-
1
-
-
0346455774
-
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
-
DOI 10.1101/gad.1158703
-
Aguirre, A. J., Bardeesy, N., Sinha, M., Lopez, L., Tuveson, D. A., Horner, J., Redston, M. S. and DePinho, R. A. (2003). Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 17, 3112-3126. (Pubitemid 38040774)
-
(2003)
Genes and Development
, vol.17
, Issue.24
, pp. 3112-3126
-
-
Aguirre, A.J.1
Bardeesy, N.2
Sinha, M.3
Lopez, L.4
Tuveson, D.A.5
Horner, J.6
Redston, M.S.7
DePinho, R.A.8
-
2
-
-
38349058510
-
Ptf1a is a molecular determinant for both glutamatergic and GABAergic neurons in the hindbrain
-
Aldinger, K. A. and Elsen, G. E. (2008). Ptf1a is a molecular determinant for both glutamatergic and GABAergic neurons in the hindbrain. J. Neurosci. 28, 338-339.
-
(2008)
J. Neurosci.
, vol.28
, pp. 338-339
-
-
Aldinger, K.A.1
Elsen, G.E.2
-
3
-
-
84874495992
-
Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development
-
Aref, D., Moffatt, C. J., Agnihotri, S., Ramaswamy, V., Dubuc, A. M., Northcott, P. A., Taylor, M. D., Perry, A., Olson, J. M., Eberhart, C. G. et al. (2013). Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development. Brain Pathol. 23, 178-191.
-
(2013)
Brain Pathol
, vol.23
, pp. 178-191
-
-
Aref, D.1
Moffatt, C.J.2
Agnihotri, S.3
Ramaswamy, V.4
Dubuc, A.M.5
Northcott, P.A.6
Taylor, M.D.7
Perry, A.8
Olson, J.M.9
Eberhart, C.G.10
-
4
-
-
84883321452
-
Signaling pathways mediating epithelial-mesenchymal crosstalk in pancreatic cancer: Hedgehog, Notch and TGFβ
-
(ed. P. J. Grippo and H. G. Munshi), Chapter 7. Trivandrum, India: Transworld Research Network
-
Bailey, J. M. and Leach, S. D. (2012). Signaling pathways mediating epithelial-mesenchymal crosstalk in pancreatic cancer: Hedgehog, Notch and TGFβ. In Pancreatic Cancer and Tumor Microenvironment (ed. P. J. Grippo and H. G. Munshi), Chapter 7. Trivandrum, India: Transworld Research Network.
-
(2012)
Pancreatic Cancer and Tumor Microenvironment
-
-
Bailey, J.M.1
Leach, S.D.2
-
5
-
-
0036883940
-
Pancreatic cancer biology and genetics
-
DOI 10.1038/nrc949
-
Bardeesy, N. and DePinho, R. A. (2002). Pancreatic cancer biology and genetics. Nat. Rev. Cancer 2, 897-909. (Pubitemid 37328891)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.12
, pp. 897-909
-
-
Bardeesy, N.1
DePinho, R.A.2
-
6
-
-
33751251034
-
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
-
DOI 10.1101/gad.1478706
-
Bardeesy, N., Cheng, K. H., Berger, J. H., Chu, G. C., Pahler, J., Olson, P., Hezel, A. F., Horner, J., Lauwers, G. Y., Hanahan, D. et al. (2006). Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev. 20, 3130-3146. (Pubitemid 44790628)
-
(2006)
Genes and Development
, vol.20
, Issue.22
, pp. 3130-3146
-
-
Bardeesy, N.1
Cheng, K.-H.2
Berger, J.H.3
Chu, G.C.4
Pahler, J.5
Olson, P.6
Hezel, A.F.7
Horner, J.8
Lauwers, G.Y.9
Hanahan, D.10
DePinho, R.A.11
-
7
-
-
84862799616
-
Hedgehog-mediated regulation of PPARã controls metabolic patterns in neural precursors and shh-driven medulloblastoma
-
Bhatia, B., Potts, C. R., Guldal, C., Choi, S., Korshunov, A., Pfister, S., Kenney, A. M. and Nahlé, Z. A. (2012). Hedgehog-mediated regulation of PPARã controls metabolic patterns in neural precursors and shh-driven medulloblastoma. Acta Neuropathol. 123, 587-600.
-
(2012)
Acta Neuropathol
, vol.123
, pp. 587-600
-
-
Bhatia, B.1
Potts, C.R.2
Guldal, C.3
Choi, S.4
Korshunov, A.5
Pfister, S.6
Kenney, A.M.7
Nahlé, Z.A.8
-
8
-
-
80051668809
-
Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1
-
Chen, X., Liao, J., Lu, Y., Duan, X. and Sun, W. (2011). Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1. Pathol. Oncol. Res. 17, 257-261.
-
(2011)
Pathol. Oncol. Res.
, vol.17
, pp. 257-261
-
-
Chen, X.1
Liao, J.2
Lu, Y.3
Duan, X.4
Sun, W.5
-
9
-
-
84874942708
-
Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death
-
Conradt, L., Henrich, A., Wirth, M., Reichert, M., Lesina, M., Algul, H., Schmid, R. M., Kramer, O. H., Saur, D. and Schneider, G. (2012). Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death. Int. J. Cancer 132, 2248-2257.
