메뉴 건너뛰기




Volumn 18, Issue 8, 2014, Pages 883-895

Osteopontin as a therapeutic target for cancer

Author keywords

Angiogenesis; Biomarker; Hypoxia; Osteopontin; RNAi technology; Stroma; Targeted therapy

Indexed keywords

ANTIBODY; APTAMER; HERMES ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OSTEOPONTIN; VASCULOTROPIN; VITRONECTIN RECEPTOR;

EID: 84904410186     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2014.925447     Document Type: Review
Times cited : (112)

References (100)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 40349098612 scopus 로고    scopus 로고
    • Migratory neighbors and distant invaders: Tumor-associated niche cells
    • DOI 10.1101/gad.1636908
    • Wels J, Kaplan RN, Rafii S, et al. Migratory neighbors and distant invaders: Tumor-associated niche cells. Genes Dev 2008;22:559-74 (Pubitemid 351342429)
    • (2008) Genes and Development , vol.22 , Issue.5 , pp. 559-574
    • Wels, J.1    Kaplan, R.N.2    Rafii, S.3    Lyden, D.4
  • 3
    • 32644467590 scopus 로고    scopus 로고
    • Osteopontin: Role in cell signaling and cancer progression
    • DOI 10.1016/j.tcb.2005.12.005, PII S0962892405003132
    • Rangaswami H, Bulbule A, Kundu GC. Osteopontin: Role in cell signalling and cancer progression. Trends Cell Biol 2006;16:79-87. (Pubitemid 43247403)
    • (2006) Trends in Cell Biology , vol.16 , Issue.2 , pp. 79-87
    • Rangaswami, H.1    Bulbule, A.2    Kundu, G.C.3
  • 5
    • 57049166456 scopus 로고    scopus 로고
    • Osteopontin: Role in immune regulation and stress responses
    • Wang KX, Denhardt DT. Osteopontin: Role in immune regulation and stress responses. Cytokine Growth Factor Rev 2008;19:333-45
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 333-345
    • Wang, K.X.1    Denhardt, D.T.2
  • 6
    • 0035021027 scopus 로고    scopus 로고
    • Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival
    • Denhardt DT, Noda M, O'Regan AW, et al. Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 2001;107:1055-61 (Pubitemid 32422899)
    • (2001) Journal of Clinical Investigation , vol.107 , Issue.9 , pp. 1055-1061
    • Denhardt, D.T.1    Noda, M.2    O'Regan, A.W.3    Pavlin, D.4    Berman, J.S.5
  • 7
    • 0027131418 scopus 로고
    • Osteopontin: A protein with diverse functions
    • Denhardt DT, Guo X. Osteopontin: A protein with diverse functions. FASEB J 1993;7:1475-82. (Pubitemid 24003267)
    • (1993) FASEB Journal , vol.7 , Issue.15 , pp. 1475-1482
    • Denhardt, D.T.1    Guo, X.2
  • 8
    • 77956212940 scopus 로고    scopus 로고
    • Tumor-conditioned macrophages secrete migration-stimulating factor: A new marker for M2-polarization influencing tumor cell motility
    • Solinas G, Schiarea S, Liguori M, et al. Tumor-conditioned macrophages secrete migration-stimulating factor: A new marker for M2-polarization influencing tumor cell motility. J Immunol 2010;185:642-52
    • (2010) J Immunol , vol.185 , pp. 642-652
    • Solinas, G.1    Schiarea, S.2    Liguori, M.3
  • 9
    • 0035671826 scopus 로고    scopus 로고
    • Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer
    • Fedarko NS, Jain A, Karadag A, et al. Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer. Clin Cancer Res 2001;7:4060-6 (Pubitemid 34044628)
    • (2001) Clinical Cancer Research , vol.7 , Issue.12 , pp. 4060-4066
    • Fedarko, N.S.1    Jain, A.2    Karadag, A.3    Van Eman, M.R.4    Fisher, L.W.5
  • 10
    • 77956442992 scopus 로고    scopus 로고
    • Osteopontin is a marker for cancer aggressiveness and patient survival
    • Weber GF, Lett GS, Haubein NC. Osteopontin is a marker for cancer aggressiveness and patient survival. Br J Cancer 2010;103:861-9
    • (2010) Br J Cancer , vol.103 , pp. 861-869
    • Weber, G.F.1    Lett, G.S.2    Haubein, N.C.3
  • 11
    • 84886800484 scopus 로고    scopus 로고
    • Association of osteopontin and cyclooxygenase-2 expression with breast cancer subtypes and their use as potential biomarkers
    • Thorat D, Sahu A, Behera R, et al. Association of osteopontin and cyclooxygenase-2 expression with breast cancer subtypes and their use as potential biomarkers. Oncol Lett 2013;6:1559-64
    • (2013) Oncol Lett , vol.6 , pp. 1559-1564
    • Thorat, D.1    Sahu, A.2    Behera, R.3
  • 12
    • 84899409082 scopus 로고    scopus 로고
    • Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF1a-mediated VEGF-dependent angiogenesis
    • Raja R, Kale S, Thorat D, et al. Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF1a-mediated VEGF-dependent angiogenesis. Oncogene 2014;33(16):2053-64.
