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Volumn 71, Issue 15, 2014, Pages 2815-2835

Transcription factor 4 (TCF4) and schizophrenia: Integrating the animal and the human perspective

Author keywords

Basic Helix Loop Helix protein; Cognition; Endophenotype; Mouse models; Neurodevelopment; Polymorphism; Schizophrenia; Transcription factor 4

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; MICRORNA; MICRORNA 137; UNCLASSIFIED DRUG;

EID: 84904392316     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-013-1553-4     Document Type: Review
Times cited : (51)

References (208)
  • 1
    • 0033980393 scopus 로고    scopus 로고
    • Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
    • DOI 10.1128/MCB.20.2.429-440.2000
    • Massari ME, Murre C (2000) Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol 20:429-440 (Pubitemid 30023084)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.2 , pp. 429-440
    • Massari, M.E.1    Murre, C.2
  • 3
  • 4
    • 77954144725 scopus 로고    scopus 로고
    • Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature
    • Skinner MK, Rawls A, Wilson-Rawls J, Roalson EH (2010) Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation 80:1-8
    • (2010) Differentiation , vol.80 , pp. 1-8
    • Skinner, M.K.1    Rawls, A.2    Wilson-Rawls, J.3    Roalson, E.H.4
  • 5
    • 0036631456 scopus 로고    scopus 로고
    • Proneural genes and the specification of neural cell types
    • DOI 10.1038/nrn874
    • Bertrand N, Castro DS, Guillemot F (2002) Proneural genes and the specification of neural cell types. Nat Rev Neurosci 3:517-530 (Pubitemid 135706662)
    • (2002) Nature Reviews Neuroscience , vol.3 , Issue.7 , pp. 517-530
    • Bertrand, N.1    Castro, D.S.2    Guillemot, F.3
  • 6
    • 4043141372 scopus 로고    scopus 로고
    • An overview of the basic helix-loop-helix proteins
    • Jones S (2004) An overview of the basic helix-loop-helix proteins. Genome Biol 5:226
    • (2004) Genome Biol , vol.5 , pp. 226
    • Jones, S.1
  • 7
    • 55049106032 scopus 로고    scopus 로고
    • The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus
    • Jin T, Liu L (2008) The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus. Mol Endocrinol 22:2383-2392
    • (2008) Mol Endocrinol , vol.22 , pp. 2383-2392
    • Jin, T.1    Liu, L.2
  • 8
    • 0021928806 scopus 로고
    • B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo
    • Ephrussi A, Church GM, Tonegawa S, Gilbert W (1985) B lineage - specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science 227:134-140 (Pubitemid 15154218)
    • (1985) Science , vol.227 , Issue.4683 , pp. 134-140
    • Ephrussi, A.1    Church, G.M.2    Tonegawa, S.3    Gilbert, W.4
  • 9
    • 79959435194 scopus 로고    scopus 로고
    • Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants
    • De Masi F, Grove CA, Vedenko A et al (2011) Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants. Nucleic Acids Res 39:4553-4563
    • (2011) Nucleic Acids Res , vol.39 , pp. 4553-4563
    • De Masi, F.1    Grove, C.A.2    Vedenko, A.3
  • 10
    • 79960327248 scopus 로고    scopus 로고
    • Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5́ exon usage and splicing
    • Sepp M, Kannike K, Eesmaa A et al (2011) Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5́ exon usage and splicing. PLoS ONE 6:e22138
    • (2011) PLoS ONE , vol.6
    • Sepp, M.1    Kannike, K.2    Eesmaa, A.3
  • 11
    • 84863518905 scopus 로고    scopus 로고
    • Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects
    • Sepp M, Pruunsild P, Timmusk T (2012) Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects. Hum Mol Genet 21:2873-2888
    • (2012) Hum Mol Genet , vol.21 , pp. 2873-2888
    • Sepp, M.1    Pruunsild, P.2    Timmusk, T.3
  • 12
    • 0028915949 scopus 로고
    • Differential expression and distinct DNA-binding specificity of ME1a and ME2 suggest a unique role during differentiation and neuronal plasticity
    • Chiaramello A, Soosaar A, Neuman T, Zuber MX (1995) Differential expression and distinct DNA-binding specificity of ME1a and ME2 suggest a unique role during differentiation and neuronal plasticity. Brain Res Mol Brain Res 29:107-118
    • (1995) Brain Res Mol Brain Res , vol.29 , pp. 107-118
    • Chiaramello, A.1    Soosaar, A.2    Neuman, T.3    Zuber, M.X.4
  • 13
    • 0028275595 scopus 로고
    • Expression of basic-helix-loop-helix transcription factor ME2 during brain development and in the regions of neuronal plasticity in the adult brain
    • DOI 10.1016/0169-328X(94)90297-6
    • Soosaar A, Chiaramello A, Zuber MX, Neuman T (1994) Expression of basic-helix-loop-helix transcription factor ME2 during brain development and in the regions of neuronal plasticity in the adult brain. Brain Res Mol Brain Res 25:176-180 (Pubitemid 24223282)
    • (1994) Molecular Brain Research , vol.25 , Issue.1-2 , pp. 176-180
    • Soosaar, A.1    Chiaramello, A.2    Zuber, M.X.3    Neuman, T.4
  • 16
    • 0024231303 scopus 로고
    • daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex
    • Caudy M, Vässin H, Brand M et al (1988) daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex. Cell 55:1061-1067
    • (1988) Cell , vol.55 , pp. 1061-1067
    • Caudy, M.1    Vässin, H.2    Brand, M.3
  • 18
    • 0034526564 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage
    • Portman DS, Emmons SW (2000) The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage. Development 127:5415-5426 (Pubitemid 32049195)
    • (2000) Development , vol.127 , Issue.24 , pp. 5415-5426
    • Portman, D.S.1    Emmons, S.W.2
  • 19
    • 80053384370 scopus 로고    scopus 로고
    • Genome-wide association study identifies five new schizophrenia loci
    • Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
    • Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (2011) Genome-wide association study identifies five new schizophrenia loci. Nat Genet 43:969-976
    • (2011) Nat Genet , vol.43 , pp. 969-976
  • 20
    • 79961168650 scopus 로고    scopus 로고
    • miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT
    • Xiang X, Zhuang X, Ju S et al (2011) miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT. Oncogene 30:3440-3453
    • (2011) Oncogene , vol.30 , pp. 3440-3453
    • Xiang, X.1    Zhuang, X.2    Ju, S.3
  • 21
    • 79955969529 scopus 로고    scopus 로고
    • Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells
    • Li G, Luna C, Qiu J et al (2011) Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells. Invest Ophthalmol Vis Sci 52:2999-3007
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 2999-3007
    • Li, G.1    Luna, C.2    Qiu, J.3
  • 22
    • 84871270974 scopus 로고    scopus 로고
    • Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets
    • Kwon E, Wang W, Tsai L-H (2013) Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets. Mol Psychiatry 18(11-12):23
    • (2013) Mol Psychiatry , vol.18 , Issue.1112 , pp. 23
    • Kwon, E.1    Wang, W.2    Tsai, L.-H.3
  • 23
    • 84871281959 scopus 로고    scopus 로고
    • TCF4 (e2-2; ITF2): A schizophrenia-associated gene with pleiotropic effects on human disease
    • Navarrete K, Pedroso I, De Jong S et al (2013) TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease. Am J Med Genet B 162:1-16
    • (2013) Am J Med Genet B , vol.162 , pp. 1-16
    • Navarrete, K.1    Pedroso, I.2    De Jong, S.3
  • 25
    • 0027472051 scopus 로고
    • A new transcriptional-activation motif restricted to a class of helix- loop-helix proteins is functionally conserved in both yeast and mammalian cells
    • Quong MW, Massari ME, Zwart R, Murre C (1993) A new transcriptional- activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells. Mol Cell Biol 13:792-800 (Pubitemid 23040244)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.2 , pp. 792-800
    • Quong, M.W.1    Massari, M.E.2    Zwart, R.3    Murre, C.4
  • 26
    • 0033166656 scopus 로고    scopus 로고
    • A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex
    • DOI 10.1016/S1097-2765(00)80188-4
    • Massari ME, Grant PA, Pray-Grant MG et al (1999) A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Mol Cell 4:63-73 (Pubitemid 29386132)
    • (1999) Molecular Cell , vol.4 , Issue.1 , pp. 63-73
    • Massari, M.E.1    Grant, P.A.2    Pray-Grant, M.G.3    Berger, S.L.4    Workman, J.L.5    Murre, C.6
  • 27
    • 0031943003 scopus 로고    scopus 로고
    • p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene
    • Qiu Y, Sharma A, Stein R (1998) p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol Cell Biol 18:2957-2964 (Pubitemid 28183465)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.5 , pp. 2957-2964
    • Qiu, Y.I.1    Sharma, A.2    Stein, R.3
  • 28
    • 77954470020 scopus 로고    scopus 로고
    • SMARCA2 and other genome-wide supported schizophrenia-associated genes: Regulation by REST/NRSF, network organization and primate-specific evolution
    • Loe-Mie Y, Lepagnol-Bestel A-M, Maussion G et al (2010) SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution. Hum Mol Genet 19:2841-2857
    • (2010) Hum Mol Genet , vol.19 , pp. 2841-2857
    • Loe-Mie, Y.1    Lepagnol-Bestel, A.-M.2    Maussion, G.3
  • 29
    • 84882960508 scopus 로고    scopus 로고
    • Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation
    • Forrest MP, Waite AJ, Martin-Rendon E, Blake DJ (2013) Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation. PLoS ONE 8:e73169
    • (2013) PLoS ONE , vol.8
    • Forrest, M.P.1    Waite, A.J.2    Martin-Rendon, E.3    Blake, D.J.4
  • 30
    • 12344254627 scopus 로고    scopus 로고
    • Phenotype of schizophrenia: A review and formulation
    • DOI 10.1038/sj.mp.4001563
    • Tamminga CA, Holcomb HH (2005) Phenotype of schizophrenia: a review and formulation. Mol Psychiatry 10:27-39 (Pubitemid 40139587)
