Molecular Epidemiology and Population Structure of Toxoplasma gondii

Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition

Volumn , Issue , 2013, Pages 61-97

  Dardé, Marie Laure ^a   Ajzenberg, Daniel ^a   Su, Chunlei ^b  

^a UNIVERSITY OF LIMOGES   (France)

^b University of Tennessee   (United States)

Author keywords

Genetic marker; Microsatellite; Polymerase chain reaction restriction fragment length polymorphism (PCR RFLP); Population genetics; Single nucleotide polymorphisms (SNP)

Indexed keywords

EID: 84904080891     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-396481-6.00003-9     Document Type: Chapter

References (158)

1. Ajzenberg D., Cogné N., Paris L., et al. Genotype of 86 Toxoplasma gondii isolates associated with human congenital toxoplasmosis, and correlation with clinical findings. J. Infect. Dis. 2002, 186:684-689.
2. Ajzenberg D., Banuls A.L., Tibayrenc M., Darde M.L. Microsatellite analysis of Toxoplasma gondii shows considerable polymorphism structured into two main clonal groups. Int. J. Parasitol. 2002, 32:27-38.
3. Ajzenberg D., Banuls A.L., Su C., et al. Genetic diversity, clonality and sexuality in. Toxoplasma gondii. Int. J. Parasitol. 2004, 34:1185-1196.
4. Ajzenberg D., Year H., Marty P., et al. Genotype of 88 Toxoplasma gondii isolates associated with toxoplasmosis in immunocompromised patients and correlation with clinical findings. J. Infect. Dis. 2009, 199:1155-1167.
5. Ajzenberg D. Type I strains in human toxoplasmosis: myth or reality?. Future Microbiol. 2010, 5:841-843.
6. Ajzenberg D., Collinet F., Mercier A., Vignoles P., Darde M.L. Genotyping of Toxoplasma gondii isolates with 15 microsatellite markers in a single multiplex PCR assay. J. Clin. Microbiol. 2010, 48:4641-4645.
7. Ajzenberg D. High burden of congenital toxoplasmosis in the United States: the strain hypothesis?. Clin. Infect. Dis. 2012, 54:1606-1607.
8. Al-Qassab S., Reichel M.P., Su C., et al. Isolation of Toxoplasma gondii from the brain of a dog in Australia and its biological and molecular characterization. Vet. Parasitol. 2009, 164:335-339.
9. Al-Kappany Y.M., Rajendran C., Abu-Elwafa S.A., Hilali M., Su C., Dubey J.P. Genetic diversity of Toxoplasma gondii isolates in Egyptian feral cats reveals new genotypes. J. Parasitol. 2010, 96:1112-1114.
10. Aubert D., Ajzenberg D., Richomme C., et al. Molecular and biological characteristics of Toxoplasma gondii isolates from wildlife in France. Vet. Parasitol. 2010, 171:346-349.
11. Barragan A., Sibley L.D. Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence. J. Exp. Med. 2002, 195:1625-1633.
12. Barragan A., Sibley L.D. Migration of Toxoplasma gondii across biological barriers. Trends Microbiol. 2003, 11:426-430.
13. Behnke M.S., Khan A., Wootton J.C., Dubey J.P., Tang K., Sibley L.D. Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases. Proc. Natl. Acad. Sci. USA 2011, 108:9631-9636.
14. Blackston C.R., Dubey J.P., Dotson E., et al. High-resolution typing of Toxoplasma gondii using microsatellite loci. J. Parasitol. 2001, 87:1472-1475.
15. Boothroyd J.C. Expansion of host range as a driving force in the evolution of Toxoplasma. Mem. Inst. Oswaldo Cruz 2009, 104:179-184.
16. Bossi P., Bricaire F. Severe acute disseminated toxoplasmosis. Lancet 2004, 364:579.
17. Bowie W.R., King A.S., Werker D.H., et al. Outbreak of toxoplasmosis associated with municipal drinking water. Lancet 1997, 350:173-177.
18. Boyle J.P., Rajasekar B., Saeij J.P., et al. Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. Proc. Natl. Acad. Sci. USA. 2006, 103:10514-10519.
19. Burg J.L., Grover C.M., Pouletty P., Boothroyd J.C. Direct and sensitive detection of a pathogenic protozoan Toxoplasma gondii by polymerase chain reaction. J. Clin. Microbiol. 1989, 27:1787-1792.
