A mutation protective against Alzheimer's disease renders amyloid β precursor protein incapable of mediating neurotoxicity

Journal of Neurochemistry

Volumn 130, Issue 2, 2014, Pages 291-300

  Hashimoto, Yuichi ^a   Matsuoka, Masaaki ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

AD protective mutation; Alzheimer's disease; amyloid independent; APP; TGF 2

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ISOPROTEIN; MUTANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA2;

ALZHEIMER DISEASE; AMYLOIDOSIS; ARTICLE; BRAIN HEMORRHAGE; CELL DEATH; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; INCIDENCE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NUCLEIC ACID BASE SUBSTITUTION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AD-PROTECTIVE MUTATION; ALZHEIMER'S DISEASE; AMYLOID Β-INDEPENDENT; APP; TGFΒ2;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOIDOSIS; ANIMALS; BLOTTING, WESTERN; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDERMAL GROWTH FACTOR; GENES, ERBB-1; HUMANS; MAP KINASE KINASE 4; MICE; MUTATION; NEURONS; NEUROTOXICITY SYNDROMES; PEPTIDE FRAGMENTS; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84904063615     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12717     Document Type: Article

References (43)

1. Austin S. A., Sens M. A., and, Combs C. K., (2009) Amyloid precursor protein mediates a tyrosine kinase-dependent activation response in endothelial cells. J. Neurosci. 29, 14451-14462.
2. Chávez-Gutiérrez L., Bammens L., Benilova I., et al,. (2012) The mechanism of γ-secretase dysfunction in familial Alzheimer disease. EMBO J. 31, 2261-2274.
3. Cruz J. C., and, Tsai L. H., (2004) Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol. Med. 10, 452-458. (Pubitemid 39209212)
4. Di Fede G., Catania M., Morbin M., et al,. (2009) A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science 323, 1473-1477.
5. Flanders K. C., Lippa C. F., Smith T. W., Pollen D. A., and, Sporn M. B., (1995) Altered expression of transforming growth factor-β in Alzheimer's disease. Neurology 45, 1561-1569.
6. Giovanni A., Wirtz-Brugger F., Keramaris E., Slack R., and, Park D. S., (1999) Involvement of cell cycle elements, cyclindependent kinases, pRb, and E2F•DP, in β-amyloid-induced neuronal death. J. Biol. Chem. 274, 19011-19016.
7. Gschwind M., and, Huber G., (1995) Apoptotic cell death induced by β-amyloid 1-42 peptide is cell type dependent. J. Neurochem. 65, 292-300.
8. Guo Q., Fu W., Sopher B. L., Miller M. W., Ware C. B., Martin G. M., and, Mattson M. P., (1999a) Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat. Med. 5, 101-106. (Pubitemid 29051006)
9. Guo Q., Sebastian L., Sopher B. L., Miller M. W., Glazner G. W., Ware C. B., Martin G. M., and, Mattson M. P., (1999b) Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc. Natl Acad. Sci. USA 96, 4125-4130. (Pubitemid 29169047)
10. Hardy J., and, Selkoe D. J., (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356. (Pubitemid 34790756)
11. Hashimoto Y., Niikura T., Ito Y., and, Nishimoto I., (2000) Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein. J. Biol. Chem. 275, 34541-34551.
12. Hashimoto Y., Niikura T., Chiba T., et al,. (2003) The cytoplasmic domain of Alzheimer's amyloid β protein precursor causes sustained ASK1/JNK mediated neurotoxic signal via dimerization. J. Pharmacol. Exp. Ther. 306, 889-902. (Pubitemid 37025294)
13. Hashimoto Y., Chiba T., Yamada M., Nawa M., Kanekura K., Suzuki H., Terashita K., Aiso S., Nishimoto I., and, Matsuoka M., (2005) Transforming growth factor β2 is a neuronal cell death-inducing ligand for amyloid-β precursor protein. Mol. Cell. Biol. 25, 9304-9317. (Pubitemid 41507832)
14. Hashimoto Y., Nawa M., Chiba T., Aiso S., Nishimoto I., and, Matsuoka M., (2006) Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta. J. Neurosci. Res. 83, 1039-1047.
15. Iwatsubo T., (2004) Assembly and activation of the γ-secretase complex: roles of presenilin cofactors. Mol. Psychiatry 9, 8-10. (Pubitemid 38175075)
16. Jonsson T., Atwal J. K., Steinberg S., et al,. (2012) A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 488, 96-99.
17. Kawasumi M., Hashimoto Y., Chiba T., Kanekura K., Yamagishi Y., Ishizaka M., Tajima H., Niikura T., and, Nishimoto I., (2002) Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein relevant insults. Neurosignals 11, 236-250. (Pubitemid 37494391)
18. Levy E., Carman M. D., Fernandez-Madrid I. J., Power M. D., Lieberburg I., van Duinen S. G., Bots G. T., Luyendijk W., and, Frangione B., (1990) Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 248, 1124-1126.
