메뉴 건너뛰기




Volumn 67, Issue 4, 2005, Pages 1371-1380

Mechanisms of antioxidant and pro-oxidant effects of α-lipoic acid in the diabetic and nondiabetic kidney

Author keywords

Diabetes; Kidney; Oxidative stress; lipoic acid

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; ALBUMIN; ANTIOXIDANT; CREATININE; GLUCOSE; PROTEIN P22; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; THIOCTIC ACID;

EID: 16244413938     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2005.00214.x     Document Type: Article
Times cited : (100)

References (50)
  • 1
    • 0035991372 scopus 로고    scopus 로고
    • Antioxidant therapy potentiates antihypertensive action of insulin in diabetic rats
    • KOO JR, NI Z, OVIESI F, VAZIRI ND: Antioxidant therapy potentiates antihypertensive action of insulin in diabetic rats. Clin Exp Hypertens 24:333-344, 2002
    • (2002) Clin Exp Hypertens , vol.24 , pp. 333-344
    • Koo, J.R.1    Ni, Z.2    Oviesi, F.3    Vaziri, N.D.4
  • 2
    • 0141755311 scopus 로고    scopus 로고
    • Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy
    • KITADA M, KOYA D, SUGIMOTO T, et al: Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. Diabetes 52:2603-2614, 2003
    • (2003) Diabetes , vol.52 , pp. 2603-2614
    • Kitada, M.1    Koya, D.2    Sugimoto, T.3
  • 3
    • 0041865372 scopus 로고    scopus 로고
    • ROS generation by nonphagocytic NADPH oxidase: Potential relevance in diabetic nephropathy
    • LI JM, SHAH AM: ROS generation by nonphagocytic NADPH oxidase: Potential relevance in diabetic nephropathy. J Am Soc Nephrol 14:S221-S226, 2003
    • (2003) J Am Soc Nephrol , vol.14
    • Li, J.M.1    Shah, A.M.2
  • 4
    • 0141483457 scopus 로고    scopus 로고
    • The breakdown of pre-existing advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes
    • FORBES JM, THALLAS V, THOMAS MC, et al: The breakdown of pre-existing advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes. FASEB J 17:1762-1764, 2003
    • (2003) FASEB J , vol.17 , pp. 1762-1764
    • Forbes, J.M.1    Thallas, V.2    Thomas, M.C.3
  • 5
    • 0036796875 scopus 로고    scopus 로고
    • Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes
    • EVANS JL, GOLDFINE ID, MADDUX BA, GRODSKY GM: Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes. Endocr Rev 23:599-622, 2002
    • (2002) Endocr Rev , vol.23 , pp. 599-622
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 6
    • 0036125180 scopus 로고    scopus 로고
    • Effect of alpha-lipoic acid on lipid peroxidation and anti-oxidant enzyme activities in diabetic rats
    • DINCER Y, TELCI A, KAYALI R, et al: Effect of alpha-lipoic acid on lipid peroxidation and anti-oxidant enzyme activities in diabetic rats. Clin Exp Pharmacol Physiol 29:281-284, 2002
    • (2002) Clin Exp Pharmacol Physiol , vol.29 , pp. 281-284
    • Dincer, Y.1    Telci, A.2    Kayali, R.3
  • 7
    • 0034920828 scopus 로고    scopus 로고
    • Nitric oxide synthesis and oxidative stress in the renal cortex of rats with diabetes mellitus
    • ISHII N, PATEL KP, LANE PH, et al: Nitric oxide synthesis and oxidative stress in the renal cortex of rats with diabetes mellitus. J Am Soc Nephrol 12:1630-1639, 2001
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1630-1639
    • Ishii, N.1    Patel, K.P.2    Lane, P.H.3
  • 9
    • 0034071307 scopus 로고    scopus 로고
    • Locally activated renin-angiotensin system associated with TGF-beta1 as a major factor for renal injury induced by chronic inhibition of nitric oxide synthase in rats
    • KASHIWAGI M, SHINOZAKI M, HIRAKATA H, et al: Locally activated renin-angiotensin system associated with TGF-beta1 as a major factor for renal injury induced by chronic inhibition of nitric oxide synthase in rats. J Am Soc Nephrol 11:616-624, 2000
    • (2000) J Am Soc Nephrol , vol.11 , pp. 616-624
    • Kashiwagi, M.1    Shinozaki, M.2    Hirakata, H.3
  • 10
