Alpha-lipoic acid modulates NF-κB activity in human monocytic cells by direct interaction with DNA

Experimental Gerontology

Volumn 37, Issue 2-3, 2002, Pages 401-410

  Lee, Heather A ^a,b   Hughes, David A ^a  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Alpha lipoic acid; Antioxidant; Direct DNA interaction; Monocytic cells; NF B

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CELL ADHESION MOLECULE; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; THIOCTIC ACID; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

AGING; ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; CELL ACTIVITY; CELL INTERACTION; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GEL SHIFT ANALYSIS; HUMAN; HUMAN CELL; MONOCYTE; OXIDATION REDUCTION REACTION; PHYSIOLOGY; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS;

ANTIOXIDANTS; CELL LINE; DNA; GENE EXPRESSION; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MONOCYTES; NF-KAPPA B; OLIGODEOXYRIBONUCLEOTIDES; RNA, MESSENGER; THIOCTIC ACID;

EID: 0037012016     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(01)00207-8     Document Type: Article

References (45)

1. Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin
2. IκB: A specific inhibitor of the NF-κB transcription factor
3. Function and activation of NF-κB in the immune system
4. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
5. Oxidative stress and nuclear factor-κB activation. A reassessment of the evidence in the light of recent discoveries
6. Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase
7. Cytokine expression in chronic inflammatory disease
8. Cloning and sequence of a deoxyribonucleic acid copy of glyceraldehyde 3-phosphate dehydrogenase messenger ribonucleic acid isolated from chicken muscle
9. Constitutive nucler NF-κB in cells of the monocyte lineage
10. α-Lipoic acid reduction by mammalian cells to the dithiol form and release into the culture medium
11. Antioxidants in vegan and rheumatic disorders
12. Characterisation of ageing-associated up-regulation of constitutive NF-kappa B binding activity
13. Inhibition of NF-κB-dependent transcription of human immunodeficiency virus 1 promoter by a phosphodiester compound of vitamin C and vitamin E, EPC-K1
14. Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB
15. Fish oil supplementation inhibits the expression of major histocompatability complex class II molecules and adhesion molecules on human monocytes
16. (n-3) polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes in vitro
17. α-tocopherol enrichment of monocytes decreases agonist-induced adhesion to human endothelial cells
18. The potential role of cell adhesion molecules in the pathogenesis of diabetic neuropathy
19. Thioredoxin regulates the DNA binding activity of NF-κB by reduction of a disulphide bond involving cysteine
20. Cellular enrichment with polyunsaturated fatty acid induces an oxidative stress and activates the transcription factors AP1 and NFκB
21. Role of ascorbate in the activation of NF-κB by tumour necrosis factor-α in T-cells
22. Inhibition of NF-kappa B transcriptional activity by alpha-tocopheryl succinate
23. α-Lipoic acid: A metabolic antioxidant which regulates NF-κB signal transduction and protects against oxidative injury
24. Alpha-lipoic acid as a biological antioxidant
25. A set of inducible genes expressed by activated human monocytic and endothelial cells contain κB-like sites that specifically bind c-Rel-p65 heterodimers
26. α-Lipoic acid supplementation prevents symptoms of vitamin E deficiency
27. PPAR-α activation modulates cellular redox status, represses NF-κB signalling and reduces inflammatory cytokine production in ageing
28. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1
29. Antioxidant regulation of phorbol ester-induced adhesion of human Jurkat T-cells to endothelial cells
30. Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependance on α-tocopherol
31. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells
32. ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM
33. Dithiocarbamates: Effects on lipid hydroperoxides and vascular inflammatory gene expression
34. Constitutive activation of NF-kappa B in an animal model of ageing
35. Adhesion receptors of the immune system
36. Inhibition of NF-κB activation by vitamin E derivatives
37. α-Lipoic acid is a potent inhibitor of NF-κB activation in human T cells
38. Redox regulation of NF-kappa B DNA binding activity by dihydrolipoate
39. Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms
40. The protection by ascorbate and glutothione against lipid peroxidation is dependent on vitamin E
41. The effect of cytokines on the expression of MHC antigens and ICAM-1 by normal and transformed synoviocytes
42. Augmented expression of inducible NO synthase in vascular smooth muscle cells during aging is associated with enhanced NF-kappa B activation
43. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: Current evidence from clinical trials
44. Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes