A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo

Cancer Immunology, Immunotherapy

Volumn 59, Issue 3, 2010, Pages 355-366

  Dai, Jianxin ^a   Li, Bohua ^a,b   Shi, Jinping ^a   Peng, Ling ^a   Zhang, Dapeng ^a,b   Qian, Weizhu ^a,b   Hou, Sheng ^a,b   Zhao, Lei ^a   Gao, Jie ^a   Cao, Zhiguo ^a   Zhao, Jian ^a   Wang, Hao ^a,b   Guo, Yajun ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b National Engineering Research Center for Antibody Medicine   (China)

Author keywords

Breast cancer; Humanized antibody; Immunogenicity; Metastasis; Osteopontin

Indexed keywords

ANTINEOPLASTIC AGENT; EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1A12; OSTEOPONTIN ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING KINETICS; BREAST CANCER; CALCIUM BINDING; CANCER CELL CULTURE; CANCER INHIBITION; CELL ADHESION; CELL INVASION; CELL MIGRATION; COLONY FORMATION; COMPLEMENTARITY DETERMINING REGION; COMPUTER MODEL; CONTROLLED STUDY; DRUG EFFICACY; EPITOPE MAPPING; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG METASTASIS; LYMPH NODE METASTASIS; METASTASIS INHIBITION; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; TUMOR XENOGRAFT;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BREAST NEOPLASMS; EPITOPE MAPPING; HUMANS; LUNG NEOPLASMS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OSTEOPONTIN; RECOMBINATION, GENETIC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 73349139190     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-009-0754-z     Document Type: Article

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