism of 1α,25-Dihydroxyvitamin D3 with C 24-C25 Bond Cleavage Catalyzed by Human CYP24A1

Biochemistry

Volumn 43, Issue 15, 2004, Pages 4530-4537

  Sawada, Natsumi ^a   Kusudo, Tatsuya ^a   Sakaki, Toshiyuki ^a   Hatakeyama, Susumi ^b   Hanada, Makoto ^b   Abe, Daisuke ^a   Kamao, Maya ^c   Okano, Toshio ^c   Ohta, Miho ^d   Inouye, Kuniyo ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^d Koshien Junior College   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL BONDS; ESCHERICHIA COLI; FREE RADICALS; HYDROXYLATION; METABOLISM; METABOLITES; VITAMINS;

BINDING AFFINITY; BOND CLEAVAGE CATALYSIS; HYDROXYLATION PATHWAY; RADICAL REARRANGEMENT;

BIOCHEMICAL ENGINEERING;

25,26,27 TRINOR 22 ENE COLECALCIFEROL; 25,26,27 TRINOR 23 ENE 1ALPHA HYDROXYCOLECALCIFEROL; CALCIFEDIOL; CALCITRIOL; CARBON; COLECALCIFEROL DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 24A1; DRUG METABOLITE; HYDROGEN; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; BINDING AFFINITY; CATALYSIS; CATALYST; DEHYDROGENATION; DISSOCIATION; DRUG INACTIVATION; DRUG METABOLISM; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE EXPRESSION SYSTEM; HUMAN; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS;

24,25-DIHYDROXYVITAMIN D 3; ANIMALS; CALCITRIOL; CARBON; CATALYSIS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; HUMANS; HYDROXYLATION; MASS SPECTROMETRY; PROTEIN BINDING; RATS; RECEPTORS, CALCITRIOL; RECOMBINANT PROTEINS; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY;

CLEYERA JAPONICA; ESCHERICHIA COLI;

EID: 3843113600     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi030207f     Document Type: Article

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