SCOPUS 정보 검색 플랫폼

Volumn 17, Issue 10, 2011, Pages 2423-2442

Can molecular dynamics simulations assist in design of specific inhibitors and imaging agents of amyloid aggregation? Structure, stability and free energy predictions for amyloid oligomers of VQIVYK, MVGGVV and LYQLEN

(2) Berhanu, Workalemahu Mikre a Masunov, Artëm E a

a UNIVERSITY OF CENTRAL FLORIDA (United States)

Author keywords

sheet; Aggregation; Amyloid fibril; Binding free energy; Cross structure; MM PBSA; Molecular dynamic simulation; Oligomer; Secondary structure; Steric zipper

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; GLYCINE; HEXAPEPTIDE; INSULIN; OLIGOMER; TAU PROTEIN;

ARTICLE; BETA SHEET; CRYSTAL STRUCTURE; ENERGY; HYDROPHOBICITY; MOLECULAR DYNAMICS; PREDICTION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; SIMULATION; STATIC ELECTRICITY; THERMODYNAMICS; X RAY ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOID; DRUG DESIGN; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTATION; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY;

EID: 80255138062 PISSN: 16102940 EISSN: 09485023 Source Type: Journal
DOI: 10.1007/s00894-010-0912-4 Document Type: Article

Times cited : (19)

References (53)

1
- 0347987853
- Folding proteins in fatal ways
- DOI 10.1038/nature02264
- DJ Selkoe 2003 Nature 426 900 904 10.1038/nature02264 1:CAS:528:DC%2BD3sXpvVGmur4%3D (Pubitemid 38056883)
- (2003) Nature , vol.426 , Issue.6968 , pp. 900-904
- Selkoe, D.J.¹

2
- 36048941372
- Peptide fibrillization
- DOI 10.1002/anie.200700861
- IW Hamley 2007 Angew Chem Int Edit 46 8128 8147 10.1002/anie.200700861 1:CAS:528:DC%2BD2sXhtlCksbzK (Pubitemid 350096583)
- (2007) Angewandte Chemie - International Edition , vol.46 , Issue.43 , pp. 8128-8147
- Hamley, I.W.¹

3
- 28244484729
- OS Makin LC Serpell 2005 Febs J272 5950 5961
- (2005) Febs , vol.272 , pp. 5950-5961
- Makin, O.S.¹ Serpell, L.C.²

4
- 33645995764
- 10.1016/j.sbi.2006.03.007 1:CAS:528:DC%2BD28Xjs1Grsbk%3D
- R Nelson D Eisenberg 2006 Cur Opin Struct Biol 16 260 265 10.1016/j.sbi.2006.03.007 1:CAS:528:DC%2BD28Xjs1Grsbk%3D
- (2006) Cur Opin Struct Biol , vol.16 , pp. 260-265
- Nelson, R.¹ Eisenberg, D.²

5
- 34249290108
- Atomic structures of amyloid cross-β spines reveal varied steric zippers
- DOI 10.1038/nature05695, PII NATURE05695
- MR Sawaya S Sambashivan R Nelson MI Ivanova SA Sievers MI Apostol MJ Thompson M Balbirnie JJW Wiltzius HT McFarlane AO Madsen C Riekel D Eisenberg 2007 Nature 447 453 457 10.1038/nature05695 1:CAS:528:DC%2BD2sXlsFOhu7o%3D (Pubitemid 46816731)
- (2007) Nature , vol.447 , Issue.7143 , pp. 453-457
- Sawaya, M.R.¹ Sambashivan, S.² Nelson, R.³ Ivanova, M.I.⁴ Sievers, S.A.⁵ Apostol, M.I.⁶ Thompson, M.J.⁷ Balbirnie, M.⁸ Wiltzius, J.J.W.⁹ McFarlane, H.T.¹⁰ Madsen, A.O.¹¹ Riekel, C.¹² Eisenberg, D.¹³