    • 0036145348 scopus 로고    scopus 로고
    • Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: Effects of ACEI and ARB
    • ONOZATO ML, TOJO A, GOTO A, et al: Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB. Kidney Int 61:186-194, 2002
    • (2002) Kidney Int , vol.61 , pp. 186-194
    • Onozato, M.L.1    Tojo, A.2    Goto, A.3
  • 11
    • 0033982133 scopus 로고    scopus 로고
    • Nitric oxide synthase isoforms and glomerular hyperfiltration in early diabetic nephropathy
    • VEELKEN R, HILGERS KF, HARTNER A, et al: Nitric oxide synthase isoforms and glomerular hyperfiltration in early diabetic nephropathy. J Am Soc Nephrol 11:71-79, 2000
    • (2000) J Am Soc Nephrol , vol.11 , pp. 71-79
    • Veelken, R.1    Hilgers, K.F.2    Hartner, A.3
  • 12
    • 0033829947 scopus 로고    scopus 로고
    • Role of neuronal nitric oxide synthase (NOS1) in the pathogenesis of renal hemodynamic changes in diabetes
    • KOMERS R, LINDSLEY JN, OYAMA TT, et al: Role of neuronal nitric oxide synthase (NOS1) in the pathogenesis of renal hemodynamic changes in diabetes. Am J Physiol Renal Physiol 279:F573-F583, 2000
    • (2000) Am J Physiol Renal Physiol , vol.279
    • Komers, R.1    Lindsley, J.N.2    Oyama, T.T.3
  • 13
    • 0035556124 scopus 로고    scopus 로고
    • The comparison of vitamin C and vitamin E on the protein oxidation of diabetic rats
    • JE HD, SHIN CY, PARK HS, et al: The comparison of vitamin C and vitamin E on the protein oxidation of diabetic rats. J Auton Pharmacol 21:231-236, 2001
    • (2001) J Auton Pharmacol , vol.21 , pp. 231-236
    • Je, H.D.1    Shin, C.Y.2    Park, H.S.3
  • 14
    • 0035215435 scopus 로고    scopus 로고
    • Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy
    • OBROSOVA IG, FATHALLAH L, STEVENS MJ: Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy. Exp Neurol 172:211-219, 2001
    • (2001) Exp Neurol , vol.172 , pp. 211-219
    • Obrosova, I.G.1    Fathallah, L.2    Stevens, M.J.3
  • 15
    • 0036191381 scopus 로고    scopus 로고
    • Evidence of oxidative stress in the renal cortex of diabetic rats: Favourable effect of vitamin E
    • JACHEC W, TOMASIK A, TARNAWSKI R, CHWALINSKA E: Evidence of oxidative stress in the renal cortex of diabetic rats: Favourable effect of vitamin E. Scand J Clin Lab Invest 62:81-88, 2002
    • (2002) Scand J Clin Lab Invest , vol.62 , pp. 81-88
    • Jachec, W.1    Tomasik, A.2    Tarnawski, R.3    Chwalinska, E.4
  • 16
    • 0042867404 scopus 로고    scopus 로고
    • Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats
    • KOYA D, HAYASHI K, KITADA M, et al: Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats. J Am Soc Nephrol 14:S250-S253, 2003
    • (2003) J Am Soc Nephrol , vol.14
    • Koya, D.1    Hayashi, K.2    Kitada, M.3
  • 17
    • 0030784837 scopus 로고    scopus 로고
    • Effects of supplementation with vitamin C or E on albuminuria, glomerular TGF-beta, and glomerular size in diabetes
    • CRAVEN PA, DERUBERTIS FR, KAGAN VE et al: Effects of supplementation with vitamin C or E on albuminuria, glomerular TGF-beta, and glomerular size in diabetes. J Am Soc Nephrol 8:1405-1414, 1997
    • (1997) J Am Soc Nephrol , vol.8 , pp. 1405-1414
    • Craven, P.A.1    Derubertis, F.R.2    Kagan, V.E.3
  • 19
    • 0018338513 scopus 로고
    • Biosynthesis of lipoic acid via unsaturated fatty acids
    • CARREAU JP: Biosynthesis of lipoic acid via unsaturated fatty acids. Methods Enzymol 62:152-158, 1979
    • (1979) Methods Enzymol , vol.62 , pp. 152-158
    • Carreau, J.P.1
  • 20
    • 0036070514 scopus 로고    scopus 로고
    • Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid
    • MOINI H, PACKER L, SARIS N: Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol 182:84-90, 2002
    • (2002) Toxicol Appl Pharmacol , vol.182 , pp. 84-90
    • Moini, H.1    Packer, L.2    Saris, N.3
  • 21
    • 0142107431 scopus 로고    scopus 로고
