메뉴 건너뛰기




Volumn 14, Issue 15, 2012, Pages 1403-1410

Virulence factors of Toxoplasma gondii

Author keywords

Genetics; Infection; Toxoplasma gondii; Virulence

Indexed keywords

CHEMOKINE RECEPTOR CCR5; INTERLEUKIN 12; VIRULENCE FACTOR;

EID: 84870845103     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2012.09.005     Document Type: Article
Times cited : (55)

References (69)
  • 1
    • 0031984591 scopus 로고    scopus 로고
    • Severe toxoplasmosis caused by a Toxoplasma gondii strain with a new isoenzyme type acquired in French Guyana
    • Darde M.L., Villena I., Pinon J.M., Beguinot I. Severe toxoplasmosis caused by a Toxoplasma gondii strain with a new isoenzyme type acquired in French Guyana. J. Clin. Microbiol. 1998, 36:324.
    • (1998) J. Clin. Microbiol. , vol.36 , pp. 324
    • Darde, M.L.1    Villena, I.2    Pinon, J.M.3    Beguinot, I.4
  • 2
    • 0242292078 scopus 로고    scopus 로고
    • Toxoplasma gondii and schizophrenia
    • Torrey E.F., Yolken R.H. Toxoplasma gondii and schizophrenia. Emerg. Infect. Dis. 2003, 9:1375-1380.
    • (2003) Emerg. Infect. Dis. , vol.9 , pp. 1375-1380
    • Torrey, E.F.1    Yolken, R.H.2
  • 3
    • 0036342974 scopus 로고    scopus 로고
    • Population biology of Toxoplasma gondii and its relevance to human infection: do different strains cause different disease?
    • Boothroyd J.C., Grigg M.E. Population biology of Toxoplasma gondii and its relevance to human infection: do different strains cause different disease?. Curr. Opin. Microbiol. 2002, 5:438-442.
    • (2002) Curr. Opin. Microbiol. , vol.5 , pp. 438-442
    • Boothroyd, J.C.1    Grigg, M.E.2
  • 5
    • 53849092760 scopus 로고    scopus 로고
    • Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps
    • Sibley L.D., Ajioka J.W. Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps. Annu. Rev. Microbiol. 2008, 62:329-351.
    • (2008) Annu. Rev. Microbiol. , vol.62 , pp. 329-351
    • Sibley, L.D.1    Ajioka, J.W.2
  • 9
    • 79955948463 scopus 로고    scopus 로고
    • The moving junction of apicomplexan parasites: a key structure for invasion
    • Besteiro S., Dubremetz J.F., Lebrun M. The moving junction of apicomplexan parasites: a key structure for invasion. Cell. Microbiol. 2011, 13:797-805.
    • (2011) Cell. Microbiol. , vol.13 , pp. 797-805
    • Besteiro, S.1    Dubremetz, J.F.2    Lebrun, M.3
  • 10
    • 80855159996 scopus 로고    scopus 로고
    • Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8
    • Pernas L., Boothroyd J.C. Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8. Int. J. Parasitol. 2010, 40:1367-1371.
    • (2010) Int. J. Parasitol. , vol.40 , pp. 1367-1371
    • Pernas, L.1    Boothroyd, J.C.2
  • 11
    • 0023946345 scopus 로고
    • Characterization of a family of rhoptry proteins of Toxoplasma gondii
    • Sadak A., Taghy Z., Fortier B., Dubremetz J.F. Characterization of a family of rhoptry proteins of Toxoplasma gondii. Mol. Biochem. Parasitol. 1988, 29:203-211.
    • (1988) Mol. Biochem. Parasitol. , vol.29 , pp. 203-211
    • Sadak, A.1    Taghy, Z.2    Fortier, B.3    Dubremetz, J.F.4
  • 14
    • 33847332992 scopus 로고    scopus 로고
    • ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondii
    • El Hajj H., Lebrun M., Arold S.T., Vial H., Labesse G., Dubremetz J.F. ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondii. PLoS Pathog. 2007, 3:e14.
