메뉴 건너뛰기




Volumn 64, Issue 1, 2014, Pages 7-15

Ethyl pyruvate ameliorates monocrotaline-induced pulmonary arterial hypertension in rats

Author keywords

ET 1; Ethyl pyruvate; IL 6; monocrotaline; pulmonary arterial hypertension; TNF

Indexed keywords

ENDOTHELIN 1; INTERLEUKIN 6; MONOCROTALINE; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ETHYL PYRUVATE;

EID: 84904265121     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000083     Document Type: Article
Times cited : (12)

References (64)
  • 1
    • 33751168945 scopus 로고    scopus 로고
    • Characterization of right ventricular function after monocrotaline- induced pulmonary hypertension in the intact rat
    • Hessel MH, Steendijk P, den Adel B, et al. Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat. Am J Physiol Heart Circ Physiol. 2006;291: H2424YH2430
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Hessel, M.H.1    Steendijk, P.2    Den Adel, B.3
  • 2
    • 12144263169 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension
    • author reply 308Y309
    • Huisman AM, Vreugdenhil SA, van Paassen HC. Treatment of pulmonary arterial hypertension. N Engl J Med. 2005;352:308Y309;author reply 308Y309
    • (2005) N Engl J Med , vol.352 , pp. 308-309
    • Huisman, A.M.1    Vreugdenhil, S.A.2    Van Paassen, H.C.3
  • 3
    • 4644290657 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension
    • Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med. 2004;351:1425Y1436
    • (2004) N Engl J Med , vol.351 , pp. 1425-1436
    • Humbert, M.1    Sitbon, O.2    Simonneau, G.3
  • 4
    • 33645104291 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: New insights and new hope
    • Martin KB, Klinger JR, Rounds SI. Pulmonary arterial hypertension: New insights and new hope. Respirology. 2006;11:6Y17
    • (2006) Respirology , vol.11 , pp. 6-17
    • Martin, K.B.1    Klinger, J.R.2    Rounds, S.I.3
  • 5
    • 33645522663 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension
    • Raiesdana A, Loscalzo J. Pulmonary arterial hypertension. Ann Med. 2006;38:95Y110
    • (2006) Ann Med , vol.38 , pp. 95-110
    • Raiesdana, A.1    Loscalzo, J.2
  • 6
    • 77954758530 scopus 로고    scopus 로고
    • Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era
    • Humbert M, Sitbon O, Chaouat A, et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation. 2010;122:156Y163
    • (2010) Circulation , vol.122 , pp. 156-163
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 7
    • 0031031440 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • Rubin LJ. Primary pulmonary hypertension. N Engl J Med. 1997;336: 111Y117
    • (1997) N Engl J Med , vol.336 , pp. 111-117
    • Rubin, L.J.1
  • 8
    • 29244486440 scopus 로고    scopus 로고
    • Oxidative damage to lens in culture: Reversibility by pyruvate and ethyl pyruvate
    • Varma SD, Hegde KR, Kovtun S. Oxidative damage to lens in culture: Reversibility by pyruvate and ethyl pyruvate. Ophthalmologica. 2006; 220:52Y57
    • (2006) Ophthalmologica , vol.220 , pp. 52-57
    • Varma, S.D.1    Hegde, K.R.2    Kovtun, S.3
  • 9
    • 33947496370 scopus 로고    scopus 로고
    • Ethyl pyruvate: A novel anti-inflammatory agent
    • Fink MP. Ethyl pyruvate: A novel anti-inflammatory agent. J Intern Med. 2007;261:349Y362
    • (2007) J Intern Med , vol.261 , pp. 349-362
    • Fink, M.P.1
  • 10
    • 0038001565 scopus 로고    scopus 로고
    • Ringer's ethyl pyruvate solution: A novel resuscitation fluid for the treatment of hemorrhagic shock and sepsis
    • Fink MP. Ringer's ethyl pyruvate solution: A novel resuscitation fluid for the treatment of hemorrhagic shock and sepsis. J Trauma. 2003;54: S141YS143
