7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Huang, Jiahn Dar ^a   Amaral, Juan ^a   Lee, Jung Wha ^a   Rodriguez, Ignacio R ^a  

^a NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 7 OXOCHOLESTEROL; ADAPTOR PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FATTY ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STERCULIC ACID; SUPPRESSOR OF CYTOKINE SIGNALING; TOLL INTERLEUKIN 1 RECEPTOR DOMAIN CONTAINING ADAPTER PROTEIN; TOLL INTERLEUKIN 1 RECEPTOR DOMAIN CONTAINING ADAPTER PROTEIN RELATED ADAPTOR MOLECULE; TOLL INTERLEUKIN 1 RECEPTOR DOMAIN CONTAINING ADAPTOR PROTEIN; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 7-KETOCHOLESTEROL; CHOLESTEROL DERIVATIVE; CHROMONE DERIVATIVE; CYCLOPROPANE DERIVATIVE; MONOUNSATURATED FATTY ACID; MORPHOLINE DERIVATIVE; PROTEIN KINASE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR EYE CHAMBER; ARTICLE; CALCIUM TRANSPORT; CELL DEATH; CONTROLLED STUDY; CYTOKINE RESPONSE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INTRACELLULAR SIGNALING; NONHUMAN; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; EXTRACELLULAR SPACE; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; CELL DEATH; CELL LINE; CHROMONES; CYCLOPROPANES; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; EXTRACELLULAR SPACE; FATTY ACIDS, MONOUNSATURATED; HUMANS; INFLAMMASOMES; INFLAMMATION; KETOCHOLESTEROLS; MORPHOLINES; NF-KAPPA B; PHOSPHORYLATION; PROTEIN KINASES; RATS; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TOLL-LIKE RECEPTOR 4;

EID: 84904488854     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100985     Document Type: Article

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