Activation of cytoprotective signaling pathways by alpha-lipoic acid

Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects

Volumn , Issue , 2008, Pages 439-460

  Kiemer, Alexandra K ^a   Diesel, Britta ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84904599920     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (87)

1. Biewenga, G.P., G.R. Haenen, and A. Bast. 1997. The pharmacology of the antioxidant lipoic acid. General Pharmacology 29:315-331.
2. Breithaupt-Grogler, K., G. Niebch, E. Schneider et al. 1999. Dose-proportionality of oral thioctic acid-coincidence of assessments via pooled plasma and individual data. European Journal of Pharmaceutical Sciences 8:57-65.
3. Bustamante, J., J.K. Lodge, L. Marcocci et al. 1998. Alpha-lipoic acid in liver metabolism and disease. Free Radical Biology and Medicine 24:1023-1039.
4. Calzado, M.A., S. Bacher, and M.L. Schmitz. 2007. NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer. Current Medicinal Chemistry. 14:367-376.
5. Chen, Z.P., K.I. Mitchelhill, B.J. Michell et al. 1999. AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Letters 443:285-289.
6. Cho, K.J., H.E. Moon, A.S. Chung et al. 2003. Alpha-lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways. Journal of Biological Chemistry 278:3482334833.
7. Cho, Y.S., J. Lee, T.H. Lee et al. 2004. Alpha-lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. The Journal of Allergy and Clinical Immunology 114:429-435.
8. Choi, B.M., H.O. Pae, S.I. Jang et al. 2002. Nitric oxide as a pro-apoptotic as well as antiapoptotic modulator. Journal of Biochemistry and Molecular Biology 35:116-126.
9. Coombes, J.S., S.K. Powers, K.L. Hamilton et al. 2000. Improved cardiac performance after ischemia in aged rats supplemented with vitamin E and alpha-lipoic acid. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 279:R2149-R2155.
10. Dicter, N., Z. Madar, and O. Tirosh. 2002. Alpha-lipoic acid inhibits glycogen synthesis in rat soleus muscle via its oxidative activity and the uncoupling of mitochondria. The Journal of Nutrition 132:3001-3006.
11. Diesel, B., S. Kulhanek-Heinze, M. Höltje et al. 2007. Alpha-lipoic acid as a directly binding activator of the insulin receptor-protection from hepatocyte apoptosis. Biochemistry 46:2146-2155.
12. Dimmeler, S., C. Hermann, A.M. Zeiher et al. 1999. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605.
13. Drew, B.G., N.H. Fidge, G. Gallon-Beaumier et al. 2004. High-density lipoprotein and apolipoprotein AI increase endothelial NO synthase activity by protein association and multisite phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 101:6999-7004.
14. Dünschede, F., K. Erbes, A. Kircher et al. 2007a. Protection from hepatic ischemia/ reperfusion injury and improvement of liver regeneration by alpha-lipoic acid. Shock 27:644-651.
15. Dünschede, F., S. Westermann, N. Riegler et al. 2007b. Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 minutes of rat liver ischemia. World Journal of Gastroenterology 13:3692-3698.
16. Dünschede, F., K. Erbes, A. Kircher et al. 2006a. Reduction of ischemia-reperfusion injury after liver resection and hepatic inflow occlusion by alpha-lipoic acid in humans. World Journal of Gastroenterology 12:6812-6817.
17. Dünschede, F., S. Westermann, N. Riegler et al. 2006b. Different protection mechanisms after pretreatment with glycine or alpha-lipoic acid in a rat model of warm hepatic ischemia. European Surgical Research 38:503-512.
18. Fang, Y., S.I. Han, C. Mitchell et al. 2004. Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes. Hepatology 40:961-971.
19. Frank, G.D., S. Eguchi, and E.D. Motley. 2005. The role of reactive oxygen species in insulin signaling in the vasculature. Antioxidants and Redox Signaling 7:1053-1061.
20. Fürst, R., C. Brueckl, W.M. Kuebler et al. 2005. Atrial natriuretic peptide induces mitogenactivated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD (P)H oxidase/Nox2-activation. Circulation Research 96:43-53.