    • (2003) J Trauma , vol.54
    • Fink, M.P.1
  • 11
    • 0037125985 scopus 로고    scopus 로고
    • Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
    • Ulloa L, Ochani M, Yang H, et al. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A. 2002;99:12351Y12356
    • (2002) Proc Natl Acad Sci U S A. , vol.99 , pp. 12351-12356
    • Ulloa, L.1    Ochani, M.2    Yang, H.3
  • 12
    • 0036088799 scopus 로고    scopus 로고
    • Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock
    • Yang R, Gallo DJ, Baust JJ, et al. Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2002;283:G212YG221
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283
    • Yang, R.1    Gallo, D.J.2    Baust, J.J.3
  • 13
    • 84884213537 scopus 로고    scopus 로고
    • Protective effect of ethyl pyruvate on pancreas injury in rats with severe acute pancreatitis
    • Luan ZG, Ma XC, Zhang H, et al. Protective effect of ethyl pyruvate on pancreas injury in rats with severe acute pancreatitis. J Surg Res. 2013; 181:76Y84
    • (2013) J Surg Res , vol.181 , pp. 76-84
    • Luan, Z.G.1    Ma, X.C.2    Zhang, H.3
  • 14
    • 84876728493 scopus 로고    scopus 로고
    • Ethyl pyruvate significantly inhibits tumour necrosis factor a, interleukin 1b and high mobility group box 1 releasing and attenuates sodium taurocholate induced severe acute pancreatitis associated with acute lung injury
    • Luan ZG, Zhang J, Yin XH, et al. Ethyl pyruvate significantly inhibits tumour necrosis factor a, interleukin 1b and high mobility group box 1 releasing and attenuates sodium taurocholate induced severe acute pancreatitis associated with acute lung injury. Clin Exp Immunol. 2013;172: 417Y426
    • (2013) Clin Exp Immunol , vol.172 , pp. 417-426
    • Luan, Z.G.1    Zhang, J.2    Yin, X.H.3
  • 15
    • 3142759947 scopus 로고    scopus 로고
    • Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis
    • Yang R, Uchiyama T, Alber SM, et al. Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. Crit Care Med. 2004;32:1453Y1459
    • (2004) Crit Care Med , vol.32 , pp. 1453-1459
    • Yang, R.1    Uchiyama, T.2    Alber, S.M.3
  • 16
    • 84873908423 scopus 로고    scopus 로고
    • Ethyl pyruvate protects against experimental acute-on-chronic liver failure in rats
    • Wang LW, Wang LK, Chen H, et al. Ethyl pyruvate protects against experimental acute-on-chronic liver failure in rats. World J Gastroenterol. 2012; 18:5709Y5718
    • (2012) World J Gastroenterol , vol.18 , pp. 5709-5718
    • Wang, L.W.1    Wang, L.K.2    Chen, H.3
  • 17
    • 84878380896 scopus 로고    scopus 로고
    • Ethyl pyruvate ameliorates intracerebral hemorrhage induced brain injury through anti-cell death and antiinflammatory mechanisms
    • Su X, Wang H, Zhu L, et al. Ethyl pyruvate ameliorates intracerebral hemorrhage induced brain injury through anti-cell death and antiinflammatory mechanisms. Neuroscience. 2013
    • (2013) Neuroscience
    • Su, X.1    Wang, H.2    Zhu, L.3
  • 18
    • 73949136193 scopus 로고    scopus 로고
    • Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model
    • Shang GH, Lin D-J, Xiao W, et al. Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model. Respir Res. 2009;10:91
    • (2009) Respir Res , vol.10 , pp. 91
    • Shang, G.H.1    Lin, D.-J.2    Xiao, W.3
  • 19
    • 79954597263 scopus 로고    scopus 로고
    • Ethyl pyruvate reduces acute lung injury via regulation of inos and ho-1 expression in endotoxemic rats
    • Kung CW, Lee YM, Cheng PY, et al. Ethyl pyruvate reduces acute lung injury via regulation of inos and ho-1 expression in endotoxemic rats. J Surg Res. 2011;167:e323Ye331
