Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle

American Journal of Physiology - Endocrinology and Metabolism

Volumn 273, Issue 1 36-1, 1997, Pages

  Streeper, Ryan S ^b   Henriksen, Erik J ^a   Jacob, Stephan ^b   Hokama, Jason Y ^b   Fogt, Donovan L ^b   Tritschler, Hans J ^b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

Epitrochlearis muscle; Glucose transport; Obese Zucker rat; Thioctic acid

Indexed keywords

THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DECARBOXYLATION; DYSLIPIDEMIA; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; HYPERINSULINEMIA; HYPERTENSION; INSULIN RESISTANCE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; STEREOISOMERISM;

EID: 0030840042     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.273.1.e185     Document Type: Article

References (40)

1. Baynes, J. W. Role of oxidative stress in development of complications in diabetes. Diabetes 40: 405-412, 1991.
2. Biewenga, G. P., M. A. Dorstijn, J. V. Verhagen, G. R. M. M. Haenen, and A. Bast. Reduction of lipoic acid by lipoamide dehydrogenase. Biochem. Pharmacol. 51: 233-238, 1996.
3. Boden, G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46: 3-10, 1997.
4. DeFronzo, R. A., and E. Ferrannini. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14: 173-194, 1991.
5. DeFronzo, R. A., E. Ferrannini, Y. Sato, P. Felig, and J. Wahren. Synergistic interaction between exercise and insulin on peripheral glucose uptake. J. Clin. Invest. 68: 1468-1474, 1981.
6. Estrada, D. E., H. S. Ewart, T. Tsakiridis, A. Volchuk, T. Ramlal, H. Tritschler, and A. Klip. Stimulation of glucose uptake by the natural coenzyme α-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 45: 1798-1804, 1996.
7. Hansen, P. A., E. A. Gulve, and J. O. Holloszy. Suitability of 2-deoxyglucose for in vitro measurement of glucose transport activity in skeletal muscle. J. Appl. Physiol. 76: 979-985, 1994.
8. Hassid, W. Z., and S. Abraham. Chemical procedure for analysis of polysaccharides. Determination of glycogen and starch. Methods Enzymol. 3: 34-37, 1957.
9. Haugaard, N., and E. S. Haugaard. Stimulation of glucose utilization by thioctic acid in rat diaphragm incubated in vitro. Biochim. Biophys. Acta 222: 583-586, 1970.
10. Helmrick, S. P., D. R. Ragland, R. W. Leung, and R. S. Paffenbarger. Physical activity and reduced occurence of non-insulin-dependent diabetes. N. Engl. J. Med. 325: 147-152, 1991.
11. Henriksen, E. J., R. E. Bourey, K. J. Rodnick, L. Koranyi, M. A. Permutt, and J. O. Holloszy. Glucose transporter protein content and glucose transport capacity in rat skeletal muscles. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E593-E598, 1990.
12. Henriksen, E. J., and A. E. Halseth. Early alterations in soleus GLUT-4, glucose transport, and glycogen in voluntary running rats. J. Appl. Physiol. 76: 1862-1867, 1994.
13. Henriksen, E. J., and L. S. Ritter. Effect of soleus unweighting on stimulation of insulin-independent glucose transport activity. J. Appl. Physiol. 74: 1653-1657, 1993.
14. Henriksen, E. J., M. E. Tischler, and D. G. Johnson. Increased response to insulin of glucose metabolism in the 6-day unloaded rat soleus muscle. J. Biol. Chem. 261: 10707-10712, 1986.
15. Hermann, R., G. Niebch, H. O. Borbe, H. Fieger-Büschges, P. Ruus, H. Nowak, H. Riethmüller-Winzen, M. Peukert, and H. Blume. Enantioselective pharmaco-kinetics and bioavailablity of different racemic α-lipoic acid formulations in healthy volunteers. Eur. J. Pharm. Sci. 4: 167-174, 1996.
16. Hughes, T. A., J. T. Gwynne, B. R. Switzer, C. Herbst, and G. White. Effects of caloric restriction and weght loss on glycemic control, insulin resistance, and atherosclerolitic risk in obese patients with type II diabetes mellitus. Am. J. Med. 77: 7-17, 1984.
17. Jacob, S., E. J. Henriksen, A. L. Schiemann, I. Simon, D. E. Clancy, H. J. Tritschler, W. I. Jung, H. J.Augustin, and G. J. Dietze. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Drug Res. 45: 872-874, 1995.
18. Jacob, S., E. J. Henriksen, H. J. Tritschler, H. J. Augustin, and G. J. Dietze. Improvement of insulin-stimulated glucose disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp. Clin. Endocrinol. Diabetes 104: 284-288, 1996.