    • (2005) Molecular Psychiatry , vol.10 , Issue.1 , pp. 27-39
    • Tamminga, C.A.1    Holcomb, H.H.2
  • 31
    • 0024320812 scopus 로고
    • Gender and schizophrenia: Implications for understanding the heterogeneity of the illness
    • DOI 10.1016/0165-1781(89)90205-9
    • Goldstein JM, Tsuang MT, Faraone SV (1989) Gender and schizophrenia: implications for understanding the heterogeneity of the illness. Psychiatry Res 28:243-253 (Pubitemid 19165765)
    • (1989) Psychiatry Research , vol.28 , Issue.3 , pp. 243-253
    • Goldstein, J.M.1    Tsuang, M.T.2    Faraone, S.V.3
  • 33
    • 0032873694 scopus 로고    scopus 로고
    • Epidemiology and natural history of schizophrenia
    • DOI 10.1016/S0006-3223(99)00153-5, PII S0006322399001535
    • Bromet EJ, Fennig S (1999) Epidemiology and natural history of schizophrenia. Biol Psychiatry 46:871-881 (Pubitemid 29452978)
    • (1999) Biological Psychiatry , vol.46 , Issue.7 , pp. 871-881
    • Bromet, E.J.1    Fennig, S.2
  • 34
    • 78149428430 scopus 로고    scopus 로고
    • Rethinking schizophrenia
    • Insel TR (2010) Rethinking schizophrenia. Nature 468:187-193
    • (2010) Nature , vol.468 , pp. 187-193
    • Insel, T.R.1
  • 35
    • 68949180394 scopus 로고    scopus 로고
    • Schizophrenia
    • Van Os J, Kapur S (2009) Schizophrenia. Lancet 374:635-645
    • (2009) Lancet , vol.374 , pp. 635-645
    • Van Os, J.1    Kapur, S.2
  • 36
    • 84970199758 scopus 로고
    • The genetics of schizophrenia: A review
    • Holzman PS, Matthysse S (1990) The genetics of schizophrenia: a review. Psychol Sci 1:279-286
    • (1990) Psychol Sci , vol.1 , pp. 279-286
    • Holzman, P.S.1    Matthysse, S.2
  • 37
    • 0026084805 scopus 로고
    • The genetic epidemiology of schizophrenia and the design of linkage studies
    • McGue M, Gottesman II (1991) The genetic epidemiology of schizophrenia and the design of linkage studies. Eur Arch Psychiatry Clin Neurosci 240:174-181
    • (1991) Eur Arch Psychiatry Clin Neurosci , vol.240 , pp. 174-181
    • McGue, M.1    Gottesman, I.I.2
  • 38
    • 0037308528 scopus 로고    scopus 로고
    • Genes for schizophrenia? Recent findings and their pathophysiological implications
    • DOI 10.1016/S0140-6736(03)12379-3
    • Harrison PJ, Owen MJ (2003) Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 361:417-419 (Pubitemid 36164980)
    • (2003) Lancet , vol.361 , Issue.9355 , pp. 417-419
    • Harrison, P.J.1    Owen, M.J.2
  • 39
    • 12344327212 scopus 로고    scopus 로고
    • Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence
    • image 5
    • Harrison PJ, Weinberger DR (2005) Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10:40-68 image 5
    • (2005) Mol Psychiatry , vol.10 , pp. 40-68
    • Harrison, P.J.1    Weinberger, D.R.2
  • 40
    • 67651160485 scopus 로고    scopus 로고
    • Meta-analysis of 32 genome-wide linkage studies of schizophrenia
    • Ng MYM, Levinson DF, Faraone SV et al (2009) Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry 14:774-785
    • (2009) Mol Psychiatry , vol.14 , pp. 774-785
    • Ng, M.Y.M.1    Levinson, D.F.2    Faraone, S.V.3
  • 41
    • 80052481818 scopus 로고    scopus 로고
    • Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain
    • Williams HJ, Moskvina V, Smith RL et al (2011) Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain. Am J Med Genet B 156B:781-784
    • (2011) Am J Med Genet B , vol.156 B , pp. 781-784
    • Williams, H.J.1    Moskvina, V.2    Smith, R.L.3
  • 42
    • 69949167205 scopus 로고    scopus 로고
    • Schizophrenia genetics: New insights from new approaches
    • Williams HJ, Owen MJ, O'Donovan MC (2009) Schizophrenia genetics: new insights from new approaches. Br Med Bull 91:61-74
    • (2009) Br Med Bull , vol.91 , pp. 61-74
    • Williams, H.J.1    Owen, M.J.2    O'Donovan, M.C.3
  • 43
    • 84863980709 scopus 로고    scopus 로고
    • Genetic architectures of psychiatric disorders: The emerging picture and its implications
    • Sullivan PF, Daly MJ, O'Donovan M (2012) Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet 13:537-551
    • (2012) Nat Rev Genet , vol.13 , pp. 537-551
    • Sullivan, P.F.1    Daly, M.J.2    O'Donovan, M.3
  • 44
    • 82855172104 scopus 로고    scopus 로고
    • Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: What have we learnt?
    • Lee KW, Woon PS, Teo YY, Sim K (2012) Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: what have we learnt? Neurosci Biobehav Rev 36:556-571
    • (2012) Neurosci Biobehav Rev , vol.36 , pp. 556-571
    • Lee, K.W.1    Woon, P.S.2    Teo, Y.Y.3    Sim, K.4
  • 45
    • 0032924127 scopus 로고    scopus 로고
    • The neuropathology of schizophrenia. A critical review of the data and their interpretation
    • Harrison PJ (1999) The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 122(Pt 4):593-624
    • (1999) Brain , vol.122 , Issue.PART 4 , pp. 593-624
    • Harrison, P.J.1
  • 46
    • 2342538196 scopus 로고    scopus 로고
    • The hippocampus in schizophrenia: A review of the neuropathological evidence and its pathophysiological implications
    • Harrison PJ (2004) The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology 174:151-162
    • (2004) Psychopharmacology , vol.174 , pp. 151-162
    • Harrison, P.J.1
  • 47
    • 0022904075 scopus 로고
    • Prenatal developmental disturbances in the limbic allocortex in schizophrenics
    • Jakob H, Beckmann H (1986) Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm 65:303-326 (Pubitemid 16073151)
    • (1986) Journal of Neural Transmission - General Section , vol.65 , Issue.3-4 , pp. 303-326
    • Jakob, H.1    Beckmann, H.2
  • 48
    • 0025915446 scopus 로고
    • Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia
    • Arnold SE, Hyman BT, Van Hoesen GW, Damasio AR (1991) Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry 48:625-632
    • (1991) Arch Gen Psychiatry , vol.48 , pp. 625-632
    • Arnold, S.E.1    Hyman, B.T.2    Van Hoesen, G.W.3    Damasio, A.R.4
  • 49
    • 0034212317 scopus 로고    scopus 로고
    • Entorhinal cortex pre-alpha cell clusters in schizophrenia: Quantitative evidence of a developmental abnormality
    • DOI 10.1016/S0006-3223(99)00250-4, PII S0006322399002504
    • Falkai P, Schneider-Axmann T, Honer WG (2000) Entorhinal cortex pre-alpha cell clusters in schizophrenia: quantitative evidence of a developmental abnormality. Biol Psychiatry 47:937-943 (Pubitemid 30320738)
    • (2000) Biological Psychiatry , vol.47 , Issue.11 , pp. 937-943
    • Falkai, P.1    Schneider-Axmann, T.2    Honer, W.G.3
  • 50
    • 0035177944 scopus 로고    scopus 로고
    • Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia
    • DOI 10.1002/hipo.1067
    • Harrison PJ, Eastwood SL (2001) Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia. Hippocampus 11:508-519 (Pubitemid 33100372)
    • (2001) Hippocampus , vol.11 , Issue.5 , pp. 508-519
    • Harrison, P.J.1    Eastwood, S.L.2
  • 51
    • 2342522657 scopus 로고    scopus 로고
    • Presynaptic Proteins and Schizophrenia
    • DOI 10.1016/S0074-7742(04)59007-4, PII S0074774204590074
    • Honer WG, Young CE (2004) Presynaptic proteins and schizophrenia. Int Rev Neurobiol 59:175-199 (Pubitemid 39752415)
    • (2004) International Review of Neurobiology , vol.59 , pp. 175-199
    • Honer, W.G.1    Young, C.E.2
  • 52
    • 0034098526 scopus 로고    scopus 로고
    • GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia
    • Lewis DA (2000) GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia. Brain Res Brain Res Rev 31:270-276
    • (2000) Brain Res Brain Res Rev , vol.31 , pp. 270-276
    • Lewis, D.A.1
  • 53
    • 0036328050 scopus 로고    scopus 로고
    • Understanding the neurotransmitter pathology of schizophrenia: Selective deficits of subtypes of cortical GABAergic neurons
    • DOI 10.1007/s007020200072
    • Reynolds GP, Beasley CL, Zhang ZJ (2002) Understanding the neurotransmitter pathology of schizophrenia: selective deficits of subtypes of cortical GABAergic neurons. J Neural Transm 109:881-889 (Pubitemid 34810780)
    • (2002) Journal of Neural Transmission , vol.109 , Issue.5-6 , pp. 881-889
    • Reynolds, G.P.1    Beasley, C.L.2    Zhang, Z.J.3
  • 54
    • 0033013591 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy in schizophrenia
    • DOI 10.1016/S0720-048X(99)00052-2, PII S0720048X99000522
    • Bertolino A, Weinberger DR (1999) Proton magnetic resonance spectroscopy in schizophrenia. Eur J Radiol 30:132-141 (Pubitemid 29281714)
    • (1999) European Journal of Radiology , vol.30 , Issue.2 , pp. 132-141
    • Bertolino, A.1    Weinberger, D.R.2
  • 55
    • 0037838880 scopus 로고    scopus 로고
    • N-acetylaspartate and N-acetylaspartylglutamate deficits in superior temporal cortex in schizophrenia and bipolar disorder: A postmortem study
    • DOI 10.1016/S0006-3223(02)01742-0
    • Nudmamud S, Reynolds LM, Reynolds GP (2003) N-acetylaspartate and N-Acetylaspartylglutamate deficits in superior temporal cortex in schizophrenia and bipolar disorder: a postmortem study. Biol Psychiatry 53:1138-1141 (Pubitemid 36695089)
    • (2003) Biological Psychiatry , vol.53 , Issue.12 , pp. 1138-1141
    • Nudmamud, S.1    Reynolds, L.M.2    Reynolds, G.P.3
  • 56
    • 0026647441 scopus 로고
    • Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: A magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins
    • Weinberger DR, Berman KF, Suddath R, Torrey EF (1992) Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. Am J Psychiatry 149:890-897
    • (1992) Am J Psychiatry , vol.149 , pp. 890-897
    • Weinberger, D.R.1    Berman, K.F.2    Suddath, R.3    Torrey, E.F.4
  • 57
    • 0029198619 scopus 로고
    • Schizophrenia: A disconnection syndrome?
    • Friston KJ, Frith CD (1995) Schizophrenia: a disconnection syndrome? Clin Neurosci 3:89-97
    • (1995) Clin Neurosci , vol.3 , pp. 89-97
    • Friston, K.J.1    Frith, C.D.2
  • 58
    • 0033936744 scopus 로고    scopus 로고
    • Schizophrenia as a disorder of developmentally reduced synaptic connectivity
    • McGlashan TH, Hoffman RE (2000) Schizophrenia as a disorder of developmentally reduced synaptic connectivity. Arch Gen Psychiatry 57:637-648 (Pubitemid 30445855)
    • (2000) Archives of General Psychiatry , vol.57 , Issue.7 , pp. 637-648
    • McGlashan, T.H.1    Hoffman, R.E.2
  • 59
    • 0035426751 scopus 로고    scopus 로고
    • Analysis of complex brain disorders with gene expression microarrays: Schizophrenia as a disease of the synapse
    • DOI 10.1016/S0166-2236(00)01862-2, PII S0166223600018622
    • Mirnics K, Middleton FA, Lewis DA, Levitt P (2001) Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends Neurosci 24:479-486 (Pubitemid 32695360)
    • (2001) Trends in Neurosciences , vol.24 , Issue.8 , pp. 479-486
    • Mirnics, K.1    Middleton, F.A.2    Lewis, D.A.3    Levitt, P.4
  • 60
    • 0042848912 scopus 로고    scopus 로고
    • The synaptic hypothesis of Schizophrenia
    • DOI 10.1016/S0896-6273(03)00423-9
    • Frankle WG, Lerma J, Laruelle M (2003) The synaptic hypothesis of schizophrenia. Neuron 39:205-216 (Pubitemid 36897544)
    • (2003) Neuron , vol.39 , Issue.2 , pp. 205-216
    • Frankle, W.G.1    Lerma, J.2    Laruelle, M.3
  • 61
    • 0034207818 scopus 로고    scopus 로고
    • The neurodevelopmental hypothesis of schizophrenia: Following a trail of evidence from cradle to grave
    • Marenco S, Weinberger DR (2000) The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave. Dev Psychopathol 12:501-527
    • (2000) Dev Psychopathol , vol.12 , pp. 501-527
    • Marenco, S.1    Weinberger, D.R.2
  • 62
    • 2342418435 scopus 로고    scopus 로고
    • Recent advances in the neurobiology of schizophrenia
    • Miyamoto S, LaMantia AS, Duncan GE et al (2003) Recent advances in the neurobiology of schizophrenia. Mol Interv 3:27-39
    • (2003) Mol Interv , vol.3 , pp. 27-39
    • Miyamoto, S.1    LaMantia, A.S.2    Duncan, G.E.3
  • 63
    • 0026752706 scopus 로고
    • A neurodevelopmental approach to the classification of schizophrenia
    • Murray RM, O'Callaghan E, Castle DJ, Lewis SW (1992) A neurodevelopmental approach to the classification of schizophrenia. Schizophr Bull 18:319-332
    • (1992) Schizophr Bull , vol.18 , pp. 319-332
    • Murray, R.M.1    O'Callaghan, E.2    Castle, D.J.3    Lewis, S.W.4
  • 64
    • 0035183947 scopus 로고    scopus 로고
    • Neural development, cell-cell signaling, and the "two-hit" hypothesis of schizophrenia
    • Maynard TM, Sikich L, Lieberman JA, LaMantia AS (2001) Neural development, cell-cell signaling, and the "two-hit" hypothesis of schizophrenia. Schizophr Bull 27:457-476 (Pubitemid 33081697)
    • (2001) Schizophrenia Bulletin , vol.27 , Issue.3 , pp. 457-476
    • Maynard, T.M.1    Sikich, L.2    Lieberman, J.A.3    LaMantia, A.-S.4
  • 65
    • 0033149175 scopus 로고    scopus 로고
    • Neurodevelopmental abnormalities in schizophrenia: Insights from neuropathology
    • Arnold SE (1999) Neurodevelopmental abnormalities in schizophrenia: insights from neuropathology. Dev Psychopathol 11:439-456
    • (1999) Dev Psychopathol , vol.11 , pp. 439-456
    • Arnold, S.E.1
  • 67
    • 0034302850 scopus 로고    scopus 로고
    • New neurochemical markers for psychosis: A working hypothesis of their operation
    • Guidotti A, Pesold C, Costa E (2000) New neurochemical markers for psychosis: a working hypothesis of their operation. Neurochem Res 25:1207-1218
    • (2000) Neurochem Res , vol.25 , pp. 1207-1218
    • Guidotti, A.1    Pesold, C.2    Costa, E.3
  • 69
    • 0034158465 scopus 로고    scopus 로고
    • Searching high and low: A review of the genetics of bipolar disorder
    • Potash JB, DePaulo JR Jr (2000) Searching high and low: a review of the genetics of bipolar disorder. Bipolar Disord 2:8-26
    • (2000) Bipolar Disord , vol.2 , pp. 8-26
    • Potash, J.B.1    DePaulo Jr., J.R.2
  • 73
    • 84883465830 scopus 로고    scopus 로고
    • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
    • Cross-Disorder Group of the Psychiatric Genomics Consortium
    • Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S et al (2013) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 45:984-994
    • (2013) Nat Genet , vol.45 , pp. 984-994
    • Lee, S.H.1    Ripke, S.2
  • 76
    • 68449090594 scopus 로고    scopus 로고
    • Common variants conferring risk of schizophrenia
    • Stefansson H, Ophoff RA, Steinberg S et al (2009) Common variants conferring risk of schizophrenia. Nature 460:744-747
    • (2009) Nature , vol.460 , pp. 744-747
    • Stefansson, H.1    Ophoff, R.A.2    Steinberg, S.3
  • 77
    • 80053159517 scopus 로고    scopus 로고
    • Common variants at VRK2 and TCF4 conferring risk of schizophrenia
    • Irish Schizophrenia Genomics Consortium
    • Steinberg S, de Jong S, Irish Schizophrenia Genomics Consortium et al (2011) Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Hum Mol Genet 20:4076-4081
    • (2011) Hum Mol Genet , vol.20 , pp. 4076-4081
    • Steinberg, S.1    De Jong, S.2
  • 78
    • 77956903409 scopus 로고    scopus 로고
    • Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese
    • Li T, Li Z, Chen P et al (2010) Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese. Biol Psychiatry 68:671-673
    • (2010) Biol Psychiatry , vol.68 , pp. 671-673
    • Li, T.1    Li, Z.2    Chen, P.3
  • 79
    • 84866616686 scopus 로고    scopus 로고
    • Genome-wide association study implicates HLA-C&z.Ast;01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia
    • Irish Schizophrenia Genomics Consortium and the Wellcome Trust Case Control Consortium 2
    • Irish Schizophrenia Genomics Consortium and the Wellcome Trust Case Control Consortium 2 (2012) Genome-wide association study implicates HLA-C&z.ast;01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia. Biol Psychiatry 72:620-628
    • (2012) Biol Psychiatry , vol.72 , pp. 620-628
  • 80
    • 84878659130 scopus 로고    scopus 로고
    • A comprehensive family-based replication study of schizophrenia genes
    • Aberg KA, Liu Y, Bukszár J et al (2013) A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry 70:1-9
    • (2013) JAMA Psychiatry , vol.70 , pp. 1-9
    • Aberg, K.A.1    Liu, Y.2    Bukszár, J.3
  • 81
    • 77953867567 scopus 로고    scopus 로고
    • Genomic analysis of mental illness: A changing landscape
    • McClellan J, King M-C (2010) Genomic analysis of mental illness: a changing landscape. JAMA 303:2523-2524
    • (2010) JAMA , vol.303 , pp. 2523-2524
    • McClellan, J.1    King, M.-C.2
  • 82
    • 80054044293 scopus 로고    scopus 로고
    • Dissociation of accumulated genetic risk and disease severity in patients with schizophrenia
    • Papiol S, Malzahn D, Kästner A et al (2011) Dissociation of accumulated genetic risk and disease severity in patients with schizophrenia. Transl Psychiatry 1:e45
    • (2011) Transl Psychiatry , vol.1
    • Papiol, S.1    Malzahn, D.2    Kästner, A.3
  • 83
    • 84861125947 scopus 로고    scopus 로고
    • TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders
    • Wirgenes KV, Sønderby IE, Haukvik UK et al (2012) TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders. Transl Psychiatry 2:e112
    • (2012) Transl Psychiatry , vol.2
    • Wirgenes, K.V.1    Sønderby, I.E.2    Haukvik, U.K.3
  • 85
    • 0003322588 scopus 로고
    • Dementia praecox oder die Gruppe der Schizophrenien
    • Aschaffenburg G (ed) 4. Abteilung, 1. Hälfte. Deutike, Leipzig
    • Bleuler E (1911) Dementia praecox oder die Gruppe der Schizophrenien. In: Aschaffenburg G (ed) Handbuch der Psychiatrie, Spezieller Teil, 4. Abteilung, 1. Hälfte. Deutike, Leipzig
    • (1911) Handbuch der Psychiatrie , Issue.SPEZIELLER TEIL
    • Bleuler, E.1
  • 87
    • 0029583266 scopus 로고
    • Neurocircuitries and neurotransmitter interactions in schizophrenia
    • Carlsson A (1995) Neurocircuitries and neurotransmitter interactions in schizophrenia. Int Clin Psychopharmacol 10(Suppl 3):21-28
    • (1995) Int Clin Psychopharmacol , vol.10 , Issue.SUPPL. 3 , pp. 21-28
    • Carlsson, A.1
  • 88
    • 0018120068 scopus 로고
    • Prestimulus effects on human startle reflex in normals and schizophrenics
    • Braff D, Stone C, Callaway E et al (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15:339-343 (Pubitemid 9016401)
    • (1978) Psychophysiology , vol.15 , Issue.4 , pp. 339-343
