Canonical TGF-β pathway activity is a predictor of shh-driven medulloblastoma survival and delineates putative precursors in cerebellar development

Brain Pathology

Volumn 23, Issue 2, 2013, Pages 178-191

  Aref, Donya ^a,b,c   Moffatt, Connor J ^b,c   Agnihotri, Sameer ^b   Ramaswamy, Vijay ^b   Dubuc, Adrian M ^b   Northcott, Paul A ^b   Taylor, Michael D ^b   Perry, Arie ^d   Olson, James M ^e   Eberhart, Charles G ^f   Croul, Sidney E ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

medulloblastoma; prognosis; Smad3; TGF beta

Indexed keywords

CYCLIN DEPENDENT KINASE 5; SMAD3 PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CELL NUCLEUS; CEREBELLUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE SEVERITY; DNA MICROARRAY; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MEDULLOBLASTOMA; METASTASIS; MOUSE; NEURAL STEM CELL; NONHUMAN; OVERALL SURVIVAL; PATHOPHYSIOLOGY; PREDICTION; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRANSCRIPTOMICS; TUMOR GROWTH; TUMOR LOCALIZATION; TUMOR RECURRENCE;

ADULT; ANIMALS; CEREBELLAR NEOPLASMS; CEREBELLUM; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; GENE REGULATORY NETWORKS; HEDGEHOG PROTEINS; HUMANS; MALE; MEDULLOBLASTOMA; MICE; NEURONS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84874495992     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2012.00631.x     Document Type: Article

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