21. Goldstein, B.J., K. Mahadev, X. Wu et al. 2005. Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxidants and Redox Signaling 7:1021-1031.
22. Ha, H., J.H. Lee, H.N. Kim et al. 2006. Alpha-lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis. Journal of Immunology 176:111-117.
23. Hagen, T.M., J. Liu, J. Lykkesfeldt et al. 2002. Feeding acetyl-l-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proceedings of the National Academy of Sciences of the United States of America 99:1870-1875.
24. Hansson, G.K. 2005. Mechanisms of disease: Inflammation, atherosclerosis, and coronary artery disease. New England Journal of Medicine 352:1685-1695.
25. Hong, Y.S., S.J. Jacobia, L. Packer et al. 1999. The inhibitory effects of lipoic compounds on mammalian pyruvate dehydrogenase complex and its catalytic components. Free Radical Biology & Medicine 26:685-694.
26. Jeschke, M.G., H. Rensing, D. Klein et al. 2005. Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats. Journal of Hepatology 42:870-879.
27. Kang, S., J. Song, H. Kang et al. 2003. Insulin can block apoptosis by decreasing oxidative stress via phosphatidylinositol-3-kinase and extracellular signal-regulated protein kinase-dependent signaling pathways in HepG2 cells. European Journal of Endocrinology 148:147-155.
28. Karunakaran, S., L. Diwakar, U. Saeed et al. 2007. Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: Protection by alpha-lipoic acid. FASEB Journal 21:2226-2236.
29. Kiemer, A.K., C. Müller, and A.M. Vollmar. 2002a. Inhibition of LPS-induced nitric oxide and TNF-alpha production by alpha-lipoic acid in rat Kupffer cells and in RAW 264.7 murine macrophages. Immunology and Cell Biology 80:550-557.
30. Kiemer, A.K., N.C. Weber, R. Fürst et al. 2002b. Inhibition of p38 MAPK activation via induction of MKP-1: Atrial natriuretic peptide reduces TNF-alpha-induced actin polymerization and endothelial permeability. Circulation Research 90:874-881.
31. Kim, M.S., J.Y. Park, I.S. Namgoong et al. 2004. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nature Medicine 10:727-733.
32. Konrad, D. 2005. Utilization of the insulin-signaling network in the metabolic actions of alpha-lipoic acid-reduction or oxidation? Antioxidants and Redox Signaling 7:1032-1039.
33. Konrad, D., R. Somwar, G. Sweeney et al. 2001. The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: Potential role of p38 mitogen-activated protein kinase in GLUT4 activation. Diabetes 50:1464-1471.
34. Kowluru, R.A. and S. Odenbach. 2004. Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes 53:3233-3238.
35. Lee, E.Y., C.K. Lee, K.U. Lee et al. 2007. Alpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in mice. Rheumatology International 27:225-233.
36. Lee, H.A. and D.A. Hughes. 2002. Alpha-lipoic acid modulates NF-kappaB activity in human monocytic cells by direct interaction with DNA. Experimental Gerontology 37:401-410.
37. Lee, K.M., K.G. Park, Y.D. Kim et al. 2006. Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery. Atherosclerosis 189:106-114.
38. Lee, S.C. and S. Pervaiz. 2007. Apoptosis in the pathophysiology of diabetes mellitus. The International Journal of Biochemistry and Cell Biology 39:497-504.
39. Lee, W.J., I.K. Lee, H.S. Kim et al. 2005a. Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of amp-activated protein kinase. Arteriosclerosis, Thrombosis, and Vascular Biology 25:2488-2494.
40. Lee, W.J., K.H. Song, E.H. Koh et al. 2005b. Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochemical and Biophysical Research Communications 332:885-891.
41. Li, H., T. Wallerath, T. Münzel et al. 2002. Regulation of endothelial-type NO synthase expression in pathophysiology and in response to drugs. Nitric Oxide-Biology and Chemistry 7:149-164.
42. Liu, J., E. Head, A.M. Gharib et al. 2002a. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or R-alpha-lipoic acid. Proceedings of the National Academy of Sciences of the United States of America 99:2356-2361.
