Iodine excess as an environmental risk factor for autoimmune thyroid disease

International Journal of Molecular Sciences

Volumn 15, Issue 7, 2014, Pages 12895-12912

  Luo, Yuqian ^a   Kawashima, Akira ^a   Ishido, Yuko ^a   Yoshihara, Aya ^a   Oda, Kenzaburo ^a   Hiroi, Naoki ^b   Ito, Tetsuhide ^c   Ishii, Norihisa ^a   Suzuki, Koichi ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b TOHO UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Autoimmune thyroid disease; Environmental toxicant; Excess iodine; Immune response; Thyroglobulin; Tissue injury

Indexed keywords

AMIODARONE; IODINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROPYLTHIOURACIL; THYROGLOBULIN;

ANTIGENICITY; AUTOIMMUNE THYROIDITIS; CELL DAMAGE; ENVIRONMENTAL RISK FACTOR; GRAVES DISEASE; HEALTH CARE ORGANIZATION; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPERTHYROIDISM; IODINE DEFICIENCY; LIPID OXIDATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; REVIEW; RISK FACTOR; SUPRAVENTRICULAR TACHYCARDIA; TISSUE INJURY; ADVERSE EFFECTS; ANIMAL; ENVIRONMENTAL EXPOSURE; IMMUNOLOGY; METABOLISM; THYROIDITIS, AUTOIMMUNE;

ANIMALS; ENVIRONMENTAL EXPOSURE; HUMANS; IODINE; RISK FACTORS; THYROGLOBULIN; THYROIDITIS, AUTOIMMUNE;

EID: 84904703398     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms150712895     Document Type: Review

References (116)

1. Heyland, A.; Moroz, L.L. Cross-kingdom hormonal signaling: An insight from thyroid hormone functions in marine larvae. J. Exp. Biol. 2005, 208, 4355-4361.
2. Hulbert, A.J. Thyroid hormones and their effects: A new perspective. Biol. Rev. Camb. Philos. Soc. 2000, 75, 519-631.
3. Everett, L.A.; Glaser, B.; Beck, J.C.; Idol, J.R.; Buchs, A.; Heyman, M.; Adawi, F.; Hazani, E.; Nassir, E.; Baxevanis, A.D.; et al. Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat. Genet. 1997, 17, 411-422.
4. Royaux, I.E.; Suzuki, K.; Mori, A.; Katoh, R.; Everett, L.A.; Kohn, L.D.; Green, E.D. Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. Endocrinology 2000, 141, 839-845.
5. Yoshida, A.; Hisatome, I.; Taniguchi, S.; Sasaki, N.; Yamamoto, Y.; Miake, J.; Fukui, H.; Shimizu, H.; Okamura, T.; Okura, T.; et al. Mechanism of iodide/chloride exchange by pendrin. Endocrinology 2004, 145, 4301-4308.
6. Yoshida, A.; Taniguchi, S.; Hisatome, I.; Royaux, I.E.; Green, E.D.; Kohn, L.D.; Suzuki, K. Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells. J. Clin Endocrinol. Metab. 2002, 87, 3356-3361.
7. - channel in FRTL-5 cells. Biochem. Biophys. Res. Commun. 1999, 259, 631-635.
8. Robbins, J.; Rall, J.E.; Gorden, P. The thyroid and iodine metabolism. In Duncan's Diseases of Metabolism; Bondy, P.K., Rosenberg, L.E., Eds.; Saunders: Philadelphia, PA, USA, 1974; pp. 1009-1104.
9. Koibuchi, N.; Chin, W.W. Thyroid hormone action and brain development. Trends Endocrinol. Metab. 2000, 11, 123-128.
10. Delange, F. The disorders induced by iodine deficiency. Thyroid 1994, 4, 107-128.
11. Pearce, E.N.; Andersson, M.; Zimmermann, M.B. Global iodine nutrition: Where do we stand in 2013? Thyroid 2013, 23, 523-528.
12. Zimmermann, M.B. Iodine deficiency and excess in children: Worldwide status in 2013. Endocr. Pract. 2013, 19, 839-846.
