Follistatin-derived peptide expression in muscle decreases adipose tissue mass and prevents hepatic steatosis

American Journal of Physiology - Endocrinology and Metabolism

Volumn 300, Issue 3, 2011, Pages

  Nakatani, Masashi ^a   Kokubo, Masahiro ^a   Ohsawa, Yutaka ^b   Sunada, Yoshihide ^b   Tsuchida, Kunihiro ^a  

^a FUJITA HEALTH UNIVERSITY   (Japan)

^b KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Adipocyte; Fatty liver; Glucose tolerance; Myostatin

Indexed keywords

ACTIVIN; FOLLISTATIN; MYOSTATIN; PEPTIDE ANTIBODY; TRANSFORMING GROWTH FACTOR BETA;

ADIPOCYTE; ADIPOSE TISSUE; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; FATTY LIVER; GENE DISRUPTION; GENE OVEREXPRESSION; GLUCOSE TOLERANCE; HISTOPATHOLOGY; IN VIVO STUDY; KNOCKOUT MOUSE; LIPID COMPOSITION; LIPID DIET; LIPID STORAGE; MALE; MOUSE; MUSCLE TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE;

ADIPOSE TISSUE; ANIMALS; BLOTTING, WESTERN; DIET; FATTY ACIDS; FATTY LIVER; FOLLISTATIN; GLUCOSE TOLERANCE TEST; LIVER; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MICE, OBESE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, SCANNING; MUSCLE, SKELETAL; OBESITY; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SMAD3 PROTEIN; TRIGLYCERIDES;

EID: 79952158513     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00430.2010     Document Type: Article

References (42)