    • (2011) J Surg Res , vol.167
    • Kung, C.W.1    Lee, Y.M.2    Cheng, P.Y.3
  • 20
    • 38449113261 scopus 로고    scopus 로고
    • Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation
    • Epperly M, Jin S, Nie S, et al. Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation. Radiat Res. 2007;168: 552Y559
    • (2007) Radiat Res , vol.168 , pp. 552-559
    • Epperly, M.1    Jin, S.2    Nie, S.3
  • 21
    • 78751629536 scopus 로고    scopus 로고
    • Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb ischemia and reperfusion
    • Alston TA. Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb ischemia and reperfusion. J Trauma 2011; 70:103Y110
    • (2011) J Trauma , vol.70 , pp. 103-110
    • Alston, T.A.1
  • 22
    • 78649935672 scopus 로고    scopus 로고
    • Effects of ethyl pyruvate and other a-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion
    • Cruz RJ Jr, Harada T, Sasatomi E, et al. Effects of ethyl pyruvate and other a-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion. J Surg Res. 2011;165:151Y157
    • (2011) J Surg Res , vol.165 , pp. 151-157
    • Cruz Jr., R.J.1    Harada, T.2    Sasatomi, E.3
  • 23
    • 84855192732 scopus 로고    scopus 로고
    • Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats
    • Hu X, Cui B, Zhou X, et al. Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Mol Biol Rep. 2012;39:227Y231
    • (2012) Mol Biol Rep , vol.39 , pp. 227-231
    • Hu, X.1    Cui, B.2    Zhou, X.3
  • 24
    • 0344309146 scopus 로고    scopus 로고
    • Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion
    • Uchiyama T, Delude RL, Fink MP. Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion. Intensive Care Med. 2003;29:2050Y2058
    • (2003) Intensive Care Med , vol.29 , pp. 2050-2058
    • Uchiyama, T.1    Delude, R.L.2    Fink, M.P.3
  • 25
    • 51349142546 scopus 로고    scopus 로고
    • Ethyl pyruvate has an anti-inflammatory effect by inhibiting ros-dependent stat signaling in activated microglia
    • Kim HS, Cho IH, Kim JE, et al. Ethyl pyruvate has an anti-inflammatory effect by inhibiting ros-dependent stat signaling in activated microglia. Free Radic Biol Med. 2008;45:950Y963
    • (2008) Free Radic Biol Med , vol.45 , pp. 950-963
    • Kim, H.S.1    Cho, I.H.2    Kim, J.E.3
  • 26
    • 79952039854 scopus 로고    scopus 로고
    • Ethyl pyruvate, an anti-inflammatory agent, inhibits tumor angiogenesis through inhibition of the nf-kb signaling pathway
    • Park SY, Yi EY, Jung M, et al. Ethyl pyruvate, an anti-inflammatory agent, inhibits tumor angiogenesis through inhibition of the nf-kb signaling pathway. Cancer Lett. 2011;303:150Y154
    • (2011) Cancer Lett , vol.303 , pp. 150-154
    • Park, S.Y.1    Yi, E.Y.2    Jung, M.3
  • 27
    • 0031925331 scopus 로고    scopus 로고
    • Platelet-derived growth factor expression in primary pulmonary hypertension: Comparison of HIV seropositive and HIV seronegative patients
    • Humbert M, Monti G, Fartoukh M, et al. Platelet-derived growth factor expression in primary pulmonary hypertension: Comparison of HIV seropositive and HIV seronegative patients. Eur Respir J. 1998;11:554Y559
    • (1998) Eur Respir J. , vol.11 , pp. 554-559
    • Humbert, M.1    Monti, G.2    Fartoukh, M.3
  • 28
    • 66949118228 scopus 로고    scopus 로고
    • Interleukin-6 modulates the expression of the bone morphogenic protein receptor type ii through a novel stat3YmicroRNA cluster 17/92 pathway
    • Brock M, Trenkmann M, Gay RE, et al. Interleukin-6 modulates the expression of the bone morphogenic protein receptor type ii through a novel stat3YmicroRNA cluster 17/92 pathway. Circ Res. 2009;104: 1184Y1191