    • Callaway, E.1    Geyer, M.2    Glick, I.3
  • 89
    • 0026581360 scopus 로고
    • Gating and habituation of the startle reflex in schizophrenic patients
    • Braff DL, Grillon C, Geyer MA (1992) Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 49:206-215
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 206-215
    • Braff, D.L.1    Grillon, C.2    Geyer, M.A.3
  • 90
    • 0021304003 scopus 로고
    • Information processing and attentional functioning in the developmental course of schizophrenic disorders
    • Nuechterlein KH, Dawson ME (1984) Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophr Bull 10:160-203
    • (1984) Schizophr Bull , vol.10 , pp. 160-203
    • Nuechterlein, K.H.1    Dawson, M.E.2
  • 91
    • 0027942724 scopus 로고
    • Information-processing abnormalities as neuropsychological vulnerability indicators for schizophrenia
    • Nuechterlein KH, Dawson ME, Green MF (1994) Information-processing abnormalities as neuropsychological vulnerability indicators for schizophrenia. Acta Psychiatr Scand Suppl 384:71-79 (Pubitemid 24356891)
    • (1994) Acta Psychiatrica Scandinavica, Supplement , vol.90 , Issue.384 , pp. 71-79
    • Nuecterlein, K.H.1    Dawson, M.E.2    Green, M.F.3
  • 92
    • 0038823525 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatry: Etymology and strategic intentions
    • DOI 10.1176/appi.ajp.160.4.636
    • Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636-645 (Pubitemid 41079594)
    • (2003) American Journal of Psychiatry , vol.160 , Issue.4 , pp. 636-645
    • Gottesman, I.I.1    Gould, T.D.2
  • 93
    • 3142657146 scopus 로고    scopus 로고
    • Preattentional and attentional cognitive deficits as targets for treating schizophrenia
    • Braff DL, Light GA (2004) Preattentional and attentional cognitive deficits as targets for treating schizophrenia. Psychopharmacology 174:75-85 (Pubitemid 38925093)
    • (2004) Psychopharmacology , vol.174 , Issue.1 , pp. 75-85
    • Braff, D.L.1    Light, G.A.2
  • 94
    • 34247615035 scopus 로고    scopus 로고
    • Prepulse Inhibition and P50 Suppression Are Both Deficient but not Correlated in Schizophrenia Patients
    • DOI 10.1016/j.biopsych.2006.08.015, PII S0006322306010456, Multiple Genotypes and Brain Development in Schizophrenia
    • Braff DL, Light GA, Swerdlow NR (2007) Prepulse inhibition and P50 suppression are both deficient but not correlated in schizophrenia patients. Biol Psychiatry 61:1204-1207 (Pubitemid 46669461)
    • (2007) Biological Psychiatry , vol.61 , Issue.10 , pp. 1204-1207
    • Braff, D.L.1    Light, G.A.2    Swerdlow, N.R.3
  • 95
    • 0033083336 scopus 로고    scopus 로고
    • Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population
    • DOI 10.1016/S0006-3223(98)00294-7, PII S0006322398002947
    • Cadenhead KS, Carasso BS, Swerdlow NR et al (1999) Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population. Biol Psychiatry 45:360-364 (Pubitemid 29100043)
    • (1999) Biological Psychiatry , vol.45 , Issue.3 , pp. 360-364
    • Cadenhead, K.S.1    Carasso, B.S.2    Swerdlow, N.R.3    Geyer, M.A.4    Braff, D.L.5
  • 96
    • 0033961241 scopus 로고    scopus 로고
    • Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder
    • Cadenhead KS, Light GA, Geyer MA, Braff DL (2000) Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder. Am J Psychiatry 157:55-59 (Pubitemid 30027421)
    • (2000) American Journal of Psychiatry , vol.157 , Issue.1 , pp. 55-59
    • Cadenhead, K.S.1    Light, G.A.2    Geyer, M.A.3    Braff, D.L.4
  • 97
    • 20444386499 scopus 로고    scopus 로고
    • P50 suppression in individuals at risk for schizophrenia: The convergence of clinical, familial, and vulnerability marker risk assessment
    • DOI 10.1016/j.biopsych.2005.03.003, PII S000632230500243X
    • Cadenhead KS, Light GA, Shafer KM, Braff DL (2005) P50 suppression in individuals at risk for schizophrenia: the convergence of clinical, familial, and vulnerability marker risk assessment. Biol Psychiatry 57:1504-1509 (Pubitemid 40805379)
    • (2005) Biological Psychiatry , vol.57 , Issue.12 , pp. 1504-1509
    • Cadenhead, K.S.1    Light, G.A.2    Shafer, K.M.3    Braff, D.L.4
  • 98
    • 0030926304 scopus 로고    scopus 로고
    • P50 suppression among schizophrenia and normal comparison subjects: A methodological analysis
    • DOI 10.1016/S0006-3223(96)00208-9
    • Clementz BA, Geyer MA, Braff DL (1997) P50 suppression among schizophrenia and normal comparison subjects: a methodological analysis. Biol Psychiatry 41:1035-1044 (Pubitemid 27225991)
    • (1997) Biological Psychiatry , vol.41 , Issue.10 , pp. 1035-1044
    • Clementz, B.A.1    Geyer, M.A.2    Braff, D.L.3
  • 99
    • 0031791660 scopus 로고    scopus 로고
    • Poor P50 suppression among schizophrenia patients and their first- degree biological relatives
    • Clementz BA, Geyer MA, Braff DL (1998) Poor P50 suppression among schizophrenia patients and their first-degree biological relatives. Am J Psychiatry 155:1691-1694 (Pubitemid 28547492)
    • (1998) American Journal of Psychiatry , vol.155 , Issue.12 , pp. 1691-1694
    • Clementz, B.A.1    Geyer, M.A.2    Braff, D.L.3
  • 100
    • 39649111304 scopus 로고    scopus 로고
    • P50 sensory gating ratios in schizophrenics and controls: A review and data analysis
    • Patterson JV, Hetrick WP, Boutros NN et al (2008) P50 sensory gating ratios in schizophrenics and controls: a review and data analysis. Psychiatry Res 158:226-247
    • (2008) Psychiatry Res , vol.158 , pp. 226-247
    • Patterson, J.V.1    Hetrick, W.P.2    Boutros, N.N.3
  • 101
    • 33846306392 scopus 로고    scopus 로고
    • Genetic and environmental influences on emotion-modulated startle reflex: A twin study
    • DOI 10.1111/j.1469-8986.2006.00486.x
    • Anokhin AP, Golosheykin S, Heath AC (2007) Genetic and environmental influences on emotion-modulated startle reflex: a twin study. Psychophysiology 44:106-112 (Pubitemid 46110456)
    • (2007) Psychophysiology , vol.44 , Issue.1 , pp. 106-112
    • Anokhin, A.P.1    Golosheykin, S.2    Heath, A.C.3
  • 102
    • 0344420114 scopus 로고    scopus 로고
    • Genetic influences on prepulse inhibition of startle reflex in humans
    • DOI 10.1016/j.neulet.2003.09.014
    • Anokhin AP, Heath AC, Myers E et al (2003) Genetic influences on prepulse inhibition of startle reflex in humans. Neurosci Lett 353:45-48 (Pubitemid 37464616)
    • (2003) Neuroscience Letters , vol.353 , Issue.1 , pp. 45-48
    • Anokhin, A.P.1    Heath, A.C.2    Myers, E.3    Ralano, A.4    Wood, S.5
  • 103
    • 33845307916 scopus 로고    scopus 로고
    • Genetic and environmental influences on sensory gating of mid-latency auditory evoked responses: A twin study
    • DOI 10.1016/j.schres.2006.08.009, PII S0920996406003598
    • Anokhin AP, Vedeniapin AB, Heath AC et al (2007) Genetic and environmental influences on sensory gating of mid-latency auditory evoked responses: a twin study. Schizophr Res 89:312-319 (Pubitemid 44881286)
    • (2007) Schizophrenia Research , vol.89 , Issue.1-3 , pp. 312-319
    • Anokhin, A.P.1    Vedeniapin, A.B.2    Heath, A.C.3    Korzyukov, O.4    Boutros, N.N.5
  • 104
    • 48749093404 scopus 로고    scopus 로고
    • Sensory gating in schizophrenia: P50 and N100 gating in antip-sychotic- free subjects at risk, first-episode, and chronic patients
    • Brockhaus-Dumke A, Schultze-Lutter F, Mueller R et al (2008) Sensory gating in schizophrenia: P50 and N100 gating in antip-sychotic- free subjects at risk, first-episode, and chronic patients. Biol Psychiatry 64:376-384
    • (2008) Biol Psychiatry , vol.64 , pp. 376-384
    • Brockhaus-Dumke, A.1    Schultze-Lutter, F.2    Mueller, R.3
  • 106
    • 80051953863 scopus 로고    scopus 로고
    • Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    • Greenwood TA, Lazzeroni LC, Murray SS et al (2011) Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. Am J Psychiatry 168:930-946
    • (2011) Am J Psychiatry , vol.168 , pp. 930-946
    • Greenwood, T.A.1    Lazzeroni, L.C.2    Murray, S.S.3
  • 107
    • 53249088295 scopus 로고    scopus 로고
    • Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia
    • Quednow BB, Frommann I, Berning J et al (2008) Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia. Biol Psychiatry 64:766-773
    • (2008) Biol Psychiatry , vol.64 , pp. 766-773
    • Quednow, B.B.1    Frommann, I.2    Berning, J.3
  • 108
    • 38149016841 scopus 로고    scopus 로고
    • Haloperidol differentially modulates prepulse inhibition and p50 suppression in healthy humans stratified for low and high gating levels
