SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase

Journal of Biological Chemistry

Volumn 288, Issue 34, 2013, Pages 24691-24704

  Takeshita, Yuji ^a   Hashimoto, Yuichi ^a   Nawa, Mikiro ^a   Uchino, Hiroyuki ^a   Matsuoka, Masaaki ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ANALYSIS; DOMAIN-BINDING PROTEINS; INTRACELLULAR PROTEINS; INTRACELLULAR SIGNALING PATHWAYS; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE EFFECTS; PROTEIN EXPRESSIONS; TRANSCRIPTIONAL TARGETS;

ENZYME ACTIVITY;

PEPTIDES;

BINDING PROTEIN; HUMANIN; MESSENGER RNA; RECOMBINANT PROTEIN; SH3 BINDING PROTEIN 5; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SH3BP5 GENE;

CELL DEATH; HUMANIN; JUN N-TERMINAL KINASE (JNK); NEUROPROTECTION; SH3 DOMAINS; SH3BP5; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALZHEIMER DISEASE; AMINO ACID MOTIFS; ANIMALS; CELL DEATH; CELL LINE, TUMOR; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JANUS KINASE 2; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MITOCHONDRIAL PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN STRUCTURE, TERTIARY;

EID: 84883162649     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.469692     Document Type: Article

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