-
1
-
-
0028929328
-
Mechanisms and genes of cellular suicide
-
Steller, H. (1995) Mechanisms and genes of cellular suicide. Science, 267, 1445-1449.
-
(1995)
Science
, vol.267
, pp. 1445-1449
-
-
Steller, H.1
-
2
-
-
14844297327
-
Control of cell proliferation and apoptosis by mob as tumor suppressor, mats
-
Lai, Z.C. et al. (2005) Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell, 120, 675-685.
-
(2005)
Cell
, vol.120
, pp. 675-685
-
-
Lai, Z.C.1
-
3
-
-
0037028249
-
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
-
Rahaman, S.O. et al. (2002) Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene, 21, 8404-8413.
-
(2002)
Oncogene
, vol.21
, pp. 8404-8413
-
-
Rahaman, S.O.1
-
4
-
-
0034658698
-
STATs in oncogenesis
-
Bowman, T. et al. (2000) STATs in oncogenesis. Oncogene, 19, 2474-2488.
-
(2000)
Oncogene
, vol.19
, pp. 2474-2488
-
-
Bowman, T.1
-
5
-
-
16344380754
-
A low-molecular-weight compound discovered through virtual database screening inhibits STAT3 function in breast cancer cells
-
Song, H. et al. (2005) A low-molecular-weight compound discovered through virtual database screening inhibits STAT3 function in breast cancer cells. Proc. Natl Acad. Sci. USA, 102, 4700-4705.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 4700-4705
-
-
Song, H.1
-
6
-
-
0033529704
-
Stat3 as an oncogene
-
Bromberg, J.F. et al. (1999) Stat3 as an oncogene. Cell, 98, 295-303.
-
(1999)
Cell
, vol.98
, pp. 295-303
-
-
Bromberg, J.F.1
-
7
-
-
0034657336
-
The role of STATs in transcriptional control and their impact on cellular function
-
Bromberg, J. et al. (2000) The role of STATs in transcriptional control and their impact on cellular function. Oncogene, 19, 2468-2473.
-
(2000)
Oncogene
, vol.19
, pp. 2468-2473
-
-
Bromberg, J.1
-
8
-
-
58149218143
-
Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas
-
Colomiere, M. et al. (2009) Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. Br. J. Cancer, 100, 134-144.
-
(2009)
Br. J. Cancer
, vol.100
, pp. 134-144
-
-
Colomiere, M.1
-
9
-
-
39749187284
-
Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
-
Bellahcéne, A. et al. (2008) Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. Nat. Rev. Cancer, 8, 212-226.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 212-226
-
-
Bellahcéne, A.1
-
11
-
-
32644467590
-
Osteopontin: role in cell signaling and cancer progression
-
Rangaswami, H. et al. (2006) Osteopontin: role in cell signaling and cancer progression. Trends Cell Biol., 16, 79-87.
-
(2006)
Trends Cell Biol.
, vol.16
, pp. 79-87
-
-
Rangaswami, H.1
-
12
-
-
0035976914
-
Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells
-
Philip, S. et al. (2001) Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells. J. Biol. Chem., 276, 44926-44935.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 44926-44935
-
-
Philip, S.1
-
13
-
-
33745253734
-
Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression, MMP-2 secretion, and cell migration by osteopontin in human melanoma cells
-
Samanna, V. et al. (2006) Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression, MMP-2 secretion, and cell migration by osteopontin in human melanoma cells. Exp. Cell Res., 312, 2214-2230.
-
(2006)
Exp. Cell Res.
, vol.312
, pp. 2214-2230
-
-
Samanna, V.1
-
14
-
-
4644231399
-
Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation
-
Rangaswami, H. et al. (2004) Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation. J. Biol. Chem., 279, 38921-38935.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38921-38935
-
-
Rangaswami, H.1
-
15
-
-
33746114248
-
The crucial role of cyclooxygenase-2 in osteopontininduced protein kinase C alpha/c-Src/IkappaB kinase alpha/beta-dependent prostate tumor progression and angiogenesis
-
Jain, S. et al. (2006) The crucial role of cyclooxygenase-2 in osteopontininduced protein kinase C alpha/c-Src/IkappaB kinase alpha/beta-dependent prostate tumor progression and angiogenesis. Cancer Res., 66, 6638-6648.
-
(2006)
Cancer Res.
, vol.66
, pp. 6638-6648
-
-
Jain, S.1
-
16
-
-
39149110606
-
Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms
-
Chakraborty, G. et al. (2008) Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms. Cancer Res., 68, 152-161.
-
(2008)
Cancer Res.
