Skeletal muscle is an endocrine organ

Journal of Pharmacological Sciences

Volumn 125, Issue 2, 2014, Pages 125-131

  Iizuka, Kenji ^a   Machida, Takuji ^a   Hirafuji, Masahiko ^a  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

Author keywords

Exercise; Myokine; Skeletal muscle cell

Indexed keywords

ACTIVIN; ADIPOCYTOKINE; BONE MORPHOGENETIC PROTEIN 4; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN NATRIURETIC PEPTIDE; FIBROBLAST GROWTH FACTOR 21; FOLLISTATIN; INHIBIN; INTERLEUKIN 11; INTERLEUKIN 1BETA; INTERLEUKIN 6; IRISIN; MUSCLE PROTEIN; MYOKINE; MYONECTIN; MYOSTATIN; NATRIURETIC PEPTIDE RECEPTOR C; SECRETORY PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; BONE MORPHOGENETIC PROTEIN; C1QTNF5 PROTEIN, HUMAN; COLLAGEN; FIBRONECTIN; FNDC5 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE;

ARTICLE; CELL DIFFERENTIATION; ENDOCRINE GLAND; EXERCISE; HUMAN; MUSCLE CONTRACTION; MUSCLE GROWTH; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SKELETAL MUSCLE SATELLITE CELL; ENERGY METABOLISM; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

ACTIVINS; ADIPOKINES; BONE MORPHOGENETIC PROTEINS; BRAIN-DERIVED NEUROTROPHIC FACTOR; COLLAGEN; ENERGY METABOLISM; EXERCISE; FIBRONECTINS; FOLLISTATIN; HUMANS; INHIBINS; INTERLEUKINS; MUSCLE, SKELETAL; MYOSTATIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84904005536     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.14R02CP     Document Type: Article

References (49)

