Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder

American Journal of Human Genetics

Volumn 73, Issue 1, 2003, Pages 49-62

  Segurado, Ricardo ^a   Detera Wadleigh, Sevilla D ^ar   Levinson, Douglas F ^c   Lewis, Cathryn M ^d   Gill, Michael ^b   Nurnberger Jr , John I ^f   Craddock, Nick ^g   DePaulo, J Raymond ^h   Baron, Miron ⁱ   Gershon, Elliot S ^k   Ekholm, Jenny ^l,m   Cichon, Sven ⁿ   Turecki, Gustavo ^p   Claes, Stephan ^n,o   Kelsoe, John R ^q   Schofield, Peter R ^r   Badenhop, Renee F ^r,s   Morissette, J ^u   Coon, Hilary ^v   Blackwood, Douglas ^w   Mclnnes, L Alison ^j   Foroud, Tatiana ^f   Edenberg, Howard J ^f   Reich, Theodore ^x   Rice, John P ^x   Goate, Alison ^x   McInnis, Melvin G ^h   McMahon, Francis J ^ar   Badner, Judith A ^k   Goldin, Lynn R ^ar   Bennett, Phil ^g   Willour, Virginia L ^h   Zandi, Peter P ^h   Liu, Jianjun ⁱ   Gilliam, Conrad ⁱ   Juo, Suh Hang ⁱ   Berrettini, Wade H ^c   Yoshikawa, Takeo ^y   Peltonen, Leena ^l,m,z   Lönnqvist, Jouko ^l   Nöthen, Markus M ⁿ   Schumacher, Johannes ^ab   Windemuth, Christine ^ab   Rietschel, Marcella ^ac   Propping, Peter ^ab   Maier, Wolfgang ^ab   Alda, Martin ^ad   Grof, Paul ^ae   Rouleau, Guy A ^p   Del Favero, Jurgen ^o   Van Broeckhoven, Christine ^o   Mendlewicz, Julien ^af   Adolfsson, Rolf ^ag   Spence, M Anne ^ah   Luebbert, Hermann ^aj   Adams, Linda J ^r   Donald, Jennifer A ^t   Mitchell, Philip B ^r,s   Barden, Nicholas ^u   Shink, Eric ^u   Byerley, William ^ai   Muir, Walter ^w   Visscher, Peter M ^w   Macgregor, Stuart ^w   Gurling, Hugh ^e   Kalsi, Gursharan ^e   McQuillin, Andrew ^e   Escamilla, Michael A ^ak   Reus, Victor I ^al   Leon, Pedro ^am   Freimer, Nelson B ^aa   Ewald, Henrik ^an   Kruse, Torben A ^ao   Mors, Ole ^an   Radhakrishna, Uppala ^ap   Blouin, Jean Louis ^ap   Antonarakis, Stylianos E ^ap   Akarsu, Nurten ^aq   more..

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ST JAMES S HOSPITAL   (Ireland)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^f INDIANA UNIVERSITY   (United States)

^g UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^j MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^k UNIVERSITY OF CHICAGO   (United States)

^l NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^m UNIVERSITY OF HELSINKI   (Finland)

ⁿ UNIVERSITY OF ANTWERP   (Belgium)

^o DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^p MONTREAL GENERAL HOSPITAL   (Canada)

^q UNIVERSITY OF CALIFORNIA   (United States)

^r UNIVERSITY OF NEW SOUTH WALES   (Australia)

^s PRINCE OF WALES HOSPITAL   (Australia)

^t MACQUARIE UNIVERSITY   (Australia)

^u UNIVERSITÉ LAVAL   (Canada)

^v UNIVERSITY OF UTAH   (United States)

^w UNIVERSITY OF EDINBURGH   (United Kingdom)

^x WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^y INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^z UNIVERSITY OF CALIFORNIA   (United States)

^aa UNIVERSITY OF CALIFORNIA   (United States)

^ab UNIVERSITY OF BONN   (Germany)