20. Burnett A.J., Shortt S.G., Isaac-Renton J., King A., Werker D., Bowie W.R. Multiple cases of acquired toxoplasmosis retinitis presenting in an outbreak. Ophthalmology 1998, 105:1032-1037.
21. Carme B., Bissuel F., Ajzenberg D., et al. Severe acquired toxoplasmosis in immunocompetent adult patients in French Guiana. J. Clin. Microbiol. 2002, 40:4037-4044.
22. Carme B., Ajzenberg D., Demar M., et al. Outbreaks of toxoplasmosis in a captive breeding colony of squirrel monkeys. Vet. Parasitol. 2009, 163:132-135.
23. Carme B., Demar M., Ajzenberg D., Dardé M.L. Severe acquired toxoplasmosis caused by wild cycle of Toxoplasma gondii, French Guiana. Emerg. Infect. Dis. 2009, 15:656-658.
24. Calderaro A., Piccolo G., Gorrini C., et al. Comparison between two real-time PCR assays and a nested-PCR for the detection of Toxoplasma gondii. Acta Biomed. 2006, 77:75-80.
25. Chen Z.W., Gao J.M., Huo X.X., et al. Genotyping of Toxoplasma gondii isolates from cats in different geographic regions of China. Vet. Parasitol. 2011, 183:166-170.
26. Cornelissen A.W., Overdulve J.P. Sex determination and sex differentiation in coccidia: gametogony and oocyst production after monoclonal infection of cats with free-living and intermediate host stages of Isospora (Toxoplasma) gondii. Parasitology 1985, 90:35-44.
27. Cristina N., Dardé M.L., Boudin C., Tavernier G., Pestre-Alexandre M., Ambroise-Thomas P. A DNA fingerprinting method for individual characterization of Toxoplasma gondii strains: combination with isoenzymatic characters for determination of linkage groups. Parasitol. Res. 1995, 81:32-37.
28. Dao A., Fortier B., Soete M., Plenat F., Dubremetz J.F. Successful reinfection of chronically infected mice by a different Toxoplasma gondii genotype. Int. J. Parasitol. 2001, 31:63-65.
29. Dardé M.L., Bouteille B., Pestre-Alexandre M. Isoenzymic characterization of seven strains of Toxoplasma gondii by isoelectrofocusing in polyacrylamide gels. Am. J. Trop. Med. Hyg. 1988, 39:551-558.
30. Darde M.L., Bouteille B., Pestre-Alexandre M. Isoenzyme analysis of 35 Toxoplasma gondii isolates and the biological and epidemiological implications. J. Parasitol. 1992, 78:786-794.
31. Dardé M.L. Toxoplasma gondii, 'new' genotypes and virulence. Parasite 2008, 15:366-371.
32. De Craeye S., Speybroeck N., Ajzenberg D., et al. Toxoplasma gondii and Neospora caninum in wildlife: common parasites in Belgian foxes and Cervidae?. Vet. Parasitol. 2011, 178:64-69.
33. de Sousa S., Ajzenberg D., Canada N., et al. Biologic and molecular characterization of Toxoplasma gondii isolates from pigs from Portugal. Vet. Parasitol. 2006, 135:133-136.
34. Delhaes L., Ajzenberg D., Sicot B., et al. Severe congenital toxoplasmosis due to a Toxoplasma gondii strain with an atypical genotype: case report and review. Prenatal Diagn. 2010, 30:902-905.
35. Demar M., Ajzenberg D., Maubon D., et al. Fatal outbreak of human toxoplasmosis along the Maroni River: epidemiological, clinical, and parasitological aspects. Clin. Infect. Dis. 2007, 45:e88-e95.
36. Demar M., Hommel D., Djossou F., et al. Acute toxoplasmoses in immunocompetent patients hospitalized in an intensive care unit in French Guiana. Clin. Microbiol. Infect. 2012, 18:E221-E231. 10.1111/j.1469-0691.2011.03648.x.
37. de Moura L., Bahia-Oliveira L.M., Wada M.Y., et al. Waterborne toxoplasmosis, Brazil, from field to gene. Emerg. Infect. Dis. 2006, 12:326-329.
38. De Salvador-Guillouët F., Ajzenberg D., Chaillou-Opitz S., et al. Severe pneumonia during primary infection with an atypical strain of Toxoplasma gondii in an immunocompetent young man. J. Infect. 2006, 53:e47-e50.
