Amyloidogenesis Abolished by Proline Substitutions but Enhanced by Lipid Binding

PLoS Computational Biology

Volumn 5, Issue 4, 2009, Pages

  Jiang, Ping ^a   Xu, Weixin ^a   Mu, Yuguang ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULES; RATS; SELF ASSEMBLY;

AMYLOIDOGENESIS; EXPLICIT SOLVENTS; HUMAN ISLETS; HYDROPHOBIC INTERACTIONS; ISLET AMYLOID POLYPEPTIDES; LIPID BINDING; LIPID MOLECULES; REORGANISATION; REPLICA-EXCHANGE MOLECULAR DYNAMICS SIMULATIONS; SOLVENT MODEL;

OLIGOMERS;

AMYLIN; LIPID; OLIGOMER; PROLINE; PROTEIN; SOLVENT; AMYLOID PRECURSOR PROTEIN;

AMYLOIDOGENESIS; ARTICLE; ATOM; BETA SHEET; CATALYSIS; CONFORMATION; EXPERIMENTAL STUDY; HUMAN; MICELLE; MODEL; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN AGGREGATION; PROTEIN SYNTHESIS; RAT; REGISTER; SIMULATION; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; PROTEIN BINDING; ULTRASTRUCTURE;

RATTUS;

AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BINDING SITES; COMPUTER SIMULATION; LIPIDS; MODELS, CHEMICAL; MODELS, MOLECULAR; PROLINE; PROTEIN BINDING; RATS;

EID: 66249130413     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000357     Document Type: Article

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