    • (2009) Circ Res , vol.104 , pp. 1184-1191
    • Brock, M.1    Trenkmann, M.2    Gay, R.E.3
  • 29
    • 59849118025 scopus 로고    scopus 로고
    • Interleukin-6 overexpression induces pulmonary hypertension
    • Steiner MK, Syrkina OL, Kolliputi N, et al. Interleukin-6 overexpression induces pulmonary hypertension. Circ Res. 2009;104:236Y244
    • (2009) Circ Res , vol.104 , pp. 236-244
    • Steiner, M.K.1    Syrkina, O.L.2    Kolliputi, N.3
  • 30
    • 0036893519 scopus 로고
    • Pulmonary hypertension in TNF-aoverexpressing mice is associated with decreased VEGF gene expression
    • Fujita M, Mason RJ, Cool C, et al. Pulmonary hypertension in TNF-aoverexpressing mice is associated with decreased VEGF gene expression. J Appl Physiol (1985). 2002;93:2162Y2170
    • (1985) J Appl Physiol , vol.2002 , Issue.93 , pp. 2162-2170
    • Fujita, M.1    Mason, R.J.2    Cool, C.3
  • 31
    • 38949159715 scopus 로고    scopus 로고
    • Ethyl pyruvate inhibits hypoxic pulmonary vasoconstriction and attenuates pulmonary artery cytokine expression
    • Tsai BM, Lahm T, Morrell ED, et al. Ethyl pyruvate inhibits hypoxic pulmonary vasoconstriction and attenuates pulmonary artery cytokine expression. J Surg Res. 2008;145:130Y134
    • (2008) J Surg Res , vol.145 , pp. 130-134
    • Tsai, B.M.1    Lahm, T.2    Morrell, E.D.3
  • 33
    • 0031798967 scopus 로고    scopus 로고
    • Enos expression is not altered in pulmonary vascular remodeling due to increased pulmonary blood flow
    • Everett AD, Le Cras TD, Xue C, et al. Enos expression is not altered in pulmonary vascular remodeling due to increased pulmonary blood flow. Am J Physiol. 1998;274:L1058YL1065
    • (1998) Am J Physiol , vol.274
    • Everett, A.D.1    Le Cras, T.D.2    Xue, C.3
  • 34
    • 78649734109 scopus 로고    scopus 로고
    • Transforming growth factor-b inhibition attenuates pulmonary arterial hypertension in rats
    • Megalou AJ, Glava C, Oikonomidis DL, et al. Transforming growth factor-b inhibition attenuates pulmonary arterial hypertension in rats. Int J Clin Exp Med. 2010;3:332
    • (2010) Int J Clin Exp Med , Issue.3 , pp. 332
    • Megalou, A.J.1    Glava, C.2    Oikonomidis, D.L.3
  • 35
    • 0027410863 scopus 로고
    • Endothelin-1 in primary pulmonary hypertension and the eisenmenger syndrome
    • Cacoub P, Dorent R, Maistre G, et al. Endothelin-1 in primary pulmonary hypertension and the eisenmenger syndrome. Am J Cardiol. 1993;71: 448Y450
    • (1993) Am J Cardiol , vol.71 , pp. 448-450
    • Cacoub, P.1    Dorent, R.2    Maistre, G.3
  • 36
    • 0029055964 scopus 로고
    • Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
    • Giaid A, Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med. 1995;333:214Y221
    • (1995) N Engl J Med , vol.333 , pp. 214-221
    • Giaid, A.1    Saleh, D.2
  • 37
    • 0033614831 scopus 로고    scopus 로고
    • Continuous infusion of epoprostenol improves the net balance between pulmonary endothelin-1 clearance and release in primary pulmonary hypertension
    • Langleben D, Barst RJ, Badesch D, et al. Continuous infusion of epoprostenol improves the net balance between pulmonary endothelin-1 clearance and release in primary pulmonary hypertension. Circulation. 1999;99:3266Y3271
    • (1999) Circulation , vol.99 , pp. 3266-3271
    • Langleben, D.1    Barst, R.J.2    Badesch, D.3
  • 38
    • 0019198926 scopus 로고
    • Prostacyclin for pulmonary hypertension
    • Szczeklik J, Szczeklik A, Nizankowski R. Prostacyclin for pulmonary hypertension. Lancet. 1980;316:1076. (Pubitemid 11225358)
    • (1980) Lancet , vol.2 , Issue.8203 , pp. 1076