13. Zimmermann, M.B.; Andersson, M. Update on iodine status worldwide. Curr. Opin. Endocrinol. Diabetes Obes. 2012, 19, 382-387.
14. Teas, J.; Pino, S.; Critchley, A.; Braverman, L.E. Variability of iodine content in common commercially available edible seaweeds. Thyroid 2004, 14, 836-841.
15. Zava, T.T.; Zava, D.T. Assessment of Japanese iodine intake based on seaweed consumption in Japan: A literature-based analysis. Thyroid Res. 2011, 4, 14:1-14:7.
16. Matsubayashi, S.; Mukuta, T.; Watanabe, H.; Fuchigami, H.; Taniguchi, J.; Chinen, M.; Ninomiya, H.; Sasaki, H. Iodine-induced hypothyroidism as a result of excessive intake of confectionery made with tangle weed, Kombu, used as a low calorie food during a bulimic period in a patient with anorexia nervosa. Eat. Weight Disord. 1998, 3, 50-52.
17. Michikawa, T.; Inoue, M.; Shimazu, T.; Sawada, N.; Iwasaki, M.; Sasazuki, S.; Yamaji, T.; Tsugane, S.; Japan Public Health Center-based Prospective Study Group. Seaweed consumption and the risk of thyroid cancer in women: The Japan Public Health Center-based Prospective Study. Eur. J. Cancer Prev. 2012, 21, 254-260.
18. Tsubota-Utsugi, M.; Imai, E.; Nakade, M.; Matsumoto, T.; Tsuboyama-Kasaoka, N.; Nishi, N.; Tsubono, Y. Evaluation of the prevalence of iodine intakes above the tolerable upper intake level from four 3-day dietary records in a Japanese population. J. Nutr. Sci. Vitaminol. Tokyo 2013, 59, 310-316.
19. Lv, S.; Wang, Y.; Xu, D.; Rutherford, S.; Chong, Z.; Du, Y.; Jia, L.; Zhao, J. Drinking water contributes to excessive iodine intake among children in Hebei, China. Eur. J. Clin. Nutr. 2013, 67, 961-965.
20. Sui, H.X.; Li, J.W.; Mao, W.F.; Zhu, J.H.; He, Y.N.; Song, X.Y.; Ma, N.; Zhang, L.; Liu, S.N.; Liu, Z.P.; et al. Dietary iodine intake in the Chinese population. Biomed. Environ. Sci. 2011, 24, 617-623.
21. Kassim, I.A.; Moloney, G.; Busili, A.; Nur, A.Y.; Paron, P.; Jooste, P.; Gadain, H.; Seal, A.J. Iodine intake in Somalia is excessive and associated with the source of household drinking water. J. Nutr. 2014, 144, 375-381.
22. Henjum, S.; Barikmo, I.; Gjerlaug, A.K.; Mohamed-Lehabib, A.; Oshaug, A.; Strand, T.A.; Torheim, L.E. Endemic goitre and excessive iodinein urine and drinking water among Saharawi refugee children. Public Health Nutr. 2010, 13, 1472-1477.
23. Andersen, S.; Guan, H.; Teng, W.; Laurberg, P. Speciation of iodine in high iodine groundwater in china associated withgoitre and hypothyroidism. Biol. Trace Elem. Res. 2009, 128, 95-103.
24. Georgitis, W.J.; McDermott, M.T.; Kidd, G.S. Aniodine load from water-purification tablets alters thyroid function in humans. Mil. Med. 1993, 158, 794-797.
25. Zhao, J.; Chen, Z.; Maberly, G. Iodine-rich drinking water of natural origin in China. Lancet 1998, 352, 2024.
26. Li, S.; Zheng, Q.; Xu, J.; Gorstein, J.; Wang, H.; Dong, H. Iodine excess or not: Analysis on the necessity of reducing the iodine content in edible salt based on the national monitoring results. Asia Pac. J. Clin. Nutr. 2011, 20, 501-506.