    • Lipoic acid: A multifunctional antioxidant
    • BAST A, HAENEN G: Lipoic acid: a multifunctional antioxidant. Biofactors 17:207-213, 2003
    • (2003) Biofactors , vol.17 , pp. 207-213
    • Bast, A.1    Haenen, G.2
  • 22
    • 0036140382 scopus 로고    scopus 로고
    • Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes
    • MELHEM MF, CRAVEN PA, LIACHENKO J, DE RUBERTIS FR: Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol 13:108-116, 2002
    • (2002) J Am Soc Nephrol , vol.13 , pp. 108-116
    • Melhem, M.F.1    Craven, P.A.2    Liachenko, J.3    De Rubertis, F.R.4
  • 23
    • 0037707713 scopus 로고    scopus 로고
    • Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats
    • MARITIM AC, SANDERS RA, WATKINS JB: Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats. J Nutr Biochem 14:288-294, 2003
    • (2003) J Nutr Biochem , vol.14 , pp. 288-294
    • Maritim, A.C.1    Sanders, R.A.2    Watkins, J.B.3
  • 24
    • 0037438946 scopus 로고    scopus 로고
    • Early oxidative stress in the diabetic kidney: Effect of DL-alpha-lipoic acid
    • OBROSOVA IG, FATHALLAH L, LIU E, NOUROOZ-ZADEH J: Early oxidative stress in the diabetic kidney: Effect of DL-alpha-lipoic acid. Free Radic Biol Med 34:186-195, 2003
    • (2003) Free Radic Biol Med , vol.34 , pp. 186-195
    • Obrosova, I.G.1    Fathallah, L.2    Liu, E.3    Nourooz-Zadeh, J.4
  • 25
    • 0029090976 scopus 로고
    • Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy
    • NAGAMATSU M, NICKANDER K, SCHMELZER J, et al: Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 18:1160-1167, 1995
    • (1995) Diabetes Care , vol.18 , pp. 1160-1167
    • Nagamatsu, M.1    Nickander, K.2    Schmelzer, J.3
  • 26
    • 0034625764 scopus 로고    scopus 로고
    • Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: Effect of DL-alpha-lipoic acid
    • OBROSOVA IG, FATHALLAH L, GREENE DA: Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: Effect of DL-alpha-lipoic acid. Eur J Pharmacol 398:139-146, 2000
    • (2000) Eur J Pharmacol , vol.398 , pp. 139-146
    • Obrosova, I.G.1    Fathallah, L.2    Greene, D.A.3
  • 27
    • 0023637202 scopus 로고
    • The enhancement of aminonucleoside nephrosis by the co-administration of protamine
    • SAITO T, SUMITHRAN E, GLASGOW EF, ATKINS RC: The enhancement of aminonucleoside nephrosis by the co-administration of protamine. Kidney Int 32:691-699, 1987
    • (1987) Kidney Int , vol.32 , pp. 691-699
    • Saito, T.1    Sumithran, E.2    Glasgow, E.F.3    Atkins, R.C.4
  • 28
    • 0037378070 scopus 로고    scopus 로고
    • Amelioration of diabetic nephropathy in SPARC-null mice
    • TANEDA S, PIPPIN JW, SAGE EH, et al: Amelioration of diabetic nephropathy in SPARC-null mice. J Am Soc Nephrol 14:968-980, 2003
    • (2003) J Am Soc Nephrol , vol.14 , pp. 968-980
    • Taneda, S.1    Pippin, J.W.2    Sage, E.H.3
  • 29
    • 0142182739 scopus 로고    scopus 로고
    • Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase
    • KITIYAKARA C, CHABRASHVILI T, CHEN Y, et al: Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase. J Am Soc Nephrol 14:2775-2782, 2003
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2775-2782
    • Kitiyakara, C.1    Chabrashvili, T.2    Chen, Y.3
  • 30
    • 0032956654 scopus 로고    scopus 로고
    • Two-week administration of tempol attenuates both hypertension and renal excretion of 8-iso prostaglandin f2alpha
    • SCHNACKENBERG CG, WILCOX CS: Two-week administration of tempol attenuates both hypertension and renal excretion of 8-iso prostaglandin f2alpha. Hypertension 33:424-428, 1999
    • (1999) Hypertension , vol.33 , pp. 424-428
    • Schnackenberg, C.G.1    Wilcox, C.S.2
  • 31
    • 0029016908 scopus 로고
    • Topological mapping of neutrophil cytochrome b epitopes with phage-display libraries
    • BURRITT JB, QUINN MT, JUTILA MA, et al: Topological mapping of neutrophil cytochrome b epitopes with phage-display libraries. J Biol Chem 270:16974-16980, 1995