    • (2014) Oncogene , vol.33 , Issue.16 , pp. 2053-2064
    • Raja, R.1    Kale, S.2    Thorat, D.3
  • 13
    • 59149104024 scopus 로고    scopus 로고
    • Senescent stromal-derived osteopontin promotes preneoplastic cell growth
    • Pazolli E, Luo X, Brehm S, et al. Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res 2009;69:1230-9
    • (2009) Cancer Res , vol.69 , pp. 1230-1239
    • Pazolli, E.1    Luo, X.2    Brehm, S.3
  • 14
    • 84880740070 scopus 로고    scopus 로고
    • Functional characterization of stromal osteopontin in melanoma progression and metastasis
    • Kumar S, Sharma P, Kumar D, et al. Functional characterization of stromal osteopontin in melanoma progression and metastasis. PLoS One 2013;8:e69116
    • (2013) PLoS One , vol.8
    • Kumar, S.1    Sharma, P.2    Kumar, D.3
  • 15
    • 84899951230 scopus 로고    scopus 로고
    • Osteopontin signalling upregulates cyclooxygenase-2 expression in tumorassociated macrophages leading to enhanced angiogenesis and melanoma growth via alpha9beta1 integrin
    • Kale S, Raja R, Thorat D, et al. Osteopontin signalling upregulates cyclooxygenase-2 expression in tumorassociated macrophages leading to enhanced angiogenesis and melanoma growth via alpha9beta1 integrin. Oncogene 2014;33(18):2295-306.
    • (2014) Oncogene , vol.33 , Issue.18 , pp. 2295-2306
    • Kale, S.1    Raja, R.2    Thorat, D.3
  • 16
    • 0035976914 scopus 로고    scopus 로고
    • Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through NF-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells
    • Philip S, Bulbule A, Kundu GC. Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through NF-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells. J Biol Chem 2001;276:44926-35
    • (2001) J Biol Chem , vol.276 , pp. 44926-44935
    • Philip, S.1    Bulbule, A.2    Kundu, G.C.3
  • 17
    • 0038191064 scopus 로고    scopus 로고
    • Osteopontin induces nuclear factor κB-mediated promatrix metalloproteinase-2 activation through IκBα/IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways
    • DOI 10.1074/jbc.M207309200
    • Philip S, Kundu GC. Osteopontin induces NF-kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha/IKK signalling pathways and curcumin (diferulolylmethane) down-regulates these pathways. J Biol Chem 2003;278:14487-97 (Pubitemid 36800002)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.16 , pp. 14487-14497
    • Philip, S.1    Kundu, G.C.2
  • 18
    • 4644231399 scopus 로고    scopus 로고
    • Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IκBα kinase-dependent nuclear factor κB-mediated promatrix metalloproteinase-9 activation
    • DOI 10.1074/jbc.M404674200
    • Rangaswami H, Bulbule A, Kundu GC. Nuclear factor inducing kinase plays crucial role in osteopontin-induced MAPK/IKK dependent nuclear factor kB-mediated promatrix metalloproteinase-9 activation. J Biol Chem 2004;279:38921-35 (Pubitemid 39296053)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.37 , pp. 38921-38935
    • Rangaswami, H.1    Bulbule, A.2    Kundu, G.C.3
  • 20
    • 33748532813 scopus 로고    scopus 로고
    • The temporal expression of osteopontin (SPP-1) in the rodent model of alcoholic steatohepatitis: A potential biomarker
    • Banerjee A, Burghardt RC, Johnson GA, et al. The temporal expression of osteopontin (SPP-1) in the rodent model of alcoholic steatohepatitis: A potential biomarker. Toxicol Pathol 2006;34:373-84
    • (2006) Toxicol Pathol , vol.34 , pp. 373-384
    • Banerjee, A.1    Burghardt, R.C.2    Johnson, G.A.3
  • 21
    • 42249097456 scopus 로고    scopus 로고
    • Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells
    • Nagasaka A, Matsue H, Matsushima H, et al. Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells. Eur J Immunol 2008;38:489-99
    • (2008) Eur J Immunol , vol.38 , pp. 489-499
    • Nagasaka, A.1    Matsue, H.2    Matsushima, H.3
  • 22
    • 84873197732 scopus 로고    scopus 로고
    • Osteopontin-dependent regulation of Th1 and Th17 cytokine responses in Trypanosoma cruzi-infected C57BL/6mice
    • Santamaŕa MH, Corral RS. Osteopontin-dependent regulation of Th1 and Th17 cytokine responses in Trypanosoma cruzi-infected C57BL/6mice. Cytokine 2013;61:491-08
    • (2013) Cytokine , vol.61 , pp. 491-508
    • Santamaŕa, M.H.1    Corral, R.S.2
  • 23
    • 84878057038 scopus 로고    scopus 로고
    • Chemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin
    • Li X, Qi Y, Ma X, et al. Chemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin. PLoS One 2013;8:e64277
    • (2013) PLoS One , vol.8
    • Li, X.1    Qi, Y.2    Ma, X.3
  • 25
    • 0023664074 scopus 로고
    • Isolation, characterization, and biosynthesis of a phosphorylated glycoprotein from rat bone
    • Prince CW, Oosawa T, Butler WT, et al. Isolation, characterization, and biosynthesis of a phosphorylated glycoprotein from rat bone. J Biol Chem 1987;262:2900-7.