    • (2007) PLoS Pathog. , vol.3
    • El Hajj, H.1    Lebrun, M.2    Arold, S.T.3    Vial, H.4    Labesse, G.5    Dubremetz, J.F.6
  • 18
    • 0035968207 scopus 로고    scopus 로고
    • Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells
    • Blader I.J., Manger I.D., Boothroyd J.C. Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. J. Biol. Chem. 2001, 276:24223-24231.
    • (2001) J. Biol. Chem. , vol.276 , pp. 24223-24231
    • Blader, I.J.1    Manger, I.D.2    Boothroyd, J.C.3
  • 21
    • 80054792189 scopus 로고    scopus 로고
    • Toxoplasma gondii effectors are master regulators of the inflammatory response
    • Melo M.B., Jensen K.D., Saeij J.P. Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends Parasitol. 2011, 27:487-495.
    • (2011) Trends Parasitol. , vol.27 , pp. 487-495
    • Melo, M.B.1    Jensen, K.D.2    Saeij, J.P.3
  • 23
    • 77956538745 scopus 로고    scopus 로고
    • Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6
    • Ong Y.C., Reese M.L., Boothroyd J.C. Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6. J. Biol. Chem. 2009, 285:28731-28740.
    • (2009) J. Biol. Chem. , vol.285 , pp. 28731-28740
    • Ong, Y.C.1    Reese, M.L.2    Boothroyd, J.C.3
  • 29
    • 78651504365 scopus 로고    scopus 로고
    • Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein
    • Rosowski E.E., Lu D., Julien L., Rodda L., Gaiser R.A., Jensen K.D., Saeij J.P. Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. J. Exp. Med. 2011, 208:195-212.
    • (2011) J. Exp. Med. , vol.208 , pp. 195-212
    • Rosowski, E.E.1    Lu, D.2    Julien, L.3    Rodda, L.4    Gaiser, R.A.5    Jensen, K.D.6    Saeij, J.P.7
  • 31
    • 38849095132 scopus 로고    scopus 로고
    • Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response
    • Plattner F., Yarovinsky F., Romero S., Didry D., Carlier M.F., Sher A., Soldati-Favre D. Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response. Cell Host Microbe 2008, 3:77-87.
    • (2008) Cell Host Microbe , vol.3 , pp. 77-87
    • Plattner, F.1    Yarovinsky, F.2    Romero, S.3    Didry, D.4    Carlier, M.F.5    Sher, A.6    Soldati-Favre, D.7
  • 34
    • 0033624164 scopus 로고    scopus 로고
    • Targeted disruption of the glycosylphosphatidylinositol-anchored surface antigen SAG3 gene in Toxoplasma gondii decreases host cell adhesion and drastically reduces virulence in mice
    • Dzierszinski F., Mortuaire M., Cesbron-Delauw M.F., Tomavo S. Targeted disruption of the glycosylphosphatidylinositol-anchored surface antigen SAG3 gene in Toxoplasma gondii decreases host cell adhesion and drastically reduces virulence in mice. Mol. Microbiol. 2000, 37:574-582.
    • (2000) Mol. Microbiol. , vol.37 , pp. 574-582
    • Dzierszinski, F.1    Mortuaire, M.2    Cesbron-Delauw, M.F.3    Tomavo, S.4
  • 35
    • 0031557392 scopus 로고    scopus 로고
    • Molecular structure of the " low molecular weight antigen" of Toxoplasma gondii: a glucose alpha 1-4 N-acetylgalactosamine makes free glycosyl-phosphatidylinositols highly immunogenic
    • Striepen B., Zinecker C.F., Damm J.B., Melgers P.A., Gerwig G.J., Koolen M., Vliegenthart J.F., Dubremetz J.F., Schwarz R.T. Molecular structure of the " low molecular weight antigen" of Toxoplasma gondii: a glucose alpha 1-4 N-acetylgalactosamine makes free glycosyl-phosphatidylinositols highly immunogenic. J. Mol. Biol. 1997, 266:797-813.
