Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus

Neuropharmacology

Volumn 39, Issue 13, 2000, Pages 2726-2739

  Alkondon, Manickavasagom ^a   Pereira, Edna F R ^a,b   Almeida, Luis E F ^a   Randall, William R ^a   Albuquerque, Edson X ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Choline; Dihydro erythroidine; Disinhibition; Electrophysiology; Methyllycaconitine; Nicotine; Smoking

Indexed keywords

CHOLINE; DIHYDRO BETA ERYTHROIDINE; METHYLLYCACONITINE; NICOTINE; NICOTINIC RECEPTOR;

ACTION POTENTIAL; ANIMAL TISSUE; CIGARETTE SMOKING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HIPPOCAMPUS; INTERNEURON; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REVIEW;

EID: 0033815626     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00156-8     Document Type: Article

References (52)

1. Initial characterization of the nicotinic acetylcholine receptors in rat hippocampal neurons
2. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes
3. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. III. Agonist actions of the novel alkaloid epibatidine and analysis of type II current
4. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons: II. The rundown and inward rectification of agonist-elicited whole-cell currents and identification of receptor subunits by in situ hybridization studies
5. Diversity of nicotinic acetylcholine receptors in rat brain. V. α-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release
6. Neuronal nicotinic acetylcholine receptor activation modulates γ-aminobutyric acid release from CA1 neurons of rat hippocampal slices
7. Choline is a selective agonist of α7 nicotinic acetylcholine receptors in rat brain neurons
8. α-Bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices
9. Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices
10. Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks
11. α7 nicotinic acetylcholine receptors and modulation of gabaergic synaptic transmission in the hippocampus
12. Pharmacokinetics, metabolism, and pharmacodynamics of nicotine
13. Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes
14. Human α4β2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: a patch clamp study
15. Computer analysis of electrophysiological signals
16. Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine
17. Upregulation of surface α4β2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine
18. Acetylcholine activates an α-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells
19. Synaptic potentials mediated via α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons
20. Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia
21. Hippocampal synaptic transmission enhanced by low concentrations of nicotine
22. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
23. Synaptic transmission at nicotinic acetylcholine receptors in rat hippocampal organotypic cultures and slices
24. Higher levels of nicotine in arterial blood than in venous blood after cigarette smoking
25. Effects of smoking in patients with early-onset Parkinson's disease
26. Functional nicotinic ACh receptors on interneurons in the rat hippocampus
27. Evidence for 'preterminal' nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus
28. Acetylcholine receptor desensitizatoin induced by nicotine in rat medial habenula neurons
29. Development of nicotinic drug therapy for cognitive disorders
30. Pharmacological characterization of nicotinic receptor-stimulated GABA release from mouse brain synaptosomes
31. Nicotinic enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
32. Nicotinic receptor activation facilitates GABAergic neurotransmission in the avian lateral spiriform nucleus
33. Nicotinic receptor activation excites distinct subtypes of interneurons in the rat hippocampus
34. Choline and acetylcholine have similar kinetic properties of activation and desensitization on the α7 nicotinic receptors in rat hippocampal neurons
35. Nicotinic systems and Alzheimer's disease: implications for therapeutics
36. An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the α7 subtype
37. Neuronal nicotinic receptors in the human brain
38. Nicotine-induced increase in neuronal receptors results from a decrease in the rate of receptor turnover
39. Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases
40. Nicotine activates and desensitizes midbrain dopamine neurons
41. 3H]5-hydroxytryptamine release from rat striatal synaptosomes
42. Fast synaptic signaling by nicotinic acetylcholine and serotonin 5-HT3 receptors in developing visual cortex
43. Nicotinic receptors in the development and modulation of CNS synapses
44. Nicotine intake and its control over smoking
45. UB-165: a novel nicotinic agonist with subtype selectivity implicates the α4β2* subtype in the modulation of dopamine release from rat striatal synaptosomes
46. Nicotine in an animal model of attention
47. Rapid synaptic transmission in the avian ciliary ganglion is mediated by two distinct classes of nicotinic receptors
48. Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed in Xenopus oocytes
49. Agonist-induced up-regulation of α4β2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition
50. Synaptic currents generated by neuronal acetylcholine receptors sensitive to α-bungarotoxin