-
(2012)
Int. J. Cancer
, vol.132
, pp. 2248-2257
-
-
Conradt, L.1
Henrich, A.2
Wirth, M.3
Reichert, M.4
Lesina, M.5
Algul, H.6
Schmid, R.M.7
Kramer, O.H.8
Saur, D.9
Schneider, G.10
-
10
-
-
84887137194
-
Emilin3 is required for notochord sheath integrity and interacts with Scube2 to regulate notochord-derived Hedgehog signals
-
Corallo, D., Schiavinato, A., Trapani, V., Moro, E., Argenton, F. and Bonaldo, P. (2013). Emilin3 is required for notochord sheath integrity and interacts with Scube2 to regulate notochord-derived Hedgehog signals. Development 140, 4594-4601.
-
(2013)
Development
, vol.140
, pp. 4594-4601
-
-
Corallo, D.1
Schiavinato, A.2
Trapani, V.3
Moro, E.4
Argenton, F.5
Bonaldo, P.6
-
11
-
-
79960383874
-
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis
-
Corcoran, R. B., Contino, G., Deshpande, V., Tzatsos, A., Conrad, C., Benes, C. H., Levy, D. E., Settleman, J., Engelman, J. A. and Bardeesy, N. (2011). STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. Cancer Res. 71, 5020-5029.
-
(2011)
Cancer Res
, vol.71
, pp. 5020-5029
-
-
Corcoran, R.B.1
Contino, G.2
Deshpande, V.3
Tzatsos, A.4
Conrad, C.5
Benes, C.H.6
Levy, D.E.7
Settleman, J.8
Engelman, J.A.9
Bardeesy, N.10
-
12
-
-
57749116315
-
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
-
De La O, J. P., Emerson, L. L., Goodman, J. L., Froebe, S. C., Illum, B. E., Curtis, A. B. and Murtaugh, L. C. (2008). Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc. Natl. Acad. Sci. USA 105, 18907-18912.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 18907-18912
-
-
De La O, J.P.1
Emerson, L.L.2
Goodman, J.L.3
Froebe, S.C.4
Illum, B.E.5
Curtis, A.B.6
Murtaugh, L.C.7
-
13
-
-
0032101178
-
Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
-
DOI 10.1093/emboj/17.11.3091
-
Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S. and Gauthier, J. M. (1998). Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17, 3091-3100. (Pubitemid 28254381)
-
(1998)
EMBO Journal
, vol.17
, Issue.11
, pp. 3091-3100
-
-
Dennler, S.1
Itoh, S.2
Vivien, D.3
Dijke, P.T.4
Huet, S.5
Gauthier, J.-M.6
-
14
-
-
84886426165
-
Crosstalk between p53 and TGF-β Signalling
-
294097
-
Elston, R. and Inman, G. J. (2012). Crosstalk between p53 and TGF-β Signalling. J. Signal Transduct. 2012, 294097.
-
(2012)
J. Signal Transduct.
, vol.2012
-
-
Elston, R.1
Inman, G.J.2
-
15
-
-
34748822998
-
Hypothetical progression model of pancreatic cancer with origin in the centroacinar-acinar compartment
-
DOI 10.1097/mpa.0b013e31805d0190, PII 0000667620071000000003
-
Esposito, I., Seiler, C., Bergmann, F., Kleeff, J., Friess, H. and Schirmacher, P. (2007). Hypothetical progression model of pancreatic cancer with origin in the centroacinar-acinar compartment. Pancreas 35, 212-217. (Pubitemid 47482512)
-
(2007)
Pancreas
, vol.35
, Issue.3
, pp. 212-217
-
-
Esposito, I.1
Seiler, C.2
Bergmann, F.3
Kleeff, J.4
Friess, H.5
Schirmacher, P.6
-
16
-
-
80053196613
-
Zebrafish as a model for the study of human cancer
-
Etchin, J., Kanki, J. P. and Look, A. T. (2011). Zebrafish as a model for the study of human cancer. Methods Cell Biol. 105, 309-337.
-
(2011)
Methods Cell Biol
, vol.105
, pp. 309-337
-
-
Etchin, J.1
Kanki, J.P.2
Look, A.T.3
-
17
-
-
79957905711
-
P53: Guardian of pancreatic epithelial identity
-
Ghosh, B. and Leach, S. D. (2011). p53: Guardian of pancreatic epithelial identity. Cell Cycle 10, 1717.