1. Akpan I, Goncalves MD, Dhir R, Yin X, Pistilli EE, Bogdanovich S, Khurana TS, Ucran J, Lachey J, Ahima RS. The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity. Int J Obes (Lond) 33: 1265-1273, 2009.
2. Amthor H, Nicholas G, McKinnell I, Kemp CF, Sharma M, Kambadur R, Patel K. Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis. Dev Biol 270: 19-30, 2004. (Pubitemid 38596926)
3. Archibald FM, Skipski VP. Determination of fatty acid content and composition in ultramicro lipid samples by gas-liquid chromatography. J Lipid Res 7: 442-445, 1966.
4. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917, 1959.
5. Boman IA, Klemetsdal G, Blichfeldt T, Nafstad O, Vage DI. A frameshift mutation in the coding region of the myostatin gene (MSTN) affects carcass conformation and fatness in Norwegian White Sheep (Ovis aries). Anim Genet 40: 418-422, 2009.
6. Brand MD, Esteves TC. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab 2: 85-93, 2005.
7. Chan CB, Harper ME. Uncoupling proteins: role in insulin resistance and insulin insufficiency. Curr Diabetes Rev 2: 271-283, 2006. (Pubitemid 44194430)
8. Clop A, Marcq F, Takeda H, Pirottin D, Tordoir X, Bibe B, Bouix J, Caiment F, Elsen JM, Eychenne F, Larzul C, Laville E, Meish F, Milenkovic D, Tobin J, Charlier C, Georges M. A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nat Genet 38: 813-818, 2006. (Pubitemid 43980603)
9. Dobrzyn A, Ntambi JM. Stearoyl-CoA desaturase as a new drug target for obesity treatment. Obes Rev 6: 169-174, 2005. (Pubitemid 40604425)
10. Feldman BJ, Streeper RS, Farese RV Jr, Yamamoto KR. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci USA 103: 15675-15680, 2006. (Pubitemid 44625651)
11. Gamer LW, Cox KA, Small C, Rosen V. Gdf11 is a negative regulator of chondrogenesis and myogenesis in the developing chick limb. Dev Biol 229: 407-420, 2001.
12. Gilson HM, Schakman OR, Kalista S, Lause P, Tsuchida K, Thissen JP. Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin. Am J Physiol Endocrinol Metab 297: E157-E164, 2009.
13. Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC. Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLoS One 4: e4937, 2009.
14. Hamrick MW, Pennington C, Webb CN, Isales CM. Resistance to body fat gain in "double-muscled" mice fed a high-fat diet. Int J Obes (Lond) 30: 868-870, 2006.
15. Hill JJ, Davies MV, Pearson AA, Wang JH, Hewick RM, Wolfman NM, Qiu Y. The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum. J Biol Chem 277: 40735-40741, 2002. (Pubitemid 35215657)
16. Hock MB, Kralli A. Transcriptional control of mitochondrial biogenesis and function. Annu Rev Physiol 71: 177-203, 2009.
17. Ishigaki Y, Katagiri H, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Gao J, Ishihara H, Shimosegawa T, Sakoda H, Asano T, Oka Y. Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. Diabetes 54: 322-332, 2005.
18. Krauss S, Zhang CY, Lowell BB. The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol 6: 248-261, 2005. (Pubitemid 40314925)
19. Lee SJ. Regulation of muscle mass by myostatin. Annu Rev Cell Dev Biol 20: 61-86, 2004.
20. Li L, Shen JJ, Bournat JC, Huang L, Chattopadhyay A, Li Z, Shaw C, Graham BH, Brown CW. Activin signaling: effects on body composition and mitochondrial energy metabolism. Endocrinology 150: 3521-3529, 2010.
21. McPherron AC, Huynh TV, Lee SJ. Redundancy of myostatin and growth/differentiation factor 11 function. BMC Dev Biol 9: 24, 2009.
22. McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387: 83-90, 1997. (Pubitemid 27202654)
23. McPherron AC, Lee SJ. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci USA 94: 12457-12461, 1997. (Pubitemid 27492550)
24. McPherron AC, Lee SJ. Suppression of body fat accumulation in myostatin-deficient mice. J Clin Invest 109: 595-601, 2002. (Pubitemid 34204838)
25. Miyazaki M, Flowers MT, Sampath H, Chu K, Otzelberger C, Liu X, Ntambi JM. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab 6: 484-496, 2007. (Pubitemid 350163054)
26. Mosher DS, Quignon P, Bustamante CD, Sutter NB, Mellersh CS, Parker HG, Ostrander EA. A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genet 3: e79, 2007.
27. Nakatani M, Takehara Y, Sugino H, Matsumoto M, Hashimoto O, Hasegawa Y, Murakami T, Uezumi A, Takeda S, Noji S, Sunada Y, Tsuchida K. Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice. FASEB J 22: 477-487, 2008. (Pubitemid 351225584)
28. Ntambi JM, Miyazaki M. Recent insights into stearoyl-CoA desaturase-1. Curr Opin Lipidol 14: 255-261, 2003. (Pubitemid 36688204)
29. Ohsawa Y, Hagiwara H, Nakatani M, Yasue A, Moriyama K, Murakami T, Tsuchida Noji S K, Sunada Y. Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition. J Clin Invest 116 : 2924-2934, 2006. (Pubitemid 44684477)
30. Pangas SA, Jorgez CJ, Tran M, Agno J, Li X, Brown CW, Kumar TR, Matzuk MM. Intraovarian activins are required for female fertility. Mol Endocrinol 21: 2458-2471, 2007. (Pubitemid 47529358)
31. Saito S, Sugino K, Yamanouchi K, Kogawa K, Titani K, Shiota K, Takahashi M, Sugino H. Characterization of antisera directed against follistatin/activin- binding protein peptides. Endocrinol Jpn 38: 377-382, 1991.
32. Schuelke M, Wagner KR, Stolz LE, Hubner C, Riebel T, Komen W, Braun T, Tobin JF, Lee SJ. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med 350: 2682-2688, 2004. (Pubitemid 38788003)
33. Shelton GD, Engvall E. Gross muscle hypertrophy in whippet dogs is caused by a mutation in the myostatin gene. Neuromuscul Disord 17: 721-722, 2007. (Pubitemid 47362683)
34. Siriett V, Salerno MS, Berry C, Nicholas G, Bower R, Kambadur R, Sharma M. Antagonism of myostatin enhances muscle regeneration during sarcopenia. Mol Ther 15: 1463-1470, 2007. (Pubitemid 47099303)
35. Stolz LE, Li D, Qadri A, Jalenak M, Klaman LD, Tobin JF. Administration of myostatin does not alter fat mass in adult mice. Diabetes Obes Metab 10: 135-142, 2008.
36. Sugino K, Kurosawa N, Nakamura T, Takio K, Shimasaki S, Ling N, Titani K, Sugino H. Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell. J Biol Chem 268: 15579-15587, 1993. (Pubitemid 23222053)
37. Tsuchida K. Activins, myostatin and related TGF-beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders. Curr Drug Targets Immune Endocr Metabol Disord 4: 157-166, 2004.
38. Tsuchida K. Targeting myostatin for therapies against muscle-wasting disorders. Curr Opin Drug Discov Devel 11: 487-494, 2008. (Pubitemid 351950844)
39. Whittemore LA, Song K, Li X, Aghajanian J, Davies M, Girgenrath S, Hill JJ, Jalenak M, Kelley P, Knight A, Maylor R, O'Hara D, Pearson A, Quazi A, Ryerson S, Tan XY, Tomkinson KN, Veldman GM, Widom A, Wright JF, Wudyka S, Zhao L, Wolfman NM. Inhibition of myostatin in adult mice increases skeletal muscle mass and strength. Biochem Biophys Res Commun 300: 965-971, 2003.
40. Wolfman NM, McPherron AC, Pappano WN, Davies MV, Song K, Tomkinson KN, Wright JF, Zhao L, Sebald SM, Greenspan DS, Lee SJ. Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases. Proc Natl Acad Sci USA 100: 15842-15846, 2003. (Pubitemid 38021077)
41. Yang J, Zhao B. Postnatal expression of myostatin propeptide cDNA maintained high muscle growth and normal adipose tissue mass in transgenic mice fed a high-fat diet. Mol Reprod Dev 73: 462-469, 2006. (Pubitemid 43376574)
42. Zhao B, Wall RJ, Yang J. Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. Biochem Biophys Res Commun 337: 248-255, 2005. (Pubitemid 41393786)