, vol.68
, pp. 152-161
-
-
Chakraborty, G.1
-
17
-
-
33845361246
-
The multifaceted roles of osteopontin in cell signaling, tumor progression and angiogenesis
-
Chakraborty, G. et al. (2006) The multifaceted roles of osteopontin in cell signaling, tumor progression and angiogenesis. Curr. Mol. Med., 6, 819-830.
-
(2006)
Curr. Mol. Med.
, vol.6
, pp. 819-830
-
-
Chakraborty, G.1
-
18
-
-
44049093342
-
Increased expression of osteopontin in patients with triple-negative breast cancer
-
Wang, X. et al. (2008) Increased expression of osteopontin in patients with triple-negative breast cancer. Eur. J. Clin. Invest., 38, 438-446.
-
(2008)
Eur. J. Clin. Invest.
, vol.38
, pp. 438-446
-
-
Wang, X.1
-
19
-
-
34250860202
-
The role of osteopontin in tumor progression and metastasis in breast cancer
-
Rodrigues, L.R. et al. (2007) The role of osteopontin in tumor progression and metastasis in breast cancer. Cancer Epidemiol. Biomarkers Prev., 16, 1087-1097.
-
(2007)
Cancer Epidemiol. Biomarkers Prev.
, vol.16
, pp. 1087-1097
-
-
Rodrigues, L.R.1
-
20
-
-
0038340658
-
Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma
-
Pan, H.W. et al. (2003) Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma. Cancer, 98, 119-127.
-
(2003)
Cancer
, vol.98
, pp. 119-127
-
-
Pan, H.W.1
-
21
-
-
33748963245
-
Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435
-
Shevde, L.A. et al. (2006) Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435. Clin. Exp. Metastasis, 23, 123-133.
-
(2006)
Clin. Exp. Metastasis
, vol.23
, pp. 123-133
-
-
Shevde, L.A.1
-
22
-
-
34548268059
-
Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling
-
Furuya, F. et al. (2007) Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling. Mol. Cell. Biol., 27, 6116-6126.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 6116-6126
-
-
Furuya, F.1
-
23
-
-
0038191064
-
Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha/IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways
-
Philip, S. et al. (2003) Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha/IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways. J. Biol. Chem., 278, 14487-14497.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14487-14497
-
-
Philip, S.1
-
24
-
-
44849139210
-
GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium
-
Kida, H. et al. (2008) GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am. J. Pathol., 172, 1542-1554.
-
(2008)
Am. J. Pathol.
, vol.172
, pp. 1542-1554
-
-
Kida, H.1
-
25
-
-
4143153849
-
Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow
-
Ni, C.W. et al. (2004) Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow. Am. J. Physiol. Cell Physiol., 287, C771-C780.
-
(2004)
Am. J. Physiol. Cell Physiol.
, vol.287
-
-
Ni, C.W.1
-
26
-
-
33751575658
-
The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis
-
Rosen, D.G. et al. (2006) The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer, 107, 2730-2740.
-
(2006)
Cancer
, vol.107
, pp. 2730-2740
-
-
Rosen, D.G.1
-
27
-
-
44849135184
-
Stat3 promotes metastatic progression of prostate cancer
-
Abdulghani, J. et al. (2008) Stat3 promotes metastatic progression of prostate cancer. Am. J. Pathol., 172, 1717-1728.
-
(2008)
Am. J. Pathol.
, vol.172
, pp. 1717-1728
-
-
Abdulghani, J.1
-
28
-
-
57449100243
-
E-cadherin decreased human breast cancer cells sensitivity to staurosporine by up-regulating Bcl-2 expression
-
Wang, L. et al. (2009) E-cadherin decreased human breast cancer cells sensitivity to staurosporine by up-regulating Bcl-2 expression. Arch. Biochem. Biophys., 481, 116-122.
-
(2009)
Arch. Biochem. Biophys.
, vol.481
, pp. 116-122
-
-
Wang, L.1
-
29
-
-
33645067376
-
Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3
-
Leslie, K. et al. (2006) Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res., 66, 2544-2552.
-
(2006)
Cancer Res.
, vol.66
, pp. 2544-2552
-
-
Leslie, K.1
-
30
-
-
29144528036
-
STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells
-
Bhattacharya, S. et al. (2005) STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells. Biochem. J., 392, 335-344.
-
(2005)
Biochem. J.
, vol.392
, pp. 335-344
-
-
Bhattacharya, S.1
-
31
-
-
20944441928
-
Validating Stat3 in cancer therapy
-
Darnell, J.E. (2005) Validating Stat3 in cancer therapy. Nat. Med., 11, 595-596.