27. Arrizabalaga, J.J.; Larranaga, N.; Espada, M.; Amiano, P.; Bidaurrazaga, J.; Latorre, K.; Gorostiza, E. Changes in iodine nutrition status in schoolchildren from the Basque Country. Endocrinol. Nutr. 2012, 59, 474-484.
28. Franke, K.; Meyer, U.; Wagner, H.; Flachowsky, G. Influence of various iodine supplementation levels and two different iodine species on the iodine content of the milk of cows fed rapeseed meal or distillers dried grains with solubles as the protein source. J. Dairy Sci. 2009, 92, 4514-4523.
29. Launer, P.; Richter, O. [Iodine concentration in the blood serum of milk cows from Saxony as well as in cows' milk and milk products (baby food)]. Berl. Munch. Tierarztl. Wochenschr. 2005, 118, 502-508.
30. Perrine, C.G.; Sullivan, K.M.; Flores, R.; Caldwell, K.L.; Grummer-Strawn, L.M. Intakes of dairy products and dietary supplements are positively associated with iodine status among U.S. children. J. Nutr. 2013, 143, 1155-1160.
31. Garcia-Solis, P.; Solis, S.J.; Garcia-Gaytan, A.C.; Reyes-Mendoza, V.A.; Robles-Osorio, L.; Villarreal-Rios, E.; Leal-Garcia, L.; Hernandez-Montiel, H.L. Iodine nutrition in elementary state schools of Queretaro, Mexico: Correlations between urinary iodine concentration with global nutrition status and social gap index. Arq. Bras. Endocrinol. Metabol. 2013, 57, 473-482.
32. Kassim, I.A.; Ruth, L.J.; Creeke, P.I.; Gnat, D.; Abdalla, F.; Seal, A.J. Excessive iodine intake during pregnancy in Somali refugees. Matern. Child Nutr. 2012, 8, 49-56.
33. Li, S.; Fan, Y.; Chen, H.; Li, X.; Wang, J.; Gu, Y.; Li, S.; Li, M.; Wang, J.; Shu, Z. Is the current iodine content in edible saltappropriate for eliminating iodine deficiency in China. Asia Pac. J. Clin. Nutr. 2010, 19, 231-235.
34. Gatseva, P.D.; Argirova, M.D. Benefits and risks from the national strategy for improvement of iodine nutrition in Bulgaria: Study on schoolchildren living in a rural area. Public Health 2009, 123, 456-458.
35. Camargo, R.Y.; Tomimori, E.K.; Neves, S.C.; Rubio, I.G.S.; Galrao, A.L.; Knobel, M.; Medeiros-Neto, G. Thyroid and the environment: Exposure to excessivenutritional iodine increases the prevalence of thyroid disorders in Sao Paulo, Brazil. Eur. J. Endocrinol. 2008, 159, 293-299.
36. Silva, K.D.; Munasinghe, D.L. Urinary iodine concentration of pregnant women and female adolescents as an indicator of excessive iodine intake in Sri Lanka. Food Nutr. Bull. 2006, 27, 12-18.
37. Assey, V.D.; Peterson, S.; Kimboka, S.; Ngemera, D.; Mgoba, C.; Ruhiye, D.M.; Ndossi, G.D.; Greiner, T.; Tylleskar, T. Tanzania national survey on iodine deficiency: Impact after twelve years of salt iodation. BMC Public Health 2009, 9, doi:10.1186/1471-2458-9-319.
38. Delange, F.; de Benoist, B.; Alnwick, D. Risks of iodine-induced hyperthyroidism after correction of iodine deficiency by iodized salt. Thyroid 1999, 9, 545-556.
39. Izzeldin, H.S.; Crawford, M.A.; Jooste, P.L. Population living in the Red Sea State of Sudan may need urgent intervention to correct the excess dietary iodine intake. Nutr. Health 2007, 18, 333-341.
40. Seal, A.J.; Creeke, P.I.; Gnat, D.; Abdalla, F.; Mirghani, Z. Excess dietary iodine intake in long-term African refugees. Public Health Nutr. 2006, 9, 35-39.