6
- 50049095633
- 10.1110/ps.036509.108 1:CAS:528:DC%2BD1cXhtV2rsb7J
- JJW Wiltzius SA Sievers MR Sawaya D Cascio D Popov C Riekel D Eisenberg 2008 Protein Sci 17 1467 1474 10.1110/ps.036509.108 1:CAS:528:DC%2BD1cXhtV2rsb7J
- (2008) Protein Sci , vol.17 , pp. 1467-1474
- Wiltzius, J.J.W.¹ Sievers, S.A.² Sawaya, M.R.³ Cascio, D.⁴ Popov, D.⁵ Riekel, C.⁶ Eisenberg, D.⁷

7
- 73149108618
- 10.1073/pnas.0910080106 1:CAS:528:DC%2BD1MXhsFGlsbvN
- MI Ivanova SA Sievers MR Sawaya JS Wall D Eisenberg 2009 Proc Natl Acad Sci USA 106 18990 18995 10.1073/pnas.0910080106 1:CAS:528:DC%2BD1MXhsFGlsbvN
- (2009) Proc Natl Acad Sci USA , vol.106 , pp. 18990-18995
- Ivanova, M.I.¹ Sievers, S.A.² Sawaya, M.R.³ Wall, J.S.⁴ Eisenberg, D.⁵

8
- 70349658765
- 10.1371/journal.pcbi.1000492
- J Park B Kahng W Hwang 2009 PLoS Comput Biol 5 17 10.1371/journal.pcbi. 1000492
- (2009) PLoS Comput Biol , vol.5 , pp. 17
- Park, J.¹ Kahng, B.² Hwang, W.³

9
- 50349099883
- 10.1529/biophysj.108.129213
- A De Simone L Esposito C Pedone L Vitagliano 2008 Biophys J 95 1965 1973 10.1529/biophysj.108.129213
- (2008) Biophys J , vol.95 , pp. 1965-1973
- De Simone, A.¹ Esposito, L.² Pedone, C.³ Vitagliano, L.⁴

10
- 0037627715
- The role of side-chain interactions in the early steps of aggregation: Molecular dynamics simulations of an amyloid-forming peptide from the yeast prion Sup35
- DOI 10.1073/pnas.0835307100
- J Gsponer U Haberthur A Caflisch 2003 Proc Natl Acad Sci USA 100 5154 5159 10.1073/pnas.0835307100 1:CAS:528:DC%2BD3sXjs1yisLo%3D (Pubitemid 36542674)
- (2003) Proceedings of the National Academy of Sciences of the United States of America , vol.100 , Issue.9 , pp. 5154-5159
- Gsponer, J.¹ Haberthur, U.² Caflisch, A.³

11
- 43849090507
- 10.1529/biophysj.107.118935 10.1529/biophysj.107.118935 1:CAS:528:DC%2BD1cXlsF2hu78%3D
- L Esposito A Paladino C Pedone L Vitagliano 2008 Biophys J 94 4031 4040 10.1529/biophysj.107.118935 10.1529/biophysj.107.118935 1:CAS:528: DC%2BD1cXlsF2hu78%3D
- (2008) Biophys J , vol.94 , pp. 4031-4040
- Esposito, L.¹ Paladino, A.² Pedone, C.³ Vitagliano, L.⁴

12
- 33746800825
- Molecular dynamics analyses of cross-β-spine steric zipper models: β-sheet twisting and aggregation
- DOI 10.1073/pnas.0602345103
- L Esposito C Pedone L Vitagliano 2006 Proc Natl Acad Sci USA 103 11533 11538 10.1073/pnas.0602345103 1:CAS:528:DC%2BD28XotFegtbs%3D (Pubitemid 44182486)
- (2006) Proceedings of the National Academy of Sciences of the United States of America , vol.103 , Issue.31 , pp. 11533-11538
- Esposito, L.¹ Pedone, C.² Vitagliano, L.³