    • Csomor PA, Stadler RR, Feldon J et al (2008) Haloperidol differentially modulates prepulse inhibition and p50 suppression in healthy humans stratified for low and high gating levels. Neuropsychopharmacology 33:497-512
    • (2008) Neuropsychopharmacology , vol.33 , pp. 497-512
    • Csomor, P.A.1    Stadler, R.R.2    Feldon, J.3
  • 109
    • 33748067772 scopus 로고    scopus 로고
    • Prepulse inhibition and P50 suppression: Commonalities and dissociations
    • DOI 10.1016/j.psychres.2005.11.002, PII S0165178105003665
    • Oranje B, Geyer MA, Bocker KBE et al (2006) Prepulse inhibition and P50 suppression: commonalities and dissociations. Psychiatry Res 143:147-158 (Pubitemid 44301523)
    • (2006) Psychiatry Research , vol.143 , Issue.2-3 , pp. 147-158
    • Oranje, B.1    Geyer, M.A.2    Bocker, K.B.E.3    Leon, K.J.4    Verbaten, M.N.5
  • 110
    • 0027254757 scopus 로고
    • Concurrent assessment of acoustic startle and auditory P50 evoked potential measures of sensory inhibition
    • Schwarzkopf SB, Lamberti JS, Smith DA (1993) Concurrent assessment of acoustic startle and auditory P50 evoked potential measures of sensory inhibition. Biol Psychiatry 33: 815-828 (Pubitemid 23234633)
    • (1993) Biological Psychiatry , vol.33 , Issue.11-12 , pp. 815-828
    • Schwarzkopf, S.B.1    Lamberti, J.S.2    Smith, D.A.3
  • 111
    • 62649112887 scopus 로고    scopus 로고
    • Endophenotypes in schizophrenia: A selective review
    • Allen AJ, Griss ME, Folley BS et al (2009) Endophenotypes in schizophrenia: a selective review. Schizophr Res 109: 24-37
    • (2009) Schizophr Res , vol.109 , pp. 24-37
    • Allen, A.J.1    Griss, M.E.2    Folley, B.S.3
  • 112
    • 77953613107 scopus 로고    scopus 로고
    • Brzózka MM, Radyushkin K, Wichert SP et al (2010) Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain. Biol Psychiatry 68:33-40
    • Biol Psychiatry , vol.68 , pp. 33-40
  • 113
    • 79955766426 scopus 로고    scopus 로고
    • The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers
    • Quednow BB, Ettinger U, Mössner R et al (2011) The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers. J Neurosci 31:6684-6691
    • (2011) J Neurosci , vol.31 , pp. 6684-6691
    • Quednow, B.B.1    Ettinger, U.2    Mössner, R.3
  • 114
    • 84859931472 scopus 로고    scopus 로고
    • Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating
    • Quednow BB, Brinkmeyer J, Mobascher A et al (2012) Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating. Proc Natl Acad Sci USA 109:6271-6276
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 6271-6276
    • Quednow, B.B.1    Brinkmeyer, J.2    Mobascher, A.3
  • 115
    • 0031786335 scopus 로고    scopus 로고
    • Nicotine dependence in schizophrenia: Clinical phenomena and laboratory findings
    • Dalack GW, Healy DJ, Meador-Woodruff JH (1998) Nicotine dependence in schizophrenia: clinical phenomena and laboratory findings. Am J Psychiatry 155:1490-1501 (Pubitemid 28512015)
    • (1998) American Journal of Psychiatry , vol.155 , Issue.11 , pp. 1490-1501
    • Dalack, G.W.1    Healy, D.J.2    Meador-Woodruff, J.H.3
  • 116
    • 23244437754 scopus 로고    scopus 로고
    • Nicotine use in schizophrenia: The self medication hypotheses
    • DOI 10.1016/j.neubiorev.2005.02.006, PII S0149763405000874, Festschrift in Honour of Jeffrey Gray - Issue 2: Schizophrenia and Consciousness
    • Kumari V, Postma P (2005) Nicotine use in schizophrenia: the self medication hypotheses. Neurosci Biobehav Rev 29:1021-1034 (Pubitemid 41097398)
    • (2005) Neuroscience and Biobehavioral Reviews , vol.29 , Issue.6 , pp. 1021-1034
    • Kumari, V.1    Postma, P.2
  • 118
    • 78650951399 scopus 로고    scopus 로고
    • Source localization of sensory gating: A combined EG and fMRI study in healthy volunteers
    • Bak N, Glenthoj BY, Rostrup E et al (2011) Source localization of sensory gating: a combined EG and fMRI study in healthy volunteers. Neuroimage 54:2711-2718
    • (2011) Neuroimage , vol.54 , pp. 2711-2718
    • Bak, N.1    Glenthoj, B.Y.2    Rostrup, E.3
  • 119
    • 84867746531 scopus 로고    scopus 로고
    • Deficits in trace fear memory in a mouse model of the schizophrenia risk gene TCF4
    • Brzózka MM, Rossner MJ (2013) Deficits in trace fear memory in a mouse model of the schizophrenia risk gene TCF4. Behav Brain Res 237:348-356
    • (2013) Behav Brain Res , vol.237 , pp. 348-356
    • Brzózka, M.M.1    Rossner, M.J.2
  • 120
    • 84860570267 scopus 로고    scopus 로고
    • Linking substance use with symptoms of subclinical psychosis in a community cohort over 30 years
    • Rössler W, Hengartner MP, Angst J, Ajdacic-Gross V (2012) Linking substance use with symptoms of subclinical psychosis in a community cohort over 30 years. Addiction 107:1174-1184
    • (2012) Addiction , vol.107 , pp. 1174-1184
    • Rössler, W.1    Hengartner, M.P.2    Angst, J.3    Ajdacic-Gross, V.4
  • 123
    • 0031903740 scopus 로고    scopus 로고
    • Neurocognitive deficit in schizophrenia: A quantitative review of the evidence
    • DOI 10.1037/0894-4105.12.3.426
    • Heinrichs RW, Zakzanis KK (1998) Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 12:426-445 (Pubitemid 28323862)
    • (1998) Neuropsychology , vol.12 , Issue.3 , pp. 426-445
    • Heinrichs, R.W.1    Zakzanis, K.K.2
  • 125
    • 43449137253 scopus 로고    scopus 로고
    • Verbal recall and recognition in twins discordant for schizophrenia
    • Van Erp TGM, Therman S, Pirkola T et al (2008) Verbal recall and recognition in twins discordant for schizophrenia. Psychiatry Res 159:271-280
    • (2008) Psychiatry Res , vol.159 , pp. 271-280
    • Van Erp, T.G.M.1    Therman, S.2    Pirkola, T.3
  • 126
    • 0034661249 scopus 로고    scopus 로고
    • Neuropsychologic functioning among the nonpsychotic relatives of schizophrenic patients: The effect of genetic loading
    • DOI 10.1016/S0006-3223(99)00263-2, PII S0006322399002632
    • Faraone SV, Seidman LJ, Kremen WS et al (2000) Neuropsychologic functioning among the nonpsychotic relatives of schizophrenic patients: the effect of genetic loading. Biol Psychiatry 48:120-126 (Pubitemid 30618801)
    • (2000) Biological Psychiatry , vol.48 , Issue.2 , pp. 120-126
    • Faraone, S.V.1    Seidman, L.J.2    Kremen, W.S.3    Toomey, R.4    Pepple, J.R.5    Tsuang, M.T.6
  • 127
    • 78651251105 scopus 로고    scopus 로고
    • Novel schizophrenia risk gene TCF4 influences verbal learning and memory functioning in schizophrenia patients
    • Lennertz L, Rujescu D, Wagner M et al (2011) Novel schizophrenia risk gene TCF4 influences verbal learning and memory functioning in schizophrenia patients. Neuropsychobiology 63:131-136
    • (2011) Neuropsychobiology , vol.63 , pp. 131-136
    • Lennertz, L.1    Rujescu, D.2    Wagner, M.3
  • 128
    • 84873730516 scopus 로고    scopus 로고
    • Associations between TCF4 gene polymorphism and cognitive functions in schizophrenia patients and healthy controls
    • Zhu X, Gu H, Liu Z et al (2013) Associations between TCF4 gene polymorphism and cognitive functions in schizophrenia patients and healthy controls. Neuropsychopharmacology 38:683-689
    • (2013) Neuropsychopharmacology , vol.38 , pp. 683-689
    • Zhu, X.1    Gu, H.2    Liu, Z.3
  • 129
    • 84891630599 scopus 로고    scopus 로고
    • TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis
    • doi:10.1016/j.schres.2013.10.038
    • Albanna A, Choudhry Z, Harvey P-O et al (2013) TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis. Schizophr Res. doi:10.1016/j.schres.2013.10.038
    • (2013) Schizophr Res
    • Albanna, A.1    Choudhry, Z.2    Harvey, P.-O.3
  • 130
    • 84879701169 scopus 로고    scopus 로고
    • Transcriptomics of cortical gray matter thickness decline during normal aging
    • Kochunov P, Charlesworth J, Winkler A et al (2013) Transcriptomics of cortical gray matter thickness decline during normal aging. Neuroimage 82:273-283
    • (2013) Neuroimage , vol.82 , pp. 273-283
    • Kochunov, P.1    Charlesworth, J.2    Winkler, A.3
  • 131
    • 84861108476 scopus 로고    scopus 로고
    • Association between SNPs and gene expression in multiple regions of the human brain
    • Kim S, Cho H, Lee D, Webster MJ (2012) Association between SNPs and gene expression in multiple regions of the human brain. Transl Psychiatry 2:e113
    • (2012) Transl Psychiatry , vol.2
    • Kim, S.1    Cho, H.2    Lee, D.3    Webster, M.J.4
  • 132
    • 84869096265 scopus 로고    scopus 로고
    • Functional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome
    • Forrest M, Chapman RM, Doyle AM et al (2012) Functional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome. Hum Mutat 33:1676-1686
