Structure-activity relationships of novel non-competitive mGluR1 antagonists: A potential treatment for chronic pain

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 2, 2007, Pages 486-490

  Owen, Dafydd R ^a   Dodd, Peter G ^a   Gayton, Simon ^a   Greener, Ben S ^a   Harbottle, Gareth W ^a   Mantell, Simon J ^a   Maw, Graham N ^a   Osborne, Simon A ^a   Rees, Huw ^a   Ringer, Tracy J ^a   Rodriguez Lens, Margarita ^a   Smith, Graham F ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

c log P; Chronic pain; CNS; Library; log D; Metabolism; mGluR; mGluR1; Pyrazine; Quinoxaline

Indexed keywords

METABOTROPIC RECEPTOR ANTAGONIST;

ARTICLE; CHRONIC PAIN; DRUG STABILITY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CHEMISTRY, PHYSICAL; CHO CELLS; CHRONIC DISEASE; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; PAIN; PYRAZINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846056113     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.10.015     Document Type: Article

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