    • Szczeklik, J.1    Szczeklik, A.2    Nizankowski, R.3
  • 39
    • 80052459025 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFa contributes to the pathogenesis of pulmonary arterial hypertension
    • Sutendra G, Dromparis P, Bonnet S, et al. Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFa contributes to the pathogenesis of pulmonary arterial hypertension. J Mol Med. 2011;89:771Y783
    • (2011) J Mol Med , vol.89 , pp. 771-783
    • Sutendra, G.1    Dromparis, P.2    Bonnet, S.3
  • 40
    • 84890601822 scopus 로고    scopus 로고
    • Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension
    • Archer SL, Fang YH, Ryan JJ, et al. Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension. Pulm Circ. 2013;3:144
    • (2013) Pulm Circ , Issue.3 , pp. 144
    • Archer, S.L.1    Fang, Y.H.2    Ryan, J.J.3
  • 41
    • 84891671691 scopus 로고    scopus 로고
    • Foxo1-mediated upregulation of pyruvate dehydrogenase kinase-4 (pdk4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: Therapeutic benefits of dichloroacetate
    • Piao L, Sidhu VK, Fang YH, et al. Foxo1-mediated upregulation of pyruvate dehydrogenase kinase-4 (pdk4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: Therapeutic benefits of dichloroacetate. J Mol Med. 2013;91:333Y346
    • (2013) J Mol Med , vol.91 , pp. 333-346
    • Piao, L.1    Sidhu, V.K.2    Fang, Y.H.3
  • 42
    • 75749133554 scopus 로고    scopus 로고
    • The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: Resuscitating the hibernating right ventricle
    • Piao L, Fang YH, Cadete VJ, et al. The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: Resuscitating the hibernating right ventricle. J Mol Med. 2010;88:47Y60
    • (2010) J Mol Med , vol.88 , pp. 47-60
    • Piao, L.1    Fang, Y.H.2    Cadete, V.J.3
  • 43
    • 26944449700 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain
    • Kim JB, Yu YM, Kim SW, et al. Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. Brain Res. 2005;1060:188Y192
    • (2005) Brain Res , vol.1060 , pp. 188-192
    • Kim, J.B.1    Yu, Y.M.2    Kim, S.W.3
  • 44
    • 33748369338 scopus 로고    scopus 로고
    • Short-term administration of a cell-permeable caveolin-1 peptide prevents the development of monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy
    • Jasmin JF, Mercier I, Dupuis J, et al. Short-term administration of a cell-permeable caveolin-1 peptide prevents the development of monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy. Circulation. 2006;114:912Y920
    • (2006) Circulation , vol.114 , pp. 912-920
    • Jasmin, J.F.1    Mercier, I.2    Dupuis, J.3
  • 45
    • 4544243724 scopus 로고    scopus 로고
    • Disruption of endothelial-cell caveolin-1a/raft scaffolding during development of monocrotaline-induced pulmonary hypertension
    • Mathew R, Huang J, Shah M, et al. Disruption of endothelial-cell caveolin-1a/raft scaffolding during development of monocrotaline-induced pulmonary hypertension. Circulation. 2004;110:1499Y1506
    • (2004) Circulation , vol.110 , pp. 1499-1506
    • Mathew, R.1    Huang, J.2    Shah, M.3
  • 46
    • 4644243924 scopus 로고    scopus 로고
    • Jtv-506, a new katp channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats
    • Tsutsumi Y, Makita T, Yamaguchi K, et al. Jtv-506, a new katp channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats. J Anesth. 2004;18:210Y215
    • (2004) J Anesth , vol.18 , pp. 210-215
    • Tsutsumi, Y.1    Makita, T.2    Yamaguchi, K.3
  • 47
    • 0031806339 scopus 로고    scopus 로고
    • Type v phosphodiesterase inhibition modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric oxide synthase in pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension
    • Takahashi T, Kanda T, Sumino H, et al. Type v phosphodiesterase inhibition modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric oxide synthase in pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension. Res Exp Med. 1998; 197:319Y328
    • (1998) Res Exp Med , vol.197 , pp. 319-328
    • Takahashi, T.1    Kanda, T.2    Sumino, H.3
  • 48
    • 84866547287 scopus 로고    scopus 로고
    • Analysis of endothelin-1 and endothelin-1 receptor a gene polymorphisms in patients with pulmonary arterial hypertension
    • Calabrò P, Limongelli G, Maddaloni V, et al. Analysis of endothelin-1 and endothelin-1 receptor a gene polymorphisms in patients with pulmonary arterial hypertension. Intern Emerg Med. 2012;7:425Y430
    • (2012) Intern Emerg Med , vol.7 , pp. 425-430
    • Calabrò, P.1    Limongelli, G.2    Maddaloni, V.3
  • 49
    • 0029847636 scopus 로고    scopus 로고
    • Pulmonary clearance of circulating endothelin-1 in dogs in vivo: Exclusive role of etbreceptors
    • Dupuis J, Goresky CA, Fournier A. Pulmonary clearance of circulating endothelin-1 in dogs in vivo: Exclusive role of etbreceptors. J Appl Physiol. 1996;81:1510Y1515
    • (1996) J Appl Physiol , vol.81 , pp. 1510-1515
    • Dupuis, J.1    Goresky, C.A.2    Fournier, A.3
  • 50
    • 0025985055 scopus 로고
    • Distribution of endothelin-like immunoreactivity and mrna in the developing and adult human lung
    • Giaid A, Polak JM, Gaitonde V, et al. Distribution of endothelin-like immunoreactivity and mrna in the developing and adult human lung. Am J Respir Cell Mol Biol. 1991;4:50Y58
    • (1991) Am J Respir Cell Mol Biol , vol.4 , pp. 50-58
    • Giaid, A.1    Polak, J.M.2    Gaitonde, V.3
  • 51
    • 0027324745 scopus 로고
    • Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
    • Giaid A, Yanagisawa M, Langleben D, et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med. 1993;328:1732Y1739
    • (1993) N Engl J Med , vol.328 , pp. 1732-1739
    • Giaid, A.1    Yanagisawa, M.2    Langleben, D.3
  • 52
    • 0026034713 scopus 로고
    • Increased plasma endothelin-1 in pulmonary hypertension: Marker or mediator of disease?
    • Stewart DJ, Levy RD, Cernacek P, et al. Increased plasma endothelin-1 in pulmonary hypertension: Marker or mediator of disease?. Ann Intern Med. 1991;114:464Y469
    • (1991) Ann Intern Med , vol.114 , pp. 464-469
    • Stewart, D.J.1    Levy, R.D.2    Cernacek, P.3
  • 53
    • 0027449163 scopus 로고
    • Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension
    • Miyauchi T, Yorikane R, Sakai S, et al. Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension. Circ Res. 1993;73:887Y897
    • (1993) Circ Res , vol.73 , pp. 887-897
    • Miyauchi, T.1    Yorikane, R.2    Sakai, S.3
  • 54
    • 0029585482 scopus 로고
    • Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow
    • Wong J, Reddy VM, Hendricks-Munoz K, et al. Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol. 1995;269:H1965YH1972
    • (1995) Am J Physiol , vol.269
    • Wong, J.1    Reddy, V.M.2    Hendricks-Munoz, K.3
  • 55
    • 0030862759 scopus 로고
    • Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats
    • Hill NS, Warburton RR, Pietras L, et al. Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats. J Appl Physiol (1985). 1997;83:1209Y1215
    • (1985) J Appl Physiol , vol.1997 , Issue.83 , pp. 1209-1215
    • Hill, N.S.1    Warburton, R.R.2    Pietras, L.3
  • 56
    • 0035895324 scopus 로고    scopus 로고
    • Effectiveness of a nonselective eta/b and a selective eta antagonist in rats with monocrotaline-induced pulmonary hypertension