39. Diana J., Persat F., Staquet M.J., et al. Migration and maturation of human dendritic cells infected with Toxoplasma gondii depend on parasite strain type. FEMS. Immunol. Med. Microbiol. 2004, 42:321-331.
40. Dubey J.P., Vianna M.C., Sousa S., et al. Characterization of Toxoplasma gondii isolates in free-range chickens from Portugal. J. Parasitol. 2006, 92:184-186.
41. Dubey J.P., Huong L.T.T., Sundar N., Su C. Genetic characterization of Toxoplasma gondii isolates in dogs from Vietnam suggests their South American origin. Vet. Parasitol. 2007, 146:347-351.
42. Dubey J.P., Zhu X.Q., Sundar N., Zhang H., Kwok O.C.H., Su C. Genetic and biologic characterization of Toxoplasma gondii isolates of cats from China. Vet. Parasitol. 2007, 145:352-356.
43. Dubey J.P., Lopez-Torres H.Y., Sundar N., et al. Mouse-virulent Toxoplasma gondii isolated from feral cats on Mona Island, Puerto Rico. J. Parasitol. 2007, 93:1365-1369.
44. Dubey J.P., Quirk T., Pitt J.A., et al. Isolation and genetic characterization of Toxoplasma gondii from raccoons (Procyon lotor), cats (Felis domesticus), striped skunk (Mephitis mephitis), black bear (Ursus americanus), and cougar (Puma concolor). J. Parasitol. 2008, 94:42-45.
45. Dubey J.P., Sundar N., Hill D., et al. High prevalence and abundant atypical genotypes of Toxoplasma gondii isolated from lambs destined for human consumption in the USA. Int. J. Parasitol. 2008, 38:999-1006.
46. Dubey J.P., Moura L., Majumdar D., et al. Isolation and characterization of viable Toxoplasma gondii isolates revealed possible high frequency of mixed infection in feral cats (Felis domesticus) from St Kitts, West Indies. Parasitology 2009, 136:589-594.
47. Dubey J.P., Pas A., Rajendran C., et al. Toxoplasmosis in Sand cats (Felis margarita) and other animals in the Breeding Centre for Endangered Arabian Wildlife in the United Arab Emirates and Al Wabra Wildlife Preservation, the State of Qatar. Vet. Parasitol. 2010, 172:195-203.
48. Dubey J.P. Toxoplasmosis of animals and humans 2010, CRC Press, Boca Raton, FL., 336 p. Second ed.
49. Dubey J.P., Rajendran C., Ferreira L.R., et al. High prevalence and genotypes of Toxoplasma gondii isolated from goats, from a retail meat store, destined for human consumption in the USA. Int. J. Parasitol. 2011, 41:827-833.
50. Dubey J.P., Velmurugan G.V., Rajendran C., et al. Genetic characterisation of Toxoplasma gondii in wildlife from North America revealed widespread and high prevalence of the fourth clonal type. Int. J. Parasitol. 2011, 41:1139-1147.
51. Dubey J.P., Lago E.G., Gennari S.M., Su C., Jones J.L. Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology. Parasitology 2012, 139:1375-1424.
52. Dubremetz J.F., Lebrun M. Virulence factors of Toxoplasma gondii. Microb. Infect. Sep 21 2012, [Epub ahead of print]. 10.1016/j.micinf.2012.09.005.
53. Dumètre A., Ajzenberg D., Rozette L., Mercier A., Dardé M.L. Toxoplasma gondii infection in sheep from Haute-Vienne, France: seroprevalence and isolate genotyping by microsatellite analysis. Vet. Parasitol. 2006, 142:376-379.
54. Elbez-Rubinstein A., Ajzenberg D., Darde M.L., et al. Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review. J. Infect. Dis. 2009, 199:280-285.
55. Fekkar A., Ajzenberg D., Bodaghi B., et al. Direct genotyping of Toxoplasma gondii in ocular fluid samples from 20 patients with ocular toxoplasmosis: predominance of type II in France. J. Clin. Microbiol. 2011, 49:1513-1517.
56. Ferreira Ade M., Vitor R.W., Carneiro A.C., Brandao G.P., Melo M.N. Genetic variability of Brazilian Toxoplasma gondii strains detected by random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) and simple sequence repeat anchored-PCR (SSR-PCR). Infect. Genet. Evol. 2004, 4:131-142.