-
(2011)
Cell Cycle
, vol.10
, pp. 1717
-
-
Ghosh, B.1
Leach, S.D.2
-
18
-
-
33644785805
-
Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma
-
DOI 10.1016/j.ejca.2005.11.023, PII S0959804905011007
-
Gilbertson, R. J., Langdon, J. A., Hollander, A., Hernan, R., Hogg, T. L., Gajjar, A., Fuller, C. and Clifford, S. C. (2006). Mutational analysis of PDGFR-RAS/ MAPK pathway activation in childhood medulloblastoma. Eur. J. Cancer 42, 646-649. (Pubitemid 43343687)
-
(2006)
European Journal of Cancer
, vol.42
, Issue.5
, pp. 646-649
-
-
Gilbertson, R.J.1
Langdon, J.A.2
Hollander, A.3
Hernan, R.4
Hogg, T.L.5
Gajjar, A.6
Fuller, C.7
Clifford, S.C.8
-
19
-
-
36048952786
-
Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
-
DOI 10.1073/pnas.0703942104
-
Gironella, M., Seux, M., Xie, M. J., Cano, C., Tomasini, R., Gommeaux, J., Garcia, S., Nowak, J., Yeung, M. L., Jeang, K. T. et al. (2007). Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. Proc. Natl. Acad. Sci. USA 104, 16170-16175. (Pubitemid 350099380)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.41
, pp. 16170-16175
-
-
Gironella, M.1
Seux, M.2
Xie, M.-J.3
Cano, C.4
Tomasini, R.5
Gommeaux, J.6
Garcia, S.7
Nowak, J.8
Man, L.Y.9
Jeang, K.-T.10
Chaix, A.11
Fazli, L.12
Motoo, Y.13
Wang, Q.14
Rocchi, P.15
Russo, A.16
Gleave, M.17
Dagorn, J.-C.18
Iovanna, J.L.19
Carrier, A.20
Pebusque, M.-J.21
Dusetti, N.J.22
more..
-
20
-
-
84863637592
-
Think small: Zebrafish as a model system of human pathology
-
817341
-
Goldsmith, J. R. and Jobin, C. (2012). Think small: zebrafish as a model system of human pathology. J. Biomed. Biotechnol. 2012, 817341.
-
(2012)
J. Biomed. Biotechnol.
, vol.2012
-
-
Goldsmith, J.R.1
Jobin, C.2
-
21
-
-
84855610890
-
Desmosomal cadherins in zebrafish epiboly and gastrulation
-
Goonesinghe, A., Luan, X. M., Hurlstone, A. and Garrod, D. (2012). Desmosomal cadherins in zebrafish epiboly and gastrulation. BMC Dev. Biol. 12, 1.
-
(2012)
BMC Dev. Biol.
, vol.12
, pp. 1
-
-
Goonesinghe, A.1
Luan, X.M.2
Hurlstone, A.3
Garrod, D.4
-
22
-
-
54049131773
-
Signaling pathways in medulloblastoma
-
Guessous, F., Li, Y. and Abounader, R. (2008). Signaling pathways in medulloblastoma. J. Cell. Physiol. 217, 577-583.
-
(2008)
J. Cell. Physiol.
, vol.217
, pp. 577-583
-
-
Guessous, F.1
Li, Y.2
Abounader, R.3
-
23
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. and Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
24
-
-
84879693699
-
Tumoral epithelial and stromal expression of SMAD proteins in pancreatic ductal adenocarcinomas
-
Handra-Luca, A., Hammel, P., Sauvanet, A., Ruszniewski, P. and Couvelard, A. (2012). Tumoral epithelial and stromal expression of SMAD proteins in pancreatic ductal adenocarcinomas. J. Hepatobiliary Pancreat. Sci. 20, 294-302.
-
(2012)
J. Hepatobiliary Pancreat. Sci.
, vol.20
, pp. 294-302
-
-
Handra-Luca, A.1
Hammel, P.2
Sauvanet, A.3
Ruszniewski, P.4
Couvelard, A.5
-
25
-
-
84859437880
-
Role of Smads in TGFβ signaling
-
Heldin, C. H. and Moustakas, A. (2012). Role of Smads in TGFβ signaling. Cell Tissue Res. 347, 21-36.
-
(2012)
Cell Tissue Res
, vol.347
, pp. 21-36
-
-
Heldin, C.H.1
Moustakas, A.2
-
26
-
-
84859081186
-
Mouse models of pancreatic cancer
-
Herreros-Villanueva, M., Hijona, E., Cosme, A. and Bujanda, L. (2012a). Mouse models of pancreatic cancer. World J. Gastroenterol. 18, 1286-1294.
-
(2012)
World J. Gastroenterol.
, vol.18
, pp. 1286-1294
-
-
Herreros-Villanueva, M.1
Hijona, E.2
Cosme, A.3
Bujanda, L.4
-
27
-
-
84873931281
-
C-Met in pancreatic cancer stem cells: Therapeutic implications
-
Herreros-Villanueva, M., Zubia-Olascoaga, A. and Bujanda, L. (2012b). c-Met in pancreatic cancer stem cells: therapeutic implications. World J. Gastroenterol. 18, 5321-5323.
-
(2012)
World J. Gastroenterol.
, vol.18
, pp. 5321-5323
-
-
Herreros-Villanueva, M.1
Zubia-Olascoaga, A.2
Bujanda, L.3
-
28
-
-
84876969576
-
Significance of Notch1-signaling pathway in human pancreatic development and carcinogenesis
-
Hu, H., Zhou, L., Awadallah, A. and Xin, W. (2012). Significance of Notch1-signaling pathway in human pancreatic development and carcinogenesis. Appl. Immunohistochem. Mol. Morphol. 21, 242-247.
-
(2012)
Appl. Immunohistochem. Mol. Morphol.
, vol.21
, pp. 242-247
-
-
Hu, H.1
Zhou, L.2
Awadallah, A.3
Xin, W.4
-
29
-
-
84858288644
-
Epithelial-mesenchymal transition in tumor microenvironment
-
Jing, Y., Han, Z., Zhang, S., Liu, Y. and Wei, L. (2011). Epithelial-mesenchymal transition in tumor microenvironment. Cell Biosci 1, 29.