13
- 52049119509
- 10.2741/3109 1:CAS:528:DC%2BD1cXnsVOisr8%3D
- GH Wei W Song P Derreumaux N Mousseau 2008 Front Biosci 13 5681 5692 10.2741/3109 1:CAS:528:DC%2BD1cXnsVOisr8%3D
- (2008) Front Biosci , vol.13 , pp. 5681-5692
- Wei, G.H.¹ Song, W.² Derreumaux, P.³ Mousseau, N.⁴

14
- 33846781516
- Dual binding modes of Congo red to amyloid protofibril surface observed in molecular dynamics simulations
- DOI 10.1021/ja0662772
- C Wu ZX Wang HX Lei W Zhang Y Duan 2007 J Am Chem Soc 129 1225 1232 10.1021/ja0662772 1:CAS:528:DC%2BD2sXlt1Crtg%3D%3D (Pubitemid 46208593)
- (2007) Journal of the American Chemical Society , vol.129 , Issue.5 , pp. 1225-1232
- Wu, C.¹ Wang, Z.² Lei, H.³ Zhang, W.⁴ Duan, Y.⁵

15
- 68849107584
- 10.1016/j.bpj.2009.03.062 1:CAS:528:DC%2BD1MXpsFOmt7w%3D
- JT Berryman SE Radford SA Harris 2009 Biophys J 97 1 11 10.1016/j.bpj.2009.03.062 1:CAS:528:DC%2BD1MXpsFOmt7w%3D
- (2009) Biophys J , vol.97 , pp. 1-11
- Berryman, J.T.¹ Radford, S.E.² Harris, S.A.³

16
- 67249143457
- 1:CAS:528:DC%2BD1MXms1Gqt7o%3D
- LK Chang JH Zhao HL Liu KT Liu JT Chen WB Tsai Y Ho 2009 J Biomol Struct Dyn 26 731 740 1:CAS:528:DC%2BD1MXms1Gqt7o%3D
- (2009) J Biomol Struct Dyn , vol.26 , pp. 731-740
- Chang, L.K.¹ Zhao, J.H.² Liu, H.L.³ Liu, K.T.⁴ Chen, J.T.⁵ Tsai, W.B.⁶ Ho, Y.⁷

17
- 63849213978
- 10.2741/3335 1:CAS:528:DC%2BD1MXltFeisrc%3D
- C Nerelius J Johansson A Sandegren 2009 Front Biosci 14 1716 U3856 10.2741/3335 1:CAS:528:DC%2BD1MXltFeisrc%3D
- (2009) Front Biosci , vol.14
- Nerelius, C.¹ Johansson, J.² Sandegren, A.³

18
- 80255130807
- Rauk A (2008) Dalt Transact 1273-1282
- (2008) Dalt Transact , pp. 1273-1282
- Rauk, A.¹

19
- 70350153272
- 10.1039/b807980n 1:CAS:528:DC%2BD1MXhtVSlsLbP
- A Rauk 2009 Chem Soc Rev 38 2698 2715 10.1039/b807980n 1:CAS:528:DC%2BD1MXhtVSlsLbP
- (2009) Chem Soc Rev , vol.38 , pp. 2698-2715
- Rauk, A.¹

20
- 33749832945
- 10.1021/ar050063s 1:CAS:528:DC%2BD28XntFahsbw%3D
- DB Teplow ND Lazo G Bitan S Bernstein T Wyttenbach MT Bowers A Baumketner JE Shea B Urbanc L Cruz J Borreguero HE Stanley 2006 Acc Chem Res 39 635 645 10.1021/ar050063s 1:CAS:528:DC%2BD28XntFahsbw%3D
- (2006) Acc Chem Res , vol.39 , pp. 635-645
- Teplow, D.B.¹ Lazo, N.D.² Bitan, G.³ Bernstein, S.⁴ Wyttenbach, T.⁵ Bowers, M.T.⁶ Baumketner, A.⁷ Shea, J.E.⁸ Urbanc, B.⁹ Cruz, L.¹⁰ Borreguero, J.¹¹ Stanley, H.E.¹²