57. Ferreira Ade M., Vitor R.W., Gazzinelli R.T., Melo M.N. Genetic analysis of natural recombinant Brazilian Toxoplasma gondii strains by multilocus PCR-RFLP. Infect. Genet. Evol. 2006, 6:22-31.
58. Ferreira I.M., Vidal J.E., de Mattos C., et al. Toxoplasma gondii isolates: multilocus RFLP-PCR genotyping from human patients in Sao Paulo State, Brazil identified distinct genotypes. Exp. Parasitol. 2011, 129:190-195.
59. Frazão-Teixeira E., Sundar N., Dubey J.P., Grigg M.E., de Oliveira F.C.R. Multi-locus DNA sequencing of Toxoplasma gondii isolated from Brazilian pigs identifies genetically divergent strains. Vet. Parasitol. 2011, 175:33-39.
60. Frey C., Berger-Schoch A., Herrmann D., et al. Incidence and genotypes of Toxoplasma gondii in the muscle of sheep, cattle, pigs as well as in cat feces in Switzerland. Schweiz Arch Tierhei. 2012, 154:251-255.
61. Ferguson D.J. Toxoplasma gondii and sex: essential or optional extra?. Trends Parasitol. 2002, 18:355-359.
62. Fux B., Rodrigues C.V., Portela R.W., et al. Role of cytokines and major histocompatibility complex restriction in mouse resistance to infection with a natural recombinant strain (type I-III) of Toxoplasma gondii. Infect. Immun. 2003, 71:6392-6401.
63. Gavrilescu L.C., Denkers E.Y. IFN-gamma overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection. J. Immunol. 2001, 167:902-909.
64. Gilbert R.E., Freeman K., Lago E.G., et al. European Multicentre Study on Congenital Toxoplasmosis (EMSCOT). Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe. PLoS. Negl. Trop. Dis. 2008, 13:e277.
65. Gibson A.K., Raverty S., Lambourn D.M., Huggins J., Magargal S.L., Grigg M.E. Polyparasitism is associated with increased disease severity in Toxoplasma gondii-infected marine sentinel species. PLoS. Negl. Trop. Dis. 2011, 5:e1142.
66. Gilot-Fromont E., Lélu M., Dardé M.L., et al. The Life Cycle of Toxoplasma gondii in the Natural Environment 2012, 'Toxoplasmosis - Recent Advances' O. Djurković Djaković (Eds.), ISBN 978-953-51-0746-0, InTech, September 9, 2012. Available from:. http://www.intechopen.com/books/toxoplasmosis-recent-advances/the-life-cycle-of-toxoplasma-gondii-in-the-natural-environment.
67. Glasner P.D., Silveira C., Kruszon-Moran D., et al. An unusually high prevalence of ocular toxoplasmosis in southern Brazil. Am. J. Ophthalmol. 1992, 114:136-144.
68. Goldstein D.B., Schlotterer C. Microsatellites: Evolution and Applications 1999, Oxford University Press, Oxford, 352 p.
69. Grigg M.E., Bonnefoy S., Hehl A.B., Suzuki Y., Boothroyd J.C. Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries. Science 2001, 294:161-165.
70. Grigg M.E., Ganatra J., Boothroyd J.C., Margolis T.P. Unusual abundance of atypical strains associated with human ocular toxoplasmosis. J. Infect. Dis. 2001, 184:633-639.
71. Grigg M.E., Suzuki Y. Sexual recombination and clonal evolution of virulence in. Toxoplasma. Microbes Infect. 2003, 5:685-690.
72. Grigg M.E., Sundar N. Sexual recombination punctuated by outbreaks and clonal expansions predicts Toxoplasma gondii population genetics. Int. J. Parasitol. 2009, 39:925-933.
73. Groh M., Faussart A., Villena I., et al. Acute lung, heart, liver, and pancreatic involvements with hyponatremia and retinochoroiditis in a 33-year-old French guianan patient. PLoS. Negl. Trop. Dis. 2012, 6:e1802.
74. Guo Z.G., Johnson A.M. Genetic characterization of Toxoplasma gondii strains by random amplified polymorphic DNA polymerase chain reaction. Parasitology 1995, 111:127-132.
75. Halos L., Thébault A., Aubert D., et al. An innovative survey underlining the significant level of contamination by Toxoplasma gondii of ovine meat consumed in France. Int. J. Parasitol. 2010, 40:193-200.