-
(2011)
Cell Biosci
, vol.1
, pp. 29
-
-
Jing, Y.1
Han, Z.2
Zhang, S.3
Liu, Y.4
Wei, L.5
-
30
-
-
82555198134
-
Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish
-
e27941
-
Jung, I. H., Jung, D. E., Park, Y. N., Song, S. Y. and Park, S. W. (2011). Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. PLoS ONE 6, e27941.
-
(2011)
PLoS ONE
, vol.6
-
-
Jung, I.H.1
Jung, D.E.2
Park, Y.N.3
Song, S.Y.4
Park, S.W.5
-
31
-
-
4143119161
-
Excision of the Tol2 transposable element of the medaka fish Oryzias latipes in Xenopus laevis and Xenopus tropicalis
-
DOI 10.1016/j.gene.2004.05.013, PII S037811190400304X
-
Kawakami, K., Imanaka, K., Itoh, M. and Taira, M. (2004). Excision of the Tol2 transposable element of the medaka fish Oryzias latipes in Xenopus laevis and Xenopus tropicalis. Gene 338, 93-98. (Pubitemid 39092415)
-
(2004)
Gene
, vol.338
, Issue.1
, pp. 93-98
-
-
Kawakami, K.1
Imanaka, K.2
Itoh, M.3
Taira, M.4
-
32
-
-
0032885350
-
TGF-β-1 up-regulates cyclin D1 expression in colo-357 cells, whereas suppression of cyclin D1 levels is associated with down-regulation of the type I TGF-β receptor
-
DOI 10.1002/(SICI)1097-0215(19991008)83:2<247::AID-IJC17>3.0.CO;2-0
-
Kornmann, M., Tangvoranuntakul, P. and Korc, M. (1999). TGF-beta-1 up-regulates cyclin D1 expression in COLO-357 cells, whereas suppression of cyclin D1 levels is associated with down-regulation of the type I TGF-beta receptor. Int. J. Cancer 83, 247-254. (Pubitemid 29449105)
-
(1999)
International Journal of Cancer
, vol.83
, Issue.2
, pp. 247-254
-
-
Kornmann, M.1
Tangvoranuntakul, P.2
Korc, M.3
-
33
-
-
36448963734
-
The Tol2kit: A multisite gateway-based construction Kit for Tol2 transposon transgenesis constructs
-
DOI 10.1002/dvdy.21343
-
Kwan, K. M., Fujimoto, E., Grabher, C., Mangum, B. D., Hardy, M. E., Campbell, D. S., Parant, J. M., Yost, H. J., Kanki, J. P. and Chien, C. B. (2007). The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs. Dev. Dyn. 236, 3088-3099. (Pubitemid 350175006)
-
(2007)
Developmental Dynamics
, vol.236
, Issue.11
, pp. 3088-3099
-
-
Kwan, K.M.1
Fujimoto, E.2
Grabher, C.3
Mangum, B.D.4
Hardy, M.E.5
Campbell, D.S.6
Parant, J.M.7
Yost, H.J.8
Kanki, J.P.9
Chien, C.-B.10
-
34
-
-
84859735599
-
The molecular basis of Notch signaling: A brief overview
-
Kwon, S. M., Alev, C., Lee, S. H. and Asahara, T. (2012). The molecular basis of Notch signaling: a brief overview. Adv. Exp. Med. Biol. 727, 1-14.
-
(2012)
Adv. Exp. Med. Biol.
, vol.727
, pp. 1-14
-
-
Kwon, S.M.1
Alev, C.2
Lee, S.H.3
Asahara, T.4
-
35
-
-
2942616871
-
Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas
-
DOI 10.1016/j.ydbio.2004.02.023, PII S0012160604001551
-
Lin, J. W., Biankin, A. V., Horb, M. E., Ghosh, B., Prasad, N. B., Yee, N. S., Pack, M. A. and Leach, S. D. (2004). Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Dev. Biol. 270, 474-486. (Pubitemid 38748566)
-
(2004)
Developmental Biology
, vol.270
, Issue.2
, pp. 474-486
-
-
Lin, J.W.1
Biankin, A.V.2
Horb, M.E.3
Ghosh, B.4
Prasad, N.B.5
Yee, N.S.6
Pack, M.A.7
Leach, S.D.8
-
36
-
-
84861944077
-
Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly-differentiated hepatocellular carcinoma cell lines
-
Lirdprapamongkol, K., Chiablaem, K., Sila-Asna, M., Surarit, R., Bunyaratvej, A. and Svasti, J. (2012). Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly-differentiated hepatocellular carcinoma cell lines. Biochem. Biophys. Res. Commun. 422, 429-435.
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.422
, pp. 429-435
-
-
Lirdprapamongkol, K.1
Chiablaem, K.2
Sila-Asna, M.3
Surarit, R.4
Bunyaratvej, A.5
Svasti, J.6
-
37
-
-
80053199978
-
Screening pancreatic oncogenes in zebrafish using the Gal4/UAS system
-
Liu, S. and Leach, S. D. (2011). Screening pancreatic oncogenes in zebrafish using the Gal4/UAS system. Methods Cell Biol. 105, 367-381.
