Neural development, cell-cell signaling, and the "two-hit" hypothesis of schizophrenia

Schizophrenia Bulletin

Volumn 27, Issue 3, 2001, Pages 457-476

  Maynard, Thomas M ^b   Sikich, Linmarie ^b   Lieberman, Jeffrey A ^b   LaMantia, Anthony Samuel ^a,b,c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c Department of Cell and Molecular Physiology ^*  (United States)

Author keywords

Development; Genetics; Neuronal circuits; Schizophrenia; Signaling; Teratogenesis

Indexed keywords

RETINOID;

CELL COMMUNICATION; CHROMOSOME 22Q; DEVELOPMENTAL BIOLOGY; ENVIRONMENTAL FACTOR; FOREBRAIN; HEREDITY; HUMAN; HYPOTHESIS; MORPHOGENESIS; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TERATOGENESIS;

EID: 0035183947     PISSN: 05867614     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.schbul.a006887     Document Type: Review

References (172)

1. Neurological disturbances in rats reared on diets deficient in vitamin A
2. Neurobehavioral teratology of isotretinoin
3. GABAA receptor subunit gene expression in human prefrontal cortex: Comparison of schizophrenics and controls
4. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics
5. Retinoic acid receptors and retinoid X receptors: Interactions with endogenous retinoic acids
6. Atypical deletions suggest five 22q11.2 critical regions related to the DiGeorge/velo-cardio-facial syndrome
7. Disruption of local retinoid-mediated gene expression accompanies abnormal development in the mammalian olfactory pathway
8. Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia
9. Notch signaling: Cell fate control and signal integration in development
10. Transgenic indicator mice for studying activated retinoic acid receptors during development
11. Genetic and non-genetic vulnerability factors in schizophrenia: The basis of the "two hit hypothesis"
12. Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics
13. Establishing the onset of psychotic illness
14. Comparison of amphetamine psychosis and schizophrenia
15. Identification of sonic hedgehogas a candidate gene responsible for holoprosencephaly
16. Selective localization of mouse aldehyde oxidase mRNA in the choroid plexus and motor neurons
17. Emerging principles of altered neural circuitry in schizophrenia
18. Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients
19. Notch1 inhibits neurite outgrowth in postmitotic primary neurons
20. Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease
21. Newly-generated cells from the rostral migratory stream in the accessory olfactory bulb of the adult rat
22. Cocaine-induced psychosis
23. Ventricular volume and asymmetry in schizotypal personality disorder and schizophrenia assessed with magnetic resonance imaging
24. Twin studies of schizophrenia: From bow-and-arrow concordances to Star Wars Mx and functional genomics
25. Molecular analysis of velo-cardiofacial syndrome patients with psychiatric disorders
26. Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients
27. Effect of retinol and retinoic acid on testosterone production by rat Leydig cells in primary culture
28. An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression
29. Velo-cardio-facial syndrome and psychotic disorders: Implications for psychiatric genetics
30. Phenotype of adults with the 22q11 deletion syndrome: A review
31. Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development
32. Abnormalities of Wnt signalling in schizophrenia - Evidence for neurodevelopmental abnormality
33. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
34. Prenatal development of monozygotic twins and concordance for schizophrenia
35. Adult rabbit brain synthesizes retinoic acid
36. Chronic hypervitaminosis A in an adult
37. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
38. The biological function of vitamin A acid
39. Genetic basis of DiGeorge and velocardiofacial syndromes
40. Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia
41. Parental origin of the deletion 22q11.2 and brain development in velocardiofacial syndrome: A preliminary study
42. Children and adolescents with velocardiofacial syndrome: A volumetric MRI study
43. Stimulant-induced psychosis, the dopamine theory of schizophrenia, and the habenula
44. The neurotoxic effects of continuous cocaine and amphetamine in habenula: Implications for the substrates of psychosis
45. Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: The New York High-Risk Project
46. No evidence for astrogliosis in brains of schizophrenic patients: A post-mortem study
47. Benign intracranial hypertension associated with hypervitaminosis A
48. Psychotic complications of long-term levodopa treatment of Parkinson's disease
49. Radial glial identity is promoted by Notch1 signaling in the murine forebrain
50. Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6
51. Velo-cardio-facial syndrome: A review of 120 patients
52. Velo-cardio-facial syndrome: Language and psychological profiles
53. Disrupted pattern of D2 dopamine receptors in the temporal lobe in schizophrenia: A postmortem study
