Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 7, 2006, Pages 2046-2051

  Yan, Li Mei ^a   Tatarek Nossol, Marianna ^a   Velkova, Aleksandra ^a   Kazantzis, Athanasios ^a   Kapurniotu, Aphrodite ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Amyloidogenesis inhibitor; Chemical design; Diabetes; Protein aggregation; Therapeutic compound

Indexed keywords

AMYLIN; AMYLIN DERIVATIVE; AMYLIN RECEPTOR AGONIST; AMYLOIDOGENESIS INHIBITOR; GLYCINE; ISLET AMYLOID POLYPEPTIDE INHIBITOR; ISOLEUCINE; UNCLASSIFIED DRUG;

AMYLOIDOSIS; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL DEATH; CELL DEGENERATION; CONCEPT FORMATION; CYTOTOXICITY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG DESIGN; FIBRILLOGENESIS; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; IN VIVO STUDY; METHYLATION; MOLECULAR MIMICRY; NONHUMAN; OLIGOMERIZATION; PANCREAS CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; RAT; RECEPTOR BLOCKING;

AMINO ACID SEQUENCE; AMYLOID; AMYLOIDOSIS; DRUG DESIGN; HUMANS; LIGANDS; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, PEPTIDE; SOLUBILITY;

ANIMALIA;

EID: 33144464982     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0507471103     Document Type: Article

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