21
- 0042307302
- Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-β structure
- DOI 10.1073/pnas.1530287100
- J Berriman LC Serpell KA Oberg AL Fink M Goedert RA Crowther 2003 Proc Natl Acad Sci USA 100 9034 9038 10.1073/pnas.1530287100 1:CAS:528: DC%2BD3sXlvVyiu7s%3D (Pubitemid 36899218)
- (2003) Proceedings of the National Academy of Sciences of the United States of America , vol.100 , Issue.15 , pp. 9034-9038
- Berriman, J.¹ Serpell, L.C.² Oberg, K.A.³ Fink, A.L.⁴ Goedert, M.⁵ Crowther, R.A.⁶

22
- 20444440728
- Structure of the cross-β spine of amyloid-like fibrils
- DOI 10.1038/nature03680
- R Nelson MR Sawaya M Balbirnie AO Madsen C Riekel R Grothe D Eisenberg 2005 Nature 435 773 778 10.1038/nature03680 1:CAS:528:DC%2BD2MXkvVGgsLY%3D (Pubitemid 40839722)
- (2005) Nature , vol.435 , Issue.7043 , pp. 773-778
- Nelson, R.¹ Sawaya, M.R.² Balbirnie, M.³ Madsen, A.O.⁴ Riekel, C.⁵ Grothe, R.⁶ Eisenberg, D.⁷

23
- 0030801746
- Academic, San Diego
- Sunde M, Blake C (1997) Adv Prot Chem, Vol 50. Academic, San Diego, pp 123-159
- (1997) Adv Prot Chem , vol.50 , pp. 123-159
- Sunde, M.¹ Blake, C.²

24
- 33745285736
- The Component Polypeptide Chains of Bovine Insulin Nucleate or Inhibit Aggregation of the Parent Protein in a Conformation-dependent Manner
- DOI 10.1016/j.jmb.2006.05.007, PII S0022283606005730
- GL Devlin TPJ Knowles A Squires MG McCammon SL Gras MR Nilsson CV Robinson CM Dobson CE MacPhee 2006 J Mol Biol 360 497 509 10.1016/j.jmb.2006.05. 007 1:CAS:528:DC%2BD28Xmt1yrt7s%3D (Pubitemid 43927830)
- (2006) Journal of Molecular Biology , vol.360 , Issue.2 , pp. 497-509
- Devlin, G.L.¹ Knowles, T.P.J.² Squires, A.³ McCammon, M.G.⁴ Gras, S.L.⁵ Nilsson, M.R.⁶ Robinson, C.V.⁷ Dobson, C.M.⁸ MacPhee, C.E.⁹

25
- 29244479548
- Independent heterologous fibrillation of insulin and its B-chain peptide
- DOI 10.1021/bi051658y
- DP Hong AL Fink 2005 Biochemistry 44 16701 16709 10.1021/bi051658y 1:CAS:528:DC%2BD2MXht1GmsrfE (Pubitemid 41832050)
- (2005) Biochemistry , vol.44 , Issue.50 , pp. 16701-16709
- Hong, D.-P.¹ Fink, A.L.²

26
- 33847738972
- 1:STN:280:DC%2BD2s7lsFOkuw%3D%3D
- KR Wilhelm K Yanamandra MA Gruden V Zamotin M Malisauskas V Casaite A Darinskas L Forsgren LA Morozova-Roche 2007 Eur J Neurol 14 327 334 1:STN:280:DC%2BD2s7lsFOkuw%3D%3D
- (2007) Eur J Neurol , vol.14 , pp. 327-334
- Wilhelm, K.R.¹ Yanamandra, K.² Gruden, M.A.³ Zamotin, V.⁴ Malisauskas, M.⁵ Casaite, V.⁶ Darinskas, A.⁷ Forsgren, L.⁸ Morozova-Roche, L.A.⁹

