A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors

ACS Chemical Neuroscience

Volumn 5, Issue 7, 2014, Pages 597-610

  Cho, Hyekyung P ^a,b   Engers, Darren W ^a,b   Venable, Daryl F ^a,b   Niswender, Colleen M ^a,b   Lindsley, Craig W ^a,b,c   Conn, P Jeffrey ^a,b   Emmitte, Kyle A ^a,b,c   Rodriguez, Alice L ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

Allosteric modulator; glutamate; metabotropic

Indexed keywords

5 [4 (HYDROXYEMTHYL)PIPERIDIN 1 YL] N (4 METHYLCYCLOHEXYL)PYRAZINE 2 CARBOXAMIDE; BAY 36 7620; LEUCINE; METABOTROPIC RECEPTOR 1; N CYCLOHEPTYLTHIENO[2,3 D]PYRIMIDIN 4 AMINE; R 214127; SUCCINIMIDE; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG; VALINE; VU 0410425; AMINO ACID RECEPTOR AFFECTING AGENT; CALCIUM; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; METABOTROPIC RECEPTOR;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; MUTAGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; CHO CELL LINE; CRICETULUS; FLUORESCENCE; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; METABOLISM; PRECLINICAL STUDY; RAT; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CELL LINE; CHO CELLS; CRICETULUS; DRUG EVALUATION, PRECLINICAL; EXCITATORY AMINO ACID AGENTS; FLUORESCENCE; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MUTATION; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SPECIES SPECIFICITY; SUCCINIMIDES; TRANSFECTION;

EID: 84904434885     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn5000343     Document Type: Article

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