-
(2011)
Methods Cell Biol
, vol.105
, pp. 367-381
-
-
Liu, S.1
Leach, S.D.2
-
38
-
-
0036479133
-
Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene
-
DOI 10.1074/jbc.M106826200
-
López-Rovira, T., Chalaux, E., Massagué, J., Rosa, J. L. and Ventura, F. (2002). Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene. J. Biol. Chem. 277, 3176-3185. (Pubitemid 34953179)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.5
, pp. 3176-3185
-
-
Lopez-Rovira, T.1
Chalaux, E.2
Massague, J.3
Rosa, J.L.4
Ventura, F.5
-
39
-
-
0038133109
-
Dysregulation of β-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma
-
DOI 10.1245/ASO.2003.05.003
-
Lowy, A. M., Fenoglio-Preiser, C., Kim, O. J., Kordich, J., Gomez, A., Knight, J., James, L. and Groden, J. (2003). Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma. Ann. Surg. Oncol. 10, 284-290. (Pubitemid 40486962)
-
(2003)
Annals of Surgical Oncology
, vol.10
, Issue.3
, pp. 284-290
-
-
Lowy, A.M.1
Fenoglio-Preiser, C.2
Kim, O.J.3
Kordich, J.4
Gomez, A.5
Knight, J.6
James, L.7
Groden, J.8
-
40
-
-
84870806275
-
Disputed paternity: The uncertain ancestry of pancreatic ductal neoplasia
-
Maitra, A. and Leach, S. D. (2012). Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia. Cancer Cell 22, 701-703.
-
(2012)
Cancer Cell
, vol.22
, pp. 701-703
-
-
Maitra, A.1
Leach, S.D.2
-
41
-
-
84861221146
-
Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration
-
Manfroid, I., Ghaye, A., Naye, F., Detry, N., Palm, S., Pan, L., Ma, T. P., Huang, W., Rovira, M., Martial, J. A. et al. (2012). Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration. Dev. Biol. 366, 268-278.
-
(2012)
Dev. Biol.
, vol.366
, pp. 268-278
-
-
Manfroid, I.1
Ghaye, A.2
Naye, F.3
Detry, N.4
Palm, S.5
Pan, L.6
Ma, T.P.7
Huang, W.8
Rovira, M.9
Martial, J.A.10
-
42
-
-
11844301282
-
Medulloblastoma: Developmental mechanisms out of control
-
DOI 10.1016/j.molmed.2004.11.008, PII S147149140400293X
-
Marino, S. (2005). Medulloblastoma: developmental mechanisms out of control. Trends Mol. Med. 11, 17-22. (Pubitemid 40092670)
-
(2005)
Trends in Molecular Medicine
, vol.11
, Issue.1
, pp. 17-22
-
-
Marino, S.1
-
43
-
-
83455176708
-
Aberrant signaling pathways in pancreatic cancer: A two compartment view
-
McCleary-Wheeler, A. L., McWilliams, R. and Fernandez-Zapico, M. E. (2012). Aberrant signaling pathways in pancreatic cancer: a two compartment view. Mol. Carcinog. 51, 25-39.
-
(2012)
Mol. Carcinog.
, vol.51
, pp. 25-39
-
-
McCleary-Wheeler, A.L.1
McWilliams, R.2
Fernandez-Zapico, M.E.3
-
44
-
-
84878754125
-
Generation and application of signaling pathway reporter lines in zebrafish
-
Moro, E., Vettori, A., Porazzi, P., Schiavone, M., Rampazzo, E., Casari, A., Ek, O., Facchinello, N., Astone, M., Zancan, I. et al. (2013). Generation and application of signaling pathway reporter lines in zebrafish. Mol. Genet. Genomics 288, 231-242.
-
(2013)
Mol. Genet. Genomics
, vol.288
, pp. 231-242
-
-
Moro, E.1
Vettori, A.2
Porazzi, P.3
Schiavone, M.4
Rampazzo, E.5
Casari, A.6
Ek, O.7
Facchinello, N.8
Astone, M.9
Zancan, I.10
-
45
-
-
76649105065
-
Betacatenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
-
Morris, J. P., 4th, Cano, D. A., Sekine, S., Wang, S. C. and Hebrok, M. (2010). Betacatenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J. Clin. Invest. 120, 508-520.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 508-520
-
-
Morris, I.V.J.P.1
Cano, D.A.2
Sekine, S.3
Wang, S.C.4
Hebrok, M.5
-
46
-
-
74949135901
-
Targeting Notch signaling in pancreatic cancer patients - Rationale for new therapy
-
Mysliwiec, P. and Boucher, M. J. (2009). Targeting Notch signaling in pancreatic cancer patients - rationale for new therapy. Adv. Med. Sci. 54, 136-142.
-
(2009)
Adv. Med. Sci.