27
- 0030959947
- Toward understanding insulin fibrillation
- DOI 10.1021/js960297s
- J Brange L Andersen ED Laursen G Meyn E Rasmussen 1997 J Pharm Sci 86 517 525 10.1021/js960297s 1:CAS:528:DyaK2sXisVOku78%3D (Pubitemid 27203397)
- (1997) Journal of Pharmaceutical Sciences , vol.86 , Issue.5 , pp. 517-525
- Brange, J.¹ Andersen, L.² Laursen, E.D.³ Meyn, G.⁴ Rasmussen, E.⁵

28
- 30044446633
- Early in the fibrillation of monomeric insulin
- DOI 10.1074/jbc.M504298200
- A Ahmad VN Uversky D Hong AL Fink 2005 J Biol Chem 280 42669 42675 10.1074/jbc.M504298200 1:CAS:528:DC%2BD2MXhtlCmsLnN (Pubitemid 43049225)
- (2005) Journal of Biological Chemistry , vol.280 , Issue.52 , pp. 42669-42675
- Ahmad, A.¹ Uversky, V.N.² Hong, D.³ Fink, A.L.⁴

29
- 34548627237
- Molecular dynamics simulations on the oligomer-formation process of the GNNQQNY peptide from yeast prion protein Sup35
- DOI 10.1529/biophysj.106.100537
- ZQ Zhang H Chen HJ Bai LH Lai 2007 Biophys J 93 1484 1492 10.1529/biophysj.106.100537 1:CAS:528:DC%2BD2sXpsVKisrY%3D (Pubitemid 47403294)
- (2007) Biophysical Journal , vol.93 , Issue.5 , pp. 1484-1492
- Zhang, Z.¹ Chen, H.² Bai, H.³ Lai, L.⁴

30
- 79959694630
- WX Xu J Ping WF Li YG Mu 2009 J Chem Phys 130 8
- (2009) J Chem Phys , vol.130 , pp. 8
- Xu, W.X.¹ Ping, J.² Li, W.F.³ Mu, Y.G.⁴

31
- 63249103989
- 10.1074/jbc.M808591200 1:CAS:528:DC%2BD1MXhsFKqur8%3D
- R Kayed A Pensalfini L Margol Y Sokolov F Sarsoza E Head J Hall C Glabe 2009 J Biol Chem 284 4230 4237 10.1074/jbc.M808591200 1:CAS:528: DC%2BD1MXhsFKqur8%3D
- (2009) J Biol Chem , vol.284 , pp. 4230-4237
- Kayed, R.¹ Pensalfini, A.² Margol, L.³ Sokolov, Y.⁴ Sarsoza, F.⁵ Head, E.⁶ Hall, J.⁷ Glabe, C.⁸

32
- 23044449398
- Amyloid ion channels: A common structural link for protein-misfolding disease
- DOI 10.1073/pnas.0502066102
- A Quist L Doudevski H Lin R Azimova D Ng B Frangione B Kagan J Ghiso R Lal 2005 Proc Natl Acad Sci USA 102 10427 10432 10.1073/pnas.0502066102 1:CAS:528:DC%2BD2MXntVSit7w%3D (Pubitemid 41061570)
- (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , Issue.30 , pp. 10427-10432
- Quist, A.¹ Doudevski, I.² Lin, H.³ Azimova, R.⁴ Ng, D.⁵ Frangione, B.⁶ Kagan, B.⁷ Ghiso, J.⁸ Lal, R.⁹