    • (1997) J. Mol. Biol. , vol.266 , pp. 797-813
    • Striepen, B.1    Zinecker, C.F.2    Damm, J.B.3    Melgers, P.A.4    Gerwig, G.J.5    Koolen, M.6    Vliegenthart, J.F.7    Dubremetz, J.F.8    Schwarz, R.T.9
  • 38
    • 77954078996 scopus 로고    scopus 로고
    • Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii
    • Buguliskis J.S., Brossier F., Shuman J., Sibley L.D. Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii. PLoS Pathog. 2010, 6:e1000858.
    • (2010) PLoS Pathog. , vol.6
    • Buguliskis, J.S.1    Brossier, F.2    Shuman, J.3    Sibley, L.D.4
  • 39
    • 84860798774 scopus 로고    scopus 로고
    • Intramembrane proteolysis of Toxoplasma apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication
    • Parussini F., Tang Q., Moin S.M., Mital J., Urban S., Ward G.E. Intramembrane proteolysis of Toxoplasma apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:7463-7468.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 7463-7468
    • Parussini, F.1    Tang, Q.2    Moin, S.M.3    Mital, J.4    Urban, S.5    Ward, G.E.6
  • 40
    • 79251602713 scopus 로고    scopus 로고
    • Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode
    • Santos J.M., Ferguson D.J., Blackman M.J., Soldati-Favre D. Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode. Science 2011, 331:473-477.
    • (2011) Science , vol.331 , pp. 473-477
    • Santos, J.M.1    Ferguson, D.J.2    Blackman, M.J.3    Soldati-Favre, D.4
  • 42
    • 0036372942 scopus 로고    scopus 로고
    • 'The glideosome': a dynamic complex powering gliding motion and host cell invasion by Toxoplasma gondii
    • Opitz C., Soldati D. 'The glideosome': a dynamic complex powering gliding motion and host cell invasion by Toxoplasma gondii. Mol. Microbiol. 2002, 45:597-604.
    • (2002) Mol. Microbiol. , vol.45 , pp. 597-604
    • Opitz, C.1    Soldati, D.2
  • 43
    • 1542364495 scopus 로고    scopus 로고
    • The toxoplasma proteins MIC2 and M2AP form a hexameric complex necessary for intracellular survival
    • Jewett T.J., Sibley L.D. The toxoplasma proteins MIC2 and M2AP form a hexameric complex necessary for intracellular survival. J. Biol. Chem. 2004, 279:9362-9369.
    • (2004) J. Biol. Chem. , vol.279 , pp. 9362-9369
    • Jewett, T.J.1    Sibley, L.D.2
  • 44
    • 33748066307 scopus 로고    scopus 로고
    • Toxoplasma MIC2 is a major determinant of invasion and virulence
    • Huynh M.H., Carruthers V.B. Toxoplasma MIC2 is a major determinant of invasion and virulence. PLoS Pathog. 2006, 2:e84.
    • (2006) PLoS Pathog. , vol.2
    • Huynh, M.H.1    Carruthers, V.B.2
  • 45
    • 0038558167 scopus 로고    scopus 로고
    • Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex
    • Huynh M.H., Rabenau K.E., Harper J.M., Beatty W.L., Sibley L.D., Carruthers V.B. Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex. Embo J. 2003, 22:2082-2090.
    • (2003) Embo J. , vol.22 , pp. 2082-2090
    • Huynh, M.H.1    Rabenau, K.E.2    Harper, J.M.3    Beatty, W.L.4    Sibley, L.D.5    Carruthers, V.B.6
  • 50
    • 77951026559 scopus 로고    scopus 로고
    • Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles
    • Alexander D.L., Mital J., Ward G.E., Bradley P., Boothroyd J.C. Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles. PLoS Pathog. 2005, 1:e17.