    • (1987) J Biol Chem , vol.262 , pp. 2900-2907
    • Prince, C.W.1    Oosawa, T.2    Butler, W.T.3
  • 26
    • 0024994985 scopus 로고
    • CDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN)
    • DOI 10.1016/0888-7543(90)90191-V
    • Young MF, Kerr JM, Termine JD, et al. cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN). Genomics 1990;7:491-502 (Pubitemid 20244451)
    • (1990) Genomics , vol.7 , Issue.4 , pp. 491-502
    • Young, M.F.1    Kerr, J.M.2    Termine, J.D.3    Wewer, U.M.4    Ge Wang McBride, M.O.W.5    Fisher, L.W.6
  • 28
    • 78651485202 scopus 로고    scopus 로고
    • Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis
    • Beausoleil MS, Schulze EB, Goodale D, et al. Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis. BMC Cancer 2011;11:25
    • (2011) BMC Cancer , vol.11 , pp. 25
    • Beausoleil, M.S.1    Schulze, E.B.2    Goodale, D.3
  • 29
    • 33645743036 scopus 로고    scopus 로고
    • An osteopontin splice variant induces anchorage independence in human breast cancer cells
    • He B, Mirza M, Weber GF. An osteopontin splice variant induces anchorage independence in human breast cancer cells. Oncogene 2006;25:2192-202.
    • (2006) Oncogene , vol.25 , pp. 2192-2202
    • He, B.1    Mirza, M.2    Weber, G.F.3
  • 30
    • 38349059722 scopus 로고    scopus 로고
    • Osteopontin-c is a selective marker of breast cancer
    • Mirza M, Shaughnessy E, Hurley JK, et al. Osteopontin-c is a selective marker of breast cancer. Int J Cancer 2008;122:889-97
    • (2008) Int J Cancer , vol.122 , pp. 889-897
    • Mirza, M.1    Shaughnessy, E.2    Hurley, J.K.3
  • 31
    • 84867088778 scopus 로고    scopus 로고
    • Both osteopontin-c and osteopontin-b splicing isoforms exert pro-tumorigenic roles in prostate cancer cells
    • Tilli TM, Mello KD, Ferreira LB, et al. Both osteopontin-c and osteopontin-b splicing isoforms exert pro-tumorigenic roles in prostate cancer cells. Prostate 2012;72:1688-99
    • (2012) Prostate , vol.72 , pp. 1688-1699
    • Tilli, T.M.1    Mello, K.D.2    Ferreira, L.B.3
  • 32
    • 67650079429 scopus 로고    scopus 로고
    • Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta through the NF-kappaB and MAPK pathways in rheumatoid arthritis
    • Zheng W, Li R, Pan H, et al. Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta through the NF-kappaB and MAPK pathways in rheumatoid arthritis. Arthritis Rheum 2009;60:1957-65
    • (2009) Arthritis Rheum , vol.60 , pp. 1957-1965
    • Zheng, W.1    Li, R.2    Pan, H.3
  • 33
    • 0033579511 scopus 로고    scopus 로고
    • The integrin alpha(9)beta (1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin
    • Yokosaki Y, Matsuura N, Sasaki T, et al. The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J Biol Chem 1999;274:36328-34
    • (1999) J Biol Chem , vol.274 , pp. 36328-36334
    • Yokosaki, Y.1    Matsuura, N.2    Sasaki, T.3
  • 34
    • 28844482875 scopus 로고    scopus 로고
    • Distinct structural requirements for binding of the integrins αvβ6, αvβ3, αvβ5, α5β1 and α9β1 to osteopontin
    • DOI 10.1016/j.matbio.2005.05.005, PII S0945053X05000661
    • Yokosaki Y, Tanaka K, Higashikawa F, et al. Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin. Matrix Biol 2005;24:418-27 (Pubitemid 41765020)
    • (2005) Matrix Biology , vol.24 , Issue.6 , pp. 418-427
    • Yokosaki, Y.1    Tanaka, K.2    Higashikawa, F.3    Yamashita, K.4    Eboshida, A.5
  • 36
    • 84894900867 scopus 로고    scopus 로고
    • Osteopontin is associated with decreased apoptosis and av integrin expression in lung adenocarcinoma
    • Stemberger C, Matusan-Ilijas K, Avirović M, et al. Osteopontin is associated with decreased apoptosis and av integrin expression in lung adenocarcinoma. Acta Histochem 2014;116:222-9
    • (2014) Acta Histochem , vol.116 , pp. 222-229
    • Stemberger, C.1    Matusan-Ilijas, K.2    Avirović, M.3
  • 37
    • 84874165243 scopus 로고    scopus 로고
    • Integrative analyses identify osteopontin, LAMB3 and ITGB1 as critical pro-metastatic genes for lung cancer
    • Wang XM, Li J, Yan MX, et al. Integrative analyses identify osteopontin, LAMB3 and ITGB1 as critical pro-metastatic genes for lung cancer. PLoS One 2013;8:e55714
    • (2013) PLoS One , vol.8
    • Wang, X.M.1    Li, J.2    Yan, M.X.3
  • 39
    • 80052445685 scopus 로고    scopus 로고
    • CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway
    • Jijiwa M, Demir H, Gupta S, et al. CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway. PLoS One 2011;6:e24217
    • (2011) PLoS One , vol.6
    • Jijiwa, M.1    Demir, H.2    Gupta, S.3
  • 40