33
- 71749100900
- 10.1002/bip.21182 1:CAS:528:DC%2BD1MXhtF2hsLvK
- L Vitagliano F Stanzione A De Simone L Esposito 2009 Biopolymers 91 1161 1171 10.1002/bip.21182 1:CAS:528:DC%2BD1MXhtF2hsLvK
- (2009) Biopolymers , vol.91 , pp. 1161-1171
- Vitagliano, L.¹ Stanzione, F.² De Simone, A.³ Esposito, L.⁴

34
- 84857795750
- http://www.doe-mbi.ucla.edu/∼sawaya/chime/xtalpept (2009)

35
- 84857796239
- D.A. Case TAD TEC, III, Simmerling CL, Wang J, Duke RE, Luo R, Crowley M, Ross C. Walker, Zhang W, Merz KM, Wang B, Hayik S, Roitberg A, Seabra G, Kolossváry I, Wong KF, Paesani F, Vanicek J, Wu X, Brozell SR, Steinbrecher T, Gohlke H, Yang L, Tan C, Mongan J, Hornak V, Cui G, Mathews DH, Seetin MG, Sagui C, Babin V, Kollman PA (2008) University of California, San Francisco
- D.A. Case TAD TEC, III, Simmerling CL, Wang J, Duke RE, Luo R, Crowley M, Ross C. Walker, Zhang W, Merz KM, Wang B, Hayik S, Roitberg A, Seabra G, Kolossváry I, Wong KF, Paesani F, Vanicek J, Wu X, Brozell SR, Steinbrecher T, Gohlke H, Yang L, Tan C, Mongan J, Hornak V, Cui G, Mathews DH, Seetin MG, Sagui C, Babin V, Kollman PA (2008) University of California, San Francisco

36
- 33645961739
- 10.1063/1.470117 1:CAS:528:DyaK2MXptlehtrw%3D
- U Essmann L Perera ML Berkowitz T Darden H Lee LG Pedersen 1995 J Chem Phys 103 8577 8593 10.1063/1.470117 1:CAS:528:DyaK2MXptlehtrw%3D
- (1995) J Chem Phys , vol.103 , pp. 8577-8593
- Essmann, U.¹ Perera, L.² Berkowitz, M.L.³ Darden, T.⁴ Lee, H.⁵ Pedersen, L.G.⁶

37
- 33646940952
- 10.1016/0021-9991(77)90098-5 1:CAS:528:DyaE2sXktVGhsL4%3D
- JP Ryckaert G Ciccotti HJC Berendsen 1977 J Comput Phys 23 327 341 10.1016/0021-9991(77)90098-5 1:CAS:528:DyaE2sXktVGhsL4%3D
- (1977) J Comput Phys , vol.23 , pp. 327-341
- Ryckaert, J.P.¹ Ciccotti, G.² Berendsen, H.J.C.³

38
- 0020997912
- 10.1002/bip.360221211 1:CAS:528:DyaL2cXkslegtQ%3D%3D
- W Kabsch C Sander 1983 Biopolymers 22 2577 2637 10.1002/bip.360221211 1:CAS:528:DyaL2cXkslegtQ%3D%3D
- (1983) Biopolymers , vol.22 , pp. 2577-2637
- Kabsch, W.¹ Sander, C.²

39
- 0029878720
- VMD: Visual molecular dynamics
- DOI 10.1016/0263-7855(96)00018-5
- W Humphrey A Dalke K Schulten 1996 J Mol Graph 14 33 38 10.1016/0263-7855(96)00018-5 1:CAS:528:DyaK28Xis12nsrg%3D (Pubitemid 26152973)
- (1996) Journal of Molecular Graphics , vol.14 , Issue.1 , pp. 33-38
- Humphrey, W.¹ Dalke, A.² Schulten, K.³