    • (1995) J Biol Chem , vol.270 , pp. 16974-16980
    • Burritt, J.B.1    Quinn, M.T.2    Jutila, M.A.3
  • 32
    • 0030054867 scopus 로고    scopus 로고
    • Assembly of the human neutrophil NADPH oxidase involves binding of p67phox and flavocytochrome b to a common functional domain in p47phox
    • DE LEO FR, ULMAN KV, DAVIS AR, et al: Assembly of the human neutrophil NADPH oxidase involves binding of p67phox and flavocytochrome b to a common functional domain in p47phox. J Biol Chem 271:17013-17020, 1996
    • (1996) J Biol Chem , vol.271 , pp. 17013-17020
    • De Leo, F.R.1    Ulman, K.V.2    Davis, A.R.3
  • 33
    • 0036175986 scopus 로고    scopus 로고
    • Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney
    • CHABRASHVILI T, TOJO A, ONOZATO ML, et al: Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney. Hypertension 39:269-274, 2002
    • (2002) Hypertension , vol.39 , pp. 269-274
    • Chabrashvili, T.1    Tojo, A.2    Onozato, M.L.3
  • 34
    • 0035174786 scopus 로고    scopus 로고
    • Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus
    • MELHEM MF, CRAVEN PA, DERUBERTIS FR: Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. J Am Soc Nephrol 12:124-133, 2001
    • (2001) J Am Soc Nephrol , vol.12 , pp. 124-133
    • Melhem, M.F.1    Craven, P.A.2    Derubertis, F.R.3
  • 35
    • 0036140382 scopus 로고    scopus 로고
    • Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes
    • MELHEM MF, CRAVEN PA, LIACHENKO J, DERUBERTIS FR: Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol 13:108-116, 2002
    • (2002) J Am Soc Nephrol , vol.13 , pp. 108-116
    • Melhem, M.F.1    Craven, P.A.2    Liachenko, J.3    Derubertis, F.R.4
  • 36
    • 0036151673 scopus 로고    scopus 로고
    • Glucose-induced oxidative stress in mesangial cells
    • CATHERWOOD MA, POWELL LA, ANDERSON P, et al: Glucose-induced oxidative stress in mesangial cells. Kidney Int 61:599-608, 2002
    • (2002) Kidney Int , vol.61 , pp. 599-608
    • Catherwood, M.A.1    Powell, L.A.2    Anderson, P.3
  • 37
    • 0038458764 scopus 로고    scopus 로고
    • Lipoic acid supplementation prevents angiotensin II-induced renal injury
    • MERVAALA E, FINCKENBERG P, LAPATTO R, et al: Lipoic acid supplementation prevents angiotensin II-induced renal injury. Kidney Int 64:501-508, 2003
    • (2003) Kidney Int , vol.64 , pp. 501-508
    • Mervaala, E.1    Finckenberg, P.2    Lapatto, R.3
  • 38
    • 0030581630 scopus 로고    scopus 로고
    • Rapid formation of advanced glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway
    • HAMADA Y, ARAKI N, KOH N, et al: Rapid formation of advanced glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway. Biochem Biophys Res Commun 228:539-543, 1996
    • (1996) Biochem Biophys Res Commun , vol.228 , pp. 539-543
    • Hamada, Y.1    Araki, N.2    Koh, N.3
  • 39
    • 0028105717 scopus 로고
    • Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy
    • DERUBERTIS F, CRAVEN P: Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes 43:1-8, 1994
    • (1994) Diabetes , vol.43 , pp. 1-8
    • Derubertis, F.1    Craven, P.2
  • 40
    • 0344548772 scopus 로고    scopus 로고
    • Pathogenesis of diabetic nephropathy: The role of oxidative stress and protein kinase C
    • HA H, KIM K: Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C. Diabetes Res Clin Pract 45:147-151, 1999
    • (1999) Diabetes Res Clin Pract , vol.45 , pp. 147-151
    • Ha, H.1    Kim, K.2
  • 41
    • 0027942025 scopus 로고
    • PKC and high glucose stimulate collagen alpha 1 (IV) transcriptional activity in a reporter mesangial cell line
    • FUMO P, KUNCIO G, ZIYADEH F: PKC and high glucose stimulate collagen alpha 1 (IV) transcriptional activity in a reporter mesangial cell line. Am J Physiol 267:F632-F638, 1994
    • (1994) Am J Physiol , vol.267