, vol.54
, pp. 136-142
-
-
Mysliwiec, P.1
Boucher, M.J.2
-
47
-
-
3042618951
-
N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma
-
DOI 10.1158/1078-0432.CCR-0578-03
-
Nakajima, S., Doi, R., Toyoda, E., Tsuji, S., Wada, M., Koizumi, M., Tulachan, S. S., Ito, D., Kami, K., Mori, T. et al. (2004). N-cadherin expression and epithelialmesenchymal transition in pancreatic carcinoma. Clin. Cancer Res. 10, 4125-4133. (Pubitemid 38812492)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.12
, pp. 4125-4133
-
-
Nakajima, S.1
Doi, R.2
Toyoda, E.3
Tsuji, S.4
Wada, M.5
Koizumi, M.6
Tulachan, S.S.7
Ito, D.8
Kami, K.9
Mori, T.10
Kawaguchi, Y.11
Fujimoto, K.12
Hosotani, R.13
Imamura, M.14
-
48
-
-
44649114063
-
Oncogenic KRAS Induces Progenitor Cell Expansion and Malignant Transformation in Zebrafish Exocrine Pancreas
-
DOI 10.1053/j.gastro.2008.02.084, PII S0016508508004198
-
Park, S. W., Davison, J. M., Rhee, J., Hruban, R. H., Maitra, A. and Leach, S. D. (2008). Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology 134, 2080-2090. (Pubitemid 351783259)
-
(2008)
Gastroenterology
, vol.134
, Issue.7
, pp. 2080-2090
-
-
Park, S.W.1
Davison, J.M.2
Rhee, J.3
Hruban, R.H.4
Maitra, A.5
Leach, S.D.6
-
49
-
-
70349487183
-
Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas
-
Parsons, M. J., Pisharath, H., Yusuff, S., Moore, J. C., Siekmann, A. F., Lawson, N. and Leach, S. D. (2009). Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mech. Dev. 126, 898-912.
-
(2009)
Mech. Dev.
, vol.126
, pp. 898-912
-
-
Parsons, M.J.1
Pisharath, H.2
Yusuff, S.3
Moore, J.C.4
Siekmann, A.F.5
Lawson, N.6
Leach, S.D.7
-
50
-
-
34247644810
-
Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression
-
DOI 10.1073/pnas.0605699104
-
Pascual, M., Abasolo, I., Mingorance-Le Meur, A., Martínez, A., Del Rio, J. A., Wright, C. V., Real, F. X. and Soriano, E. (2007). Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression. Proc. Natl. Acad. Sci. USA 104, 5193-5198. (Pubitemid 47186198)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.12
, pp. 5193-5198
-
-
Pascual, M.1
Abasolo, I.2
Meur, A.M.-L.3
Martinez, A.4
Del Rio, J.A.5
Wright, C.V.E.6
Real, F.X.7
Soriano, E.8
-
51
-
-
79952698464
-
12D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin
-
12D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin. Br. J. Cancer 104, 1038-1048.
-
(2011)
Br. J. Cancer
, vol.104
, pp. 1038-1048
-
-
Rachagani, S.1
Senapati, S.2
Chakraborty, S.3
Ponnusamy, M.P.4
Kumar, S.5
Smith, L.M.6
Jain, M.7
Batra, S.K.8
-
52
-
-
84856088337
-
EMT and dissemination precede pancreatic tumor formation
-
Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H. et al. (2012). EMT and dissemination precede pancreatic tumor formation. Cell 148, 349-361.
-
(2012)
Cell
, vol.148
, pp. 349-361
-
-
Rhim, A.D.1
Mirek, E.T.2
Aiello, N.M.3
Maitra, A.4
Bailey, J.M.5
McAllister, F.6
Reichert, M.7
Beatty, G.L.8
Rustgi, A.K.9
Vonderheide, R.H.10
-
53
-
-
79251591067
-
Aberrant signaling pathways in medulloblastomas: A stem cell connection
-
Rodini, C. O., Suzuki, D. E., Nakahata, A. M., Pereira, M. C., Janjoppi, L., Toledo, S. R. and Okamoto, O. K. (2010). Aberrant signaling pathways in medulloblastomas: a stem cell connection. Arq. Neuropsiquiatr. 68, 947-952.
-
(2010)
Arq. Neuropsiquiatr.
, vol.68
, pp. 947-952
-
-
Rodini, C.O.1
Suzuki, D.E.2
Nakahata, A.M.3
Pereira, M.C.4
Janjoppi, L.5
Toledo, S.R.6
Okamoto, O.K.7
-
54
-
-
84866875005
-
Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential
-
e46391
-
Salnikov, A. V., Liu, L., Platen, M., Gladkich, J., Salnikova, O., Ryschich, E., Mattern, J., Moldenhauer, G., Werner, J., Schemmer, P. et al. (2012). Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential. PLoS ONE 7, e46391.
-
(2012)
PLoS ONE
, vol.7
-
-
Salnikov, A.V.1
Liu, L.2
Platen, M.3
Gladkich, J.4
Salnikova, O.5
Ryschich, E.6
Mattern, J.7
Moldenhauer, G.8
Werner, J.9
Schemmer, P.10
-
55
-
-
80052267874
-
Vimentin in cancer and its potential as a molecular target for cancer therapy
-
Satelli, A. and Li, S. (2011). Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell. Mol. Life Sci. 68, 3033-3046.
-
(2011)
Cell. Mol. Life Sci.
, vol.68
, pp. 3033-3046
-
-
Satelli, A.1
Li, S.2
-
56
-
-
78649369742
-
The epithelial-mesenchymal transition (EMT) phenomenon
-
Savagner, P. (2010). The epithelial-mesenchymal transition (EMT) phenomenon. Ann. Oncol. 21 Suppl. 7, vii89-vii92.
-
(2010)
Ann. Oncol.
, vol.21
, Issue.SUPPL. 7
-
-
Savagner, P.1
-
57
-
-
84872416422
-
Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma
-
Scanlon, C. S., Van Tubergen, E. A., Inglehart, R. C. and D'Silva, N. J. (2013). Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma. J. Dent. Res. 92, 114-121.