40
- 0034521981
- Calculating structures and free energies of complex molecules: Combining molecular mechanics and continuum models
- DOI 10.1021/ar000033j
- PA Kollman I Massova C Reyes B Kuhn SH Huo L Chong M Lee T Lee Y Duan W Wang O Donini P Cieplak J Srinivasan DA Case TE Cheatham 2000 Acc Chem Res 33 889 897 10.1021/ar000033j 1:CAS:528:DC%2BD3cXmvFGiu7g%3D (Pubitemid 32056774)
- (2000) Accounts of Chemical Research , vol.33 , Issue.12 , pp. 889-897
- Kollman, P.A.¹ Massova, I.² Reyes, C.³ Kuhn, B.⁴ Huo, S.⁵ Chong, L.⁶ Lee, M.⁷ Lee, T.⁸ Duan, Y.⁹ Wang, W.¹⁰ Donini, O.¹¹

41
- 0033405041
- Molecular dynamics and free-energy calculations applied to affinity maturation in antibody 48G7
- DOI 10.1073/pnas.96.25.14330
- LT Chong Y Duan L Wang I Massova PA Kollman 1999 Proc Natl Acad Sci USA 96 14330 14335 10.1073/pnas.96.25.14330 1:CAS:528:DyaK1MXnvFKlurw%3D (Pubitemid 30000650)
- (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.25 , pp. 14330-14335
- Chong, L.T.¹ Duan, Y.² Wang, L.³ Massova, I.⁴ Kollman, P.A.⁵

42
- 0037135111
- The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
- DOI 10.1126/science.1072994
- J Hardy DJ Selkoe 2002 Science 297 353 356 10.1126/science.1072994 1:CAS:528:DC%2BD38Xls1Cju7s%3D (Pubitemid 34790756)
- (2002) Science , vol.297 , Issue.5580 , pp. 353-356
- Hardy, J.¹ Selkoe, D.J.²

43
- 33645038471
- 10.1038/nature04533 1:CAS:528:DC%2BD28XitlKgurg%3D
- S Lesne MT Koh L Kotilinek R Kayed CG Glabe A Yang M Gallagher KH Ashe 2006 Nature 440 352 357 10.1038/nature04533 1:CAS:528:DC%2BD28XitlKgurg%3D
- (2006) Nature , vol.440 , pp. 352-357
- Lesne, S.¹ Koh, M.T.² Kotilinek, L.³ Kayed, R.⁴ Glabe, C.G.⁵ Yang, A.⁶ Gallagher, M.⁷ Ashe, K.H.⁸

44
- 33749522024
- Pt C Elsevier Academic Press Inc San Diego
- Sciarretta KL, Gordon DJ, Meredith SC (2006) Amyloid, Prions, and Other Protein Aggregates. Pt C Elsevier, San Diego, pp 273-312
- (2006) Amyloid, Prions, and Other Protein Aggregates , pp. 273-312
- Sciarretta, K.L.¹ Gordon, D.J.² Meredith, S.C.³

45
- 0032479179
- Anatomy of hot spots in protein interfaces
- DOI 10.1006/jmbi.1998.1843
- AA Bogan KS Thorn 1998 J Mol Biol 280 1 9 10.1006/jmbi.1998.1843 1:STN:280:DyaK1czhslSgtg%3D%3D (Pubitemid 28312802)
- (1998) Journal of Molecular Biology , vol.280 , Issue.1 , pp. 1-9
- Bogan, A.A.¹ Thorn, K.S.²

46
- 77549088259
- Elsevier Academic Press Inc San Diego. 10.1016/S0065-7743(09)04403-0
- Haydar SN, Yun HED, Staal RGW, Hirst WD (2009) Annu Rep Med Chem, Vol 44. Elsevier, San Diego, pp 51-69
- (2009) Annu Rep Med Chem, Vol 44 , pp. 51-69
- Haydar, S.N.¹ Yun, H.E.D.² Staal, R.G.W.³ Hirst, W.D.⁴

47
- 57649138736
- 10.1038/npp.2008.151 1:CAS:528:DC%2BD1cXhsVyru7rE
- LL Blazer RR Neubig 2009 Neuropsychopharmacology 34 126 141 10.1038/npp.2008.151 1:CAS:528:DC%2BD1cXhsVyru7rE
- (2009) Neuropsychopharmacology , vol.34 , pp. 126-141
- Blazer, L.L.¹ Neubig, R.R.²