    • Jasmin JF, Lucas M, Cernacek P, et al. Effectiveness of a nonselective eta/b and a selective eta antagonist in rats with monocrotaline-induced pulmonary hypertension. Circulation. 2001;103:314Y318
    • (2001) Circulation , vol.103 , pp. 314-318
    • Jasmin, J.F.1    Lucas, M.2    Cernacek, P.3
  • 57
    • 0032474287 scopus 로고    scopus 로고
    • EndothelinA receptor blockade improves nitric oxideYmediated vasodilation in monocrotaline-induced pulmonary hypertension
    • Prié S, Stewart DJ, Dupuis J. EndothelinA receptor blockade improves nitric oxideYmediated vasodilation in monocrotaline-induced pulmonary hypertension. Circulation. 1998;97:2169Y2174
    • (1998) Circulation , vol.97 , pp. 2169-2174
    • Prié, S.1    Stewart, D.J.2    Dupuis, J.3
  • 58
    • 0037432296 scopus 로고    scopus 로고
    • Bosentan for the prevention of overcirculation-induced experimental pulmonary arterial hypertension
    • Rondelet B, Kerbaul F, Motte S, et al. Bosentan for the prevention of overcirculation-induced experimental pulmonary arterial hypertension. Circulation. 2003;107:1329Y1335
    • (2003) Circulation , vol.107 , pp. 1329-1335
    • Rondelet, B.1    Kerbaul, F.2    Motte, S.3
  • 59
    • 33646255654 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan
    • Barst RJ, Langleben D, Badesch D, et al. Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. J Am Coll Cardiol. 2006;47:2049Y2056
    • (2006) J Am Coll Cardiol , vol.47 , pp. 2049-2056
    • Barst, R.J.1    Langleben, D.2    Badesch, D.3
  • 60
    • 0036283401 scopus 로고    scopus 로고
    • Clinical efficacy of sitaxsentan, an endothelin - A receptor antagonist, in patients with pulmonary arterial hypertension: Open-label pilot study
    • Barst RJ, Rich S, Widlitz A, et al. Clinical efficacy of sitaxsentan, an endothelin-a receptor antagonist, in patients with pulmonary arterial hypertension: Open-label pilot study. Chest. 2002;121:1860Y1868
    • (2002) Chest , vol.121 , pp. 1860-1868
    • Barst, R.J.1    Rich, S.2    Widlitz, A.3
  • 61
    • 0035818316 scopus 로고    scopus 로고
    • Effects of the dual endothelinreceptor antagonist bosentan in patients with pulmonary hypertension: A randomised placebocontrolled study
    • Channick RN, Simonneau G, Sitbon O, et al. Effects of the dual endothelinreceptor antagonist bosentan in patients with pulmonary hypertension: A randomised placebocontrolled study. Lancet. 2001;358:1119Y1123
    • (2001) Lancet , vol.358 , pp. 1119-1123
    • Channick, R.N.1    Simonneau, G.2    Sitbon, O.3
  • 62
    • 0037149718 scopus 로고    scopus 로고
    • Bosentan therapy for pulmonary arterial hypertension
    • Rubin LJ, Badesch DB, Barst RJ, et al. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med. 2002;346:896Y903
    • (2002) N Engl J Med , vol.346 , pp. 896-903
    • Rubin, L.J.1    Badesch, D.B.2    Barst, R.J.3
  • 63
    • 84856779653 scopus 로고    scopus 로고
    • Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension
    • Sandoval J, Torbicki A, Souza R, et al. Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension. Pulm Pharmacol Ther. 2012;25:33Y39
    • (2012) Pulm Pharmacol Ther , vol.25 , pp. 33-39
    • Sandoval, J.1    Torbicki, A.2    Souza, R.3
  • 64
    • 0037484589 scopus 로고    scopus 로고
    • Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: A 1-year follow-up study
    • Sitbon O, Badesch DB, Channick RN, et al. Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: A 1-year follow-up study. Chest. 2003;124:247Y254
    • (2003) Chest , vol.124 , pp. 247-254
    • Sitbon, O.1    Badesch, D.B.2    Channick, R.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.