-
(2005)
Nat. Med.
, vol.11
, pp. 595-596
-
-
Darnell, J.E.1
-
32
-
-
16844373256
-
Aberrant Stat3 signaling by interleukin-4 in malignant glioma cells: involvement of IL-13Rα2
-
Rahaman, S.O. et al. (2005) Aberrant Stat3 signaling by interleukin-4 in malignant glioma cells: involvement of IL-13Rα2. Cancer Res., 65, 2956-2963.
-
(2005)
Cancer Res
, vol.65
, pp. 2956-2963
-
-
Rahaman, S.O.1
-
33
-
-
33645532055
-
Activation of stat3 in human melanoma promotes brain metastasis
-
Xie, T.X. et al. (2006) Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res., 66, 3188-3196.
-
(2006)
Cancer Res.
, vol.66
, pp. 3188-3196
-
-
Xie, T.X.1
-
34
-
-
33645506849
-
Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor
-
Alvarez, J.V. et al. (2006) Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer Res., 66, 3162-3168.
-
(2006)
Cancer Res
, vol.66
, pp. 3162-3168
-
-
Alvarez, J.V.1
-
35
-
-
33644773438
-
STAT3 as a therapeutic target in head and neck cancer
-
Leeman, R.J. et al. (2006) STAT3 as a therapeutic target in head and neck cancer. Expert Opin. Biol. Ther., 6, 231-241.
-
(2006)
Expert Opin. Biol. Ther.
, vol.6
, pp. 231-241
-
-
Leeman, R.J.1
-
36
-
-
31544460437
-
Activation of Stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated Src and survivin expression
-
Diaz, N. et al. (2006) Activation of Stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated Src and survivin expression. Clin. Cancer Res., 12, 20-28.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 20-28
-
-
Diaz, N.1
-
37
-
-
33847194593
-
Stat3 activation in human endometrial and cervical cancers
-
Chen, C.L. et al. (2007) Stat3 activation in human endometrial and cervical cancers. Br. J. Cancer, 96, 591-599.
-
(2007)
Br. J. Cancer
, vol.96
, pp. 591-599
-
-
Chen, C.L.1
-
38
-
-
0034163461
-
Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells
-
Ni, Z. et al. (2000) Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells. Cancer Res., 60, 1225-1228.
-
(2000)
Cancer Res.
, vol.60
, pp. 1225-1228
-
-
Ni, Z.1
-
39
-
-
33745905938
-
STAT3: a multifaceted oncogene
-
Levy, D.E. et al. (2006) STAT3: a multifaceted oncogene. Proc. Natl Acad. Sci. USA, 103, 9964-9969.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 9964-9969
-
-
Levy, D.E.1
-
40
-
-
20444446371
-
Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors
-
Alvarez, J.V. et al. (2005) Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res., 65, 5054-5062.
-
(2005)
Cancer Res
, vol.65
, pp. 5054-5062
-
-
Alvarez, J.V.1
-
41
-
-
54249155141
-
Prostaglandin E2 regulates tumor angiogenesis in prostate cancer
-
Jain, S. et al. (2008) Prostaglandin E2 regulates tumor angiogenesis in prostate cancer. Cancer Res., 68, 7750-7759.
-
(2008)
Cancer Res.
, vol.68
, pp. 7750-7759
-
-
Jain, S.1
-
42
-
-
49249095430
-
Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells
-
Zhao, S. et al. (2008) Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells. Cancer Res., 68, 4221-4228.
-
(2008)
Cancer Res.
, vol.68
, pp. 4221-4228
-
-
Zhao, S.1
-
43
-
-
59149083547
-
Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation
-
Shain, K.H. et al. (2009) Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation. Cancer Res., 69, 1009-1015.
-
(2009)
Cancer Res.
, vol.69
, pp. 1009-1015
-
-
Shain, K.H.1
-
44
-
-
0035066613
-
Staurosporine-induced apoptosis of HPV positive and negative human cervical cancer cells from different points in the cell cycle
-
Bernard, B. et al. (2001) Staurosporine-induced apoptosis of HPV positive and negative human cervical cancer cells from different points in the cell cycle. Cell Death Differ., 8, 234-244.
-
(2001)
Cell Death Differ.
, vol.8
, pp. 234-244
-
-
Bernard, B.1
-
45
-
-
40149094813
-
Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells
-
Xiong, H. et al. (2008) Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. Neoplasia, 10, 287-297.
-
(2008)
Neoplasia
, vol.10
, pp. 287-297
-
-
Xiong, H.1
|