41. Leung, A.M.; Pearce, E.N.; Braverman, L.E. Iodinecontent of prenatal multivitamins in the United States. N. Engl. J. Med. 2009, 360, 939-940.
42. Connelly, K.J.; Boston, B.A.; Pearce, E.N.; Sesser, D.; Snyder, D.; Braverman, L.E.; Pino, S.; LaFranchi, S.H. Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion. J. Pediatr. 2012, 161, 760-762.
43. Minelli, R.; Gardini, E.; Bianconi, L.; Salvi, M.; Roti, E. Subclinical hypothyroidism, overt thyrotoxicosis and subclinical hypothyroidism: The subsequent phases of thyroid function in a patient chronically treated with amiodarone. J. Endocrinol. Investig. 1992, 15, 853-855.
44. Sato, K.; Yamazaki, K.; Kanaji, Y.; Ohnishi, S.; Kasanuki, H.; Demura, H. Amiodarone-induced thyrotoxicosis associated withthyrotropin receptor antibody. Thyroid 1998, 8, 1123-1126.
45. Padovani, R.P.; Kasamatsu, T.S.; Nakabashi, C.C.; Camacho, C.P.; Andreoni, D.M.; Malouf, E.Z.; Marone, M.M.; Maciel, R.M.; Biscolla, R.P. One month is sufficient for urinary iodine to return to its baseline value after the use of water-soluble iodinated contrast agents in post-thyroidectomy patients requiring radioiodine therapy. Thyroid 2012, 22, 926-930.
46. Alkhuja, S.; Pyram, R.; Odeyemi, O. In the eye ofthe storm: Iodinated contrast medium induced thyroid storm presenting ascardiopulmonary arrest. Heart Lung 2013, 42, 267-269.
47. Gartner, W.; Weissel, M. Do iodine-containing contrast media induce clinically relevant changes in thyroid function parameters of euthyroid patients within the first week? Thyroid 2004, 14, 521-524.
48. Koroscil, T.M.; Pelletier, P.R.; Slauson, J.W.; Hennessey, J. Short-termeffects of coronary angiographic contrast agents on thyroid function. Endocr. Pract. 1997, 3, 219-221.
49. Ozkan, S.; Oysu, A.S.; Kayatas, K.; Demirtunc, R.; Eren, M.; Uslu, H.; Altuntas, Y. Thyroid functions after contrast agent administration for coronary angiography: A prospective observational study in euthyroid patients. Anadolu Kardiyol. Derg. 2013, 13, 363-369.
50. Rhee, C.M.; Bhan, I.; Alexander, E.K.; Brunelli, S.M. Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism. Arch. Intern. Med. 2012, 172, 153-159.
51. Ader, A.W.; Paul, T.L.; Reinhardt, W.; Safran, M.; Pino, S.; McArthur, W.; Braverman, L.E. Effect of mouth rinsing with two polyvinylpyrrolidone-iodine mixtures on iodine absorption and thyroid function. J. Clin. Endocrinol. Metab. 1988, 66, 632-635.
52. Linder, N.; Davidovitch, N.; Reichman, B.; Kuint, J.; Lubin, D.; Meyerovitch, J.; Sela, B.A.; Dolfin, Z.; Sack, J. Topical iodine-containing antiseptics and subclinical hypothyroidism in preterm infants. J. Pediatr. 1997, 131, 434-439.
53. Nobukuni, K.; Kawahara, S. Thyroid function in nurses: The influence of povidone-iodine hand washing and gargling. Dermatology 2002, 204 (Suppl. 1), 99-102.
54. Duntas, L.H. Environmental factors and autoimmune thyroiditis. Nat. Clin. Pract. Endocrinol. Metab. 2008, 4, 454-460.
55. Alsanosy, R.M.; Gaffar, A.M.; Khalafalla, H.E.; Mahfouz, M.S.; Zaid, A.N.; Bani, I.A. Current iodine nutrition status and progress toward elimination of iodine deficiency disorders in Jazan, Saudi Arabia. BMC Public Health 2012, 12, doi:10.1186/1471-2458-12-1006.
