Ethyl pyruvate reduces acute lung injury via regulation of iNOS and HO-1 expression in endotoxemic rats

Journal of Surgical Research

Volumn 167, Issue 2, 2011, Pages

  Kung, Ching Wen ^a,b   Lee, Yen Mei ^a   Cheng, Pao Yun ^c   Peng, Yi Jen ^d   Yen, Mao Hsiung ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TZU CHI COLLEGE OF TECHNOLOGY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

acute lung injury; ethyl pyruvate; heme oxygenase 1; iNOS; lipopolysaccharide

Indexed keywords

HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRATE; NITRIC OXIDE; NITRITE; PROTOPORPHYRIN TIN; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; DRUG EFFECT; EDEMA; ENDOTOXEMIA; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ACUTE LUNG INJURY; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; ENZYME INHIBITORS; HEME OXYGENASE-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; METALLOPORPHYRINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NITRIC OXIDE SYNTHASE TYPE II; PROTOPORPHYRINS; PYRUVATES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79954597263     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.01.006     Document Type: Article

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