    • (2012) Hum Mutat , vol.33 , pp. 1676-1686
    • Forrest, M.1    Chapman, R.M.2    Doyle, A.M.3
  • 133
    • 63749123537 scopus 로고    scopus 로고
    • Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome
    • De Pontual L, Mathieu Y, Golzio C et al (2009) Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome. Hum Mutat 30:669-676
    • (2009) Hum Mutat , vol.30 , pp. 669-676
    • De Pontual, L.1    Mathieu, Y.2    Golzio, C.3
  • 134
    • 84881230851 scopus 로고    scopus 로고
    • Pitt-Hopkins Syndrome: Intellectual disability due to loss of TCF4-regulated gene transcription
    • Sweatt JD (2013) Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription. Exp Mol Med 45:e21
    • (2013) Exp Mol Med , vol.45
    • Sweatt, J.D.1
  • 136
    • 77955828721 scopus 로고    scopus 로고
    • Two percent of patients suspected of having Angelman syndrome have TCF4 mutations
    • Takano K, Lyons M, Moyes C et al (2010) Two percent of patients suspected of having Angelman syndrome have TCF4 mutations. Clin Genet 78:282-288
    • (2010) Clin Genet , vol.78 , pp. 282-288
    • Takano, K.1    Lyons, M.2    Moyes, C.3
  • 137
    • 84866393094 scopus 로고    scopus 로고
    • Development, cognition, and behaviour in Pitt-Hopkins syndrome
    • Van Balkom IDC, Vuijk PJ, Franssens M et al (2012) Development, cognition, and behaviour in Pitt-Hopkins syndrome. Dev Med Child Neurol 54:925-931
    • (2012) Dev Med Child Neurol , vol.54 , pp. 925-931
    • Van Balkom, I.D.C.1    Vuijk, P.J.2    Franssens, M.3
  • 138
    • 84860347597 scopus 로고    scopus 로고
    • Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries
    • Talkowski ME, Rosenfeld JA, Blumenthal I et al (2012) Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries. Cell 149:525-537
    • (2012) Cell , vol.149 , pp. 525-537
    • Talkowski, M.E.1    Rosenfeld, J.A.2    Blumenthal, I.3
  • 139
  • 140
    • 84862658331 scopus 로고    scopus 로고
    • Proposal of a clinical score for the molecular test for Pitt-Hopkins syndrome
    • Marangi G, Ricciardi S, Orteschi D et al (2012) Proposal of a clinical score for the molecular test for Pitt-Hopkins syndrome. Am J Med Genet A 158A:1604-1611
    • (2012) Am J Med Genet A , vol.158 A , pp. 1604-1611
    • Marangi, G.1    Ricciardi, S.2    Orteschi, D.3
  • 141
    • 79959502528 scopus 로고    scopus 로고
    • Fetal pads as a clue to the diagnosis of Pitt-Hopkins syndrome
    • Lehalle D, Williams C, Siu VM, Clayton-Smith J (2011) Fetal pads as a clue to the diagnosis of Pitt-Hopkins syndrome. Am J Med Genet A 155A:1685-1689
    • (2011) Am J Med Genet A , vol.155 A , pp. 1685-1689
    • Lehalle, D.1    Williams, C.2    Siu, V.M.3    Clayton-Smith, J.4
  • 142
    • 0022453506 scopus 로고
    • Correlates of lateral ventricular size in chronic schizophrenia, I: Behavioral and treatment response measures
    • Losonczy MF, Song IS, Mohs RC et al (1986) Correlates of lateral ventricular size in chronic schizophrenia, I: behavioral and treatment response measures. Am J Psychiatry 143:976-981 (Pubitemid 16073945)
    • (1986) American Journal of Psychiatry , vol.143 , Issue.8 , pp. 976-981
    • Losonczy, M.F.1    Song, I.S.2    Mohs, R.C.3
  • 144
    • 0027479973 scopus 로고
    • ME1 and GE1: Basic helix-loop-helix transcription factors expressed at high levels in the developing nervous system and in morphogenetically active regions
    • Neuman T, Keen A, Knapik E et al (1993) ME1 and GE1: basic helix-loop-helix transcription factors expressed at high levels in the developing nervous system and in morphogenetically active regions. Eur J Neurosci 5:311-318 (Pubitemid 23108585)
    • (1993) European Journal of Neuroscience , vol.5 , Issue.4 , pp. 311-318
    • Neuman, T.1    Keen, A.2    Knapik, E.3    Shain, D.4    Ross, M.5    Nornes, H.O.6    Zuber, M.X.7
  • 145
    • 0033967022 scopus 로고    scopus 로고
    • Differential expression patterns of the basic Helix-Loop-Helix transcription factors during aging of the murine brain
    • DOI 10.1016/S0304-3940(00)00761-8, PII S0304394000007618
    • Uittenbogaard M, Chiaramello A (2000) Differential expression patterns of the basic helix-loop-helix transcription factors during aging of the murine brain. Neurosci Lett 280:95-98 (Pubitemid 30109141)
    • (2000) Neuroscience Letters , vol.280 , Issue.2 , pp. 95-98
    • Uittenbogaard, M.1    Chiaramello, A.2
  • 146
    • 43149124200 scopus 로고    scopus 로고
    • E protein dosage influences brain development more than family member identity
    • DOI 10.1002/jnr.21615
    • Ravanpay AC, Olson JM (2008) E protein dosage influences brain development more than family member identity. J Neurosci Res 86:1472-1481 (Pubitemid 351642441)
    • (2008) Journal of Neuroscience Research , vol.86 , Issue.7 , pp. 1472-1481
    • Ravanpay, A.C.1    Olson, J.M.2
  • 147
    • 0028296937 scopus 로고
    • Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system
    • Ishibashi M, Moriyoshi K, Sasai Y et al (1994) Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system. EMBO J 13:1799-1805
    • (1994) EMBO J , vol.13 , pp. 1799-1805
    • Ishibashi, M.1    Moriyoshi, K.2    Sasai, Y.3
  • 149
    • 0037968010 scopus 로고    scopus 로고
    • Basic helix-loop-helix factors in cortical development
    • DOI 10.1016/S0896-6273(03)00365-9
    • Ross SE, Greenberg ME, Stiles CD (2003) Basic helix-loophelix factors in cortical development. Neuron 39:13-25 (Pubitemid 36830945)
    • (2003) Neuron , vol.39 , Issue.1 , pp. 13-25
    • Ross, S.E.1    Greenberg, M.E.2    Stiles, C.D.3
  • 150
    • 84856491887 scopus 로고    scopus 로고
    • Neurologic and ocular phenotype in Pitt-Hopkins syndrome and a zebrafish model
    • Brockschmidt A, Filippi A, Charbel Issa P et al (2011) Neurologic and ocular phenotype in Pitt-Hopkins syndrome and a zebrafish model. Hum Genet 130:645-655
    • (2011) Hum Genet , vol.130 , pp. 645-655
    • Brockschmidt, A.1    Filippi, A.2    Charbel Issa, P.3
  • 152
    • 0029896451 scopus 로고    scopus 로고
    • B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB
    • Zhuang Y, Cheng P, Weintraub H (1996) B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol Cell Biol 16:2898-2905 (Pubitemid 26161295)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.6 , pp. 2898-2905
    • Zhuang, Y.1    Cheng, P.2    Weintraub, H.3
  • 153
    • 0033793216 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factor E2-2 is involved in T lymphocyte development
    • Bergqvist I, Eriksson M, Saarikettu J et al (2000) The basic helix-loop-helix transcription factor E2-2 is involved in T lymphocyte development. Eur J Immunol 30:2857-2863
    • (2000) Eur J Immunol , vol.30 , pp. 2857-2863
    • Bergqvist, I.1    Eriksson, M.2    Saarikettu, J.3
  • 154
    • 84880134983 scopus 로고    scopus 로고
    • Analysis of miR- 137 expression and rs1625579 in dorsolateral prefrontal cortex
    • Guella I, Sequeira A, Rollins B et al (2013) Analysis of miR- 137 expression and rs1625579 in dorsolateral prefrontal cortex. J Psychiatr Res 47(9):1215-1221
    • (2013) J Psychiatr Res , vol.47 , Issue.9 , pp. 1215-1221
    • Guella, I.1    Sequeira, A.2    Rollins, B.3
  • 155
    • 79955884485 scopus 로고    scopus 로고
    • Modelling schizophrenia using human induced pluripotent stem cells
    • Brennand KJ, Simone A, Jou J et al (2011) Modelling schizophrenia using human induced pluripotent stem cells. Nature 473:221-225
    • (2011) Nature , vol.473 , pp. 221-225
    • Brennand, K.J.1    Simone, A.2    Jou, J.3
  • 157
    • 77950431449 scopus 로고    scopus 로고
    • Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia
    • Sigurdsson T, Stark KL, Karayiorgou M et al (2010) Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia. Nature 464:763-767
    • (2010) Nature , vol.464 , pp. 763-767
    • Sigurdsson, T.1    Stark, K.L.2    Karayiorgou, M.3
  • 159
    • 71549152798 scopus 로고    scopus 로고
    • Temporally anticorrelated brain networks during working memory performance reveal aberrant prefrontal and hippocampal connectivity in patients with schizophrenia
    • Wolf RC, Vasic N, Sambataro F et al (2009) Temporally anticorrelated brain networks during working memory performance reveal aberrant prefrontal and hippocampal connectivity in patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 33:1464-1473
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 1464-1473
    • Wolf, R.C.1    Vasic, N.2    Sambataro, F.3
  • 160
    • 79951612327 scopus 로고    scopus 로고
    • Gating in schizophrenia: From genes to cognition (to real world function?)
