Aberrant hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Jung, In Hye ^a   Jung, Dawoon E ^a   Park, Young Nyun ^a   Song, Si Young ^a   Park, Seung Woo ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPAMINE; ENZYME INHIBITOR; GELATINASE B; HEDGEHOG PRIMARY INHIBITOR 4; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; IHHA PROTEIN, ZEBRAFISH; LIGAND; PRIMER DNA; SHHA PROTEIN, ZEBRAFISH; ZEBRAFISH PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYSTIC FIBROSIS; EMBRYO; ENZYME ACTIVATION; EPIGENETICS; IMMUNOREACTIVITY; MORPHOLOGY; MYOFIBROBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREATIC STELLATE CELL; PHENOTYPE; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; TRANSGENE; ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; CYTOLOGY; FIBROBLAST; FIBROSIS; GENETICS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; METABOLISM; METHODOLOGY; PANCREAS; PATHOLOGY; TRANSGENIC ANIMAL; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL DIFFERENTIATION; DNA PRIMERS; FIBROBLASTS; FIBROSIS; GREEN FLUORESCENT PROTEINS; HEDGEHOG PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIGANDS; PANCREAS; PHENOTYPE; TRANSGENES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 82555198134     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027941     Document Type: Article

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