    • (2005) PLoS Pathog. , vol.1
    • Alexander, D.L.1    Mital, J.2    Ward, G.E.3    Bradley, P.4    Boothroyd, J.C.5
  • 51
    • 24344439282 scopus 로고    scopus 로고
    • Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion
    • Mital J., Meissner M., Soldati D., Ward G.E. Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion. Mol. Biol. Cell 2005, 16:4341-4349.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 4341-4349
    • Mital, J.1    Meissner, M.2    Soldati, D.3    Ward, G.E.4
  • 52
    • 58849087549 scopus 로고    scopus 로고
    • Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells
    • Kafsack B.F., Pena J.D., Coppens I., Ravindran S., Boothroyd J.C., Carruthers V.B. Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells. Science 2009, 323:530-533.
    • (2009) Science , vol.323 , pp. 530-533
    • Kafsack, B.F.1    Pena, J.D.2    Coppens, I.3    Ravindran, S.4    Boothroyd, J.C.5    Carruthers, V.B.6
  • 53
    • 78449308526 scopus 로고    scopus 로고
    • Toxoplasma gondii protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites
    • Lagal V., Binder E.M., Huynh M.H., Kafsack B.F., Harris P.K., Diez R., Chen D., Cole R.N., Carruthers V.B., Kim K. Toxoplasma gondii protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites. Cell. Microbiol. 2010, 12:1792-1808.
    • (2010) Cell. Microbiol. , vol.12 , pp. 1792-1808
    • Lagal, V.1    Binder, E.M.2    Huynh, M.H.3    Kafsack, B.F.4    Harris, P.K.5    Diez, R.6    Chen, D.7    Cole, R.N.8    Carruthers, V.B.9    Kim, K.10
  • 55
    • 79953287282 scopus 로고    scopus 로고
    • The moving junction protein RON8 facilitates firm attachment and host cell invasion in Toxoplasma gondii
    • Straub K.W., Peng E.D., Hajagos B.E., Tyler J.S., Bradley P.J. The moving junction protein RON8 facilitates firm attachment and host cell invasion in Toxoplasma gondii. PLoS Pathog. 2011, 7:e1002007.
    • (2011) PLoS Pathog. , vol.7
    • Straub, K.W.1    Peng, E.D.2    Hajagos, B.E.3    Tyler, J.S.4    Bradley, P.J.5
  • 57
    • 77649207443 scopus 로고    scopus 로고
    • A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin during Toxoplasma gondii infection
    • Lodoen M.B., Gerke C., Boothroyd J.C. A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin during Toxoplasma gondii infection. Cell. Microbiol. 2010, 12:55-66.
    • (2010) Cell. Microbiol. , vol.12 , pp. 55-66
    • Lodoen, M.B.1    Gerke, C.2    Boothroyd, J.C.3
  • 58
    • 0022759007 scopus 로고
    • Immunoelectron microscopic demonstration of the exocytosis of dense granule contents into the secondary parasitophorous vacuole of Sarcocystis muris (Protozoa, Apicomplexa)
    • Entzeroth R., Dubremetz J.F., Hodick D., Ferreira E. Immunoelectron microscopic demonstration of the exocytosis of dense granule contents into the secondary parasitophorous vacuole of Sarcocystis muris (Protozoa, Apicomplexa). Eur. J. Cell Biol. 1986, 41:182-188.
    • (1986) Eur. J. Cell Biol. , vol.41 , pp. 182-188
    • Entzeroth, R.1    Dubremetz, J.F.2    Hodick, D.3    Ferreira, E.4
  • 61
    • 0031662948 scopus 로고    scopus 로고
    • Targeted disruption of the GRA2 locus in Toxoplasma gondii decreases acute virulence in mice
    • Mercier C., Howe D.K., Mordue D., Lingnau M., Sibley L.D. Targeted disruption of the GRA2 locus in Toxoplasma gondii decreases acute virulence in mice. Infect. Immun. 1998, 66:4176-4182.
