A Novel Role of Spinal Astrocytic Connexin 43: Mediating Morphine Antinociceptive Tolerance by Activation of NMDA Receptors and Inhibition of Glutamate Transporter-1 in Rats

CNS Neuroscience and Therapeutics

Volumn 20, Issue 8, 2014, Pages 728-736

  Shen, Ning ^a   Mo, Li Qiu ^b   Hu, Fen ^b   Chen, Pei Xi ^a   Guo, Rui Xian ^a   Feng, Jian Qiang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Astrocyte; Connexin 43; Glutamate transporter 1; Morphine tolerance; N methyl D aspartic acid receptor

Indexed keywords

CONNEXIN 43; DIZOCILPINE; GAP26 PEPTIDE; HOT WATER; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PEPTIDE; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; AMINO ACID RECEPTOR BLOCKING AGENT; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID TRANSPORTER 2; GAP 26 PEPTIDE; GLIAL FIBRILLARY ACIDIC PROTEIN; NARCOTIC ANALGESIC AGENT;

ADULT; ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; IMMUNOHISTOCHEMISTRY; LONG TERM CARE; MALE; MORPHINE TOLERANCE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; RAT; SPINAL CORD NERVE CELL; TAIL FLICK TEST; UPREGULATION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PHOSPHORYLATION; SPINAL CORD; SPRAGUE DAWLEY RAT;

ANALGESICS, OPIOID; ANIMALS; ASTROCYTES; CONNEXIN 43; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY AMINO ACID TRANSPORTER 2; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; MALE; MORPHINE; PEPTIDES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD;

EID: 84904638685     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12244     Document Type: Article

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