^ac CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^ad DALHOUSIE UNIVERSITY   (Canada)

^ae UNIVERSITY OF OTTAWA   (Canada)

^af ERASME HOSPITAL   (Belgium)

^ag UMEÅ UNIVERSITY   (Sweden)

^ah UNIVERSITY OF CALIFORNIA   (United States)

^ai UNIVERSITY OF CALIFORNIA   (United States)

^aj Biofrontera Pharmaceuticals GmbH   (Germany)

^ak UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^al UNIVERSITY OF CALIFORNIA   (United States)

^am UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^an AARHUS UNIVERSITY HOSPITAL   (Denmark)

^ao ODENSE UNIVERSITY HOSPITAL   (Denmark)

^ap UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^aq HACETTEPE UNIVERSITY   (Turkey)

^ar NONE

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIPOLAR DISORDER; CHROMOSOME 10Q; CHROMOSOME 14Q; CHROMOSOME 18P; CHROMOSOME 18Q; CHROMOSOME 9P; DISEASE MODEL; GENE MAPPING; GENETIC LINKAGE; GENOME SCAN META ANALYSIS; HUMAN; LINKAGE ANALYSIS; MAJOR DEPRESSION; METHODOLOGY; PEDIGREE; PRIORITY JOURNAL; RECURRENT DISEASE; SAMPLE SIZE; SCHIZOPHRENIA; SIMULATION;

EID: 0038341184     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/376547     Document Type: Article

References (55)