    • (1998) Infect. Immun. , vol.66 , pp. 4176-4182
    • Mercier, C.1    Howe, D.K.2    Mordue, D.3    Lingnau, M.4    Sibley, L.D.5
  • 62
    • 34247505657 scopus 로고    scopus 로고
    • Increased efficiency of homologous recombination in Toxoplasma gondii dense granule protein 3 demonstrates that GRA3 is not necessary in cell culture but does contribute to virulence
    • Craver M.P., Knoll L.J. Increased efficiency of homologous recombination in Toxoplasma gondii dense granule protein 3 demonstrates that GRA3 is not necessary in cell culture but does contribute to virulence. Mol. Biochem. Parasitol. 2007, 153:149-157.
    • (2007) Mol. Biochem. Parasitol. , vol.153 , pp. 149-157
    • Craver, M.P.1    Knoll, L.J.2
  • 64
    • 55849084997 scopus 로고    scopus 로고
    • Intervacuolar transport and unique topology of GRA14, a novel dense granule protein in Toxoplasma gondii
    • Rome M.E., Beck J.R., Turetzky J.M., Webster P., Bradley P.J. Intervacuolar transport and unique topology of GRA14, a novel dense granule protein in Toxoplasma gondii. Infect. Immun. 2008, 76:4865-4875.
    • (2008) Infect. Immun. , vol.76 , pp. 4865-4875
    • Rome, M.E.1    Beck, J.R.2    Turetzky, J.M.3    Webster, P.4    Bradley, P.J.5
  • 65
    • 77649243266 scopus 로고    scopus 로고
    • TgMORN1 is a key organizer for the basal complex of Toxoplasma gondii
    • Heaslip A.T., Dzierszinski F., Stein B., Hu K. TgMORN1 is a key organizer for the basal complex of Toxoplasma gondii. PLoS Pathog 2010, 6:e1000754.
    • (2010) PLoS Pathog , vol.6
    • Heaslip, A.T.1    Dzierszinski, F.2    Stein, B.3    Hu, K.4
  • 66
    • 80052061997 scopus 로고    scopus 로고
    • Targeted disruption of TgPhIL1 in Toxoplasma gondii results in altered parasite morphology and fitness
    • Barkhuff W.D., Gilk S.D., Whitmarsh R., Tilley L.D., Hunter C., Ward G.E. Targeted disruption of TgPhIL1 in Toxoplasma gondii results in altered parasite morphology and fitness. PLoS One 2011, 6:e23977.
    • (2011) PLoS One , vol.6
    • Barkhuff, W.D.1    Gilk, S.D.2    Whitmarsh, R.3    Tilley, L.D.4    Hunter, C.5    Ward, G.E.6
  • 67
    • 46249083369 scopus 로고    scopus 로고
    • A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence
    • Saeij J.P., Arrizabalaga G., Boothroyd J.C. A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence. Infect. Immun. 2008, 76:2402-2410.
    • (2008) Infect. Immun. , vol.76 , pp. 2402-2410
    • Saeij, J.P.1    Arrizabalaga, G.2    Boothroyd, J.C.3
  • 68
    • 34147108730 scopus 로고    scopus 로고
    • Bradyzoite-specific surface antigen SRS9 plays a role in maintaining Toxoplasma gondii persistence in the brain and in host control of parasite replication in the intestine
    • Kim S.K., Karasov A., Boothroyd J.C. Bradyzoite-specific surface antigen SRS9 plays a role in maintaining Toxoplasma gondii persistence in the brain and in host control of parasite replication in the intestine. Infect. Immun. 2007, 75:1626-1634.
    • (2007) Infect. Immun. , vol.75 , pp. 1626-1634
    • Kim, S.K.1    Karasov, A.2    Boothroyd, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.