54. Chromosomal locations and modes of action of genes of the retinoid (vitamin A) system support their involvement in the etiology of schizophrenia
55. Three independent lines of evidence suggest retinoids as causal to schizophrenia
56. Minor physical anomalies in alcoholic and schizophrenic adults and hyperactive and autistic children
57. Expression of the murine RanBP1 and Htf9-c genes is regulated from a shared bidirectional promoter during cell cycle progression
58. Non-over-lapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo
59. The incidence of minor physical anomalies in adult male schizophrenics
60. Premorbid and onset features of first-episode schizophrenia
61. The dopamine hypothesis: An overview of studies with schizophrenic patients
62. Vitamin A deficiency and its effects on the eye
63. Differential expression of Notch1 and Notch2 in developing and adult mouse brain
64. Schizoid personality disorder after prenatal exposure to famine
65. Two different enzymes are primarily responsible for retinoic acid synthesis in rabbit liver cytosol
66. Prenatal exposure to famine and brain morphology in schizophrenia
67. A decrease of reelin expression as a putative vulnerability factor in schizophrenia
68. Minor physical anomalies in schizophrenic patients and their siblings
69. Recent advances in the phencyclidine model of schizophrenia
70. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
71. Molecular models for vertebrate limb development
72. Cerebral ventricle dimensions as risk factors for schizophrenia and affective psychosis: An epidemiological approach to analysis
73. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics
74. Deletion of 150 kb in the minimal DiGeorge/velocardiofacial syndrome critical region in mouse
75. Notch signaling is essential for vascular morphogenesis in mice
76. RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable
77. Impaired locomotion and dopamine signaling in retinoid receptor mutant mice
78. Differential expression of retinoid receptors in the adult mouse central nervous system
79. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses
80. Molecular cloning of the cDNA coding for mouse aldehyde oxidase: Tissue distribution and regulation in vivo by testosterone
81. Mesenchymal/epithelial induction mediates olfactory pathway formation
82. The usual suspects: GABA and glutamate may regulate proliferation in the neocortex
83. Forebrain induction, retinoic acid, and vulnerability to schizophrenia: Insights from molecular and genetic analysis in developing mice
84. Retinoic acid induction and regional differentiation prefigure olfactory pathway formation in the mammalian forebrain
85. Retinoic acid embryopathy
86. Imaging dopamine transmission in schizophrenia: A review meta-analysis
87. Neurotransmitters as growth regulatory signals: Role of receptors and second messengers
88. Stress pathway activation induces phosphorylation of retinoid X receptor
89. Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene
90. Provocative tests with psychostimulant drugs in schizophrenia
91. Factors influencing treatment response and outcome of first-episode schizophrenia: Implications for understanding the pathophysiology of schizophrenia
92. Congenital heart disease in mice deficient for the DiGeorge syndrome region
93. Retinoid signaling in mouse embryos
94. Duration of psychosis and outcome in first-episode schizophrenia
95. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid
96. Cell interactions within nascent neural crest cell populations transiently promote death of neurogenic precursors
97. Patient with a 22q11.2 deletion with no overlap of the minimal DiGeorge syndrome critical region (MDGCR)
98. The dopamine hypothesis of schizophrenia: A review
99. Arbiter of differentiation death: Notch signaling meets apoptosis
100. Retinoid receptors in transcriptional regulation
101. Increased expression of Wnt-1 in schizophrenic brains
102. Olfactory dysfunction in schizophrenia: A qualitative and quantitative review
103. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
104. Psychoeducational profile of the 22q11.2 microdeletion: A complex pattern
105. High rates of schizophrenia in adults with velo-cardio-facial syndrome
106. Is schizophrenia a neurodevelopmental disorder?
107. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
108. Effects of small amygdala lesions on fear, but not aggression, in the rat
109. Glutamate receptor dysfunction and schizophrenia
110. Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: Does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder?
111. Spatial and temporal pattern of expression of the cellular retinoic acid-binding protein and the cellular retinol-binding protein during mouse embryogenesis
112. Cocaine, kindling, and psychosis
113. Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region
114. Linkage and associated studies of schizophrenia
115. Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder
116. Central amygdala lesions affect behavioral and autonomic balance during stress in rats
117. Phenomenologic comparison of the idiopathic psychosis of schizophrenia and drag-induced cocaine and phencyclidine psychoses: A retrospective study
118. Ectodermal-mesodermal interactions in the growth of limb buds in the chick embryo: Constancy and temporal limits of the ectodermal induction
119. Spectrum of clinical features associated with interstitial chromosome 22q11 deletions: A European collaborative study
120. Potential behavioral modification of glucocorticoid damage to the hippocampus
121. Habenular lesion attenuates methamphetamine-induced inhibition of dopamine neuronal activity in the substantia nigra pars compacta of rats
122. Involvement of the entopeduncular nucleus and the habenula in methamphetamine-induced inhibition of dopamine neurons in the substantia nigra of rats
123. The reduced neuropil hypothesis: A circuit based model of schizophrenia
124. Abnormally high neuronal density in the schizophrenic cortex. A morphometric analysis of prefrontal area 9 and occipital area 17
125. Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: Application of a three-dimensional, stereologic counting method
126. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling
127. The natural history and pathophysiology of treatment resistant schizophrenia
128. Morphogenesis of malformations in hamsters caused by retinoic acid: Relation to dose and stage at treatment
129. Inductive interactions direct early regionalization of the mouse forebrain
130. Velo-cardio-facial syndrome: A distinctive behavioral phenotype
131. Late-onset psychosis in the velo-cardio-facial syndrome
132. Attenuation of positional signalling in the chick limb by high doses of gamma-radiation
133. Catecholamines in the brain as mediators of amphetamine psychosis
134. Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons
135. Effect of vitamin A deficiency on the retina of the experimental rabbit
136. Retinoic acid and retinoic acid receptors in development
137. The behavioural phenotype in velo-cardio-facial syndrome (VCFS): From infancy to adolescence
138. The initiation of the limb bud: Growth factors, Hox genes, and retinoids
139. Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients
140. Factors affecting the development and regeneration of visual purple in the mammalian retina
141. Altered levels of the synaptosomal associated protein SNAP-25 in schizophrenia
142. Effort and stress influence the effect of lesion of the habenula complex in one-way active avoidance learning
143. Increased immobility in an automated forced swimming test following lesion of the habenula in rats: Absence of evidence for a contribution from motor impairment
144. Positional signalling and specification of digits in chick limb morphogenesis
145. Seasonality of births in schizophrenia and bipolar disorder: A review of the literature
146. E2F-6, a member of the E2F family that can behave as a transcriptional repressor
147. Reduced olfactory bulb volume in patients with schizophrenia
148. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
149. Effects of habenular lesions upon two-way active avoidance conditioning in rats
150. Abnormal expression of cell recognition molecules in schizophrenia
151. 22q11 deletion in DGS/VCFS monozygotic twins with discordant phenotypes
152. Transmitters contained in the efferents of the habenula
153. NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1
154. The molecular basis of visual excitation
155. Newborn minor physical anomalies predict short attention span, peer aggression, and impulsivity at age 3
156. Minor physical anomalies and behavior in preschool children
157. Childhood behavioral characteristics and adult brain morphology in schizophrenia
158. Physiological evidence for habenula as major link between forebrain and midbrain raphe
159. The NOTCH4 locus is associated with susceptibility to schizophrenia
160. Implications of normal brain development for the pathogenesis of schizophrenia
161. From neuropathology to neurodevelopment
162. The ins and outs of notch signaling
163. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis
164. Meta-analysis of regional brain volumes in schizophrenia
165. Retinoid-binding proteins in the cerebellum and choroid plexus and their relationship to regionalized retinoic acid synthesis and degradation
166. Influence of the choroid plexus on cerebellar development: Analysis of retinoic acid synthesis
167. Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor
168. Viruses, schizophrenia, and bipolar disorder
169. Neuropsychiatric adverse effects of antiparkinsonian drugs: Characteristics, evaluation and treatment
170. Localization of cellular retinoid-binding proteins suggests specific roles for retinoids in the adult central nervous system
171. Lesions of the nervous system in vitamin deficiency: I. Rats on a diet low in vitamin A