Analysis of complex brain disorders with gene expression microarrays: Schizophrenia as a disease of the synapse

Trends in Neurosciences

Volumn 24, Issue 8, 2001, Pages 479-486

  Mirnics, Károly ^a   Middleton, Frank A ^a   Lewis, David A ^a   Levitt, Pat ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CASEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; N ETHYLMALEIMIDE; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE C; SYNAPSIN; SYNAPTOBREVIN; SYNAPTOJANIN; SYNAPTOPHYSIN; SYNAPTOTAGMIN; SYNTAXIN;

BRAIN DISEASE; DEVELOPMENTAL DISORDER; DNA MICROARRAY; GENE EXPRESSION; HUMAN; NERVE CONDUCTION; NERVOUS SYSTEM DEVELOPMENT; PRESYNAPTIC NERVE; PRIORITY JOURNAL; REGULATOR GENE; REVIEW; SCHIZOPHRENIA; SYNAPSE; SYNAPTIC TRANSMISSION;

BRAIN CHEMISTRY; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SCHIZOPHRENIA; SYNAPSES;

EID: 0035426751     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-2236(00)01862-2     Document Type: Review

References (93)

1. The Human Genome Project
2. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
3. Use of a cDNA microarray to analyse gene expression patterns in human cancer
4. Quantitative RT-PCR: Pitfalls and potential
5. Real time quantitative PCR
6. Serial analysis of gene expression
7. TOGA: An automated parsing technology for analyzing expression of nearly all genes
8. Accurate sequencing by hybridization for DNA diagnostics and individual genomics
9. A fiber-optic DNA biosensor microarray for the analysis of gene expression
10. Techview: Molecular biology. Bead-based fiber-optic arrays
11. Comparative gene-expression analysis
12. The 'chip' as a specific genetic tool
13. High throughput analysis of gene expression in the human brain
14. An electron microscopic study of the types and proportions of neurons in the cortex of the motor and visual areas of the cat and rat
15. Numbers and proportions of GABA-immunoreactive neurons in different areas of monkey cerebral cortex
16. DNA microarrays and human brain disorders
17. Genomics, gene expression and DNA arrays
18. Linkage-disequilibrium mapping without genotyping
19. Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis
20. Klinefelter's syndrome as a model of anomalous cerebral laterality: Testing gene dosage in the X chromosome pseudoautosomal region using a DNA microarray
21. Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays
22. Comparative performance of high-density oligonucleotide sequencing and dideoxynucleotide sequencing of HIV type 1 pol from clinical samples
23. Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes
24. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray
25. A genetic analysis of neural progenitor differentiation
26. Molecular classification of cancer: C lass discovery and class prediction by gene expression monitoring
27. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
28. Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes
29. Catching up on schizophrenia: Natural history and neurobiology
30. Schizophrenia
31. Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
32. Expression profiling using cDNA microarrays
33. High density synthetic oligonucleotide arrays
34. Expression monitoring by hybridization to high-density oligonucleotide arrays
35. Mice, microarrays, and the genetic diversity of the brain
36. Neural gene expression analysis using DNA arrays
37. Options available - from start to finish - for obtaining expression data by microarray
38. Sensitivity issues in DNA array-based expression measurements and performance of nylon microarrays for small samples
39. Genome-wide expression monitoring in Saccharomyces cerevisiae
40. Assessment of the sensitivity and specificity of oligonucleotide (50mer) microarrays
41. Decreased hippocampal expression of a glutamate receptor gene in schizophrenia
42. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics
43. A subclass of prefrontal gamma-aminobutyric acid axon terminals are selectively altered in schizophrenia
44. Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia
45. From the cover: Regional and strain-specific gene expression mapping in the adult mouse brain
46. Expressing what's on your mind: DNA arrays and the brain
47. A concise guide to cDNA microarray analysis
48. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
49. Use of SMART-generated cDNA for differential gene expression studies
50. Use of SMART-generated cDNA for gene expression studies in multiple human tumors
51. Gene-expression profiles of laser-captured adjacent neuronal sub-types
52. Analysis of gene expression in single live neurons
53. Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons
54. A novel, sensitive detection system for high-density microarrays using dendrimer technology
55. MICROMAX: A highly sensitive system for differential gene expression on microarrays
56. Application of cDNA microarrays to examine gene expression differences in schizophrenia
57. Importance of replication in microarray gene expression studies: Statistical methods and evidence from repetitive cDNA hybridizations
58. Cluster analysis and display of genome-wide expression patterns
59. Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns
60. Supervised harvesting of expression trees
61. Knowledge-based analysis of microarray gene expression data by using support vector machines
62. Analysis of gene expression data using self-organizing maps
63. Computational methods for the identification of differential and coordinated gene expression
64. Support vector machine classification and validation of cancer tissue samples using microarray expression data
65. Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation
66. KEGG: Kyoto encyclopedia of genes and genomes
67. Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays
68. Predominance of neuronal mRNAs in individual Alzheimer's disease senile plaques
69. Membrane fusion and exocytosis
70. SNARE proteins - Why so many, why so few?
71. Pieces of the schizophrenia puzzle fall into place
72. From neuropathology to neurodevelopment
73. Schizophrenia: Genes and environment
74. Search for schizophrenia susceptibility genes
75. Hypofrontality in schizophrenia: Distributed dysfunctional circuits in neuroleptic-naive patients
76. Specific relationship between prefrontal neuronal N-acetylaspartate and activation of the working memory cortical network in schizophrenia
77. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence
78. The regulator of G protein signaling family
79. The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis
80. Region-specific regulation of RGS4 (Regulator of G-protein-signaling protein type 4) in brain by stress and glucocorticoids: In vivo and in vitro studies
81. Serotonergic basis of antipsychotic drug effects in schizophrenia
82. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22
83. Alterations in chandelier neuron axon terminals in the prefrontal cortex of schizophrenic subjects
84. Gene expression in human alcoholism: Microarray analysis of frontal cortex
85. Gene expression changes in adult prefrontal cortex and nucleus accumbens following neonatal ventral hippocampal lesions
86. Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood
87. Synaptic density in human frontal cortex-developmental changes and effects of aging
88. Formation, elimination and stabilization of synapses in the primate cerebral cortex
89. Synaptic assembly of the brain in the absence of neurotransmitter secretion
90. Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release
91. Essential functions of synapsins I and II in synaptic vesicle regulation
92. Proteomic analysis
93. New advances in pharmacogenomics