1. Adams LJ, Mitchell PB, Fielder SL, Rosso A, Donald JA, Schofield PR (1998) A susceptibility locus for bipolar affective disorder on chromosome 4q35. Am J Hum Genet 62:1084-1091
2. Badenhop RF, Moses MJ, Scimone A, Mitchell PB, Ewen-White KR, Rosso A, Donald JA, Adams LJ, Schofield PR (2002) A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes 9, 13 and 19. Mol Psychiatry 7:851-859
3. Badner JA, Gershon ES (2002) Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7:405-411
4. Baron M (2002) Manic depression genes and the new millennium: poised for discovery. Mol Psychiatry 7:342-358
5. Baron M, Risch N, Hamburger R, Mandel B, Kushner S, Newman M, Drumer D, Belmaker RH (1987) Genetic linkage between X-chromosome markers and bipolar affective illness. Nature 326:289-292
6. Bennett P, Segurado R, Jones I, Bort S, McCandless F, Lambert D, Heron J, Comerford C, Middle F, Corvin A, Pelios G, Kirov G, Larsen B, Mulcahy T, Williams N, O'Connell R, O'Mahony E, Payne A, Owen M, Holmans P, Craddock N, Gill M (2002) The Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report. Mol Psychiatry 7:189-200
7. Berrettini WH, Ferraro TN, Goldin LR, Detera-Wadleigh SD, Choi H, Muniec D, Guroff JJ, Kazuba DM, Nurnberger JI Jr, Hsieh WT, Hoehe MR, Gershon ES (1997) A linkage study of bipolar illness. Arch Gen Psychiatry 54:27-35
8. Berrettini WH, Ferraro TN, Goldin LR, Weeks DE, Detera-Wadleigh S, Nurnberger JI Jr, Gershon ES (1994) Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci USA 91:5918-5921
9. Blacker D, Faraone SV, Rosen AE, Guroff JJ, Adams P, Weissman MM, Gershon ES (1996) Unipolar relatives in bipolar pedigrees: a search for elusive indicators of underlying bipolarity. Am J Med Genet 67:445-454
10. Blackwood DHR, He L, Morris SW, McLean A, Whitton C, Thomson M, Walker MT, Woodburn K, Sharp CM, Wright AF, Shibasaki Y, St. Clair DM, Porteous DJ, Muir WJ (1996) A locus for bipolar affective disorder on chromosome 4p. Nat Genet 12:427-430
11. Cichon S, Schumacher J, Muller DJ, Hurter M, Windemuth C, Strauch K, Hemmer S, et al (2001) A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q. Hum Mol Genet 10:2933-2944
12. Coon H, Jensen S, Hoff M, Holik J, Plaetke R, Reimherr F, Wender P, Leppert M, Byerley W (1993) A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance. Am J Hum Genet 52:1234-1249
13. Craddock N, Jones I (1999) Genetics of bipolar disorder. J Med Genet 36:585-594
14. Craddock N, Khodel V, Van Eerdewegh P, Reich T (1995) Mathematical limits of multilocus models: the genetic transmission of bipolar disorder. Am J Hum Genet 57:690-702
15. Curtis D, Kalsi G, Brynjolfsson J, McInnis M, O'Neill J, Smyth C, Moloney E, Murphy P, McQuillin A, Petursson H, Gurling H (2003) Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p36 and 1q42. Psychiatr Genet 13:77-84
16. Detera-Wadleigh, SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G, Rollins DY, Moses T, Sanders AR, Karkera JD, Esterling LE, Zeng J, Ferraro TN, Guroff JJ, Kazuba D, Maxwell ME, Nurnberger JI Jr, Gershon ES (1999) A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 96:5604-5609
17. Detera-Wadleigh SD, Badner JA, Yoshikawa T, Sanders AR, Goldin LR, Turner G, Rollins DY, Moses T, Guroff JJ, Kazuba D, Maxwell ME, Edenberg HJ, Foroud T, Lahiri D, Nurnberger JI Jr, Stine OC, McMahon F, Meyers DA, MacKinnon D, Simpson S, McInnis M, DePaulo JR, Rice J, Goate A, Gershon ES (1997) Initial genome scan of the NIMH Genetics Initiative bipolar pedigrees: chromosomes 4, 7, 9, 18, 19, 20, and 21q. Am J Med Genet 74:254-262
18. Detera-Wadleigh SD, Hsieh WT, Berrettini WH, Goldin LR, Rollins DY, Muniec D, Grewal R, Guroff JJ, Turner G, Coffman D, Barrick J, Mills K, Murray J, Donohue SJ, Klein DC, Sanders J, Nurnberger JI Jr, Gershon ES (1994) Genetic linkage mapping for a susceptibility locus to bipolar illness: chromosomes 2, 3, 4, 7, 9, 10p, 11p, 22 and Xpter. Am J Med Genet 54:206-218
