Ameliorating effect of hypothalamic brain-derived neurotrophic factor against impaired glucose metabolism after cerebral ischemic stress in mice

Journal of Pharmacological Sciences

Volumn 118, Issue 1, 2012, Pages 109-116

  Harada, Shinichi ^a   Fujita Hamabe, Wakako ^a   Tokuyama, Shogo ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Brain derived neurotrophic factor; Cerebral ischemic stress; Gluconeogenesis; Insulin receptor; Middle cerebral artery occlusion

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; GLUCOSE; INSULIN; INSULIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DAMAGE; BRAIN ISCHEMIA; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HYPOTHALAMUS; INSULIN BLOOD LEVEL; LEARNING; LIVER; MALE; MEMORY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROLOGIC EXAMINATION; NONHUMAN; PANCREAS; PROTEIN EXPRESSION; SKELETAL MUSCLE;

EID: 84856568227     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11164FP     Document Type: Article

References (31)

1. Zhang RL, Lu CZ, Ren HM, Xiao BG. Metabolic changes of arachidonic acid after cerebral ischemia-reperfusion in diabetic rats. Exp Neurol. 2003;184:746-752.
2. Li ZG, Britton M, Sima AA, Dunbar JC. Diabetes enhances apoptosis induced by cerebral ischemia. Life Sci. 2004;76:249-262. (Pubitemid 39452909)
3. Harada S, Fujita WH, Shichi K, Tokuyama S. The development of glucose intolerance after focal cerebral ischemia participates in subsequent neuronal damage. Brain Res. 2009;1279:174-181.
4. Kahn BB, Rosen AS, Bak JF, Andersen PH, Damsbo P, Lund S, et al. Expression of GLUT1 and GLUT4 glucose transporters in skeletal muscle of humans with insulin-dependent diabetes mellitus: regulatory effects of metabolic factors. J Clin Endocrinol Metab. 1992;74:1101-1109.
5. Zick Y. Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol. 2001;11:437-441.
6. Fekete C, Singru PS, Sanchez E, Sarkar S, Christoffolete MA, Riberio RS, et al. Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary- thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology. 2006;147:520-529. (Pubitemid 43004308)
7. Auer RN. Insulin, blood glucose levels, and ischemic brain damage. Neurology. 1998;51:S39-S43. (Pubitemid 28429323)
8. Rizk NN, Rafols JA, Dunbar JC. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain Res. 2006;1096:204-212. (Pubitemid 43928921)
9. Collino M, Aragno M, Castiglia S, Tomasinelli C, Thiemermann C, Boccuzzi G, et al. Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta. Diabetes. 2009;58:235-242.
10. Han BH, Holtzman DM. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J Neurosci. 2000;20:5775-5781. (Pubitemid 30636906)
11. Nakagawa T, Tsuchida A, Itakura Y, Nonomura T, Ono M, Hirota F, et al. Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Diabetes. 2000;49:436-444. (Pubitemid 30131790)
12. Nonomura T, Tsuchida A, Ono-Kishino M, Nakagawa T, Taiji M, Noguchi H. Brain-derived neurotrophic factor regulates energy expenditure through the central nervous system in obese diabetic mice. Int J Exp Diabetes Res. 2001;2:201-209.
13. Tsuchida A, Nakagawa T, Itakura Y, Ichihara J, Ogawa W, Kasuga M, et al. The effects of brain-derived neurotrophic factor on insulin signal transduction in the liver of diabetic mice. Diabetologia. 2001;44:555-566. (Pubitemid 32411271)
14. Harada S, Hamabe W, Kamiya K, Satake T, Yamamoto J, Tokuyama S. Preventive effect of Morinda citrifolia fruit juice on neuronal damage induced by focal ischemia. Biol Pharm Bull. 2009;32:405-409.
15. Harada S, Fujita-Hamabe W, Kamiya K, Mizushina Y, Satake T, Tokuyama S. Morinda citrifolia fruit juice prevents ischemic neuronal damage through suppression of the development of post-ischemic glucose intolerance. J Nat Med. 2010;64:468-473.
16. Harada S, Fujita-Hamabe W, Tokuyama S. Effect of orexin-A on post-ischemic glucose intolerance and neuronal damage. J Pharmacol Sci. 2011;115:155-163.
17. Tsao D, Thomsen HK, Chou J, Stratton J, Hagen M, Loo C, et al. TrkB agonists ameliorate obesity and associated metabolic conditions in mice. Endocrinology. 2008;149:1038-1048. (Pubitemid 351397944)
18. Takahashi M, Fukunaga H, Kaneto H, Fukudome S, Yoshikawa M. Behavioral and pharmacological studies on gluten exorphin A5, a newly isolated bioactive food protein fragment, in mice. Jpn J Pharmacol. 2000;84:259-265. (Pubitemid 32000451)
19. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999;22:391-397. (Pubitemid 29453643)
20. Mochizuki N, Takagi N, Kurokawa K, Onozato C, Moriyama Y, Tanonaka K, et al. Injection of neural progenitor cells improved learning and memory dysfunction after cerebral ischemia. Exp Neurol. 2008;211:194-202.
21. Schabitz WR, Schwab S, Spranger M, Hacke W. Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 1997;17:500-506. (Pubitemid 27250976)
22. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763-770. (Pubitemid 28485436)
23. Uyama N, Geerts A, Reynaert H. Neural connections between the hypothalamus and the liver. Anat Rec A Discov Mol Cell Evol Biol. 2004;280:808-820. (Pubitemid 39330960)
24. Yamada T, Katagiri H. Avenues of communication between the brain and tissues/organs involved in energy homeostasis. Endocr J. 2007;54:497-505. (Pubitemid 47414595)
25. Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, et al. Regulation of pancreatic beta cell mass by neuronal signals from the liver. Science. 2008;322:1250-1254.
26. Nibuya M, Takahashi M, Russell DS, Duman RS. Repeated stress increases catalytic TrkB mRNA in rat hippocampus. Neurosci Lett. 1999;267:81-84. (Pubitemid 29251591)
27. Prasad RC, Herzog B, Boone B, Sims L, Waltner-Law M. An extract of Syzygium aromaticum represses genes encoding hepatic gluconeogenic enzymes. J Ethnopharmacol. 2005;96:295-301. (Pubitemid 39575063)
28. Li S, Brown MS, Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A. 2010;107:3441-3446.
29. Shimazu T, Ogasawara S. Effects of hypothalamic stimulation on gluconeogenesis and glycolysis in rat liver. Am J Physiol. 1975;228:1787-1793.
30. Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, et al. Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. Cell Metab. 2009;10:466-480.
31. Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci. 2003; 6:736-742. (Pubitemid 36792889)