76. Herrmann D.C., Pantchev N., Vrhovec M.G., et al. Atypical Toxoplasma gondii genotypes identified in oocysts shed by cats in Germany. Int. J. Parasitol. 2010, 40:285-292.
77. Herrmann D.C., Bärwald A., Maksimov A., et al. Toxoplasma gondii sexual cross in a single naturally infected feline host: Generation of highly mouse-virulent and avirulent clones, genotypically different from clonal types I, II and III. Vet. Res. 2012, 43:39.
78. Herrmann D.C., Maksimov P., Maksimov A., et al. Toxoplasma gondii in foxes and rodents from the German Federal States of Brandenburg and Saxony-Anhalt: seroprevalence and genotypes. Vet. Parasitol. 2012, 185:78-85.
79. Herrmann D.C., Wibbelt G., Götz M., Conraths F.J., Schares G. Genetic characterisation of Toxoplasma gondii isolates from European beavers (Castor fiber) and European wildcats (Felis silvestris silvestris). Vet. Parasitol. 2013, 191:108-111.
80. Hide G., Morley E.K., Hughes J.M., et al. Evidence for high levels of vertical transmission in Toxoplasma gondii. Parasitology 2009, 136:1877-1885.
81. Holland G.N. Ocular toxoplasmosis: a global reassessment. Part I: epidemiology and course of disease. Am. J. Ophthalmol. 2003, 136:973-988.
82. Homan W.L., Vercammen M., De Braekeleer J., Verschueren H. Identification of a 200- to 300-fold repetitive 529 bp DNA fragment in Toxoplasma gondii, and its use for diagnostic and quantitative PCR. Int. J. Parasitol. 2000, 30:69-75.
83. Howe D.K., Sibley L.D. Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease. J. Infect. Dis. 1995, 172:1561-1566.
84. Huang S.Y., Cong W., Zhou P., et al. First report of genotyping of Toxoplasma gondii isolates from wild birds in China. J. Parasitol. 2012, 98:681-682.
85. Hurtado A., Aduriz G., Moreno B., Barandika J., Garcia-Perez A.L. Single tube nested PCR for the detection of Toxoplasma gondii in fetal tissues from naturally aborted ewes. Vet. Parasitol. 2001, 102:17-27.
86. Innes E.A., Bartley P.M., Buxton D., Katzer F. Ovine toxoplasmosis. Parasitology 2009, 136:1887-1894.
87. Jamieson S.E., de Roubaix L.A., Cortina-Borja M., et al. Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis. PLoS One 2008, 3:e2285.
88. Jauregui L.H., Higgins J., Zarlenga D., Dubey J.P., Lunney J.K. Development of a real-time PCR assay for detection of Toxoplasma gondii in pig and mouse tissues. J. Clin. Microbiol. 2001, 39:2065-2071.
89. Jokelainen P., Isomursu M., Näreaho A., Oksanen A. Natural Toxoplasma gondii infections in European brown hares and mountain hares in Finland: proportional mortality rate, antibody prevalence, and genetic characterization. J. Wildl. Dis. 2011, 47:154-163.
90. Jokelainen P., Nylund M. Acute fatal toxoplasmosis in three Eurasian red squirrels (Sciurus vulgaris) caused by genotype II of Toxoplasma gondii. J. Wildl. Dis. 2012, 48:454-457.
91. Kasper D.C., Sadeghi K., Prusa A.R., et al. Quantitative real-time polymerase chain reaction for the accurate detection of Toxoplasma gondii in amniotic fluid. Diagnostic Microbiol. Infect. Dis. 2009, 63:10-15.
92. Khan A., Su C., German M., Storch G.A., Clifford D.B., Sibley L.D. Genotyping of Toxoplasma gondii strains from immunocompromised patients reveals high prevalence of type I strains. J. Clin. Microbiol. 2005, 43:5881-5887.
93. Khan A., Jordan C., Muccioli C., et al. Genetic divergence of Toxoplasma gondii strains associated with ocular toxoplasmosis. Brazil. Emerg. Infect. Dis. 2006, 12:942-949.
94. Khan A., Fux B., Su C., et al. Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosome. Proc. Natl. Acad. Sci. USA 2007, 104:14872-14877.
95. Khan A., Dubey J.P., Su C., Ajioka J.W., Rosenthal B.M., Sibley L.D. Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America. Int. J. Parasitol. 2011, 41:645-655.