48
- 40949119905
- Neurochemical approaches of cerebrospinal fluid diagnostics in neurodegenerative diseases
- DOI 10.1016/j.ymeth.2007.06.012, PII S1046202307001259
- M Otto P Lewczuk J Wiltfang 2008 Methods 44 289 298 10.1016/j.ymeth.2007. 06.012 1:CAS:528:DC%2BD1cXktV2ks7o%3D (Pubitemid 351406506)
- (2008) Methods , vol.44 , Issue.4 , pp. 289-298
- Otto, M.¹ Lewczuk, P.² Wiltfang, J.³

49
- 0034723150
- 10.1006/jmbi.1999.3422 1:CAS:528:DC%2BD3cXotlSjtA%3D%3D
- K Tenidis M Waldner J Bernhagen W Fischle M Bergmann M Weber ML Merkle W Voelter H Brunner A Kapurniotu 2000 J Mol Biol 295 1055 1071 10.1006/jmbi.1999.3422 1:CAS:528:DC%2BD3cXotlSjtA%3D%3D
- (2000) J Mol Biol , vol.295 , pp. 1055-1071
- Tenidis, K.¹ Waldner, M.² Bernhagen, J.³ Fischle, W.⁴ Bergmann, M.⁵ Weber, M.⁶ Merkle, M.L.⁷ Voelter, W.⁸ Brunner, H.⁹ Kapurniotu, A.¹⁰

50
- 8544272519
- Inhibition of islet amyloid polypeptide fibril formation: A potential role for heteroaromatic interactions
- DOI 10.1021/bi048582a
- Y Porat Y Mazor S Efrat E Gazit 2004 Biochemistry 43 14454 14462 10.1021/bi048582a 1:CAS:528:DC%2BD2cXos1WjtLY%3D (Pubitemid 39491980)
- (2004) Biochemistry , vol.43 , Issue.45 , pp. 14454-14462
- Porat, Y.¹ Mazor, Y.² Efrat, S.³ Gazit, E.⁴

51
- 33646371260
- Inhibitors of amyloid toxicity based on β-sheet packing of Aβ40 and Aβ42
- DOI 10.1021/bi052485f
- T Sato P Kienlen-Campard M Ahmed W Liu HL Li JI Elliott S Aimoto SN Constantinescu JN Octave SO Smith 2006 Biochemistry 45 5503 5516 10.1021/bi052485f 1:CAS:528:DC%2BD28Xjt1Wls7g%3D (Pubitemid 43673181)
- (2006) Biochemistry , vol.45 , Issue.17 , pp. 5503-5516
- Sato, T.¹ Kienlen-Campard, P.² Ahmed, M.³ Liu, W.⁴ Li, H.⁵ Elliott, J.I.⁶ Aimoto, S.⁷ Constantinescu, S.N.⁸ Octave, J.-N.⁹ Smith, S.O.¹⁰

52
- 77449106299
- Takahashi T, Ohta K, Mihara H. Prot Struct Func Bioinf 78:336-347
- Prot Struct Func Bioinf , vol.78 , pp. 336-347
- Takahashi, T.¹ Ohta, K.² Mihara, H.³

53
- 65549161050
- 10.2174/138161209787315648 1:CAS:528:DC%2BD1MXkvVSns7g%3D
- YS Kim JH Lee J Ryu DJ Kim 2009 Curr Pharm Des 15 637 658 10.2174/138161209787315648 1:CAS:528:DC%2BD1MXkvVSns7g%3D
- (2009) Curr Pharm des , vol.15 , pp. 637-658
- Kim, Y.S.¹ Lee, J.H.² Ryu, J.³ Kim, D.J.⁴

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.