Full length amylin oligomer aggregation: Insights from molecular dynamics simulations and implications for design of aggregation inhibitors

Journal of Biomolecular Structure and Dynamics

Volumn 32, Issue 10, 2014, Pages 1651-1669

  Berhanu, Workalemahu Mikre ^a   Masunov, Artëm E ^a  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

amylin; cluster analysis; critical nucleation; cross seeding; free energy; lag phase; MM PBSA; oligomer; pramlintide; RMSD; RMSF; secondary structure

Indexed keywords

AMYLIN; OLIGOMER; PRAMLINTIDE; PROTEIN AGGREGATE;

AMINO ACID SUBSTITUTION; ARTICLE; BETA SHEET; CLUSTER ANALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG DESIGN; DRUG SOLUBILITY; HYDROGEN BOND; HYDROPHILICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SOLVATION; STATIC ELECTRICITY; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; HUMAN; MOLECULAR GENETICS; MOUSE; PROTEIN MULTIMERIZATION; SEQUENCE HOMOLOGY; THERMODYNAMICS; TIME;

AMINO ACID SEQUENCE; ANIMALS; CLUSTER ANALYSIS; DRUG DESIGN; HUMANS; HYDROGEN BONDING; ISLET AMYLOID POLYPEPTIDE; MICE; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN AGGREGATES; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS; TIME FACTORS;

EID: 84904042704     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2013.832635     Document Type: Article

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