56. Alsayed, A.; Gad, A.M.; Abdel-Baset, H.; Abdel-Fattah, A.; Ahmed, A.; Azab, A. Excess urinary iodine is associated with autoimmune subclinical hypothyroidism among Egyptian women. Endocr. J. 2008, 55, 601-605.
57. Bastemir, M.; Emral, R.; Erdogan, G.; Gullu, S. High prevalence of thyroid dysfunction and autoimmune thyroiditis in adolescents after elimination of iodine deficiency in the Eastern Black Sea Region of Turkey. Thyroid 2006, 16, 1265-1271.
58. Laurberg, P.; Cerqueira, C.; Ovesen, L.; Rasmussen, L.B.; Perrild, H.; Andersen, S.; Pedersen, I.B.; Carle, A. Iodine intake as a determinant of thyroid disorders in populations. Best. Pract. Res. Clin. Endocrinol. Metab. 2010, 24, 13-27
59. Teng, X.; Shan, Z.; Chen, Y.; Lai, Y.; Yu, J.; Shan, L.; Bai, X.; Li, Y.; Li, N.; Li, Z.; et al. More than adequate iodine intake may increase subclinicalhypothyroidism and autoimmune thyroiditis: A cross-sectional study based on two Chinese communities with different iodine intake levels. Eur. J. Endocrinol. 2011, 164, 943-950.
60. Allen, E.M.; Appel, M.C.; Braverman, L.E. The effect of iodide ingestion on the development of spontaneous lymphocytic thyroiditis in the diabetes-prone BB/W rat. Endocrinology 1986, 118, 1977-1981.
61. Bagchi, N.; Brown, T.R.; Urdanivia, E.; Sundick, R.S. Induction of autoimmune thyroiditis in chickens by dietary iodine. Science 1985, 230, 325-327.
62. Sundick, R.S.; Bagchi, N.; Brown, T.R. The role of iodine in thyroid autoimmunity: From chickens to humans: A review. Autoimmunity 1992, 13, 61-68.
63. Allen, E.M.; Braverman, L.E. The effect of iodine on lymphocytic thyroiditis in the thymectomized buffalo rat. Endocrinology 1990, 127, 1613-1616.
64. Rasooly, L.; Burek, C.L.; Rose, N.R. Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice. Clin. Immunol. Immunopathol. 1996, 81, 287-292.
65. Braley-Mullen, H.; Sharp, G.C.; Medling, B.; Tang, H. Spontaneous autoimmune thyroiditis in NOD. H-2h4 mice. J. Autoimmun. 1999, 12, 157-165.
66. Teng, X.; Shan, Z.; Teng, W.; Fan, C.; Wang, H.; Guo, R. Experimental study on the effects of chronic iodine excess on thyroid function, structure, and autoimmunity in autoimmune-prone NOD. H-2h4 mice. Clin. Exp. Med. 2009, 9, 51-59.
67. Wolff, J. Iodide goiter and the pharmacologic effects of excess iodide. Am. J. Med. 1969, 47, 101-124.
68. Wolff, J.; Chaikoff, I.L.; Goldberg, R.C.; Meier, J.R. The temporary nature of the inhibitory action of excess iodine on organic iodine synthesis in the normal thyroid. Endocrinology 1949, 45, 504-513.
69. Schuppert, F.; Taniguchi, S.; Schroder, S.; Dralle, H.; von zur Muhlen, A.; Kohn, L.D. In vivo andin vitroevidence for iodide regulation of major histocompatibility complex class I and class II expression in Graves' disease. J. Clin. Endocrinol. Metab. 1996, 81, 3622-3628.
70. Schuppert, F.; Ehrenthal, D.; Frilling, A.; Suzuki, K.; Napolitano, G.; Kohn, L.D. Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. J. Clin. Endocrinol. Metab. 2000, 85, 858-867.
71. Bonita, R.E.; Rose, N.R.; Rasooly, L.; Caturegli, P.; Burek, C.L. Kinetics of mononuclear cell infiltration and cytokine expression in iodine-induced thyroiditis inthe NOD-H2h4 mouse. Exp. Mol. Pathol. 2003, 74, 1-12.
