Identification of hot regions of the Aβ-IAPP Interaction interface as high-affinity binding sites in both cross- and self-association

Angewandte Chemie - International Edition

Volumn 49, Issue 17, 2010, Pages 3081-3085

  Andreetto, Erika ^a   Yan, Li Mei ^a   Tatarek Nossol, Marianna ^b   Velkova, Aleksandra ^a   Frank, Ronald ^c   Kapurniotu, Aphrodite ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

amyloid peptides; Islet amyloid polypeptides; Molecular recognition; Protein interactions; Protein self assembly

Indexed keywords

ALZHEIMER'S DISEASE; AMYLOID PEPTIDES; HIGH AFFINITY LIGANDS; HIGH-AFFINITY BINDING SITES; HOT REGIONS; INTERACTION INTERFACE; ISLET AMYLOID POLYPEPTIDES; PEPTIDE SEQUENCES; PROTEIN INTERACTION; PROTEIN INTERACTIONS; SELF-ASSOCIATIONS; TYPE-2 DIABETES;

ASSOCIATION REACTIONS; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; PEPTIDES; POLYPEPTIDES; SELF ASSEMBLY;

GLYCOPROTEINS;

AMYLIN; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN BINDING;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID; AMYLOID BETA-PROTEIN; BINDING SITES; DIABETES MELLITUS, TYPE 2; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING;

EID: 77951177586     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.200904902     Document Type: Article

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