    • 78650367878 scopus 로고    scopus 로고
    • P38 Kinase is crucial for osteopontininduced furin expression that supports cervical cancer progression
    • Kumar V, Behera R, Lohite K, et al. p38 Kinase is crucial for osteopontininduced furin expression that supports cervical cancer progression. Cancer Res 2010;70:10381-91
    • (2010) Cancer Res , vol.70 , pp. 10381-10391
    • Kumar, V.1    Behera, R.2    Lohite, K.3
  • 42
    • 70449701416 scopus 로고    scopus 로고
    • Osteopontin induces beta-catenin signalling through activation of Akt in prostate cancer cells
    • Robertson BW, Chellaiah MA. Osteopontin induces beta-catenin signalling through activation of Akt in prostate cancer cells. Exp Cell Res 2010;316:1-11
    • (2010) Exp Cell Res , vol.316 , pp. 1-11
    • Robertson, B.W.1    Chellaiah, M.A.2
  • 43
    • 1642565264 scopus 로고    scopus 로고
    • Osteopontin Induces AP-1-mediated Secretion of Urokinase-type Plasminogen Activator through c-Src-dependent Epidermal Growth Factor Receptor Transactivation in Breast Cancer Cells
    • DOI 10.1074/jbc.M310256200
    • Das R, Mahabeleshwar GH, Kundu GC. Osteopontin induces AP-1 mediated secretion of urokinase-type plasminogen activator through c-Src-dependent EGF receptor transactivation in breast cancer cells. J Biol Chem 2004;279:11051-64 (Pubitemid 38401597)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.12 , pp. 11051-11064
    • Das, R.1    Mahabeleshwar, G.H.2    Kundu, G.C.3
  • 44
    • 80052316134 scopus 로고    scopus 로고
    • Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines
    • Zhang R, Pan X, Huang Z, et al. Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines. PLoS One 2011;6:e23831
    • (2011) PLoS One , vol.6
    • Zhang, R.1    Pan, X.2    Huang, Z.3
  • 45
    • 79551583112 scopus 로고    scopus 로고
    • Osteopontin expression correlates with nuclear factor-kB activation and apoptosis down regulation in clear cell renal cell carcinoma
    • Matusan-Ilijas K, Damante G, Fabbro D, et al. Osteopontin expression correlates with nuclear factor-kB activation and apoptosis down regulation in clear cell renal cell carcinoma. Pathol Res Pract 2011;207:104-10
    • (2011) Pathol Res Pract , vol.207 , pp. 104-110
    • Matusan-Ilijas, K.1    Damante, G.2    Fabbro, D.3
  • 46
    • 80054120984 scopus 로고    scopus 로고
    • Osteopontin increases breast cancer cell sensitivity to specific signalling pathway inhibitors in preclinical models
    • Mutrie JC, Chambers AF, Tuck AB. Osteopontin increases breast cancer cell sensitivity to specific signalling pathway inhibitors in preclinical models. Cancer Biol Ther 2011;12:680-90
    • (2011) Cancer Biol Ther , vol.12 , pp. 680-690
    • Mutrie, J.C.1    Chambers, A.F.2    Tuck, A.B.3
  • 47
    • 77649207043 scopus 로고    scopus 로고
    • Activation of JAK2/STAT3 signalling by osteopontin promotes tumor growth in human breast cancer cells
    • Behera R, Kumar V, Lohite K, et al. Activation of JAK2/STAT3 signalling by osteopontin promotes tumor growth in human breast cancer cells. Carcinogenesis 2010;31:192-200
    • (2010) Carcinogenesis , vol.31 , pp. 192-200
    • Behera, R.1    Kumar, V.2    Lohite, K.3
  • 48
    • 79551602459 scopus 로고    scopus 로고
    • Down-regulation of osteopontin inhibits metastasis of hepatocellular carcinoma cells via a mechanism involving MMP-2 and uPA
    • Chen RX, Xia YH, Xue TC, et al. Down-regulation of osteopontin inhibits metastasis of hepatocellular carcinoma cells via a mechanism involving MMP-2 and uPA. Oncol Rep 2011;25:803-8
    • (2011) Oncol Rep , vol.25 , pp. 803-808
    • Chen, R.X.1    Xia, Y.H.2    Xue, T.C.3
  • 49
    • 74849090624 scopus 로고    scopus 로고
    • Fibronectin supports TNF-alpha-induced osteopontin expression through beta1integrin and ERK in HN-22 cells
    • Kaomongkolgit R, Manokawinchoke J, Sanchavanakit N. Fibronectin supports TNF-alpha-induced osteopontin expression through beta1integrin and ERK in HN-22 cells. Arch Oral Biol 2010;55:101-7
    • (2010) Arch Oral Biol , vol.55 , pp. 101-107
    • Kaomongkolgit, R.1    Manokawinchoke, J.2    Sanchavanakit, N.3
  • 50
    • 79952850691 scopus 로고    scopus 로고
    • Osteopontin-c splicing isoform contributes to ovarian cancer progression
    • Tilli TM, Franco VF, Robbs BK, et al. Osteopontin-c splicing isoform contributes to ovarian cancer progression. Mol Cancer Res 2011;9:280-93
    • (2011) Mol Cancer Res , vol.9 , pp. 280-293
    • Tilli, T.M.1    Franco, V.F.2    Robbs, B.K.3
  • 51
    • 39149110606 scopus 로고    scopus 로고
    • Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms
    • DOI 10.1158/0008-5472.CAN-07-2126
    • Chakraborty G, Jain S, Kundu GC. Osteopontin promotes VEGF-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms. Cancer Res 2008;68:152-61. (Pubitemid 351380116)
    • (2008) Cancer Research , vol.68 , Issue.1 , pp. 152-161
    • Chakraborty, G.1    Jain, S.2    Kundu, G.C.3
  • 52
    • 33746114248 scopus 로고    scopus 로고
    • The crucial role of cyclooxygenase-2 in osteopontin-induced protein kinase C α/c-Src/IκB kinase α/β-dependent prostate tumor progression and angiogenesis
    • DOI 10.1158/0008-5472.CAN-06-0661
    • Jain S, Chakraborty G, Kundu GC. The crucial role of cyclooxygenase-2 in osteopontin-induced PKCalpha/c-Src/IKKalpha/beta-dependent prostate tumor progression and angiogenesis. Cancer Res 2006;66:6638-48 (Pubitemid 44085620)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6638-6648
    • Jain, S.1    Chakraborty, G.2    Kundu, G.C.3
  • 53
    • 3042854048 scopus 로고    scopus 로고
    • Hypoxic gene expression and metastasis
    • DOI 10.1023/B:CANC.0000031768.89246.d7
    • Le QT, Denko NC, Giaccia AJ. Hypoxic gene expression and metastasis. Cancer Metastasis Rev 2004;23:293-310 (Pubitemid 38881813)
    • (2004) Cancer and Metastasis Reviews , vol.23 , Issue.3-4 , pp. 293-310
    • Le, Q.-T.1    Denko, N.C.2    Giaccia, A.J.3
  • 54
    • 16344378769 scopus 로고    scopus 로고
    • Hypoxia-inducible factor regulates αvβ3 integrin cell surface expression
    • DOI 10.1091/mbc.E04-12-1082
    • Cowden Dahl KD, Robertson SE, Weaver VM, et al. Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Mol Biol Cell 2005;16:1901-12 (Pubitemid 40471958)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.4 , pp. 1901-1912
    • Cowden Dahl, K.D.1    Robertson, S.E.2    Weaver, V.M.3    Simon, M.C.4
  • 55
    • 26944478634 scopus 로고    scopus 로고
    • Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer
    • DOI 10.1038/sj.onc.1208800, PII 1208800
    • Zhu Y, Denhardt DT, Cao H, et al. Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer. Oncogene 2005;24:6555-63 (Pubitemid 41486638)
    • (2005) Oncogene , vol.24 , Issue.43 , pp. 6555-6563
    • Zhu, Y.1    Denhardt, D.T.2    Cao, H.3    Sutphin, P.D.4    Koong, A.C.5    Giaccia, A.J.6    Le, Q.-T.7
  • 56
    • 84881476071 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF)-1alpha suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction
    • Storti P, Bolzoni M, Donofrio G, et al. Hypoxia-inducible factor (HIF)-1alpha suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction. Leukemia 2013;27:1697-706
    • (2013) Leukemia , vol.27 , pp. 1697-1706
    • Storti, P.1    Bolzoni, M.2    Donofrio, G.3
  • 57
    • 84862947384 scopus 로고    scopus 로고
    • Silencing of osteopontin promotes the radiosensitivity of breast cancer cells by reducing the expression of hypoxia inducible factor 1 and vascular endothelial growth factor
    • Yang L, Zhao W, Zuo WS, et al. Silencing of osteopontin promotes the radiosensitivity of breast cancer cells by reducing the expression of hypoxia inducible factor 1 and vascular endothelial growth factor. Chin Med J (Engl) 2012;125:293-9
    • (2012) Chin Med J (Engl) , vol.125 , pp. 293-299
    • Yang, L.1    Zhao, W.2    Zuo, W.S.3
  • 58
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med 2013;19:1423-37.
    • (2013) Nat Med , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 59
    • 84860503063 scopus 로고    scopus 로고
    • Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression
    • Pazolli E, Alspach E, Milczarek A, et al. Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res 2012;72:2251-61
    • (2012) Cancer Res , vol.72 , pp. 2251-2261
    • Pazolli, E.1    Alspach, E.2    Milczarek, A.3
  • 60
    • 84863249949 scopus 로고    scopus 로고
    • Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells
    • Liu J, Xu K, Chase M, et al. Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells. J Cell Sci 2012;125:376-86
    • (2012) J Cell Sci , vol.125 , pp. 376-386
    • Liu, J.1    Xu, K.2    Chase, M.3
  • 61
    • 80051985501 scopus 로고    scopus 로고
    • Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway
    • Luo X, Ruhland MK, Pazolli E, et al. Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway. Mol Cancer Res 2011;9:1018-29
    • (2011) Mol Cancer Res , vol.9 , pp. 1018-1029
    • Luo, X.1    Ruhland, M.K.2    Pazolli, E.3
  • 62
    • 84879554043 scopus 로고    scopus 로고
    • Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype
    • Li NY, Weber CE, Mi Z, et al. Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype. J Am Coll Surg 2013;217:17-26.
