Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model

World Journal of Gastroenterology

Volumn 13, Issue 27, 2007, Pages 3692-3698

  Düenschede, Friedrich ^a   Erbes, Kirsten ^a   Riegler, Nina ^a   Ewald, Patrick ^a   Kircher, Achim ^a   Westermann, Stefanie ^a   Schad, Arno ^a   Miesmer, Imke ^a   Albrecht Schöck, Simon ^a   Gockel, Ines ^a   Kiemer, Alexandra K ^b   Junginger, Theodor ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Apoptosis; Lipid peroxidation; Liver preconditioning; Pharmacological preconditioning; Warm liver ischemia

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; PROTEIN BAX; PROTEIN BCL 2; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG TOLERANCE; ENZYME ACTIVITY; LIPID PEROXIDATION; LIVER CELL DAMAGE; LIVER FUNCTION; LIVER ISCHEMIA; LIVER PROTECTION; MALE; NICK END LABELING; NONHUMAN; PROTEIN DETERMINATION; RAT; SURVIVAL RATE;

EID: 34547623793     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i27.3692     Document Type: Article

References (24)

1. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74: 1124-1136
2. Tsai BM, Wang M, March KL, Turrentine MW, Brown JW, Meldrum DR. Preconditioning: evolution of basic mechanisms to potential therapeutic strategies. Shock 2004; 21: 195-209
3. Carini R, Albano E. Recent insights on the mechanisms of liver preconditioning. Gastroenterology 2003; 125: 1480-1491
4. Yadav SS, Sindram D, Perry DK, Clavien PA. Ischemic preconditioning protects the mouse liver by inhibition of apoptosis through a caspase-dependent pathway. Hepatology 1999; 30: 1223-1231
5. Glanemann M, Vollmar B, Nussler AK, Schaefer T, Neuhaus P, Menger MD. Ischemic preconditioning protects from hepatic ischemia/ reperfusion-injury by preservation of microcirculation and mitochondrial redox-state. J Hepatol 2003; 38: 59-66
6. Schulz R, Walz MK, Behrends M, Neumann T, Gerken G, Heusch G. Minimal protection of the liver by ischemic preconditioning in pigs. Am J Physiol Heart Circ Physiol 2001; 280: H198-H207
7. Carini R, De Cesaris MG, Splendore R, Bagnati M, Albano E. Ischemic preconditioning reduces Na(+) accumulation and cell killing in isolated rat hepatocytes exposed to hypoxia. Hepatology 2000; 31: 166-172
8. Rudiger HA, Graf R, Clavien PA. Sub-lethal oxidative stress triggers the protective effects of ischemic preconditioning in the mouse liver. J Hepatol 2003; 39: 972-977
9. Clavien PA, Selzner M, Rudiger HA, Graf R, Kadry Z, Rousson V, Jochum W. A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning. Ann Surg 2003; 238: 843-850; discussion 851-852
10. Clavien PA, Yadav S, Sindram D, Bentley RC. Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans. Ann Surg 2000; 232: 155-162
11. Lee WY, Lee SM. Ischemic preconditioning protects post-ischemic oxidative damage to mitochondria in rat liver. Shock 2005; 24: 370-375
12. Reed JC. Bcl-2 family proteins. Oncogene 1998; 17: 3225-3236
13. Muller C, Dunschede F, Koch E, Vollmar AM, Kiemer AK. Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway. Am J Physiol Gastrointest Liver Physiol 2003; 285: G769-G778
14. Packer L. alpha-Lipoic acid: a metabolic antioxidant which regulates NF-kappa B signal transduction and protects against oxidative injury. Drug Metab Rev 1998; 30: 245-275
15. van tier Bilt JD, Kranenburg O, Verheem A, van Hillegersberg R, Borel Rinkes IH. Selective portal clamping to minimize hepatic ischaemia-reperfusion damage and avoid accelerated outgrowth of experimental colorectal liver metastases. Br J Surg 2006; 93: 1015-1022
16. Gurtu V, Kain SR, Zhang G. Fluorometric and colorimetric detection of caspase activity associated with apoptosis. Anal Biochem 1997; 251: 98-102
17. Duenschede F, Westermann S, Riegler N, Miesner I, Erbes K, Ewald P, Kircher A, Schaefer H, Schneider J, Schad A, Dutkowski P, Kiemer AK, Junginger T. Different protection mechanisms after pretreatment with glycine or alpha-lipoic acid in a rat model of warm hepatic ischemia. Eur Surg Res 2006; 38: 503-512
18. Knapen MF, Peters WH, Mulder TP, Steegers EA. A marker for hepatocellular damage. Lancet 2000; 355: 1463-1464
19. Duenachede F, Erbes K, Kircher A, Westermann S, Schad A, Riegler N, Ewald P, Dutkowski P, Kiemer AK, Kempski O, Junginger T. Protection from hepatic ischemia/reperfusion injury and improvement of liver regeneration by alpha-lipoic acid. Shock 2007; 27: 644-651
20. Zhao Y, Li S, Childs EE, Kuharsky DK, Yin XM. Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury. J Biol Chem 2001; 276: 27432-27440
21. Peralta C, Bulbena O, Xaus C, Prats N, Cutrin JC, Poli G, Gelpi E, Rosello-Catafau J. Ischemic preconditioning: a defense mechanism against the reactive oxygen species generated after hepatic ischemia reperfusion. Transplantation 2002; 73: 1203-1211
22. Jaeschke H, Farhood A. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am J Physiol 1991; 260: G355-G362
23. Teoh N, Dela Pena A, Farrell G. Hepatic ischemic preconditioning in mice is associated with activation of NF-kappaB, p38 kinase, and cell cycle entry. Hepatology 2002; 36: 94-102
24. Diesel B, Kulhanek-Heinze S, Holtje M, Brandt B, Holtje HD, Vollmar AM, Kiemer AK. Alpha-lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis. Biochemistry 2007; 46: 2146-2155