-
(2013)
J. Dent. Res.
, vol.92
, pp. 114-121
-
-
Scanlon, C.S.1
Van Tubergen, E.A.2
Inglehart, R.C.3
D'Silva, N.J.4
-
58
-
-
9644255692
-
Mutations in PTF1A cause pancreatic and cerebellar agenesis
-
DOI 10.1038/ng1475
-
Sellick, G. S., Barker, K. T., Stolte-Dijkstra, I., Fleischmann, C., Coleman, R. J., Garrett, C., Gloyn, A. L., Edghill, E. L., Hattersley, A. T., Wellauer, P. K. et al. (2004). Mutations in PTF1A cause pancreatic and cerebellar agenesis. Nat. Genet. 36, 1301-1305. (Pubitemid 39577939)
-
(2004)
Nature Genetics
, vol.36
, Issue.12
, pp. 1301-1305
-
-
Sellick, G.S.1
Barker, K.T.2
Stolte-Dijkstra, I.3
Fleischmann, C.4
Coleman, R.J.5
Garrett, C.6
Gloyn, A.L.7
Edghill, E.L.8
Hattersley, A.T.9
Wellauer, P.K.10
Goodwin, G.11
Houlston, R.S.12
-
59
-
-
48349089940
-
Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: Evidence for three protein isoforms of IBtk
-
Spatuzza, C., Schiavone, M., Di Salle, E., Janda, E., Sardiello, M., Fiume, G., Fierro, O., Simonetta, M., Argiriou, N., Faraonio, R. et al. (2008). Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. Nucleic Acids Res. 36, 4402-4416.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 4402-4416
-
-
Spatuzza, C.1
Schiavone, M.2
Di Salle, E.3
Janda, E.4
Sardiello, M.5
Fiume, G.6
Fierro, O.7
Simonetta, M.8
Argiriou, N.9
Faraonio, R.10
-
60
-
-
24944572259
-
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
-
DOI 10.1016/j.ccr.2005.07.015, PII S1535610805002369
-
Stanger, B. Z., Stiles, B., Lauwers, G. Y., Bardeesy, N., Mendoza, M., Wang, Y., Greenwood, A., Cheng, K. H., McLaughlin, M., Brown, D. et al. (2005). Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 8, 185-195. (Pubitemid 41317590)
-
(2005)
Cancer Cell
, vol.8
, Issue.3
, pp. 185-195
-
-
Stanger, B.Z.1
Stiles, B.2
Lauwers, G.Y.3
Bardeesy, N.4
Mendoza, M.5
Wang, Y.6
Greenwood, A.7
Cheng, K.-H.8
McLaughlin, M.9
Brown, D.10
DePinho, R.A.11
Wu, H.12
Melton, D.A.13
Dor, Y.14
-
61
-
-
48649088341
-
Catch of the day: Zebrafish as a human cancer model
-
Stoletov, K. and Klemke, R. (2008). Catch of the day: zebrafish as a human cancer model. Oncogene 27, 4509-4520.
-
(2008)
Oncogene
, vol.27
, pp. 4509-4520
-
-
Stoletov, K.1
Klemke, R.2
-
62
-
-
33751257769
-
Pancreatic Regeneration in Chronic Pancreatitis Requires Activation of the Notch Signaling Pathway
-
DOI 10.1016/j.gassur.2006.08.017, PII S1091255X06003878
-
Su, Y., Büchler, P., Gazdhar, A., Giese, N., Reber, H. A., Hines, O. J., Giese, T., Büchler, M. W. and Friess, H. (2006). Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. J. Gastrointest. Surg. 10, 1230-1242. (Pubitemid 44781199)
-
(2006)
Journal of Gastrointestinal Surgery
, vol.10
, Issue.9
, pp. 1230-1242
-
-
Su, Y.1
Buchler, P.2
Gazdhar, A.3
Giese, N.4
Reber, H.A.5
Hines, O.J.6
Giese, T.7
Buchler, M.W.8
Friess, H.9
-
63
-
-
0036804438
-
BMP signalling regulates anteroposterior endoderm patterning in zebrafish
-
DOI 10.1016/S0925-4773(02)00252-6, PII S0925477302002526
-
Tiso, N., Filippi, A., Pauls, S., Bortolussi, M. and Argenton, F. (2002). BMP signalling regulates anteroposterior endoderm patterning in zebrafish. Mech. Dev. 118, 29-37. (Pubitemid 35292119)
-
(2002)
Mechanisms of Development
, vol.118
, Issue.1-2
, pp. 29-37
-
-
Tiso, N.1
Filippi, A.2
Pauls, S.3
Bortolussi, M.4
Argenton, F.5
-
64
-
-
35348901453
-
Basics of TGF-beta and pancreatic cancer
-
Truty, M. J. and Urrutia, R. (2007). Basics of TGF-beta and pancreatic cancer. Pancreatology 7, 423-435.
-
(2007)
Pancreatology
, vol.7
, pp. 423-435
-
-
Truty, M.J.1
Urrutia, R.2
-
65
-
-
79957580066
-
Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: Control by Rac1
-
Ungefroren, H., Groth, S., Sebens, S., Lehnert, H., Gieseler, F. and Fändrich, F. (2011). Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. Mol. Cancer 10, 67.