    • Braff DL (2011) Gating in schizophrenia: from genes to cognition (to real world function?). Biol Psychiatry 69:395-396
    • (2011) Biol Psychiatry , vol.69 , pp. 395-396
    • Braff, D.L.1
  • 161
    • 0025190458 scopus 로고
    • Sensorimotor gating and schizophrenia: Human and animal model studies
    • Braff DL, Geyer MA (1990) Sensorimotor gating and schizophrenia. Human and animal model studies. Arch Gen Psychiatry 47:181-188 (Pubitemid 20058094)
    • (1990) Archives of General Psychiatry , vol.47 , Issue.2 , pp. 181-188
    • Braff, D.L.1    Geyer, M.A.2
  • 162
    • 32344443686 scopus 로고    scopus 로고
    • Attenuation of the prepulse inhibition of the acoustic startle response within and between sessions
    • Quednow BB, Kühn K-U, Beckmann K et al (2006) Attenuation of the prepulse inhibition of the acoustic startle response within and between sessions. Biol Psychol 71:256-263
    • (2006) Biol Psychol , vol.71 , pp. 256-263
    • Quednow, B.B.1    Kühn, K.-U.2    Beckmann, K.3
  • 163
    • 36549046563 scopus 로고    scopus 로고
    • Spatial and temporal specification of neural fates by transcription factor codes
    • Guillemot F (2007) Spatial and temporal specification of neural fates by transcription factor codes. Development 134:3771-3780
    • (2007) Development , vol.134 , pp. 3771-3780
    • Guillemot, F.1
  • 167
    • 48749131747 scopus 로고    scopus 로고
    • Calcium regulation of myogenesis by differential calmodulin inhibition of basic helix-loop-helix transcription factors
    • Hauser J, Saarikettu J, Grundström T (2008) Calcium regulation of myogenesis by differential calmodulin inhibition of basic helix-loop-helix transcription factors. Mol Biol Cell 19:2509-2519
    • (2008) Mol Biol Cell , vol.19 , pp. 2509-2519
    • Hauser, J.1    Saarikettu, J.2    Grundström, T.3
  • 168
    • 0030751495 scopus 로고    scopus 로고
    • Basic helix-loop-helix protein sequences determining differential inhibition by calmodulin and S-100 proteins
    • DOI 10.1074/jbc.272.38.23930
    • Onions J, Hermann S, Grundström T (1997) Basic helix-loophelix protein sequences determining differential inhibition by calmodulin and S-100 proteins. J Biol Chem 272:23930-23937 (Pubitemid 27410975)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.38 , pp. 23930-23937
    • Onions, J.1    Hermann, S.2    Grundstrom, T.3
  • 169
    • 4644369697 scopus 로고    scopus 로고
    • Calcium/calmodulin inhibition of transcriptional activity of E-proteins by prevention of their binding to DNA
    • DOI 10.1074/jbc.M408120200
    • Saarikettu J, Sveshnikova N, Grundström T (2004) Calcium/ calmodulin inhibition of transcriptional activity of E-proteins by prevention of their binding to DNA. J Biol Chem 279:41004-41011 (Pubitemid 39287701)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.39 , pp. 41004-41011
    • Saarikettu, J.1    Sveshnikova, N.2    Grundstrom, T.3
  • 170
    • 84883138799 scopus 로고    scopus 로고
    • Nuclear calcium signalling in the regulation of brain function
    • Bading H (2013) Nuclear calcium signalling in the regulation of brain function. Nat Rev Neurosci 14:593-608
    • (2013) Nat Rev Neurosci , vol.14 , pp. 593-608
    • Bading, H.1
  • 171
    • 52049127039 scopus 로고    scopus 로고
    • From synapse to nucleus: Calcium-dependent gene transcription in the control of synapse development and function
    • Greer PL, Greenberg ME (2008) From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. Neuron 59:846-860
    • (2008) Neuron , vol.59 , pp. 846-860
    • Greer, P.L.1    Greenberg, M.E.2
  • 172
    • 84876296688 scopus 로고    scopus 로고
    • Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis
    • Cross-Disorder Group of the Psychiatric Genomics Consortium
    • Cross-Disorder Group of the Psychiatric Genomics Consortium, Smoller JW, Craddock N et al (2013) Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381:1371-1379
    • (2013) Lancet , vol.381 , pp. 1371-1379
    • Smoller, J.W.1    Craddock, N.2
  • 173
    • 50449089356 scopus 로고    scopus 로고
    • Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    • Ferreira MAR, O'Donovan MC, Meng YA et al (2008) Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 40:1056-1058
    • (2008) Nat Genet , vol.40 , pp. 1056-1058
    • Ferreira, M.A.R.1    O'Donovan, M.C.2    Meng, Y.A.3
  • 174
    • 80053385384 scopus 로고    scopus 로고
    • Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
    • Psychiatric GWAS Consortium Bipolar Disorder Working Group
    • Psychiatric GWAS Consortium Bipolar Disorder Working Group (2011) Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet 43:977-983
    • (2011) Nat Genet , vol.43 , pp. 977-983
  • 175
    • 77954510735 scopus 로고    scopus 로고
    • The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia
    • Green EK, Grozeva D, Jones I et al (2010) The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatry 15:1016-1022
    • (2010) Mol Psychiatry , vol.15 , pp. 1016-1022
    • Green, E.K.1    Grozeva, D.2    Jones, I.3
  • 176
    • 79958789771 scopus 로고    scopus 로고
    • Effects of a CACNA1C genotype on attention networks in healthy individuals
    • Thimm M, Kircher T, Kellermann T et al (2011) Effects of a CACNA1C genotype on attention networks in healthy individuals. Psychol Med 41:1551-1561
    • (2011) Psychol Med , vol.41 , pp. 1551-1561
    • Thimm, M.1    Kircher, T.2    Kellermann, T.3
  • 177
    • 77955595254 scopus 로고    scopus 로고
    • Brain function in carriers of a genome-wide supported bipolar disorder variant
    • Erk S, Meyer-Lindenberg A, Schnell K et al (2010) Brain function in carriers of a genome-wide supported bipolar disorder variant. Arch Gen Psychiatry 67:803-811
    • (2010) Arch Gen Psychiatry , vol.67 , pp. 803-811
    • Erk, S.1    Meyer-Lindenberg, A.2    Schnell, K.3
  • 178
    • 33750433556 scopus 로고    scopus 로고
    • V1.2 Encodes a Transcription Factor
    • DOI 10.1016/j.cell.2006.10.017, PII S0092867406013432
    • Gomez-Ospina N, Tsuruta F, Barreto-Chang O et al (2006) The C terminus of the L-type voltage-gated calcium channel CaV1.2 encodes a transcription factor. Cell 127:591-606 (Pubitemid 44647432)
    • (2006) Cell , vol.127 , Issue.3 , pp. 591-606
    • Gomez-Ospina, N.1    Tsuruta, F.2    Barreto-Chang, O.3    Hu, L.4    Dolmetsch, R.5
  • 180
    • 1642493720 scopus 로고    scopus 로고
    • A CaM-KII- NeuroD signaling pathway specifies dendritic morphogenesis
    • Gaudillière B, Konishi Y, de la Iglesia N et al (2004) A CaM-KII- NeuroD signaling pathway specifies dendritic morphogenesis. Neuron 41:229-241
    • (2004) Neuron , vol.41 , pp. 229-241
    • Gaudillière, B.1    Konishi, Y.2    De La Iglesia, N.3
  • 182
    • 84863422026 scopus 로고    scopus 로고
    • NeuroD2 regulates the development of hippocampal mossy fiber synapses
    • Wilke SA, Hall BJ, Antonios JK et al (2012) NeuroD2 regulates the development of hippocampal mossy fiber synapses. Neural Dev 7:9
    • (2012) Neural Dev , vol.7 , pp. 9
    • Wilke, S.A.1    Hall, B.J.2    Antonios, J.K.3
  • 184
    • 77956114374 scopus 로고    scopus 로고
    • MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1
    • Smrt RD, Szulwach KE, Pfeiffer RL et al (2010) MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1. Stem Cells 28:1060-1070
    • (2010) Stem Cells , vol.28 , pp. 1060-1070
    • Smrt, R.D.1    Szulwach, K.E.2    Pfeiffer, R.L.3
  • 185
    • 77950565107 scopus 로고    scopus 로고
    • Cross talk between microRNA and epigenetic regulation in adult neurogenesis
    • Szulwach KE, Li X, Smrt RD et al (2010) Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol 189:127-141
    • (2010) J Cell Biol , vol.189 , pp. 127-141