43. Liu, J., D.W. Killilea, and B.N. Ames. 2002b. Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-l-carnitine and/or R-alpha-lipoic acid. Proceedings of the National Academy of Sciences of the United States of America 99:1876-1881.
44. Maitra, I., E. Serbinova, H.J. Tritschler et al. 1996. Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. Biochemical and Biophysical Research Communications 221:422-429.
45. Maric, C., F. Bhatti, R.W. Mankhey et al. 2005. Mechanisms of antioxidant and prooxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidney. Kidney International 67:1371-1380.
46. Marsh, S.A., J.S. Coombes, B.K. Pat et al. 2005. Evidence for a non-antioxidant, dosedependent role of alpha-lipoic acid in caspase-3 and ERK2 activation in endothelial cells. Apoptosis 10:657-665.
47. Matthews, J.R., W. Kaszubska, G. Turcatti et al. 1993. Role of cysteine62 in DNA recognition by the P50 subunit of NF-kappa B. Nucleic Acids Research 21:1727-1734.
48. Moini, H., O. Tirosh, Y.C. Park et al. 2002. R-Alpha-lipoic acid action on cell redox status, the insulin receptor, and glucose uptake in 3T3-L1 adipocytes. Archives of Biochemistry and Biophysics 397:384-391.
49. Moungjaroen, J., U. Nimmannit, P.S. Callery et al. 2006. Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation. The Journal of Pharmacology and Experimental Therapeutics 319:1062-1069.
50. Müller, C., F. Dünschede, E. Koch, A.M. Vollmar, and A.K. Kiemer. 2003. Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway. American Journal of Physiology. Gastrointestinal and Liver Physiology 285:G769-G778.
51. Münzel, T., A. Daiber, A. Mülsch et al. 2005. Vascular consequences of endothelial nitric oxide synthase uncoupling for the activity and expression of the soluble guanylyl cyclase and the cGMP-dependent protein kinase. Arteriosclerosis, Thrombosis, and Vascular Biology 25:1551-1557.
52. Musi, N., T. Hayashi, N. Fujii et al. 2001. AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism 280:E677-E684.
53. Nagata, D., R. Takeda, M. Sata et al. 2004. AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation. Circulation 110:444-451.
54. Ogborne, R.M., S.A. Rushworth, and M.A. O'Connell. 2005. Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by 2 and p38 mitogen-activated protein kinase in human monocytic cells. Arteriosclerosis, Thrombosis, and Vascular Biology 25:2100-2105.
55. Pack, R.A., K. Hardy, M.C. Madigan et al. 2002. Differential effects of the antioxidant alpha-lipoic acid on the proliferation of mitogen-stimulated peripheral blood lymphocytes and leukaemic T cells. Molecular Immunology 38:733-745.
56. Pershadsingh, H.A. 2005. Alpha-lipoic acid is a weak dual PPARa/g agonist an ester derivative with increased PPARa/gefficacy and antioxidant activity. Journal of Applied Research 5:510-523.
57. Pershadsingh, H.A. 2007. Alpha-lipoic acid: Physiologic mechanisms and indications for the treatment of metabolic syndrome. Expert Opinion on Investigational Drugs 16:291-302.
58. Pierce, R.H., J.S. Campbell, A.B. Stephenson et al. 2000. Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line. American Journal of Pathology 157:221-236.
59. Saperstein, R., P.P. Vicario, H.V. Strout et al. 1989. Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells. Biochemistry 28:5694-5701.
60. Schreck, R., K. Albermann, and P.A. Baeuerle. 1992. Nuclear factor kappa B: An oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radical Research Communications. 17:221-237.
61. Scott, B.C., O.I. Aruoma, P.J. Evans et al. 1994. Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation. Free Radical Research 20:119-133.
62. Sen, C.K., S. Roy, and L. Packer. 1999. Fas mediated apoptosis of human Jurkat T-cells: Intracellular events and potentiation by redox-active alpha-lipoic acid. Cell Death and Differentiation 6:481-191.