72. + regulatory T cells in NOD. H-2 h4 mice with iodine-induced autoimmune thyroiditis. Biol. Trace Elem. Res. 2011, 143, 292-301.
73. Hutchings, P.R.; Cooke, A.; Dawe, K.; Champion, B.R.; Geysen, M.; Valerio, R.; Roitt, I.M. A thyroxine-containing peptide can induce murine experimental autoimmune thyroiditis. J. Exp. Med. 1992, 175, 869-872.
74. Yu, S.; Dunn, R.; Kehry, M.R.; Braley-Mullen, H. B cell depletion inhibits spontaneous autoimmune thyroiditis in NOD. H-2h4 mice. J. Immunol. 2008, 180, 7706-7713.
75. Yu, S.; Medling, B.; Yagita, H.; Braley-Mullen, H. Characteristics of inflammatory cells in spontaneous autoimmune thyroiditis of NOD. H-2h4 mice. J. Autoimmun. 2001, 16, 37-46.
76. Mooij, P.; de Wit, H.J.; Drexhage, H.A. An excess of dietary iodine accelerates the development of a thyroid-associated lymphoid tissue in autoimmune prone BB rats. Clin. Immunol. Immunopathol. 1993, 69, 189-198.
77. Sharma, R.B.; Alegria, J.D.; Talor, M.V.; Rose, N.R.; Caturegli, P.; Burek, C.L. Iodine and IFN-γsynergistically enhance intercellular adhesion molecule 1 expression on NOD. H2 h4 mouse thyrocytes. J. Immunol. 2005, 174, 7740-7745.
78. Yamazaki, K.; Tanigawa, K.; Suzuki, K.; Yamada, E.; Yamada, T.; Takano, K.; Obara, T.; Sato, K. Iodide-induced chemokines and genes related to immunologicalfunction in cultured human thyroid follicles in the presence of thyrotropin. Thyroid 2010, 20, 67-76.
79. Yamazaki, K.; Yamada, E.; Kanaji, Y.; Yanagisawa, T.; Kato, Y.; Takano, K.; Obara, T.; Sato, K. Genes regulated by thyrotropin and iodide in cultured human thyroid follicles: Analysis by cDNA microarray. Thyroid 2003, 13, 149-158.
80. Horie, I.; Abiru, N.; Nagayama, Y.; Kuriya, G.; Saitoh, O.; Ichikawa, T.; Iwakura, Y.; Eguchi, K. T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice. Endocrinology 2009, 150, 5135-5142.
81. Yu, S.; Sharp, G.C.; Braley-Mullen, H. Dual roles for IFN-γ, but not for IL-4, in spontaneous autoimmune thyroiditis in NOD. H-2h4 mice. J. Immunol. 2002, 169, 3999-4007.
82. + regulatory T cells in CD28-deficient NOD. H-2h4 mice leads to increased severity of spontaneous autoimmune thyroiditis. J. Immunol. 2013, 191, 4940-4949.
83. Yu, S.; Fang, Y.; Sharp, G.C.; Braley-Mullen, H. Transgenic expression of TGF-βon thyrocytes inhibits development of spontaneous autoimmune thyroiditis and increases regulatory T cells in thyroids of NOD. H-2h4 mice. J. Immunol. 2010, 184, 5352-5359.
84. + naturally occurring regulatory T cells and not lymphopenia play a role in the pathogenesis of iodide-induced autoimmune thyroiditis in NOD-H2h4 mice. J. Autoimmun. 2007, 29, 195-202.
85. Many, M.C.; Maniratunga, S.; Varis, I.; Dardenne, M.; Drexhage, H.A.; Denef, J.F. Two-step development of Hashimoto-like thyroiditis in genetically autoimmune prone non-obese diabetic mice: Effects of iodine-induced cell necrosis. J. Endocrinol. 1995, 147, 311-320.
86. Yu, X.; Li, L.; Li, Q.; Zang, X.; Liu, Z. TRAIL and DR5 promote thyroid follicular cell apoptosis in iodine excess-induced experimental autoimmune thyroiditis in NOD mice. Biol. Trace Elem. Res. 2011, 143, 1064-1076.