96. Khan A., Miller N., Roos D.S., et al. A monomorphic haplotype of chromosome Ia is associated with widespread success in clonal and nonclonal populations of Toxoplasma gondii. MBio. 2011, 2:e00228-00211.
97. Kieffer F., Rigourd V., Ikounga P., Bessieres B., Magny J.F., Thulliez P. Disseminated congenital toxoplasma infection with a type II strain. Pediatr. Infect. Dis. J. 2011, 30:813-815.
98. Kong J.T., Grigg M.E., Uyetake L., Parmley S.F., Boothroyd J.C. Serotyping of Toxoplasma gondii infections in humans using synthetic peptides. J. Infect. Dis. 2003, 187:1484-1495.
99. Lehmann T., Blackstone C.R., Parmley S.F., Remington J.S., Dubey J.P. Strain typing of Toxoplasma gondii: comparison of antigen-coding and housekeeping genes. J. Parasitol. 2000, 86:960-971.
100. Lehmann T., Graham D.H., Dahl E., et al. Transmission dynamics of Toxoplasma gondii on a pig farm. Infect. Genet. Evol. 2003, 3:135-141.
101. Lehmann T., Graham D.H., Dahl E.R., Bahia-Oliveira L.M.G., Gennari S.M., Dubey J.P. Variation in the structure of Toxoplasma gondii and the roles of selfing, drift, and epistatic selection in maintaining linkage disequilibria. Infect. Genet. Evol. 2004, 4:107-114.
102. Lehmann T., Marcet P.L., Graham D.H., Dahl E.R., Dubey J.P. Globalization and the population structure of Toxoplasma gondii. Proc. Natl. Acad. Sci. USA 2006, 103:11423-11428.
103. Lindström I., Sundar N., Lindh J., et al. Isolation and genotyping of Toxoplasma gondii from Ugandan chickens reveals frequent multiple infections. Parasitology 2008, 135:39-45.
104. Mack D.G., Johnson J.J., Roberts F., et al. HLA-class II genes modify outcome of Toxoplasma gondii infection. Int. J. Parasitol. 1999, 29:1351-1358.
105. McLeod R., Boyer K.M., Lee D., et al. Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981-2009). Clin. Infect. Dis. 2012, 54:1595-1605.
106. Mercier A., Devillard S., Ngoubangoye B., et al. Additional haplogroups of Toxoplasma gondii out of Africa: population structure and mouse-virulence of strains from Gabon. PLoS Negl. Trop. Dis. 2010, 4:e876.
107. Mercier A., Ajzenberg D., Devillard S., et al. Human impact on genetic diversity of Toxoplasma gondii: example of the anthropized environment from French Guiana. Infect. Genet. Evol. 2011, 11:1378-1387.
108. Messaritakis I., Detsika M., Koliou M., Sifakis S., Antoniou M. Prevalent genotypes of Toxoplasma gondii in pregnant women and patients from Crete and Cyprus. Am. J. Trop. Med. Hyg. 2008, 79:205-209.
109. Miller M.A., Grigg M.E., Kreuder C., et al. An unusual genotype of Toxoplasma gondii is common in California sea otters (Enhydra lutris nereis) and is a cause of mortality. Int. J. Parasitol. 2004, 34:275-284.
110. Miller M., Conrad P., James E.R., et al. Transplacental toxoplasmosis in a wild southern sea otter (Enhydra lutris nereis). Vet. Parasitol. 2008, 153:12-18.
111. Miller M.A., Miller W.A., Conrad P.A., et al. Type X Toxoplasma gondii in a wild mussel and terrestrial carnivores from coastal California: new linkages between terrestrial mammals, runoff and toxoplasmosis of sea otters. Int. J. Parasitol. 2008, 38:1319-1328.
112. Minot S., Melo M.B., Li F., et al. Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity. Proc. Natl. Acad. Sci. USA 2012, 109:13458-13463.
113. Montoya J.G., Liesenfeld O. Toxoplasmosis. Lancet 2004, 363:1965-1976.
114. Moré G., Maksimov P., Pardini L., et al. Toxoplasma gondii infection in sentinel and free-range chickens from Argentina. Vet. Parasitol. 2012, 184:116-121.
115. Morisset S., Peyron F., Lobry J.R., et al. Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America. Microbes Infect. 2008, 10:742-747.
