Lipids deposited in human atheromatous lesions induce apoptosis of human vascular smooth muscle cells

Journal of Atherosclerosis and Thrombosis

Volumn 13, Issue 5, 2006, Pages 256-262

  Ohtsuka, Masaki ^a   Miyashita, Yoh ^a   Shirai, Kohji ^a  

^a TOHO UNIVERSITY SAKURA MEDICAL CENTER   (Japan)

Author keywords

7 ketocholesterol; Apoptosis; Deposited lipids; Plaque rupture

Indexed keywords

7 OXOCHOLESTEROL; 7-KETOCHOLESTEROL; CHOLESTEROL DERIVATIVE;

AORTA; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CELL CULTURE; CHEMISTRY; CORONARY BLOOD VESSEL; CYTOLOGY; HUMAN; INTIMA; NICK END LABELING; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

AORTA; APOPTOSIS; ATHEROSCLEROSIS; CELLS, CULTURED; CORONARY VESSELS; HUMANS; IN SITU NICK-END LABELING; KETOCHOLESTEROLS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; TUNICA INTIMA;

EID: 39049179735     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.13.256     Document Type: Article

References (28)

1. Fuster V, Stein B, Ambrose JA, Badimon L, Badimon JJ, and Chesebro JH: Atherosclerotic plaque rupture and thrombosis. Evolving concepts. Circulation, 1990; 82 (supl):II47-II59
2. Bennett MR, Evan GI, and Schwartz SM: Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest, 1995; 95:2266-2274
3. Geng YJ, Wu Q, Muszynski M, Hansson GK, and Libby P: Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-γ, tumor necrosis factor-α, and interleukin-1β. Arterioscler Thromb Vasc Biol, 1996; 7:19-27
4. Kockx MM and Knaapen MW: The role of apoptosis in vascular disease. J Pathol, 2000; 190:267-280
5. Hessler JR, Morel DW, Lewis LJ, and Chisholm GM: Lipoprotein oxidation and lipoprotein-induced cytotoxicity. Atherosclerosis, 1983; 3:215-222
6. Peng SK, Tham P, Taylor CB, and Mikkelson B: (Zytotoxicity of oxidation derivatives of cholesterol on cultured aortic smooth muscle cells and their effect on cholesterol biosynthesis. Am J Clin Nutr, 1979; 32:1033-1042
7. Peng SK, Taylor B, Tham P, Werthessen NT, and Mikkelson B: Effect of auto-oxidation products from cholesterol on aortic smooth muscle cells. Arch Pathol Lab Med, 1978; 102:57-61
8. Naseem SM and Heald FP: Cytotoxicity of cholesterol oxides and their effects on cholesterol metabolism in cultured human aortic smooth muscle cells. Biochem Int, 1987; 14:71-84
9. Miyashita Y, Shirai K, Ito Y, Watanabe H, Urano Y, Murano T, and Tomioka H: Cytotoxicity of some oxysterols on human vascular smooth muscle cells was mediated by apoptosis. J Atheroscler Thromb, 1997; 4:73-78
10. Miyashita Y, Ozaki H, Koide N, Otsuka M, Oyama T, Itoh Y, Matsuzaka T, and Shirai K: Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin. J Athroscle Thromb, 2002; 9:65-71
11. Miyashira Y, Koide N, Oyama T, Itoh Y, and Shirai K: Apoptosis induced by 7-ketocholesterol is enhanced in smooth muscle cells derived from OLETF rats. J Athroscle Thromb, 2005; 12:92-97
12. Thiry M: Highly sensitive immunodetection of DNA on sections with exogenous terminal deoxynucleotidyl transferase and non-isotopic nucleotide analogs. J Histochem Cytochem, 1992; 40:411-419
13. Leszczynski D: Regulation of cell cycle and apoptosis by protein kinase C in rat myeloid leukemia cell line. Oncol Res, 1995; 7:471-480
14. Brown AJ and Jessup W: Oxysterols and atherosclerosis. Atherosclerosis, 1999; 142:1-28
15. Geng YJ and Libby P: Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin- 1β -converting enzyme. Am J Pathol, 1995; 147:251-266
16. Han DK, Haudenschild CC, Hong MK, Tinkle BT, Leon MB, and Liau G: Evidence for apoptosis in human atherogenesis and in a rat vascular injury model. Am J Pathol, 1995; 147:267-277
17. Shiomi M, Yamada S, and Ito T: Atheroma stabilizing effects of simvastatin due to depression of macrophages or lipid accumulation in the atheromarous plaques of coronary plaque-prone WHHL rabbits. Atherosclerosis, 2005; 178:287-294
18. Miyamoto A, Prieto AR, Friedl SE, Lin FC, Muller JE, Nesto RW, and Abela GS 2nd: Atheromatous plaque cap thickness can be determined by quantitative color analysis during angioscopy: implications for identifying the vulnerable plaque. Clin Cardiol, 2004; 27:9-15
19. Davies MJ: Stability and instability: two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995. Circulation, 1996; 94:2013-2020
20. Rosklint T, Ohlsson BG, Wiklund O, Noren K, and Hulten LM: Oxysterols induce interleukin-1beta production in human macrophages. Eur J Clin Invest, 2002; 32:35-42
21. Oyama T, Miyashita Y, Kinoshita K, Watanabe H, Shirai K, and Yagima T: Effect of deposited lipids in atheromatous lesions on the migration of vascular smooth muscle cells. J Atheroscler Thromb, 2002; 9:109-113
22. Hodis HN, Crawford DW, and Sevanian A: Cholesterol feeding increases plasma and aortic tissue cholesterol oxide levels in parallel: further evidence for the role of cholesterol oxidation in atherosclerosis. Atherosclerosis, 1991; 89:117-126
23. Breuer O and Björkhem I: Simultaneous quantification of several cholesterol autoxidation and monohydroxylation products by isotope-dilution mass spectrometry. Steroids, 1990; 55:185-192
24. Harik-Khan R and Holmes RP: Estimation of 26-hydroxycholesterol in serum by high-performance liquid chromatography and its measurement in patients with atherosclerosis. J Steroid Biochem, 1990; 36:351-355
25. Smith LL, Teng JI, Lin YY, Seitz PK, and McGehee MF: Sterol metabolism-XLVII. Oxidized cholesterol esters in human tissues. J Steroid Biochem, 1981; 14:889-900
26. Dzeletovic S, Breuer O, Lund E, and Diczfalusy U: Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal Biochem, 1995; 225:73-80
27. Bodin K, Bretillon L, Aden Y, Bertilsson L, Broom U, Einarsson C, and Diczfalusy U: Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. J Biol Chem, 2001; 276:38685-38689
28. Babiker A and Diczfalucy U: Transport of side-chain oxidized oxysterols in the human circulation. Biochem Biophys Acta, 1998; 1392:333-339