19. Lichtenthaler S. F., Wang R., Grimm H., Uljon S. N., Masters C. L., and, Beyreuther K., (1999) Mechanism of the cleavage specificity of Alzheimer's disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein. Proc. Natl Acad. Sci. USA 96, 3053-3058. (Pubitemid 29148842)
20. Loo D. T., Copani A., Pike C. J., Whittemore E. R., Walencewicz A. J., and, Cotman C. W., (1993) Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc. Natl Acad. Sci. USA 90, 7951-7955. (Pubitemid 23260832)
21. Matsuoka M., (2009) HUMANIN: A Defender against Alzheimer's disease. Recent Pat. CNS Drug Discov. 4, 37-42.
22. Matsuoka M., Hashimoto Y., Aiso S., and, Nishimoto I., (2006) Humanin and Colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis. CNS Drug Rev. 12, 113-122. (Pubitemid 44300379)
23. Mattson M. P., (2007) Calcium and neurodegeneration. Aging Cell 6, 337-350.
24. McPhie D. L., Coopersmith R., Hines-Peralta A., Chen Y., Ivins K. J., Manly S. P., Kozlowski M. R., Neve K. A., and, Neve R. L., (2003) DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. J. Neurosci. 23, 6914-6927. (Pubitemid 36951220)
25. Néve R. L., (2008) Alzheimer's disease sends the wrong signals-a perspective. Amyloid 15, 1-4. (Pubitemid 351238491)
26. Niikura T., Hashimoto Y., Tajima H., and, Nishimoto I., (2002) Death and survival of neuronal cells exposed to Alzheimer's insults. J. Neurosci. Res. 70, 380-391. (Pubitemid 35222377)
27. Niikura T., Yamada M., Chiba T., Aiso S., Matsuoka M., and, Nishimoto I., (2004) Characterization of V642I-AβPP-induced cytotoxicity in primary neurons. J. Neurosci. Res. 77, 54-62. (Pubitemid 38850055)
28. Noguchi A., Nawa M., Okamoto K., Aiso S., and, Matsuoka M., (2010) TGFβ2 is upregulated in Alzheimer's disease brain. Int. J. Neurosci. 120, 168-175.
29. Platika D., Boulos M., and, H., Baizer L., and, Fishman M.C., (1985) Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells. Proc. Natl Acad. Sci. USA 82, 3499-3503. (Pubitemid 15030712)
30. Popugaeva E., and, Bezprozvanny I., (2014) Can the calcium hypothesis explain synaptic loss in Alzheimer's disease? Neurodegener. Dis. 13, 139-141.
31. Rohn T. T., Ivins K. J., Bahr B. A., Cotman C. W., and, Cribbs D. H., (2000) A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis. J. Neurochem. 74, 2331-2342. (Pubitemid 30314208)
32. Sudo H., Jiang H., Yasukawa T., et al,. (2000) Antibody-regulated neurotoxic function of cell-surface β-amyloid precursor protein. Mol. Cell. Neurosci. 16, 708-723. (Pubitemid 32062059)
33. Sudo H., Hashimoto Y., Niikura T., et al,. (2001) Secreted Aβ does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein. Biochem. Biophys. Res. Commun. 282, 548-556. (Pubitemid 32917906)
34. Tachi N., Hashimoto Y., and, Matsuoka M., (2012) MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins. Biochem. J. 442, 413-422.
35. Tagami S., Okochi M., Yanagida K., Kodama T., Arai T., Kuwano R., Ikeuchi T., and, Takeda M., (2014) Relative ratio and level of amyloid-β 42 surrogate in cerebrospinal fluid of familial Alzheimer disease patients with presenilin 1 mutations. Neurodegener. Dis. 13, 166-170.
36. Takeshita Y., Hashimoto Y., Nawa M., Uchino H., and, Matsuoka M., (2013) SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide Humanin by inhibiting c-Jun NH2-terminal kinase. J. Biol. Chem. 288, 24691-24704.
37. Wattendorff A. R., Frangione B., Luyendijk W., and, Bots G. T., (1995) Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): clinicopathological studies. J. Neurol. Neurosurg. Psychiatry 58, 699-705.
38. Wolozin B., Iwasaki K., Vito P., Ganjei J. K., Lacana E., Sunderland T., Zhao B., Kusiak J. W., Wasco W., and, D'Adamio L., (1996) Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 274, 1710-1713.
39. Yamatsuji T., Matsui T., Okamoto T., et al,. (1996) G protein-mediated neuronal DNA fragmentation by familial Alzheimer's disease associated V642 mutants of APP. Science 272, 1349-1352. (Pubitemid 26199978)
40. Yankner B. A., Dawes L. R., Fisher S., Villa-Komaroff L., Oster-Granite M. L., and, Néve R. L., (1989) Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245, 417-420. (Pubitemid 19203368)
41. Zhang Z., Hartmann H., Do V. M., et al,. (1998) Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395, 698-702. (Pubitemid 28475966)
42. Zhu X., Raina A. K., Rottkamp C. A., Aliev G., Perry G., Boux H., and, Smith M. A., (2001) Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J. Neurochem. 76, 435-441. (Pubitemid 32097021)
43. Zhu X., Ogawa O., Wang Y., Perry G., and, Smith M. A., (2003) JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease. J. Neurochem. 85, 87-93. (Pubitemid 36389698)