116. Nguyen T.D., Bigaignon G., Markine-Goriaynoff D., et al. Virulent Toxoplasma gondii strain RH promotes T-cell-independent overproduction of proinflammatory cytokines IL12 and gamma-interferon. J. Med. Microbiol. 2003, 52:869-887.
117. Niedelman W., Gold D.A., Rosowski E.E., et al. The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog. 2012, 8:e1002784.
118. Nowakowska D., Colón I., Remington J.S., et al. Genotyping of Toxoplasma gondii by multiplex PCR and peptide-based serological testing of samples from infants in Poland diagnosed with congenital toxoplasmosis. J. Clin. Microbiol. 2006, 44:1382-1389.
119. Pan S., Thompson R.C.A., Grigg M.E., Sundar N., Smith A., Lymbery A.J. Western Australian marsupials are multiply infected with genetically diverse strains of Toxoplasma gondii. PLoS One 2012, 7:e45147.
120. Parameswaran N., Thompson R.C., Sundar N., et al. Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia. Int. J. Parasitol. 2010, 40:635-640.
121. Pena H.F.J., Gennari S.M., Dubey J.P., Su C. Population structure and mouse-virulence of Toxoplasma gondii in Brazil. Int. J. Parasitol. 2008, 38:561-569.
122. Pfefferkorn E.R., Pfefferkorn L.C., Colby E.D. Development of gametes and oocysts in cats fed cysts derived from cloned trophozoites of Toxoplasma gondii. J. Parasitol. 1977, 63:158-159.
123. Pomares C., Ajzenberg D., Bornard L., et al. Toxoplasmosis and horse meat, France. Emerg. Infect. Dis. 2011, 17:1327-1328.
124. Prestrud K.W., Åsbakk K., Mørk T., Fuglei E., Tryland M., Su C. Direct high-resolution genotyping of Toxoplasma gondii in arctic foxes (Vulpes lagopus) in the remote arctic Svalbard archipelago reveals widespread clonal Type II lineage. Vet. Parasitol. 2008, 158:121-128.
125. Qian W., Wang H., Su C., et al. Isolation and characterization of Toxoplasma gondii strains from stray cats revealed a single genotype in Beijing, China. Vet. Parasitol. 2012, 187:408-413.
126. Rajendran C., Su C., Dubey J.P. Molecular genotyping of Toxoplasma gondii from Central and South America revealed high diversity within and between populations. Infect. Genet. Evol. 2012, 12:359-368.
127. Reese M.L., Zeiner G.M., Saeij J.P., Boothroyd J.C., Boyle J.P. Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence. Proc. Natl. Acad. Sci. USA 2011, 108:9625-9630.
128. Richomme C., Aubert D., Gilot-Fromont E., et al. Genetic characterization of Toxoplasma gondii from wild boar (Sus scrofa) in France. Vet. Parasitol. 2009, 164:296-300.
129. Robben P.M., Mordue D.G., Truscott S.M., Takeda K., Akira S., Sibley L.D. Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype. J. Immunol. 2004, 172:3686-3694.
130. Rosowski E.E., Lu D., Julien L., et al. Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. J. Exp. Med. 2011, 17:195-212.
131. Saeij J.P., Boyle J.P., Coller S., et al. Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science 2006, 314:1780-1783.
132. Saeij J.P., Boyle J.P., Boothroyd J.C. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. Trends Parasitol. 2005, 21:476-481.
133. Sibley L.D., Boothroyd J.C. Virulent strains of Toxoplasma gondii comprise a single clonal lineage. Nature 1992, 359:82-85.
134. Sibley L.D., Ajioka J.W. Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps. Annu. Rev. Microbiol. 2008, 62:329-351.
135. Silveira C., Vallochi A.L., Rodrigues da Silva U., et al. Toxoplasma gondii in the peripheral blood of patients with acute and chronic toxoplasmosis. Br. J. Ophthalmol. 2011, 95:396-400.
136. Soete M., Fortier B., Camus D., Dubremetz J.F. Toxoplasma gondii: kinetics of bradyzoite-tachyzoite interconversion in vitro. Exp. Parasitol. 1993, 76:259-264.
137. Sousa S., Ajzenberg D., Marle M., et al. Selection of polymorphic peptides from GRA6 and GRA7 sequences of Toxoplasma gondii strains to be used in serotyping. Clin. Vac. Immunol. 2009, 16:1158-1169.