19. Jacob, S., R. S. Streeper, D. L. Fogt, J. Y. Hokama, H. J. Tritschler, G. J. Dietze, and E. J. Henriksen. The antioxidant α-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant skeletal muscle. Diabetes 45: 1024-1029, 1996.
20. Johnson, M. B., E. W. Heineke, B. L. Rhinehart, M. J. Sheetz, B. L. Barnhart, and K. M. Robinson. MDL29311. Antioxidant with marked lipid- and glucose-lowering activity in diabetic rats and mice. Diabetes 42: 1179-1186, 1993.
21. Kern, M., J. A. Wells, J. M. Stephens, C. W. Elton, J. E. Friedman, B. Tapscott, P. H. Pekala, and G. L. Dohm. Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level. Biochem. J. 270: 397-400, 1990.
22. King, P. A., E. D. Horton, M. F. Hirshman, and E. S. Horton. Insulin resistance in obese Zucker rat (fα/fα) is associated with a failure of glucose transporter translocation. J. Clin. Invest. 90: 1568-1575, 1993.
23. Laakso, M., M. Uusitupa, J. Takala, H. Majander, T. Reijonen, and I. Penttilä. Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms in obese noninsulin-dependent diabetic subjects. Metabolism 37: 1092-1100, 1988.
24. Loeblein, K., K. Rett, E. Maerker, H. J. Tritschler, K. Wessel, M. Wicklmayr, and H. U. Häring. Thioctic acid stimulates translocation of glucose transports in hearts of insulin resistant Zucker rats (Abstract). Diabetologia 38: A132, 1995.
25. Low, P. A., and K. K. Nickander. Oxygen free radical effects in sciatic nerve in experimental diabetes. Diabetes 40: 873-877, 1991.
26. Nagamatsu, M., K. K. Nickander, J. D. Schmelzer, A. Raya, D. A. Wittrock, H. Tritschler, and P. A. Low. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 18: 1160-1167, 1995.
27. Ou, P., H. J. Tritschler, and S. P. Wolff. Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? Biochem. Pharmacol. 50: 123-126, 1995.
28. Ozden, I., G. Deniz, E. Tasali, A. Ulusarac, T. Altug, and S. Buyukdevrim. The effect of vitamin E on glycosylated hemoglobin levels in diabetic rats: a preliminary report. Diabetes Res. Clin. Pract. 12: 123-124, 1989.
29. Packer, L., E. H. Witt, and H. J. Tritschler. α-Lipoic acid as a biological antioxidant. Free Radic. Biol. Med. 19: 227-250, 1995.
30. Paolisso, G., A. D'Amore, D. Galzerno, V. Balbi, D. Giugliano, M. Varricchio, and F. D'Onofrio. Daily vitamin E supplements improve metabolic control but not insulin secretion in elderly type II diabetic patients. Diabetes Care 16: 1433-1437, 1993.
31. Paolisso, G., A. D'Amore, D. Giugliano, A. Ceriello, M. Varricchio, and F. D'Onofrio. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am. J. Clin. Nutr. 57: 650-656, 1993.
32. Pritchard, K. A., S. T. Patel, C. W. Karpen, H. A. Newman, and R. V. Panganamala. Triglyceride lowering effect of dietary vitamin E in streptozocin-induced diabetic rats. Increased lipoprotein lipase acitivity in livers of diabetic rats fed high dietary vitamin E. Diabetes 35: 278-281, 1986.
33. Reaven, G. R. Role of insulin resistance in human disease (Syndrome X): an expanded definition. Annu. Rev. Med. 44: 121-131, 1993.
34. Rogers, M. A., C. Yamamoto, D. S. King, J. M. Hagberg, A. A. Ehsani, and J. O. Holloszy. Improvements in glucose tolerance after 1 week of exercise in patients with mild NIDDM. Diabetes Care 11: 613-618, 1988.
35. 2+ in solution. Arch. Biochem. Biophys. 187: 208-214, 1978.
36. Singh, H. P., and R. H. Bowman. Effect of DL-alpha-lipoic acid on the citrate concentration and phosphofructokinase activity of perfused hearts from normal and diabetic rats. Biochem. Biophys. Res. Commun. 41: 555-561, 1970.
37. Srere, P. A. Citrate synthase.Methods Enzymol. 13: 3-5, 1969.
38. Strödter, D., E. Lehmann, U. Lehmann, H. J. Tritschler, R. G. Bretzel, and K. Federlin. The influence of thioctic acid on metabolism and function of the diabetic heart. Diabetes Res. Clin. Pract. 29: 19-26, 1995.
39. Uyeda, K., and E. Racker. Regulatory mechanisms in carbohydrate metabolism. VII. Hexokinase and phosphofructokinase. J. Biol. Chem. 240: 4682-4688, 1965.
40. 1 bei der diabetischen Neuropathie. Diab. Stoffw. 2: 443-448, 1993.