-
(2011)
Mol. Cancer
, vol.10
, pp. 67
-
-
Ungefroren, H.1
Groth, S.2
Sebens, S.3
Lehnert, H.4
Gieseler, F.5
Fändrich, F.6
-
66
-
-
79960834796
-
Bone morphogenetic protein -4 and -5 in pancreatic cancer - Novel bidirectional players
-
Virtanen, S., Alarmo, E. L., Sandström, S., Ampuja, M. and Kallioniemi, A. (2011). Bone morphogenetic protein -4 and -5 in pancreatic cancer - novel bidirectional players. Exp. Cell Res. 317, 2136-2146.
-
(2011)
Exp. Cell Res.
, vol.317
, pp. 2136-2146
-
-
Virtanen, S.1
Alarmo, E.L.2
Sandström, S.3
Ampuja, M.4
Kallioniemi, A.5
-
67
-
-
33646148038
-
Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter
-
Wan, H., Korzh, S., Li, Z., Mudumana, S. P., Korzh, V., Jiang, Y. J., Lin, S. and Gong, Z. (2006). Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter. Exp. Cell Res. 312, 1526-1539.
-
(2006)
Exp. Cell Res.
, vol.312
, pp. 1526-1539
-
-
Wan, H.1
Korzh, S.2
Li, Z.3
Mudumana, S.P.4
Korzh, V.5
Jiang, Y.J.6
Lin, S.7
Gong, Z.8
-
68
-
-
33645049305
-
Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells
-
Wang, Z., Banerjee, S., Li, Y., Rahman, K. M., Zhang, Y. and Sarkar, F. H. (2006a). Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res. 66, 2778-2784.
-
(2006)
Cancer Res
, vol.66
, pp. 2778-2784
-
-
Wang, Z.1
Banerjee, S.2
Li, Y.3
Rahman, K.M.4
Zhang, Y.5
Sarkar, F.H.6
-
69
-
-
33645473185
-
Downregulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
-
Wang, Z., Zhang, Y., Li, Y., Banerjee, S., Liao, J. and Sarkar, F. H. (2006b). Downregulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol. Cancer Ther. 5, 483-493.
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 483-493
-
-
Wang, Z.1
Zhang, Y.2
Li, Y.3
Banerjee, S.4
Liao, J.5
Sarkar, F.H.6
-
70
-
-
73149105708
-
Role of Sonic hedgehog signaling and the expression of its components in human embryonic stem cells
-
Wu, S. M., Choo, A. B., Yap, M. G. and Chan, K. K. (2010). Role of Sonic hedgehog signaling and the expression of its components in human embryonic stem cells. Stem Cell Res. 4, 38-49.
-
(2010)
Stem Cell Res
, vol.4
, pp. 38-49
-
-
Wu, S.M.1
Choo, A.B.2
Yap, M.G.3
Chan, K.K.4
-
71
-
-
84903945049
-
The role of EMT in pancreatic cancer progression
-
1000e121
-
Wu, Q., Miele, L., Sarkar, F. H. and Wang, Z. (2012). The role of EMT in pancreatic cancer progression. Pancreat. Disord. Ther. 2, 1000e121.
-
(2012)
Pancreat. Disord. Ther
, vol.2
-
-
Wu, Q.1
Miele, L.2
Sarkar, F.H.3
Wang, Z.4
-
72
-
-
80755187146
-
Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells
-
Xu, X., Browning, V. L. and Odorico, J. S. (2011). Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mech. Dev. 128, 412-427.
-
(2011)
Mech. Dev.
, vol.128
, pp. 412-427
-
-
Xu, X.1
Browning, V.L.2
Odorico, J.S.3
-
73
-
-
84864353742
-
Wnt signaling in development and disease
-
Yang, Y. (2012). Wnt signaling in development and disease. Cell Biosci 2, 14.
-
(2012)
Cell Biosci
, vol.2
, pp. 14
-
-
Yang, Y.1
-
74
-
-
1642287386
-
Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates
-
DOI 10.1016/j.ydbio.2003.12.016, PII S0012160604000120
-
Zecchin, E., Mavropoulos, A., Devos, N., Filippi, A., Tiso, N., Meyer, D., Peers, B., Bortolussi, M. and Argenton, F. (2004). Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates. Dev. Biol. 268, 174-184. (Pubitemid 38367859)
-
(2004)
Developmental Biology
, vol.268
, Issue.1
, pp. 174-184
-
-
Zecchin, E.1
Mavropoulos, A.2
Devos, N.3
Filippi, A.4
Tiso, N.5
Meyer, D.6
Peers, B.7
Bortolussi, M.8
Argenton, F.9
-
75
-
-
84863229401
-
Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP)
-
Zhou, B., Liu, Y., Kahn, M., Ann, D. K., Han, A., Wang, H., Nguyen, C., Flodby, P., Zhong, Q., Krishnaveni, M. S. et al. (2012). Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J. Biol. Chem. 287, 7026-7038
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(2012)
J. Biol. Chem.
, vol.287
, pp. 7026-7038
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Zhou, B.1
Liu, Y.2
Kahn, M.3
Ann, D.K.4
Han, A.5
Wang, H.6
Nguyen, C.7
Flodby, P.8
Zhong, Q.9
Krishnaveni, M.S.10
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