87. Bagchi, N.; Brown, T.R.; Sundick, R.S. Thyroid cell injury is an initial event in the induction of autoimmune thyroiditis by iodine in obese strain chickens. Endocrinology 1995, 136, 5054-5060.
88. Burek, C.L.; Rose, N.R. Autoimmune thyroiditis and ROS. Autoimmun. Rev. 2008, 7, 530-537.
89. Sharma, R.; Traore, K.; Trush, M.A.; Rose, N.R.; Burek, C.L. Intracellular adhesion molecule-1 up-regulation on thyrocytes by iodine of non-obese diabetic. H2 h4 mice is reactive oxygen species-dependent. Clin. Exp. Immunol. 2008, 152, 13-20
90. Duthoit, C.; Estienne, V.; Delom, F.; Durand-Gorde, J.M.; Mallet, B.; Carayon, P.; Ruf, J. Production of immunoreactive thyroglobulin C-terminal fragments during thyroid hormone synthesis. Endocrinology 2000, 141, 2518-2525.
91. Duthoit, C.; Estienne, V.; Giraud, A.; Durand-Gorde, J.M.; Rasmussen, A.K.; Feldt-Rasmussen, U.; Carayon, P.; Ruf, J. Hydrogen peroxide-induced production of a 40kDa immunoreactive thyroglobulin fragment in human thyroid cells: The onset of thyroid autoimmunity? Biochem. J. 2001, 360, 557-562.
92. Basalaeva, N.L.; Sychugov, G.V.; Strizhikov, V.K.; Mikhailova, E.N. Iodine concentration and signs of apoptosis in the thyroid and pituitary of female rats after different single doses of potassium iodide. Endocr. Regul. 2011, 45, 183-190.
93. Foley, T.P., Jr. The relationship between autoimmune thyroid disease and iodine intake: A review. Endokrynol. Pol. 1992, 43 (Suppl. 1), 53-69.
94. Poncin, S.; Gerard, A.C.; Boucquey, M.; Senou, M.; Calderon, P.B.; Knoops, B.; Lengele, B.; Many, M.C.; Colin, I.M. Oxidative stress in the thyroid gland: From harmlessness to hazard depending on the iodine content. Endocrinology 2008, 149, 424-433.
95. Xia, Y.; Qu, W.; Zhao, L.N.; Han, H.; Yang, X.F.; Sun, X.F.; Hao, L.P.; Xu, J. Iodine excess induces hepatic steatosisthrough disturbance of thyroid hormone metabolism involving oxidative stress in BALB/c mice. Biol. Trace Elem. Res. 2013, 154, 103-110.
96. Many, M.C.; Mestdagh, C.; van den Hove, M.F.; Denef, J.F. In vitrostudy of acute toxic effects of high iodide doses in human thyroid follicles. Endocrinology 1992, 131, 621-630.
97. Mahmoud, I.; Colin, I.; Many, M.C.; Denef, J.F. Direct toxic effect of iodide in excess on iodine-deficient thyroid glands: Epithelial necrosis and inflammation associated with lipofuscin accumulation. Exp. Mol. Pathol. 1986, 44, 259-271.
98. Kawashima, A.; Tanigawa, K.; Akama, T.; Yoshihara, A.; Ishii, N.; Suzuki, K. Innate immune activation and thyroid autoimmunity. J. Clin. Endocrinol. Metab. 2011, 96, 3661-3671.
99. Kawashima, A.; Tanigawa, K.; Akama, T.; Wu, H.; Sue, M.; Yoshihara, A.; Ishido, Y.; Kobiyama, K.; Takeshita, F.; Ishii, K.J.; et al. Fragments of genomic DNA released by injured cells activate innate immunity and suppress endocrine function in the thyroid. Endocrinology 2011, 152, 1702-1712.