19. Edenberg HJ, Foroud T, Conneally PM, Sorbel JJ, Carr K, Crose C, Willig C, Zhao J, Miller M, Bowman E, Mayeda A, Rau NL, Smiley C, Rice JP, Goate A, Reich T, Stine OC, McMahon F, DePaulo JR, Meyers D, Detera-Wadleigh SD, Goldin LR, Gershon ES, Blehar MC, Nurnberger JI Jr (1997) Initial genomic scan of the NIMH Genetics Initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 21 and 22. Am J Med Genet 74:238-246
20. Egeland JA, Gerhard DS, Pauls DL, Sussex JN, Kidd KK, Allen CR, Hostetter AM, Housman DE (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 325:783-787
21. Ekholm JM, Pekkarinen P, Pajukanta P, Kieseppa T, Partonen T, Paunio T, Varilo T, Perola M, Lonnqvist J, Peltonen L (2002) Bipolar disorder susceptibility region on Xq24-q27.1 in Finnish families. Mol Psychiatry 7:453-459
22. Endicott J, Nee J, Andreasen N, Clayton P, Keller M, Coryell W (1985) Bipolar II: combine or keep separate. J Affect Disord 8:17-28
23. Ewald H, Flint T, Kruse TA, Mors O (2002) A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. Mol Psychiatry 7:734-744
24. Gerhard DS, LaBuda MC, Bland SD, Allen C, Egeland JA, Pauls DL (1994) Initial report of a genome search for the affective disorder predisposition gene in the Old Order Amish pedigrees: chromosomes 1 and 11. Am J Med Genet 54:398-404
25. Gershon ES, Badner JA, Detera-Wadley SD, Ferraro TN, Berrettini WH (1996) Maternal inheritance and chromosome 18 allele sharing in uni-lineal bipolar illness pedigrees. Am J Med Genet 67:202-207
26. Ginns EI, Ott J, Egeland JA, Allen CR, Fann CSJ, Pauls DL, Weissenhach J, Carulli JP, Falls KM, Keith TP, Paul SM (1996) A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nat Genet 12:431-435
27. Grigoroiu-Serbanescu M, Martinez M, Nöthen MM, Propping P, Milea S, Mihailescu R, Marinescu E (1998) Patterns of parental transmission and familial aggregation models in bipolar affective disorder. Am J Med Genet 81:397-404
28. Hauser ER, Boehnke M, Guo SW, Risch N (1996) Affected sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations. Genet Epidemiol 13:117-138
29. Heun R, Maier W (1993) The distinction of bipolar II disorder from bipolar I and recurrent unipolar depression: results of a controlled family study. Acta Psychiatr Scand 87:279-284
30. Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL, Masser D, Ungerleider S, Rapaport MH, Wishart WL, Luebbert H (2001) A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci USA 98:585-590
31. LaBuda MC, Maldonado M, Marshall D, Otten K, Gerhard DS (1996) A follow-up report of a genome search for affective disorder predisposition loci in the Old Order Amish. Am J Hum Genet 59:1343-1362
32. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
33. Leboyer M, Maier W, Teherani M, Lichtermann D, D'Amato T, Franke P. Lepine JP, Minges J, McGuffin P (1991) The reliability of the SADS-LA in a family study setting. Eur Arch Psychiatry Clin Neurosci 241:165-169
34. Levinson DF, Levinson MD, Segurado R, Lewis CM (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: methods and power analysis. Am J Hum Genet 73:17-33 (in this issue)
35. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, et al (2003) Genome scan meta-analysis of schizophrenia and bipolor disorder, part II: schizophrenia. Am J Hum Genet 73:34-48 (in this issue)
36. Liu J, Juo SH, Dewan A, Grunn A, Tong X, Brito M, Park N, Loth JE, Kanyas K, Lerer B, Endicott J, Penchaszadeh G, Knowles JA, Ott J, Gilliam TC, Baron M (2003) Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12. Mol Psychiatry 8:333-342
37. Maier W, Lichtermann D, Minges J, Hallmayer J, Heun R, Benkert O, Levinson DF (1993) Continuity and discontinuity of affective disorders anti schizophrenia: results of a controlled family study. Arch Gen Psychiatry 50:871-883
38. McInnes LA, Escamilla MA, Service SK, Reus VI, Leon P, Silva S, Rojas E, Spesny M, Baharloo S, Blankenship K, Peterson A, Tyler D, Shimayoshi N, Tobey C, Batki S, Vinogradov S, Meza L, Gallegos A, Fournier E, Smith LB, Barondes SH, Sandkuijl LA, Freimer NB (1996) A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees. Proc Natl Acad Sci USA 93:13060-13065