    • Fumo, P.1    Kuncio, G.2    Ziyadeh, F.3
  • 42
    • 0036942182 scopus 로고    scopus 로고
    • Effects of alpha lipoic acid, ascorbic acid-6-palmitate, and fish oil on the glutathione, malonaldehyde, and fatty acids levels in erythrocytes of streptozotocin induced diabetic male rats
    • YILMAZ O, OZKAN Y, YILDIRIM M, et al: Effects of alpha lipoic acid, ascorbic acid-6-palmitate, and fish oil on the glutathione, malonaldehyde, and fatty acids levels in erythrocytes of streptozotocin induced diabetic male rats. J Cell Biochem 86:530-539, 2002
    • (2002) J Cell Biochem , vol.86 , pp. 530-539
    • Yilmaz, O.1    Ozkan, Y.2    Yildirim, M.3
  • 43
    • 0042864155 scopus 로고    scopus 로고
    • Increased expression of NAD(P)H oxidase subunits, NOX4 and p22nhox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment
    • ETOH T, INOGUCHI T, KAKIMOTO M, et al: Increased expression of NAD(P)H oxidase subunits, NOX4 and p22nhox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment. Diabetologia 46:1428-1437, 2003
    • (2003) Diabetologia , vol.46 , pp. 1428-1437
    • Etoh, T.1    Inoguchi, T.2    Kakimoto, M.3
  • 44
    • 0347362495 scopus 로고    scopus 로고
    • Up-regulation of kidney NAD(P)H oxidase and calcineurin in SHR: Reversal by lifelong antioxidant supplementation
    • ZHAN CD, SINDHU RK, VAZIRI ND: Up-regulation of kidney NAD(P)H oxidase and calcineurin in SHR: Reversal by lifelong antioxidant supplementation. Kidney Int 65:219-227, 2004
    • (2004) Kidney Int , vol.65 , pp. 219-227
    • Zhan, C.D.1    Sindhu, R.K.2    Vaziri, N.D.3
  • 45
    • 0028345285 scopus 로고
    • Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation
    • SCOTT B, ARUOMA O, EVANS P, et al: Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation. Free Radic Res 20:119-133, 1994
    • (1994) Free Radic Res , vol.20 , pp. 119-133
    • Scott, B.1    Aruoma, O.2    Evans, P.3
  • 46
    • 0036070514 scopus 로고    scopus 로고
    • Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid
    • MOINI H, PACKER L, SARIS NE: Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol 182:84-90, 2002
    • (2002) Toxicol Appl Pharmacol , vol.182 , pp. 84-90
    • Moini, H.1    Packer, L.2    Saris, N.E.3
  • 47
    • 0032881613 scopus 로고    scopus 로고
    • Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): A two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha lipoic acid in diabetic neuropathy
    • RELJANOVIC M, REICHEL G, RETT K, et al: Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): A two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha lipoic acid in diabetic neuropathy. Free Radic Res 31:171-179, 1999
    • (1999) Free Radic Res , vol.31 , pp. 171-179
    • Reljanovic, M.1    Reichel, G.2    Rett, K.3
  • 48
    • 0033010474 scopus 로고    scopus 로고
    • alpha-lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria
    • BORCEA V, NOUROOZ-ZADEH J, WOLFF S, et al: alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Free Radic Biol Med 26:1495-1500, 1999
    • (1999) Free Radic Biol Med , vol.26 , pp. 1495-1500
    • Borcea, V.1    Nourooz-Zadeh, J.2    Wolff, S.3
  • 49
    • 0004570568 scopus 로고    scopus 로고
    • Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy
    • RUHNAU KJ, MEISSNER HP, FINN JR, et al: Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med 16:1040-1043, 1999
    • (1999) Diabet Med , vol.16 , pp. 1040-1043
    • Ruhnau, K.J.1    Meissner, H.P.2    Finn, J.R.3
  • 50
    • 0033231196 scopus 로고    scopus 로고
    • Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress
    • MARANGON K, DEVARAJ S, TIROSH O, et al: Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress. Free Radic Biol Med 27:1114-1121, 1999
    • (1999) Free Radic Biol Med , vol.27 , pp. 1114-1121
    • Marangon, K.1    Devaraj, S.2    Tirosh, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.