Hedgehog-mediated regulation of PPARc controls metabolic patterns in neural precursors and shh-driven medulloblastoma

Acta Neuropathologica

Volumn 123, Issue 4, 2012, Pages 587-600

  Bhatia, Bobby ^a,e   Potts, Chad R ^b   Guldal, Cemile ^a   Choi, SunPhil ^b   Korshunov, Andrey ^d   Pfister, Stefan ^d   Kenney, Anna M ^b,c   Nahlé, Zaher A ^b,c  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e MILLIPORE CORPORATION   (United States)

Author keywords

Cancer; Cerebellum; Glycolysis; Medulloblastoma; Metabolism; PPAR ; Sonic hedgehog; Tumor metabolism

Indexed keywords

GLUCOSE TRANSPORTER 4; HEXOKINASE; HEXOKINASE 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PYRUVATE KINASE; PYRUVATE KINASE M2; RETINOBLASTOMA PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CELL CYCLE REGULATION; CELL DEATH; CELL METABOLISM; CELL PROLIFERATION; CEREBELLAR GRANULE NEURAL PRECURSOR; CEREBELLUM; CONTROLLED STUDY; EX VIVO STUDY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; IN VIVO STUDY; MEDULLOBLASTOMA; METABOLIC REGULATION; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL;

ANILIDES; ANIMALS; ANIMALS, NEWBORN; AZO COMPOUNDS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARRIER PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; CEREBELLAR NEOPLASMS; CEREBELLUM; DNA-BINDING PROTEINS; E2F1 TRANSCRIPTION FACTOR; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOGS; HEXOKINASE; HUMANS; KI-67 ANTIGEN; MEDULLOBLASTOMA; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURAL STEM CELLS; NEUROPEPTIDES; POSITRON-EMISSION TOMOGRAPHY; PPAR GAMMA; THYROID HORMONES; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSDUCTION, GENETIC;

EID: 84862799616     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-012-0968-6     Document Type: Article

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