100. Kawashima, A.; Yamazaki, K.; Hara, T.; Akama, T.; Yoshihara, A.; Sue, M.; Tanigawa, K.; Wu, H.; Ishido, Y.; Takeshita, F.; et al. Demonstration of innate immune responses in the thyroid gland: Potential to sense danger and a possible trigger for autoimmune reactions. Thyroid 2013, 23, 477-487.
101. McLachlan, S.M.; Rapoport, B. Breaking tolerance to thyroid antigens: Changing concepts in thyroid autoimmunity. Endocr. Rev. 2014, 35, 59-105.
102. Edelhoch, H.; Carlomagno, M.S.; Salvatore, G. Iodine and the structure of thyroglobulin. Arch. Biochem. Biophys. 1969, 134, 264-265.
103. Lamas, L.; Ingbar, S.H. The effect of varying iodine content on the susceptibility of thyroglobulin to hydrolysis by thyroid acid protease. Endocrinology 1978, 102, 188-197.
104. Ebner, S.A.; Lueprasitsakul, W.; Alex, S.; Fang, S.L.; Appel, M.C.; Braverman, L.E. Iodine content of rat thyroglobulin affects its antigenicity in inducing lymphocytic thyroiditis in the BB/Wor rat. Autoimmunity 1992, 13, 209-214
105. Champion, B.R.; Rayner, D.C.; Byfield, P.G.; Page, K.R.; Chan, C.T.; Roitt, I.M. Critical role of iodination for T cell recognition of thyroglobulin in experimental murine thyroid autoimmunity. J. Immunol. 1987, 139, 3665-3670.
106. Barin, J.G.; Talor, M.V.; Sharma, R.B.; Rose, N.R.; Burek, C.L. Iodination of murine thyroglobulin enhances autoimmune reactivity in the NOD. H2 mouse. Clin. Exp. Immunol. 2005, 142, 251-259.
107. Carayanniotis, G. Recognition of thyroglobulin by T cells: The role of iodine. Thyroid 2007, 17, 963-973.
108. Gentile, F.; Conte, M.; Formisano, S. Thyroglobulinas an autoantigen: What can we learn about immunopathogenicity from the correlation of antigenic properties withprotein structure? Immunology 2004, 112, 13-25.
109. Carayanniotis, G. Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis. Hormones Athens 2011, 10, 27-35.
110. Champion, B.R.; Page, K.R.; Parish, N.; Rayner, D.C.; Dawe, K.; Biswas-Hughes, G.; Cooke, A.; Geysen, M.; Roitt, I.M. Identification of a thyroxine-containing self-epitope of thyroglobulin which triggers thyroid autoreactive T cells. J. Exp. Med. 1991, 174, 363-370.
111. Kong, Y.C.; McCormick, D.J.; Wan, Q.; Motte, R.W.; Fuller, B.E.; Giraldo, A.A.; David, C.S. Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis. Secondaryrole of iodination. J. Immunol. 1995, 155, 5847-5854.
112. Dawe, K.I.; Hutchings, P.R.; Geysen, M.; Champion, B.R.; Cooke, A.; Roitt, I.M. Unique role of thyroxine in T cell recognition of a pathogenic peptide in experimental autoimmune thyroiditis. Eur. J. Immunol. 1996, 26, 768-772.
113. Flynn, J.C.; McCormick, D.J.; Brusic, V.; Wan, Q.; Panos, J.C.; Giraldo, A.A.; David, C.S.; Kong, Y.C. Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis. Cell. Immunol. 2004, 229, 79-85.
114. Li, H.S.; Carayanniotis, G. Iodination of tyrosyls in thyroglobulin generates neoantigenic determinants that cause thyroiditis. J. Immunol. 2006, 176, 4479-4483.
115. Jiang, H.Y.; Li, H.S.; Carayanniotis, K.; Carayanniotis, G. Variable influences of iodine on the T-cell recognition of a single thyroglobulin epitope. Immunology 2007, 121, 370-376.
116. Dai, Y.D.; Rao, V.P.; Carayanniotis, G. Enhanced iodination of thyroglobulin facilitates processing and presentation of a cryptic pathogenic peptide. J. Immunol. 2002, 168, 5907-5911.