    • (2013) J Am Coll Surg , vol.217 , pp. 17-26
    • Li, N.Y.1    Weber, C.E.2    Mi, Z.3
  • 63
    • 79956134378 scopus 로고    scopus 로고
    • Mesenchymal stem cells require integrin beta1 for directed migration induced by osteopontin in vitro
    • Zou C, Song G, Luo Q, et al. Mesenchymal stem cells require integrin beta1 for directed migration induced by osteopontin in vitro. In Vitro Cell Dev Biol Anim 2011;47:241-50
    • (2011) In Vitro Cell Dev Biol Anim , vol.47 , pp. 241-250
    • Zou, C.1    Song, G.2    Luo, Q.3
  • 64
    • 84875228023 scopus 로고    scopus 로고
    • Osteopontin promotes mesenchymal stem cell migration and lessens cell stiffness via integrin beta1, FAK and ERK pathways
    • Zou C, Luo Q, Qin J, et al. Osteopontin promotes mesenchymal stem cell migration and lessens cell stiffness via integrin beta1, FAK and ERK pathways. Cell Biochem Biophys 2013;65:455-62
    • (2013) Cell Biochem Biophys , vol.65 , pp. 455-462
    • Zou, C.1    Luo, Q.2    Qin, J.3
  • 65
    • 84865702871 scopus 로고    scopus 로고
    • Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: Concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers
    • Bhattacharya SD, Mi Z, Talbot LJ, et al. Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: Concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers. Surgery 2012;152:449-54
    • (2012) Surgery , vol.152 , pp. 449-454
    • Bhattacharya, S.D.1    Mi, Z.2    Talbot, L.J.3
  • 66
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
    • DOI 10.1038/35888
    • Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806-11 (Pubitemid 28099681)
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 67
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • DOI 10.1038/35078107
    • Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-8 (Pubitemid 32494397)
    • (2001) Nature , vol.411 , Issue.6836 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 68
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • Davidson BL, McCray PB Jr. Current prospects for RNA interference-based therapies. Nat Rev Genet 2011;12:329-40
    • (2011) Nat Rev Genet , vol.12 , pp. 329-340
    • Davidson, B.L.1    McCray Jr., P.B.2
  • 69
    • 49549089944 scopus 로고    scopus 로고
    • Down-regulation of osteopontin attenuates breast tumor progression in vivo
    • Chakraborty G, Jain S, Patil TV, et al. Down-regulation of osteopontin attenuates breast tumor progression in vivo. J Cell Mol Med 2008;12:2305-18
    • (2008) J Cell Mol Med , vol.12 , pp. 2305-2318
    • Chakraborty, G.1    Jain, S.2    Patil, T.V.3
  • 70
    • 77950518941 scopus 로고    scopus 로고
    • Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells
    • Tajima K, Ohashi R, Sekido Y, et al. Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells. Oncogene 2010;29:1941-51
    • (2010) Oncogene , vol.29 , pp. 1941-1951
    • Tajima, K.1    Ohashi, R.2    Sekido, Y.3
  • 71
    • 84862934553 scopus 로고    scopus 로고
    • Down-regulation of osteopontin expression by RNA interference affects cell proliferation and chemotherapy sensitivity of breast cancer MDA-MB-231 cells
    • Yang L, Wei L, Zhao W, et al. Down-regulation of osteopontin expression by RNA interference affects cell proliferation and chemotherapy sensitivity of breast cancer MDA-MB-231 cells. Mol Med Rep 2012;5:373-6
    • (2012) Mol Med Rep , vol.5 , pp. 373-376
    • Yang, L.1    Wei, L.2    Zhao, W.3
  • 72
    • 77955282960 scopus 로고    scopus 로고
    • Micro-RNA-181a regulates osteopontin-dependent metastatic function in hepatocellular cancer cell lines
    • Bhattacharya SD, Garrison J, Guo H, et al. Micro-RNA-181a regulates osteopontin-dependent metastatic function in hepatocellular cancer cell lines. Surgery 2010;148:291-7
    • (2010) Surgery , vol.148 , pp. 291-297
    • Bhattacharya, S.D.1    Garrison, J.2    Guo, H.3
  • 73
    • 79952338249 scopus 로고    scopus 로고
    • Suppressing tumourigenicity of prostate cancer cells by inhibiting osteopontin expression
    • Zhang Y, Forootan SS, Kamalian L, et al. Suppressing tumourigenicity of prostate cancer cells by inhibiting osteopontin expression. Int J Oncol 2011;38:1083-91
    • (2011) Int J Oncol , vol.38 , pp. 1083-1091
    • Zhang, Y.1    Forootan, S.S.2    Kamalian, L.3
  • 74
    • 77954258432 scopus 로고    scopus 로고
    • Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells
    • Sharma P, Kumar S, Kundu GC. Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells. Mol Cancer 2010;9:178
    • (2010) Mol Cancer , vol.9 , pp. 178
    • Sharma, P.1    Kumar, S.2    Kundu, G.C.3
  • 75
    • 70349504538 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitors downregulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers
    • Zagani R, Hamzaoui N, Cacheux W, et al. Cyclooxygenase-2 inhibitors downregulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers. Gastroenterology 2009;137:1358-66
