Pharmacokinetic characterization of an RNA aptamer against osteopontin and demonstration of in vivo efficacy in reversing growth of human breast cancer cells

Surgery

Volumn 150, Issue 2, 2011, Pages 224-230

  Talbot, Lindsay Jones ^a   Mi, Zhiyong ^a   Bhattacharya, Syamal Dave ^a   Kim, Victoria ^a   Guo, Hongtao ^a   Kuo, Paul C ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; OPN R3 APTAMER; OSTEOPONTIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CANCER REGRESSION; CANCER SIZE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG EFFICACY; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; INOCULATION; INTRACELLULAR SIGNALING; MEAN RESIDENCE TIME; METHYLATION; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; APTAMERS, NUCLEOTIDE; BREAST NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MICE; OSTEOPONTIN; TREATMENT OUTCOME; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79960919903     PISSN: 00396060     EISSN: 15327361     Source Type: Journal    
DOI: 10.1016/j.surg.2011.05.015     Document Type: Article

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