63. Shen, Q.W., C.S. Jones, N. Kalchayanand et al. 2005. Effect of dietary alpha-lipoic acid on growth, body composition, muscle pH, and AMP-activated protein kinase phosphorylation in mice. Journal of Animal Science 83:2611-2617.
64. Shimizu, S., Y. Yamada, M. Okuno et al. 2005. Liver injury induced by lipopolysaccharide is mediated by TNFR-1 but not by TNFR-2 or Fas in mice. Hepatology Research 31:136-142.
65. Sierra, C. and A. De La Sierra. 2005. Antihypertensive, cardiovascular, and pleiotropic effects of angiotensin-receptor blockers. Current Opinion in Nephrology and Hypertension 14:435-441.
66. Simbula, G., A. Columbano, G.M. Ledda-Columbano et al. 2007. Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells. Apoptosis 12:113-123.
67. Smith, J.R., H.V. Thiagaraj, B. Seaver et al. 2005. Differential activity of lipoic acid enantiomers in cell culture. Journal of Herbal Pharmacotherapy 5:43-54.
68. Sola, S., M.Q. Mir, F.A. Cheema et al. 2005. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: Results of the Irbesartan and lipoic acid in endothelial dysfunction (ISLAND) study. Circulation 111:343-348.
69. Streeper, R.S., E.J. Henriksen, S. Jacob et al. 1997. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. American Journal of Physiology 273:E185-E191.
70. Sung, M.J., W. Kim, S.Y. Ahn et al. 2005. Protective effect of alpha-lipoic acid in lipopolysaccharide-induced endothelial fractalkine expression. Circulation Research 97:880-890.
71. Terry, C., A. Dhawan, R.R. Mitry et al. 2006. Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing. Liver Transplantation 12:165-177.
72. Thors, B., H. Halldrsson, and G. Thorgeirsson. 2004. Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt. FEBS Letters 573:175-180.
73. Trappoliere, M., C. Tuccillo, A. Federico et al. 2005. The treatment of NAFLD. European Review for Medical and Pharmacological Sciences 9:299-304.
74. Valverde, A.M., I. Fabregat, D.J. Burks, M.F. White, and M. Benito. 2004. IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology 40:1285-1294.
75. Van de Mark, K., J.S. Chen, K. Steliou et al. 2003. Alpha-lipoic acid induces p27Kip-dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines. Journal of Cellular Physiology 194:325-340.
76. Van den Berghe, G., P. Wouters, F. Weekers et al. 2001. Intensive insulin therapy in critically ill patients. New England Journal of Medicine 345:1359-1367.
77. Van den Berg, R., G.R. Haenen, H. van den Berg et al. 2001. Transcription factor NF-kappaB as a potential biomarker for oxidative stress. The British Journal of Nutrition 86 Suppl 1:S121-S127.
78. Walgren, J.L., Z. Amani, J.M. McMillan et al. 2004. Effect of R(+)alpha-lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes. Metabolism 53:165-173.
79. Wenzel, U., A. Nickel, and H. Daniel. 2005. Alpha-lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-generation. Apoptosis 10:359-368.
80. Widlansky, M., A.R. Smith, S.V. Shenvi et al. 2004. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Current Medicinal Chemistry 11:1135-1146.
81. Yaworsky, K., R. Somwar, T. Ramlal et al. 2000. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes. Diabetologia 43:294-303.
82. Yi, X. and N. Maeda. 2006. Alpha-lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes 55:2238-2244.
83. Zhang, L., G.Q. Xing, J.L. Barker et al. 2001. Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signaling pathway. Neuroscience Letters 312:125-128.
84. Zhang, W.J. and B. Frei. 2001. Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells. FASEB Journal 15:2423-2432.
85. Zhang, W.J., H. Wei, T. Hagen et al. 2007. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Proceedings of the National Academy of Sciences of the United States of America 104:4077-4082.
86. Ziegler, D., H. Nowak, P. Kempler et al. 2004. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabetic Medicine 21:114-121.
87. Zimmermann, K.C. and D.R. Green. 2001. How cells die: Apoptosis pathways. The Journal of Allergy and Clinical Immunology 108:S99-S103.