    • (2009) Gastroenterology , vol.137 , pp. 1358-1366
    • Zagani, R.1    Hamzaoui, N.2    Cacheux, W.3
  • 76
    • 77954844604 scopus 로고    scopus 로고
    • Osteopontin is a new target molecule for ovarian clear cell carcinoma therapy
    • Matsuura M, Suzuki T, Saito T. Osteopontin is a new target molecule for ovarian clear cell carcinoma therapy. Cancer Sci 2010;101:1828-33
    • (2010) Cancer Sci , vol.101 , pp. 1828-1833
    • Matsuura, M.1    Suzuki, T.2    Saito, T.3
  • 77
    • 84885092904 scopus 로고    scopus 로고
    • Effects and mechanisms of curcumin and basil polysaccharide on the invasion of SKOV3 cells and dendritic cells
    • Lv J, Shao Q, Wang H, et al. Effects and mechanisms of curcumin and basil polysaccharide on the invasion of SKOV3 cells and dendritic cells. Mol Med Rep 2013;8:1580-6
    • (2013) Mol Med Rep , vol.8 , pp. 1580-1586
    • Lv, J.1    Shao, Q.2    Wang, H.3
  • 78
    • 84866544769 scopus 로고    scopus 로고
    • Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signalling pathway
    • Kumar S, Patil HS, Sharma P, et al. Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signalling pathway. Curr Mol Med 2012;12:952-66
    • (2012) Curr Mol Med , vol.12 , pp. 952-966
    • Kumar, S.1    Patil, H.S.2    Sharma, P.3
  • 79
    • 33745605192 scopus 로고    scopus 로고
    • Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells
    • DOI 10.1093/carcin/bgi352
    • Mi Z, Guo H, Wai PY, et al. Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. Carcinogenesis 2006;27:1134-45 (Pubitemid 43985428)
    • (2006) Carcinogenesis , vol.27 , Issue.6 , pp. 1134-1145
    • Mi, Z.1    Guo, H.2    Wai, P.Y.3    Gao, C.4    Kuo, P.C.5
  • 80
    • 77951966160 scopus 로고    scopus 로고
    • Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-kB dependent AP-1-mediated ICAM-1 expression in breast cancer cells
    • Ahmed M, Kundu GC. Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-kB dependent AP-1-mediated ICAM-1 expression in breast cancer cells. Mol Cancer 2010;9:101
    • (2010) Mol Cancer , vol.9 , pp. 101
    • Ahmed, M.1    Kundu, G.C.2
  • 81
    • 70349439129 scopus 로고    scopus 로고
    • Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells
    • Dai J, Peng L, Fan K, et al. Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells. Oncogene 2009;28:3412-22
    • (2009) Oncogene , vol.28 , pp. 3412-3422
    • Dai, J.1    Peng, L.2    Fan, K.3
  • 82
    • 73349139190 scopus 로고    scopus 로고
    • A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo
    • Dai J, Li B, Shi J, et al. A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo. Cancer Immunol Immunother 2010;59:355-66
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 355-366
    • Dai, J.1    Li, B.2    Shi, J.3
  • 83
    • 77950561915 scopus 로고    scopus 로고
    • CD44, a therapeutic target for metastasising tumours
    • Orian-Rousseau V. CD44, a therapeutic target for metastasising tumours. Eur J Cancer 2010;46:1271-7
    • (2010) Eur J Cancer , vol.46 , pp. 1271-1277
    • Orian-Rousseau, V.1
  • 84
    • 80051756835 scopus 로고    scopus 로고
    • Osteopontin: A potentially important therapeutic target in cancer
    • Ahmed M, Behera R, Chakraborty G, et al. Osteopontin: A potentially important therapeutic target in cancer. Expert Opin Ther Targets 2011;15:1113-26
    • (2011) Expert Opin Ther Targets , vol.15 , pp. 1113-1126
    • Ahmed, M.1    Behera, R.2    Chakraborty, G.3
  • 85
    • 77955133838 scopus 로고    scopus 로고
    • Anti-CD44 induces apoptosis in T lymphoma via mitochondrial depolarization
    • Rajasagi M, von Au A, Singh R, et al. Anti-CD44 induces apoptosis in T lymphoma via mitochondrial depolarization. J Cell Mol Med 2010;14:1453-67
    • (2010) J Cell Mol Med , vol.14 , pp. 1453-1467
    • Rajasagi, M.1    Von Au, A.2    Singh, R.3
  • 86
    • 13244284603 scopus 로고    scopus 로고
    • Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12
    • DOI 10.1038/sj.onc.1208209
    • Teramoto H, Castellone MD, Malek RL, et al. Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12. Oncogene 2005;24:489-501 (Pubitemid 40188596)
    • (2005) Oncogene , vol.24 , Issue.3 , pp. 489-501
    • Teramoto, H.1    Castellone, M.D.2    Malek, R.L.3    Letwin, N.4    Frank, B.5    Gutkind, J.S.6    Lee, N.H.7
  • 87
    • 58149240891 scopus 로고    scopus 로고
    • RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB-231 breast cancer cells
    • Mi Z, Guo H, Russell MB, et al. RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB-231 breast cancer cells. Mol Ther 2009;17:153-61
    • (2009) Mol Ther , vol.17 , pp. 153-161
    • Mi, Z.1    Guo, H.2    Russell, M.B.3
  • 88
    • 84862014396 scopus 로고    scopus 로고
    • The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity
    • Hunter C, Bond J, Kuo PC, et al. The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity. J Surg Res 2012;176:348-58
    • (2012) J Surg Res , vol.176 , pp. 348-358
    • Hunter, C.1    Bond, J.2    Kuo, P.C.3
  • 89
    • 79960919903 scopus 로고    scopus 로고
    • Pharmacokinetic characterization of an RNA aptamer against osteopontin and demonstration of in vivo efficacy in reversing growth of human breast cancer cells
    • Talbot LJ, Mi Z, Bhattacharya SD, et al. Pharmacokinetic characterization of an RNA aptamer against osteopontin and demonstration of in vivo efficacy in reversing growth of human breast cancer cells. Surgery 2011;150:224-30
    • (2011) Surgery , vol.150 , pp. 224-230
    • Talbot, L.J.1    Mi, Z.2    Bhattacharya, S.D.3
  • 90
    • 0032533862 scopus 로고    scopus 로고
    • Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo
    • Crawford HC, Matrisian LM, Liaw L. Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo. Cancer Res 1998;58:5206-15 (Pubitemid 28521184)
    • (1998) Cancer Research , vol.58 , Issue.22 , pp. 5206-5215
    • Crawford, H.C.1    Matrisian, L.M.2    Liaw, L.3
  • 91
    • 1642340048 scopus 로고    scopus 로고
    • Impaired anti-tumor cytotoxicity of macrophages from osteopontin- deficient mice
    • DOI 10.1016/j.cellimm.2004.01.001, PII S0008874904000024
    • Bourassa B, Monaghan S, Rittling SR. Impaired anti-tumor cytotoxicity of macrophages from osteopontin-deficient mice. Cell Immunol 2004;227:1-11 (Pubitemid 38393724)
    • (2004) Cellular Immunology , vol.227 , Issue.1 , pp. 1-11
    • Bourassa, B.1    Monaghan, S.2    Rittling, S.R.3
  • 92
    • 78651376714 scopus 로고    scopus 로고
    • Categorical meta-analysis of osteopontin as a clinical cancer marker
    • Weber GF, Lett GS, Haubein NC. Categorical meta-analysis of osteopontin as a clinical cancer marker. Oncol Rep 2011;25:433-41.
    • (2011) Oncol Rep , vol.25 , pp. 433-441
    • Weber, G.F.1    Lett, G.S.2    Haubein, N.C.3
  • 93
    • 84877952099 scopus 로고    scopus 로고
    • The osteopontin tissue level as a breast cancer biomarker in females after mastectomy measured by the capillary gel electrophoresis technique
    • Konieczna L, Skokowski J, Oledzka I, et al. The osteopontin tissue level as a breast cancer biomarker in females after mastectomy measured by the capillary gel electrophoresis technique. Comb Chem High Throughput Screen 2013;16:331-8
    • (2013) Comb Chem High Throughput Screen , vol.16 , pp. 331-338
    • Konieczna, L.1    Skokowski, J.2    Oledzka, I.3
  • 94
    • 84871508773 scopus 로고    scopus 로고
    • Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers
    • Cao DX, Li ZJ, Jiang XO, et al. Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers. World J Gastroenterol 2012;18:3923-30
    • (2012) World J Gastroenterol , vol.18 , pp. 3923-3930
    • Cao, D.X.1    Li, Z.J.2    Jiang, X.O.3
  • 95
    • 84873431493 scopus 로고    scopus 로고
    • Significance of plasma osteopontin levels in patients with bladder urothelial carcinomas
    • Zhao L, Wang Y, Qu N, et al. Significance of plasma osteopontin levels in patients with bladder urothelial carcinomas. Mol DiagnTher 2012;16:311-6
    • (2012) Mol DiagnTher , vol.16 , pp. 311-316
    • Zhao, L.1    Wang, Y.2    Qu, N.3
  • 96
    • 84873318410 scopus 로고    scopus 로고
    • Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage
    • Yamaguchi Y, Shao Z, Sharif S, et al. Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. J Biol Chem 2013;288:3097-111
    • (2013) J Biol Chem , vol.288 , pp. 3097-3111
    • Yamaguchi, Y.1    Shao, Z.2    Sharif, S.3
  • 97
    • 84888142119 scopus 로고    scopus 로고
    • Plasma osteopontin is a useful diagnostic biomarker for advanced non-small cell lung cancer
    • Han SS, Lee SJ, Kim WJ, et al. Plasma osteopontin is a useful diagnostic biomarker for advanced non-small cell lung cancer. Tuberc Respir Dis (Seoul) 2013;75:104-10
    • (2013) Tuberc Respir Dis (Seoul) , vol.75 , pp. 104-110
    • Han, S.S.1    Lee, S.J.2    Kim, W.J.3
  • 98
    • 84887174613 scopus 로고    scopus 로고
    • Osteopontin is a prognostic biomarker in non-small cell lung cancer
    • Rud AK, Boye K, Oijordsbakken M, et al. Osteopontin is a prognostic biomarker in non-small cell lung cancer. BMC Cancer 2013;13:540
    • (2013) BMC Cancer , vol.13 , pp. 540
    • Rud, A.K.1    Boye, K.2    Oijordsbakken, M.3
  • 99
    • 84865434420 scopus 로고    scopus 로고
    • Plasma osteopontin as a biomarker of prostate cancer aggression: Relationship to risk category and treatment response
    • Thoms JW, Dal Pra A, Anborgh PH, et al. Plasma osteopontin as a biomarker of prostate cancer aggression: Relationship to risk category and treatment response. Br J Cancer 2012;107:840-6
    • (2012) Br J Cancer , vol.107 , pp. 840-846
    • Thoms, J.W.1    Dal Pra, A.2    Anborgh, P.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.