Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes

Journal of Bone and Mineral Research

Volumn 26, Issue 9, 2011, Pages 2112-2124

  Gharibi, Borzo ^a   Abraham, Anju A ^a   Ham, Jack ^a   Evans, Bronwen Aj ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

ADENOSINE RECEPTOR; ADIPOCYTE; DIFFERENTIATION; MESENCHYMAL STEM CELL; OSTEOBLAST

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ALKALINE PHOSPHATASE; CCAAT ENHANCER BINDING PROTEIN ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR RUNX2;

ADIPOCYTE; ADIPOGENESIS; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID STORAGE; LIPOGENESIS; MESENCHYMAL STEM CELL; OSTEOBLAST; PROTEIN EXPRESSION; UPREGULATION;

ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ADIPOCYTES; ADIPOGENESIS; ALKALINE PHOSPHATASE; ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CALCIFICATION, PHYSIOLOGIC; CELL COUNT; CELL DIFFERENTIATION; CYCLIC AMP; GENE EXPRESSION REGULATION; HUMANS; LIPID METABOLISM; MESENCHYMAL STEM CELLS; OSTEOBLASTS; OSTEOGENESIS; PURINERGIC P1 RECEPTOR AGONISTS; PURINERGIC P1 RECEPTOR ANTAGONISTS; RATS; RECEPTORS, PURINERGIC P1; SIGNAL TRANSDUCTION;

EID: 80052003962     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.424     Document Type: Article

References (43)