138. Sousa S., Ajzenberg D., Vilanova M., Costa J., Darde M.-L. Use of GRA6-derived synthetic polymorphic peptides in an immunoenzymatic assay to serotype Toxoplasma gondii in human serum samples collected from three continents. Clin. Vac. Immunol. 2008, 15:1380-1386.
139. Sousa S., Canada N., Correia da Costa J.M., Dardé M.-L. Serotyping of naturally Toxoplasma gondii infected meat-producing animals. Vet. Parasitol. 2010, 169:24-28.
140. Sreekumar C., Graham D.H., Dahl E., et al. Genotyping of Toxoplasma gondii isolates from chickens from India. Vet. Parasitol. 2003, 118:187-194.
141. Su C., Evans D., Cole R.H., et al. Recent expansion of Toxoplasma through enhanced oral transmission. Science 2003, 299:414-416.
142. Su C., Zhang X., Dubey J.P. Genotyping of Toxoplasma gondii by multilocus PCR-RFLP markers: A high resolution and simple method for identification of parasites. Int. J. Parasitol. 2006, 36:841-848.
143. Su C., Shwab E.K., Zhou P., Zhu X.Q., Dubey J.P. Moving towards an integrated approach to molecular detection and identification of Toxoplasma gondii. Parasitology 2010, 137:1-11.
144. Su C., Khan A., Zhou P., et al. Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages. Proc. Natl. Acad. Sci. USA 2012, 109:5844-5849.
145. Subauste C.S., Ajzenberg D., Kijlstra A. Review of the series 'Disease of the year 2011: toxoplasmosis' pathophysiology of toxoplasmosis. Ocul. Immunol. Inflamm. 2011, 19:297-306.
146. Sundar N., Cole R.A., Thomas N.J., Majumdar D., Dubey J.P., Su C. Genetic diversity among sea otter isolates of Toxoplasma gondii. Vet. Parasitol. 2008, 151:125-132.
147. Taylor S., Barragan A., Su C., et al. A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii. Science 2006, 314:1776-1780.
148. Terry R.S., Smith J.E., Duncanson P., Hide G. MGE-PCR: a novel approach to the analysis of Toxoplasma gondii strain differentiation using mobile genetic elements. Int. J. Parasitol. 2001, 31:155-161.
149. Tibayrenc M., Ayala F.J. The clonal theory of parasitic protozoa: 12 years on. Trends Parasitol. 2002, 18:405-410.
150. Vaudaux J.D., Muccioli C., James E.R., et al. Identification of an atypical strain of Toxoplasma gondii as the cause of a waterborne outbreak of toxoplasmosis in Santa Isabel do Ivai, Brazil. J. Infect. Dis. 2010, 202:1226-1233.
151. Velmurugan G.V., Dubey J.P., Su C. Genotyping studies of Toxoplasma gondii isolates from Africa revealed that the archetypal clonal lineages predominate as in North America and Europe. Vet. Parasitol. 2008, 155:314-318.
152. Velmurugan G.V., Su C., Dubey J.P. Isolate designation and characterization of Toxoplasma gondii isolates from pigs in the United States. J. Parasitol. 2009, 95:95-99.
153. Wendte J.M., Miller M.A., Lambourn D.M., et al. Self-mating in the definitive host potentiates clonal outbreaks of the Apicomplexan parasites Sarcocystis neurona and Toxoplasma gondii. PLoS Genet. 2010, 6:e1001261.
154. Wendte J.M., Gibson A.K., Grigg M.E. Population genetics of Toxoplasma gondii: new perspectives from parasite genotypes in wildlife. Vet. Parasitol. 2011, 182:96-111.
155. Williams R.H., Morley E.K., Hughes J.M., et al. High levels of congenital transmission of Toxoplasma gondii in longitudinal and cross-sectional studies on sheep farms provides evidence of vertical transmission in ovine hosts. Parasitology 2005, 130:301-307.
156. Zhou P., Zhang H., Lin R.-Q., et al. Genetic characterization of Toxoplasma gondii isolates from China. Parasitol. Int. 2009, 58:193-195.
157. Zhou P., Nie H., Zhang L.-X., et al. Genetic characterization of Toxoplasma gondii isolates from pigs in China. J. Parasitol. 2010, 96:1027-1029.
158. Zia-Ali N., Fazaeli A., Khoramizadeh M., Ajzenberg D., Dardé M., Keshavarz-Valian H. Isolation and molecular characterization of Toxoplasma gondii strains from different hosts in Iran. Parasitol. Res. 2007, 101:111-115.