A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells

Journal of Cellular and Molecular Medicine

Volumn 14, Issue 12, 2010, Pages 2729-2738

  Alves, Hugo ^a   Munoz Najar, Ursula ^b   De Wit, Jan ^c   Renard, Auke J S ^d   Hoeijmakers, Jan H J ^c   Sedivy, John M ^b   Van Blitterswijk, Clemens ^a   De Boer, Jan ^a  

^a UNIVERSITY OF TWENTE   (Netherlands)

^b BROWN UNIVERSITY   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d MEDISCH SPECTRUM TWENTE   (Netherlands)

Author keywords

Ageing; Clinical application; DNA damage; Human mesenchymal stem cells; in vitro expansion; Senescence

Indexed keywords

BETA GALACTOSIDASE;

ARTICLE; BONE MARROW CELL; CELL AGING; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CYTOLOGY; DNA DAMAGE; DNA REPAIR; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; IMMUNOPHENOTYPING; MESODERM; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; STROMA CELL; TIME; WESTERN BLOTTING;

BETA-GALACTOSIDASE; BLOTTING, WESTERN; BONE MARROW CELLS; CELL AGING; CELL CYCLE; CELL DIFFERENTIATION; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOPHENOTYPING; MESODERM; OXIDATIVE STRESS; STROMAL CELLS; TIME FACTORS;

EID: 78650041767     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00931.x     Document Type: Article

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