1. Rosen CJ, Bouxsein ML,. Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheum. 2006; 2: 35-43. (Pubitemid 43153647)
2. Kawai M, Rosen CJ,. Bone: adiposity and bone accrual-still an established paradigm? Nat Rev Endocrinol. 2010; 6: 63-64.
3. Minguell JJ, Erices A, Conget P,. Mesenchymal stem cells. Exp Biol Med. 2001; 226: 507-520. (Pubitemid 32524497)
4. Blair HC, Zaidi M, Schlesinger PH,. Mechanisms balancing skeletal matrix synthesis and degradation. Biochem J. 2002; 364: 329-341. (Pubitemid 34620792)
5. Caplan AI, Dennis JE,. Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006; 98: 1076-1084. (Pubitemid 44128350)
6. Huang W, Yang SY, Shao JZ, Li YP,. Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci. 2007; 12: 3068-3092.
7. Otto TC, Lane MD,. Adipose Development: From Stem Cell to Adipocyte. Crit Rev Biochem Mol. 2005; 40: 229-242. (Pubitemid 41140883)
8. Di Iorgi N, Rosol M, Mittelman SD, Gilsanz V,. Reciprocal Relation between Marrow Adiposity and the Amount of Bone in the Axial and Appendicular Skeleton of Young Adults. J Clin Endocrinol Metab. 2008; 93: 2281-2286. (Pubitemid 351831548)
9. Di Iorgi N, Mo AO, Grimm K, Wren TAL, Dorey F, Gilsanz V,. Bone Acquisition in Healthy Young Females Is Reciprocally Related to Marrow Adiposity. J Clin Endocrinol Metab. 2010; 95: 2977-2982.
10. Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ,. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol. 2002; 55: 693-698. (Pubitemid 34970093)
11. Qiu W, Andersen TE, Bollerslev J, Mandrup S, Abdallah BM, Kassem M,. Patients With High Bone Mass Phenotype Exhibit Enhanced Osteoblast Differentiation and Inhibition of Adipogenesis of Human Mesenchymal Stem Cells. J Bone Miner Res. 2007; 22: 1720-1731. (Pubitemid 351235138)
12. Valentin D, Aline M, Lafage-Proust M-H, et al. Mechanical Loading Down-Regulates Peroxisome Proliferator-Activated Receptor g in Bone Marrow Stromal Cells and Favors Osteoblastogenesis at the Expense of Adipogenesis. Endocrinology. 2007; 148: 2553-2562. (Pubitemid 47007541)
13. Fredholm BB,. Adenosine receptors as drug targets. Exp Cell Res. 2010; 316: 1284-1288.
14. Evans BAJ, Elford C, Pexa A, et al. Human Osteoblast Precursors Produce Extracellular Adenosine, Which Modulates Their Secretion of IL-6 and Osteoprotegerin. J Bone Miner Res. 2006; 21: 228-236. (Pubitemid 43265288)
15. Montesinos MC, Gadangi P, Longaker M, et al. Wound healing is accelerated by agonists of adenosine A(2) (G(alphas)-linked) receptors. J Exp Med. 1997; 186: 1615-1620. (Pubitemid 27479823)
16. Linden J,. Molecular approach to adenosine receptors: Receptor-Mediated Mechanisms of Tissue Protection. Ann Rev Pharmacol. 2001; 41: 775-787. (Pubitemid 32385906)
17. Ohta A, Sitkovsky M,. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature. 2001; 414: 916-920. (Pubitemid 34024743)
18. Montesinos MC, Desai A, Chen J-F, et al. Adenosine Promotes Wound Healing and Mediates Angiogenesis in Response to Tissue Injury Via Occupancy of A2A Receptors. Am J Pathol. 2002; 160: 2009-2018. (Pubitemid 34663394)
19. Katebi M, Soleimani M, Cronstein BN,. Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development. J Leukocyte Biol. 2009; 85: 438-444.
20. Vassaux G, Gaillard D, Mari B, Ailhaud G, Negrel R,. Differential Expression of Adenosine-A1 and Adenosine-A2 Receptors in Preadipocytes and Adipocytes. Biochem Biophysl Res Co. 1993; 193: 1123-1130. (Pubitemid 23209711)
21. Børglum JD, Vassaux G, Richelsen B, et al. Changes in adenosine A1- and A2-receptor expression during adipose cell differentiation. Mol Cell Endocrinol. 1996; 117: 17-25.
22. Rice AM, Fain JN, Rivkees SA,. A1 Adenosine Receptor Activation Increases Adipocyte Leptin Secretion. Endocrinology. 2000; 141: 1442-1445. (Pubitemid 32269112)
23. 1 adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance. Diabetes Obes Metab. 2001; 3: 360-366. (Pubitemid 33072216)
24. Sen A, Lea-Currie YR, Sujkowska D, et al. Adipogenic potential of human adipose derived stromal cells from multiple donors is heterogeneous. J Cell Biochem. 2001; 81: 312-319. (Pubitemid 32298263)
25. Pastor-Anglada M, Casado FJ, Valdes R, Mata J, Garcia-Manteiga J, Molina M,. Complex regulation of nucleoside transporter expression in epithelial and immune system cells. Mol Membr Biol. 2001; 18: 81-85. (Pubitemid 32521600)
26. Hyde RJ, Cass CE, Young JD, Baldwin SA,. The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms. Mol Membr Biol. 2001; 18: 53-63. (Pubitemid 32521597)
27. Latini S, Pedata F,. Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J Neurochem. 2001; 79: 463-484. (Pubitemid 33029920)
28. Ferro F, Falini G, Spelat R, et al. Biochemical and biophysical analyses of tissue-engineered bone obtained from three-dimensional culture of a subset of bone marrow mesenchymal stem cells. Tissue Eng Part A. 2010; 16: 3657-3667.
29. Mohamadnejad M, Sohail MA, Watanabe A, Krause DS, Swenson ES, Mehal WZ,. Adenosine inhibits chemotaxis and induces hepatocyte-specific genes in bone marrow mesenchymal stem cells. Hepatology. 2010; 51: 963-973.
30. Russell J, Stephenson G, Yellowley C, Benton H,. Adenosine Inhibition of Lipopolysaccharide-Induced Interleukin-6 Secretion by the Osteoblastic Cell Line MG-63. Calcif Tissue Int. 2007; 81: 316-326. (Pubitemid 47498103)
31. Fatokun AA, Stone TW, Smith RA,. Hydrogen peroxide-induced oxidative stress in MC3T3-E1cells: The effects of glutamate and protection by purines. Bone. 2006; 39: 542-551. (Pubitemid 44149273)
32. Larsen KH, Frederiksen CM, Burns JS, Abdallah BM, Kassem M,. Identifying a molecular phenotype for bone marrow stromal cells with in vivo bone-forming capacity. J Bone Miner Res. 2010; 25: 796-808.
33. Fatholahi M, Xiang Y, Wu Y, et al. A Novel Partial Agonist of the A1 -Adenosine Receptor and Evidence of Receptor Homogeneity in Adipocytes. J Pharmacol Exp Ther. 2006; 317: 676-684.
34. Dhalla AK, Chisholm JW, Reaven GM, Belardinelli L,. A1 Adenosine Receptor: Role in Diabetes and Obesity. Handb Exp Pharmacol. 2009; 193: 271-295.
35. Dhalla AK, Shryock JC, Shreeniwas R, Belardinelli L,. Pharmacology and Therapeutic Applications of A1 Adenosine Receptor Ligands. Curr Top Med Chem. 2003; 3: 369-385.
36. Dhalla AK, Santikul M, Smith M, Wong M-Y, Shryock JC, Belardinelli L,. Antilipolytic Activity of a Novel Partial A1 Adenosine Receptor Agonist Devoid of Cardiovascular Effects: Comparison with Nicotinic Acid. J Pharmacol Exp Ther. 2007; 321: 327-333. (Pubitemid 46456970)
37. Barakat H, Davis J, Lang D, Mustafa SJ, McConnaughey MM,. Differences in the Expression of the Adenosine A1 Receptor in Adipose Tissue of Obese Black and White Women. J Clin Endocrinol Metab. 2006; 91: 1882-1886.
38. Petersen RK, Madsen L, Pedersen LM, Hallenborg P, Hagland H, Viste K, Doskeland SO, Kristiansen K,. Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes. Mol Cell Biol. 2008; 28: 3804-3816. (Pubitemid 351732914)
39. Yang D-C, Tsay H-J, Lin S-Y, Chiou S-H, Li M-J, Chang T-J, Hung S-C,. cAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin. PLoS One. 2008; 3: e1540.
40. Zhang J-W, Klemm DJ, Vinson C, Lane MD,. Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein b gene during adipogenesis. J Biol Chem. 2004; 279: 4471-4478. (Pubitemid 38199037)
41. Fox KE, Fankell DM, Erickson PF, Majka SM, Crossno JT Jr, Klemm DJ,. Depletion of cAMP-response element-binding protein/ATF1 inhibits adipogenic conversion of 3T3-L1cells ectopically expressing CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBP beta, or PPAR gamma2. J Biol Chem. 2006; 281: 40341-40353. (Pubitemid 46041839)
42. Muruganandan S, Roman A, Sinal C,. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program. Cell Mol Life Sci. 2009; 66: 236-253.
43. Henney NC, Li B, Elford C, et al. A large-conductance (BK) potassium channel subtype affects both growth and mineralization of human osteoblasts. Am J Physiol Cell Physiol. 2009; 97: C1397-1408.