1. Demontis F, Piccirillo R, Goldberg AL, Perrimon N. The influence of skeletal muscle on systemic aging and lifespan. Aging Cell. 2013;12:943-949.
2. Andersen CJ, Fernandez ML. Dietary strategies to reduce metabolic syndrome. Rev Endocr Metab Disord. 2013;14:241-254.
3. Jans A, van Hees AM, Gjelstad IM, Sparks LM, Tierney AC, Risérus U, et al. Impact of dietary fat quantity and quality on skeletal muscle fatty acid metabolism in subjects with the metabolic syndrome. Metabolism. 2012;61:1554-1565.
4. Iizuka K, Machida T, Hirafuji M. Extracellular MCT4 is a possible indicator for skeletal muscle MHC fiber type change. Ann Clin Lab Sci. 2014. In press.
5. Leal V de O, Mafra D. Adipokines in obesity. Clin Chim Acta. 2013;419:87-94.
6. Pedersen BK. Muscles and their myokines. Exp Biol. 2011; 214:337-346.
7. Sheehan SM, Tatsumi R, Temm-Grove CJ, Allen RE. HGF is an autocrine growth factor for skeletal muscle satellite cells in vitro. Muscle Nerve. 2000;23:239-245. (Pubitemid 30064948)
8. Morita N, Iizuka K, Okita K, Oikawa T, Yonezawa K, Nagai T, et al. Exposure to pressure stimulus enhances succinate dehydrogenase activity in L6 myoblasts. Am J Physiol Endocrinol Metab. 2004;287:E1064-E1069. (Pubitemid 39491947)
9. Feng XH, Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol. 2005;21: 659-693. (Pubitemid 41740650)
10. McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997;387:83-90. (Pubitemid 27202654)
11. Burks TN, Cohn RD. Role of TGF-β signaling in inherited and acquired myopathies. Skelet Muscle. 2011;1:19.
12. Kollias HD, McDermott JC. Transforming growth factor-beta and myostatin signaling in skeletal muscle. J Appl Physiol. 2008;104:579-587. (Pubitemid 351468784)
13. Rausch ME, Barnhart KT. Serum biomarkers for detecting ectopic pregnancy. Clin Obstet Gynecol. 2012;55:418-423.
14. Lee SJ, Reed LA, Davies MV, Girgenrath S, Goad ME, Tomkinson KN, et al. Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc Natl Acad Sci U S A. 2005;102:18117-18122. (Pubitemid 41798511)
15. Bernard DJ, Chapman SC, Woodruff TK. Mechanisms of inhibin signal transduction. Recent Prog Horm Res. 2001;56:417-450.
16. Diel P, Schiffer T, Geisler S, Hertrampf T, Mosler S, Schulz S, et al. Analysis of the effects of androgens and training on myostatin propeptide and follistatin concentrations in blood and skeletal muscle using highly sensitive immuno PCR. Mol Cell Endocrinol. 2010;330:1-9.
17. Görgens SW, Raschke S, Holven KB, Jensen J, Eckardt K, Eckel J. Regulation of follistatin-like protein 1 expression and secretion in primary human skeletal muscle cells. Arch Physiol Biochem. 2013;119:75-80.
18. Vamvini MT, Aronis KN, Panagiotou G, Huh JY, Chamberland JP, Brinkoetter MT, et al. Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans. Eur J Endocrinol. 2013;169:829-834.
19. Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, et al. Evidence against a beneficial effect of irisin in humans. PLoS One. 2013;8:e73680.
20. Li X, Cao X. BMP signaling and skeletogenesis. Ann N Y Acad Sci. 2006;1068:26-40. (Pubitemid 43824134)
21. Umemoto T, Furutani Y, Murakami M, Matsui T, Funaba M. Endogenous Bmp4 in myoblasts is required for myotube formation in C2C12 cells. Biochim Biophys Acta. 2011;1810: 1127-1135.
22. Kluk MW, Ji Y, Shin EH, Amrani O, Onodera J, Jackson WM, Nesti LJ. Fibroregulation of mesenchymal progenitor cells by BMP-4 after traumatic muscle injury. J Orthop Trauma. 2012; 26:693-698.
23. Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005;98:1154-1162. (Pubitemid 40396484)
24. Pedersen BK, Fischer CP. Beneficial health effects of exercise - the role of IL-6 as a myokine. Trends Pharmacol Sci. 2007;28:152-156. (Pubitemid 46505167)
25. Muñoz-Cánoves P, Scheele C, Pedersen BK, Serrano AL. Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword? FEBS J. 2013;280:4131-4148.
26. Seldin MM, Tan SY, Wong GW. Metabolic function of the CTRP family of hormones. Rev Endocr Metab Disord. 2013. In press.
27. Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 2012; 287:11968-11980.
28. Lim S, Choi SH, Koo BK, Kang SM, Yoon JW, Jang HC, et al. Effects of aerobic exercise training on C1q tumor necrosis factorα-related protein isoform 5 (myonectin): association with insulin resistance and mitochondrial DNA density in women. J Clin Endocrinol Metab. 2012;97:E88-E93.
29. Huang EJ, Reichardt LF. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci. 2001;24: 677-736. (Pubitemid 32695243)
30. Rojas Vega S, Strüder HK, Vera Wahrmann B, Schmidt A, Bloch W, Hollmann W. Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans. Brain Res. 2006;1121:59-65. (Pubitemid 44708897)
31. Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, et al. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol. 2009;94: 1062-1069.
32. Matthews VB, Aström MB, Chan MH, Bruce CR, Krabbe KS, Prelovsek O, et al. Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. Diabetologia. 2009;52:1409-1418.
33. Yasui A, Nishizawa H, Okuno Y, Morita K, Kobayashi H, Kawai K, et al. Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor. Biochem Biophys Res Commun. 2007;364:358-365. (Pubitemid 47633422)
34. Izumiya Y, Bina HA, Ouchi N, Akasaki Y, Kharitonenkov A, Walsh K. FGF21 is an Akt-regulated myokine. FEBS Lett. 2008;582:3805-3810.
35. Kawashima K, Fujii T. Basic and clinical aspects of non-neuronal acetylcholine: overview of non-neuronal cholinergic systems and their biological significance. J Pharmacol Sci. 2008;106: 167-173. (Pubitemid 351366333)
36. Tsuchida K. Activins, myostatin and related TGF-beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders. Curr Drug Targets Immune Endocr Metabol Disord. 2004;4:157-166.
37. Nakatani M, Kokubo M, Ohsawa Y, Sunada Y, Tsuchida K. Follistatin-derived peptide expression in muscle decreases adipose tissue mass and prevents hepatic steatosis. Am J Physiol Endocrinol Metab. 2011;300:E543-E553.
38. Shan T1, Liang X, Bi P, Kuang S. Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle. FASEB J. 2013;27: 1981-1989.
39. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481: 463-468.
40. Tsuchida A, Nakagawa T, Itakura Y, Ichihara J, Ogawa W, Kasuga M, et al. The effects of brain-derived neurotrophic factor on insulin signal transduction in the liver of diabetic mice. Diabetologia. 2001;44:555-566. (Pubitemid 32411271)
41. Rodino-Klapac LR, Haidet AM, Kota J, Handy C, Kaspar BK, Mendell JR. Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease. Muscle Nerve. 2009;39: 283-296.
42. Amthor H, Hoogaars WM. Interference with myostatin/ActRIIB signaling as a therapeutic strategy for Duchenne muscular dystrophy. Curr Gene Ther. 2012;12:245-259.
43. Tisdale MJ. Reversing cachexia. Cell. 2010;142:511-512.
44. Bowser M, Herberg S, Arounleut P, Shi X, Fulzele S, Hill WD, et al. Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells. Exp Gerontol. 2013; 48:290-297.
45. Demontis F, Piccirillo R, Goldberg AL, Perrimon N. The influence of skeletal muscle on systemic aging and lifespan. Aging Cell. 2013;12:943-949.
46. Harada S1, Fujita-Hamabe W, Tokuyama S. Ameliorating effect of hypothalamic brain-derived neurotrophic factor against impaired glucose metabolism after cerebral ischemic stress in mice. J Pharmacol Sci. 2012;118:109-116.
47. Chou HJ1, Lai DM, Huang CW, McLennan IS, Wang HD, Wang PY. BMP4 is a peripherally-derived factor for motor neurons and attenuates glutamate-induced excitotoxicity in vitro. PLoS One. 2013;8:e58441.
48. Okita K, Kinugawa S, Tsutsui H. Exercise intolerance in chronic heart failure - skeletal muscle dysfunction and potential therapies. Circ J. 2013;77:293-300.
49. Hojman P, Dethlefsen C, Brandt C, Hansen J, Pedersen L, Pedersen BK. Exercise-induced muscle-derived cytokines inhibit mammary cancer cell growth. Am J Physiol Endocrinol Metab. 2011;301:E504-E510.