Membrane-protein interactions contribute to efficient 27-hydroxylation of cholesterol by mitochondrial cytochrome P450 27A1

Journal of Biological Chemistry

Volumn 277, Issue 40, 2002, Pages 37582-37589

  Murtazina, Dilyara ^a   Puchkaev, Andrei V ^a   Schein, Catherine H ^b   Oezguen, Numan ^a   Braun, Werner ^a   Nanavati, Amit ^a   Pikuleva, Irina A ^a,b,c  

^a Department of Pharmacology and Toxicology ^*  (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c INSTITUTE OF BIOORGANIC CHEMISTRY   (Belarus)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CATALYSIS; CHOLESTEROL; CRYSTAL STRUCTURE; ESCHERICHIA COLI; PHOSPHOLIPIDS;

STRUCTURAL INFORMATIONS;

ENZYMES;

CHOLESTEROL; CYTOCHROME P450; CYTOCHROME P450 27A1; MEMBRANE PROTEIN; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; ESCHERICHIA COLI; HYDROPHOBICITY; HYDROXYLATION; MEMBRANE STRUCTURE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BLOTTING, WESTERN; CHOLESTEROL; CLONING, MOLECULAR; CONSERVED SEQUENCE; CYTOCHROME P-450 CYP27A1; ESCHERICHIA COLI; HYDROXYLATION; KINETICS; MICROSOMES; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STEROID HYDROXYLASES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA;

EID: 0037020268     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M204909200     Document Type: Article

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