Effects of ethyl pyruvate and other α-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion

Journal of Surgical Research

Volumn 165, Issue 1, 2011, Pages 151-157

  Cruz Jr , Ruy J ^a   Harada, Tomoyuki ^a   Sasatomi, Eizaburo ^a   Fink, Mitchell P ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Ethyl pyruvate; Intestinal; Ischemia; Permeability; Pyruvate; Reperfusion; Resuscitation

Indexed keywords

ALANINE AMINOTRANSFERASE; CARBOXYLIC ACID DERIVATIVE; MALONALDEHYDE; PARAHYDROXYPHENYL PYRUVATE; PHENYLGLYOXYLIC ACID; PYRUVATE SODIUM; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; RINGER LACTATE SOLUTION; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; HYPOTENSION; INTESTINE MUCOSA PERMEABILITY; ISCHEMIA; LIPOPHILICITY; MALE; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; RAT; REPERFUSION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD PRESSURE; CYTOPROTECTION; DISEASE MODELS, ANIMAL; FLUID THERAPY; GLYOXYLATES; INTESTINAL MUCOSA; ISCHEMIA; LIPID PEROXIDATION; LIVER; MALE; MANDELIC ACIDS; PERMEABILITY; PHENYLPYRUVIC ACIDS; PYRUVATES; RATS; REPERFUSION INJURY; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78649935672     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2009.07.008     Document Type: Article

References (32)

1. R. Venkataraman, J.A. Kellum, and M. Song Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock Shock 18 2002 507
2. L. Ulloa, M. Ochani, and H. Yang Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation Proc Natl Acad Sci USA 99 2002 12351
3. F. Su, Z. Wang, and Y. Cai Beneficial effects of ethyl pyruvate in septic shock from peritonitis Arch Surg 142 2007 166
4. T. Harada, B.A. Moore, and R. Yang Ethyl pyruvate ameliorates ileus induced by bowel manipulation in mice Surgery 138 2005 530
5. Y.Q. Dong, Y.M. Yao, and P. Wei Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17 2005 12
6. M. Karabeyolu, B. Unal, and B. Bozkurt The effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injury J Surg Res 144 2008 59
7. R. Yang, T. Uchiyama, and S.M. Alber Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis Crit Care Med 32 2004 1453
8. C.A. Sims, S. Wattanasirichaigoon, and M.J. Menconi Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats Crit Care Med 29 2001 1513
9. T. Uchiyama, R.L. Delude, and M.P. Fink Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion Intensive Care Med 29 2003 2050
10. A. Tsung, T. Kaizu, and A. Nakao Ethyl pyruvate ameliorates liver ischemia-reperfusion injury by decreasing hepatic necrosis and apoptosis Transplantation 79 2005 196
11. R. Yang, T. Uchiyama, and S.K. Watkins Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis Shock 22 2004 369
12. Z.S. Tawadrous, R.L. Delude, and M.P. Fink Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats Shock 17 2002 473
13. R. Yang, D.J. Gallo, and J.J. Baust Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock Am J Physiol Gastrointest Liver Physiol 283 2002 G212
14. P.L. Sappington, X. Han, and R. Yang Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers J Pharmacol Exp Ther 304 2003 464
15. R. Yang, X. Han, and R.L. Delude Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice J Lab Clin Med 142 2003 322
16. S.D. Varma, P.S. Devamanoharan, and A.H. Ali Prevention of intracellular oxidative stress to lens by pyruvate and its ester Free Radic Res 28 1998 131
17. Y. Chi, J. Duan, and X. Qi Electrochemical study on the keto-enol tautomerization of p-hydroxyphenylpyruvic acid in aqueous solution Bioelectrochemistry 60 2003 37
18. S. Wattanasirichaigoon, M.J. Menconi, and R.L. Delude Effect of mesenteric ischemia and reperfusion or hemorrhagic shock on intestinal mucosal permeability and ATP content in rats Shock 12 1999 127
19. P. Sileri, S. Schena, and S. Morini Pyruvate inhibits hepatic ischemia-reperfusion injury in rats Transplantation 72 2001 27
20. R. Bünger, R.T. Mallet, and D.A. Hartman Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Near-complete prevention of reperfusion contractile failure Eur J Biochem 180 1989 221
21. L. Cicalese, K. Lee, and W. Schraut Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine Am J Surg 171 1996 97
22. C.M. Montgomery, and J.L. Webb Metabolic studies on heart mitochondria. II. The inhibitory action of parapyruvate on the tricarboxylic acid cycle J Biol Chem 221 1956 359
23. A.S. Johansson, K. Johansson-Haque, and S. Okret Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-κB pathway Br J Pharmacol 154 2008 1318
24. J. Zeng, J. Liu, and G.Y. Yang Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices Anesthesiology 107 2007 630
25. J.B. Kim, Y.M. Yu, and S.W. Kim Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain Brain Res 1060 2005 188
26. P.L. Sappington, R.J. Cruz Jr., and T. Harada The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro Biochem Pharmacol 70 2005 1579
27. J. O'Donnell-Tormey, C.F. Nathan, and K. Lanks Secretion of pyruvate. An antioxidant defense of mammalian cells J Exp Med 165 1987 500
28. K.A. Brand, and U. Hermfisse Aerobic glycolysis by proliferating cells: A protective strategy against reactive oxygen species FASEB J 11 1997 388
29. P. Dobsak, C. Courderot-Masuyer, and M. Zeller Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia J Cardiovasc Pharmacol 34 1999 651
30. Y.H. Jo, W.Y. Kwon, and J.H. Lee The effect of ethyl pyruvate on dapsone-induced methemoglobinemia in rats Clin Toxicol 46 2008 811
31. S. Payabvash, S. Kiumehr, and S.M. Tavangar Ethyl pyruvate reduces germ cell-specific apoptosis and oxidative stress in rat model of testicular torsion/detorsion J Pediatr Surg 43 2008 705
32. M. Hollenbach, A. Hintersdorf, and K. Huse Ethyl pyruvate and ethyl lactate down-regulate the production of pro-inflammatory cytokines and modulate expression of immune receptors Biochem Pharmacol 76 2008 631