Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis

Critical Care Medicine

Volumn 32, Issue 7, 2004, Pages 1453-1459

  Yang, Runkuan ^a   Uchiyama, Takashi ^a   Alber, Sean M ^a   Han, Xiaonan ^a   Watkins, Simon K ^a   Delude, Russell L ^a   Fink, Mitchell P ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Critical Therapeutics Inc   (United States)

Author keywords

Acute pancreatitis; Anti inflammatory agent; Disease severity; Ethyl pyruvate; Murine model

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIINFLAMMATORY AGENT; BACTERIUM LIPOPOLYSACCHARIDE; CERULETIDE; CHOLINE; ETHIONINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MESSENGER RNA; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; RINGER LACTATE SOLUTION; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ACUTE HEMORRHAGIC PANCREATITIS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL TRANSLOCATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA BINDING; DRUG EFFECT; LIVER INJURY; LUNG INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL TIME; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ISOTONIC SOLUTIONS; MALE; MICE; MICE, INBRED C57BL; PANCREATITIS, ACUTE NECROTIZING; PYRUVATES; RESPIRATORY DISTRESS SYNDROME, ADULT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 3142759947     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000130835.65462.06     Document Type: Article

References (36)

1. Eland IA, Sturkenboom MJ, Wilson JH, et al: Incidence and mortality of acute pancreatitis between 1985 and 1995. Scand J Gastroenterol 2000; 35:1110-1116
2. Gukovsky I, Gukovsky AS, Blinman TA, et al: Early NF-kappaB activation is associated with hormone-induced pancreatitis. Am J Physiol 1998; 275:G1402-G1414
3. Ethridge RT, Hashimoto K, Chung DH, et al: Selective inhibition of NF-kappaB attenuates the severity of cerulein-induced acute pancreatitis. J Am Coll Surg 2002; 195:497-505
4. Ulloa L, Ochani M, Yang H, et al: Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Nat Acad Sci U S A 2002; 99: 12351-12356
5. Sappington PL, Han X, Yang R, et al: Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated Caco-2 enterocytic monolayers. J Pharmacol Exp Ther 2003; 304:464-476
6. Yang R, Gallo DJ, Baust JJ, et al: Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 2002; 283:G212-G222
7. Miyaji T, Hu X, Yuen PST, et al: Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int 2003; 64:1620-1631
8. Niederau C, Luthen R, Niederau MC, et al: Acute experimental hemorrhagic-necrotizing pancreatitis induced by feeding a choline-deficient, ethionine-supplemented diet. Methodology and standards. Eur Surg Res 1992; 24(Suppl 1):40-54
9. Powers RE, Grady T, Orchard JL, et al: Different effects of hyperstimulation by similar classes of secretagogues on the exocrine pancreas. Pancreas 1993; 8:58-63
10. Kikuchi Y, Shimosegawa T, Satoh A, et al: The role of nitric oxide in mouse cerulein-induced pancreatitis with and without lipopolysaccharide pretreatment. Pancreas 1996; 12:68-75
11. Vaccaro MI, Calvo EL, Suburo AM, et al: Lipopolysaccharide directly affects pancreatic acinar cells: implications on acute pancreatitis pathophysiology. Dig Dis Sci 2000; 45:915-926
12. Winslet M, Hall C, London JJ, et al: Relation of diagnostic serum amylase levels to aetiology and severity of acute pancreatitis. Gut 1992; 34:982-986
13. Pezzilli R, Billi P, Miglioli M, et al: Serum amylase and lipase concentrations and lipase/amylase ratio in assessment of etiology and severity of acute pancreatitis. Dig Dis Sci 1993; 38:1265-1269
14. Puolakkainen PA: Early assessment of acute pancreatitis. A comparative study of computed tomography and laboratory tests. Acta Chir Scand 1989; 155:25-30
15. Imrie CW, Ferguson JC, Murphy D, et al: Arterial hypoxia in acute pancreatitis. Br J Surg 1977; 64:185-188
16. Ranson JH, Turner JW, Roses DF, et al: Respiratory complications in acute pancreatitis. Ann Surg 1974; 179:557-566
17. Tenner S, Sica G, Hughes M, et al: Relationship of necrosis to organ failure in severe acute pancreatitis. Gastroenterology 1997; 113:899-903
18. Bernard GR, Luce JM, Sprung CL, et al: High-dose corticosteroids in patients with the adult respiratory distress syndrome. N Engl J Med 1987; 317:1565-1570
19. Ammori BJ, Leeder PC, King RFGJ, et al: Early increase in intestinal permeability in patients with severe acute pancreatitis: Correlation with endotoxemia, organ failure, and mortality. J Gastrointest Surg 1999; 3:252-262
20. Norman J: The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998; 175:76-83
21. Vaquero E, Gukovsky I, Zaninovic V, et al: Localized pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol 2001; 280:G1197-G1208
22. Steinle AU, Weidenbach H, Wagner M, et al: NF-kappaB/Rel activation in cerulein pancreatitis. Gastroenterology 1999; 116:420-430
23. Rakonczay Z, Jarmay K, Kaszaki J, et al: NF-kappaB activation is detrimental in arginine-induced acute pancreatitis. Free Radic Biol Med 2003; 34:696-709
24. Yang R, Han X, Delude RL, et al: Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice. J Lab Clin Med 2003; 142:322-331
25. Bunton CA: Oxidation of a-diketones and a-keto-acids by hydrogen peroxide. Nature 1949; 163:144
26. Constantopoulos G, Barranger JA: Non-enzymatic decarboxylation of pyruvate. Anal Biochem 1984; 139:353-358
27. Crestanello JA, Lingle DM, Millili J, et al: Pyruvate improves myocardial tolerance to reperfusion injury by acting as an antioxidant: A chemiluminescence study. Surgery 2001; 124:92-99
28. Tawadrous ZS, Delude RL, Fink MP: Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats. Shock 2002; 17: 473-477
29. Song M, Kellum JA, Kaldas H, et al: Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured LPS-stimulated RAW 264.7 cells. J Pharmacol Exp Ther 2004; 308:307-331
30. Altavilla D, Famulari C, Passaniti M, et al: Lipid peroxidation inhibition reduces NF-kappaB activation and attenuates cerulein-induced pancreatitis. Free Radic Res 2003; 37:425-435
31. Qi W, Tan DX, Reiter RJ, et al: Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats. Dig Dis Sci 1999; 44:2257-2262
32. Yu JH, Lim JW, Namkung W, et al: Suppression of cerulein-induced cytokine expression by antioxidants in pancreatic acinar cells. Lab Invest 2002; 82:1359-1368
33. Kefer J, Rahman A, Anwar KN, et al: Decreased oxidant buffering impairs NF-kappaB activation and ICAM-1 transcription in endothelial cells. Shock 2001; 15:11-15
34. Fan J, Shek PN, Suntres ZE, et al: Liposomal antioxidants provide prolonged protection against acute respiratory distress syndrome. Surgery 2000; 128:332-338
35. Nathens AB, Bitar R, Watson RW, et al: Thiol-mediated regulation of ICAM-1 expression in endotoxin-induced acute lung injury. J Immunol 1998; 160:2959-2966
36. Nathens AB, Marshall JC, Watson RW, et al: Diethylmaleate attenuates endotoxin-induced lung injury. Surgery 1996; 120: 360-366