    • Szulwach, K.E.1    Li, X.2    Smrt, R.D.3
  • 187
    • 51349156208 scopus 로고    scopus 로고
    • Variants in nicotinic receptors and risk for nicotine dependence
    • Bierut LJ, Stitzel JA, Wang JC et al (2008) Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry 165:1163-1171
    • (2008) Am J Psychiatry , vol.165 , pp. 1163-1171
    • Bierut, L.J.1    Stitzel, J.A.2    Wang, J.C.3
  • 188
    • 84864279400 scopus 로고    scopus 로고
    • Genome-wide and candidate gene association study of cigarette smoking behaviors
    • Caporaso N, Gu F, Chatterjee N et al (2009) Genome-wide and candidate gene association study of cigarette smoking behaviors. PLoS ONE 4:e4653
    • (2009) PLoS ONE , vol.4
    • Caporaso, N.1    Gu, F.2    Chatterjee, N.3
  • 189
    • 77951751034 scopus 로고    scopus 로고
    • Meta-analysis and imputation refines the association of 15q25 with smoking quantity
    • Liu JZ, Tozzi F, Waterworth DM et al (2010) Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 42:436-440
    • (2010) Nat Genet , vol.42 , pp. 436-440
    • Liu, J.Z.1    Tozzi, F.2    Waterworth, D.M.3
  • 190
    • 66649097962 scopus 로고    scopus 로고
    • Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    • Saccone NL, Saccone SF, Hinrichs AL et al (2009) Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B 150B:453-466
    • (2009) Am J Med Genet B , vol.150 B , pp. 453-466
    • Saccone, N.L.1    Saccone, S.F.2    Hinrichs, A.L.3
  • 191
    • 84881611015 scopus 로고    scopus 로고
    • The effect of nicotine on sensorimotor gating is modulated by a CHRNA3 polymorphism
    • Petrovsky N, Ettinger U, Kessler H et al (2013) The effect of nicotine on sensorimotor gating is modulated by a CHRNA3 polymorphism. Psychopharmacology (Berl) 229(1):31-40
    • (2013) Psychopharmacology (Berl) , vol.229 , Issue.1 , pp. 31-40
    • Petrovsky, N.1    Ettinger, U.2    Kessler, H.3
  • 192
    • 78851471766 scopus 로고    scopus 로고
    • Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3- CHRNB4 cluster are associated with cognitive performance
    • Winterer G, Mittelstrass K, Giegling I et al (2010) Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3- CHRNB4 cluster are associated with cognitive performance. Am J Med Genet B 153B:1448-1458
    • (2010) Am J Med Genet B , vol.153 B , pp. 1448-1458
    • Winterer, G.1    Mittelstrass, K.2    Giegling, I.3
  • 193
    • 0035974511 scopus 로고    scopus 로고
    • Projections of the pontine nuclei to the cochlear nucleus in rats
    • DOI 10.1002/cne.1068
    • Ohlrogge M, Doucet JR, Ryugo DK (2001) Projections of the pontine nuclei to the cochlear nucleus in rats. J Comp Neurol 436:290-303 (Pubitemid 32613620)
    • (2001) Journal of Comparative Neurology , vol.436 , Issue.3 , pp. 290-303
    • Ohlrogge, M.1    Doucet, J.R.2    Ryugo, D.K.3
  • 194
    • 32844466805 scopus 로고    scopus 로고
    • Decoding the auditory corticofugal systems
    • Winer JA (2006) Decoding the auditory corticofugal systems. Hear Res 212:1-8
    • (2006) Hear Res , vol.212 , pp. 1-8
    • Winer, J.A.1
  • 195
    • 0024849294 scopus 로고
    • Cholinergic systems in the rat brain: IV. Descending projections of the pontomesencephalic tegmentum
    • DOI 10.1016/0361-9230(89)90197-4
    • Woolf NJ, Butcher LL (1989) Cholinergic systems in the rat brain: IV. Descending projections of the pontomesencephalic tegmentum. Brain Res Bull 23:519-540 (Pubitemid 20035317)
    • (1989) Brain Research Bulletin , vol.23 , Issue.6 , pp. 519-540
    • Woolf, N.J.1    Butcher, L.L.2
  • 197
    • 0034914857 scopus 로고    scopus 로고
    • Brain stem circuits mediating prepulse inhibition of the startle reflex
    • DOI 10.1007/s002130100794
    • Fendt M, Li L, Yeomans JS (2001) Brain stem circuits mediating prepulse inhibition of the startle reflex. Psychopharmacology 156:216-224 (Pubitemid 32702214)
    • (2001) Psychopharmacology , vol.156 , Issue.2-3 , pp. 216-224
    • Fendt, M.1    Li, L.2    Yeomans, J.S.3
  • 198
    • 0025362884 scopus 로고
    • Cholinergic neurons of the feline pontomesencephalon. I. Essential role in 'Wave A' generation
    • DOI 10.1016/0006-8993(90)91690-I
    • Harrison JB, Woolf NJ, Buchwald JS (1990) Cholinergic neurons of the feline pontomesencephalon. I. Essential role in "Wave A" generation. Brain Res 520:43-54 (Pubitemid 20220828)
    • (1990) Brain Research , vol.520 , Issue.1-2 , pp. 43-54
    • Harrison, J.B.1    Woolf, N.J.2    Buchwald, J.S.3
  • 199
    • 0028932301 scopus 로고
    • Auditory input to the pedunculopontine nucleus: I. Evoked potentials
    • Reese NB, Garcia-Rill E, Skinner RD (1995) Auditory input to the pedunculopontine nucleus: I. Evoked potentials. Brain Res Bull 37:257-264
    • (1995) Brain Res Bull , vol.37 , pp. 257-264
    • Reese, N.B.1    Garcia-Rill, E.2    Skinner, R.D.3
  • 200
    • 23144452990 scopus 로고    scopus 로고
    • Nicotinic cholinergic intercellular communication: Implications for the developing auditory system
    • Morley BJ (2005) Nicotinic cholinergic intercellular communication: implications for the developing auditory system. Hear Res 206:74-88
    • (2005) Hear Res , vol.206 , pp. 74-88
    • Morley, B.J.1
  • 201
    • 0033815626 scopus 로고    scopus 로고
    • Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus
    • Alkondon M, Pereira EF, Almeida LE et al (2000) Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus. Neuropharmacology 39: 2726-2739
    • (2000) Neuropharmacology , vol.39 , pp. 2726-2739
    • Alkondon, M.1    Pereira, E.F.2    Almeida, L.E.3
  • 202
    • 0035726679 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptor subunit knockout mice: Physiological and behavioral phenotypes and possible clinical implications
    • DOI 10.1016/S0163-7258(01)00161-9, PII S0163725801001619
    • Picciotto MR, Caldarone BJ, Brunzell DH et al (2001) Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacol Ther 92:89-108 (Pubitemid 34251128)
    • (2001) Pharmacology and Therapeutics , vol.92 , Issue.2-3 , pp. 89-108
    • Picciotto, M.R.1    Caldarone, B.J.2    Brunzell, D.H.3    Zachariou, V.4    Stevens, T.R.5    King, S.L.6
  • 204
    • 0033832470 scopus 로고    scopus 로고
    • Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia
    • Breese CR, Lee MJ, Adams CE et al (2000) Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia. Neuropsychopharmacology 23:351-364
    • (2000) Neuropsychopharmacology , vol.23 , pp. 351-364
    • Breese, C.R.1    Lee, M.J.2    Adams, C.E.3
  • 206
    • 55849115277 scopus 로고    scopus 로고
    • Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons
    • Satta R, Maloku E, Zhubi A et al (2008) Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. Proc Natl Acad Sci USA 105:16356-16361
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16356-16361
    • Satta, R.1    Maloku, E.2    Zhubi, A.3
  • 207
    • 77349102500 scopus 로고    scopus 로고
    • The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood
    • Philibert RA, Beach SRH, Gunter TD et al (2010) The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood. Am J Med Genet B 153B:619-628
    • (2010) Am J Med Genet B , vol.153 B , pp. 619-628
    • Philibert, R.A.1    Beach, S.R.H.2    Gunter, T.D.3
  • 208
    • 84857686531 scopus 로고    scopus 로고
    • Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: Clinical score and further delineation of the TCF4 mutational spectrum
    • Whalen S, Héron D, Gaillon T et al (2012) Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: clinical score and further delineation of the TCF4 mutational spectrum. Hum Mutat 33:64-72
    • (2012) Hum Mutat , vol.33 , pp. 64-72
    • Whalen, S.1    Héron, D.2    Gaillon, T.3


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