39. McInnis MG, Lan T-H, Willour VL, McMahon FJ, Simpson SG, Addington AM, MacKinnon DF, Potash JB, Mahoney AT, Chellis J, Huo Y, Swift-Scanlan T, Chen H, Koskela R, Stine OC, Jamison KR, Holmans P, Folstein SE, Ranade K, Friddle C, Botstein D, Marr T, Beaty TH, Zandi P, DePaulo JR (2003) Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage on 8q24, 18q22, 4q32, 2p12, and 13q12. Mol Psychiatry 8:288-298
40. McMahon FJ, Colin Stine O, Meyers DA, Simpson SG, DePaulo JR (1995) Patterns of maternal transmission in bipolar affective disorder. Am J Hum Genet 56:1277-1286
41. McMahon FJ, Simpson SG, McInnis MG, Badner JA, MacKinnon DF, DePaulo JR (2001) Linkage of bipolar disorder to chromosome 18q and the validity of bipolar II disorder. Arch Gen Psychiatry 58:1025-1031
42. Merikangas KR, Chakravarti A, Moldin SO, Araj H, Blangero JC, Burmeister M, Crabbe J Jr, Depaulo JR Jr, Foulks E, Freimer NB, Koretz DS, Lichtenstein W, Mignot E, Reiss AL, Risch NJ, Takahashi JS (2002) Future of genetics of mood disorders research. Biol Psychiatry 52:457-477
43. Morissette J, Villeneuve A, Bordeleau L, Rochette D, Laberge C, Gagne B, Laprise C, Bouchard G, Plante M, Gobeil L, Shink E, Weissenbach J, Barden N (1999) Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24. Am J Med Genet 88:567-587
44. Polymeropoulos MH, Schaffer AA (1996) Scanning the genome with 1772 microsatellite markers in search of a bipolar disorder susceptibility gene. Mol Psychiatry 1:404-407
45. Radhakrishna U, Senol S, Herken H, Gucuyener K, Gehrig C, Blouin JL, Akarsu NA, Antonarakis SE (2001) An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree. Eur J Hum Genet 9:39-44
46. Rice J, McDonald-Scott P, Endicott J, Coryell W, Grove WM, Keller MB, Altis D (1986) The stability of diagnosis with an application to BPII disorder. Psychiatry Res 19:285-296
47. Rice JP, Goate A, Williams JT, Bierut L, Dorr D, Wu W, Shears S, Gopalakrishnan G, Edenberg HJ, Foroud T, Nurnberger J Jr, Gershon ES, Detera-Wadleigh SD, Goldin LR, Guroff JJ, McMahon FJ, Simpson S, MacKinnon D, McInnis M, Stine OC, DePaulo JR, Blehar MC, Reich T (1997) Initial genome scan of the NIMH Genetics Initiative bipolar pedigrees: chromosomes 1, 6, 8, 10, and 12. Am J Med Genet 74:247-253
48. Roberts SB, MacLean CJ, Neale MC, Eaves LJ, Kendler KS (1999) Replication of linkage studies of complex traits: an examination of variation in location estimates. Am J Hum Genet 65:876-884
49. Segurado R, Gill M (2001) Genome-wide genetic linkage studies in bipolar disorder: review and meta-analysis. Am J Med Genet 105:580
50. Simpson SG, McMahon FJ, McInnis MG, MacKinnon DF, Edwin D, Folstein SE, DePaulo JR (2002) Diagnostic reliability of bipolar II disorder. Arch Gen Psychiatry 59:736-740
51. Stine OC, McMahon FJ, Chen L, Xu J, Meyers DA, MacKinnon DF, Simpson S, McInnis MG, Rice JP, Goate A, Reich T, Edenberg HJ, Foroud T, Nurnberger JI Jr, Detera-Wadleigh SD, Goldin LR, Guroff J, Gershon ES, Blehar MC, DePaulo JR (1997) Initial genome scan for bipolar disorder in the NIMH Genetics Initiative pedigrees: chromosomes 2, 11, 13, 14, and X. Am J Med Genet 74:263-269
52. Taylor L, Faraone SV, Tsuang MT (2002) Family, twin, and adoption studies of bipolar disease. Curr Psychiatry Rep 4:130-133
53. Todd RD (2002) Genetics of early onset bipolar affective disorder: are we making progress? Curr Psychiatry Rep 4:141-145
54. Turecki G, Grof P, Grof E, D'Souza V, Lebuis L, Marineau C, Cavazzoni P, Duffy A, Bétard C, Zvolský P, Robertson C, Brewer C, Hudson T, Rouleau GA, Alda M (2001) Mapping susceptibility genes for bipolar disorder: a pharmacogenetic approach based on excellent response to lithium. Mol Psychiatry 6:570-578
55. Wise LH, Lanchbury JS, Lewis CM (1999) Meta-analysis of genome searches. Ann Hum Genet 63:263-272